CN112168891A

CN112168891A - Preparation method and application of essential oil blasting bead containing traditional Chinese medicine composition

Info

Publication number: CN112168891A
Application number: CN202011061800.6A
Authority: CN
Inventors: 贾振华; 李晓燕; 许红辉; 李文烈; 马军; 林志宏; 李世松; 王谦; 信璨; 赵美红
Original assignee: Shijiazhuang Yiling Pharmaceutical Co Ltd
Current assignee: Shijiazhuang Yiling Pharmaceutical Co Ltd
Priority date: 2020-09-30
Filing date: 2020-09-30
Publication date: 2021-01-05
Anticipated expiration: 2040-09-30
Also published as: CN112168891B

Abstract

The invention discloses a preparation method and application of an essential oil bead containing a traditional Chinese medicine composition, and adopts the technical scheme that the method comprises a bead blasting forming liquid preparation process, a bead blasting primary forming process is carried out on the essential oil containing the traditional Chinese medicine composition and the bead blasting forming liquid by means of equipment, and a drying and shaping process is carried out on the formed bead blasting, wherein the key is as follows: and a bead blasting and recoating procedure is added after the bead blasting initial forming procedure and before the drying and shaping procedure. The invention has the beneficial effects that through two-step wrapping, the coating forming of the essential oil of the traditional Chinese medicine composition can be realized, and the volatilization of the components of the traditional Chinese medicine composition can be avoided. The product is particularly suitable for masks, sachets, fragrance products or cigarette products, is convenient to store, is designed to be a cavity for placing the popping beads in an application product when in use, only needs to be pinched and exploded when in use, can volatilize the traditional Chinese medicine essential oil components, and can be pinched and exploded or the popping beads are taken out and put into the cavity after volatilizing for a period of time.

Description

Preparation method and application of essential oil blasting bead containing traditional Chinese medicine composition

Technical Field

The invention belongs to the field of bead blasting preparation, relates to a preparation method and application of essential oil bead blasting, and particularly relates to a preparation method and application of essential oil bead blasting containing a traditional Chinese medicine composition.

Background

The puffed beads are also called as fragrant pills, brittle capsules and beads. The popping beads are crushable beads that have a popping feel when crushed. The prior art pops are typically used in cigarettes.

With the appearance and spread of globalized Xinguan pneumonia diseases, medical supplies such as masks, disinfection and sterilization aromatherapy products and the like become indispensable articles for people in daily life. Through a plurality of experiments, the Chinese herbal medicine ingredients are approved by the world to have resistance to the novel coronavirus. If the mask and other medical supplies can contain traditional Chinese medicine components, the mask is not a good thing but a harmless thing for resisting the novel coronavirus. However, it is the subject to be solved by the way that some medical care products such as a mask contain traditional Chinese medicine components.

Let us take a mask as an example to analyze the characteristics of the medical care products. The mask mainly plays a role in filtering and purifying outside air, and prevents substances from being inhaled into respiratory tracts and lungs from the outside. The main function of some traditional Chinese medicine fumigation products is to enable people to inhale some traditional Chinese medicine components into the bodies of people, and the combination of the traditional Chinese medicine fumigation products and the traditional Chinese medicine components is very contradictory. The final approach is only one, namely the function of volatilizing traditional Chinese medicine components is added on the inner side of the mask. Some existing cigarette products have a popping bead, and a cigarette holder can inhale various tastes contained in the popping bead when the popping bead is crushed and smoking is carried out. Through this inspiration, researchers have discovered that if herbal ingredients can be placed in the mask, inhalation of herbal ingredients through the nose and mouth of the person can also be achieved. The form of the popping beads is selected because the Chinese herbal medicines have strong volatility, the popping beads can be conveniently stored when not used, and the Chinese herbal medicines can be directly squeezed to be broken when the Chinese herbal medicines need to be supplemented, so that the Chinese herbal medicine components in the popping beads can be adhered to the mask.

The skilled in the art is also exploring gradually, the preparation process of the exploded bead is already mature, for example, patent application No. 2019100986108 discloses a preparation method of the exploded bead with essential oil components, which is mainly to drop an essential oil emulsion into an exploded bead forming liquid by using a three-phase flow pill dropping device, to coat the oil emulsion with the exploded bead forming liquid, and then to produce the exploded bead of the essential oil through post-treatment procedures such as drying and shaping. The essential oil is not easy to volatilize at normal temperature and is easy to volatilize only when heated to a certain temperature. However, the traditional Chinese medicine components are volatile at normal temperature, so the preparation of the popple containing the traditional Chinese medicine components is a more serious problem, and after the preparation is finished, the popple is used on a mask product, and then a user purchases and uses the product, and a long period is needed, so that how to ensure that the traditional Chinese medicine components are always kept in the popple is a great problem faced by technical personnel in the field.

Disclosure of Invention

The invention aims to solve the technical problem that traditional Chinese medicine components in the exploded bead are not easy to volatilize, designs a preparation method and application of an essential oil exploded bead containing a traditional Chinese medicine composition, and is realized by improving a preparation process of the exploded bead.

The invention adopts the technical scheme that the preparation method of the essential oil bead containing the traditional Chinese medicine composition comprises a bead blasting forming liquid preparation process, wherein the bead blasting primary forming process is carried out on the essential oil containing the traditional Chinese medicine composition and the bead blasting forming liquid by means of equipment, and the drying and shaping process is carried out on the formed bead blasting, and the key is as follows: adding a bead blasting recoating procedure after the bead blasting primary forming procedure and before the drying and shaping procedure, wherein the bead blasting recoating procedure is to put the primary formed bead blasting into a storage hopper of a pill press, convey capsule shell glue solution into a glue solution box of the pill press, start the pill press to press pills, and finish the recoating procedure, wherein the capsule shell thickness is controlled to be 0.2-1mm, the recoated bead blasting weight is 0.2-0.25g, the ambient temperature is 18-24 ℃, and the humidity is 45-65%;

the preparation method of the capsule shell glue solution comprises the following steps:

a. preparing raw materials in parts by weight: 90-110 parts of gelatin, 130 parts of sorbitol solution 110-90 parts of glycerin, 4-6 parts of sucralose, 0.2-0.3 part of lemon yellow, 0.1-0.2 part of brilliant blue and 4-6 parts of acetate starch;

b. mixing acetate starch and partial glycerin, grinding by using a colloid grinder, and sieving by using a 300-mesh sieve to obtain a mixture of the acetate starch and the glycerin for later use;

c. putting the sorbitol solution, the residual glycerol, the sucralose, the lemon yellow, the brilliant blue and the glycerol mixture into a vacuum gelatin tank, starting a stirring paddle, heating to 60-70 ℃, putting the gelatin, stirring while adding the gelatin to obtain a uniform gelatin solution, stopping stirring, standing, vacuumizing until the vacuum degree is-0.05-0.08 Mpa, degassing for 0.8-1.2 hours until the gelatin solution is free of bubbles, cooling to 58-60 ℃, discharging the gelatin, and placing in a 50 ℃ heat-preserving container for heat preservation to obtain the capsule shell gelatin solution.

In the step a, the following raw materials are prepared according to the parts by weight: 100 parts of gelatin, 120 parts of sorbitol solution, 80 parts of glycerin, 5 parts of sucralose, 0.25 part of lemon yellow, 0.125 part of brilliant blue and 5 parts of acetate starch.

The preparation method of the bead blasting forming liquid comprises the following steps: mixing and stirring 70-80 parts of sodium alginate aqueous solution, 15-20 parts of glycerol, 5-8 parts of surfactant, 2-4 parts of curing agent and 3-5 parts of emulsifier uniformly at 35-40 ℃ to form emulsion molding liquid.

The initial forming process of the exploded bead is to drop essential oil containing the traditional Chinese medicine composition into the forming liquid of the exploded bead by means of three-phase flow dropping pill equipment, and the forming is carried out when the thickness of the outer skin reaches 0.5-1 mm.

In the drying and shaping process, the recoiled blasting beads are placed in a rotating cage for shaping, the ambient temperature is 18-24 ℃, the humidity is 45-65%, and the shaping time is controlled to be 1-2 h.

The drying and shaping process also comprises the step of putting the recoiled exploded beads into a rotating cage for air drying, wherein the ambient temperature is 28-40 ℃, the humidity is less than or equal to 30%, and the drying time is controlled within 12-14 h.

The drying and shaping process also comprises standing and drying, wherein standing and drying are carried out after air drying is finished, the environment temperature is 28-40 ℃, the humidity is less than or equal to 30%, and the standing time is controlled to be 1-2 h.

The invention also relates to application of the essential oil blasting bead containing the traditional Chinese medicine composition to a mask.

The invention also relates to application of the essential oil bead containing the traditional Chinese medicine composition in a sachet or a fragrance product.

The invention also relates to application of the essential oil exploded bead containing the traditional Chinese medicine composition in cigarettes.

The key point of the invention is that on the basis of the existing bead blasting preparation process, a one-step forming process is improved into two-step wrapping, primary wrapping is carried out outside the essential oil of the traditional Chinese medicine composition, the purpose is to form, the first layer wrapping is equivalent to underwear of the essential oil of the traditional Chinese medicine composition, the underwear is in a shape and is breathable, and the second step wrapping is carried out, the purpose is to add a layer of coat outside the initially formed bead blasting to the essential oil of the traditional Chinese medicine composition, so that the sealing effect is achieved, and the components of the traditional Chinese medicine composition are prevented from being scattered.

The invention has the beneficial effects that through two-step wrapping, the coating forming of the essential oil of the traditional Chinese medicine composition can be realized, and the volatilization of the components of the traditional Chinese medicine composition can be avoided. The coat formed by the raw material proportion of the capsule shell glue solution and the preparation process has very dense pores, prevents the volatilization of the components of the traditional Chinese medicine composition, and has better water absorption performance through a plurality of experiments, thereby realizing the function of drying the surrounding air. Especially when exploding the pearl and being used for the gauze mask product, people daily exhalation steam can produce the water smoke around the mouth nose because taking the gauze mask, and water smoke leads to bacterial growing easily, consequently the pearl of exploding of this application can also avoid bacterial growing, further avoids other diseases to produce. Furthermore, as the water around the bead is adsorbed, a part of water molecules can be adsorbed on the outer surface of the 'coat' of the bead explosion, and if the bead explosion is not used for a long time or stored, a layer of water film is formed due to the water absorption, so that the sealing performance of the bead explosion can be further improved.

Detailed Description

The technical effects and technical details of the present invention are described below with reference to specific embodiments.

The experimental process comprises the following steps:

a preparation stage: 1) the essential oil of the Chinese medicinal composition is selected according to the required efficacy, one Chinese medicinal essential oil can be directly purchased, and various Chinese medicaments can be used for extracting the essential oil for later use.

2) Preparing an exploded bead forming liquid: see the example weight ratio parts of each component and the performance of the as-formed bead "underwear" shown in table one.

Table one:

As can be seen from the table I, the pore diameters of 5 groups of examples are respectively measured by a nanometer microscope, the pore diameters of the blasting bead "underwear" are all 0.37-0.38nm, most gas molecules can pass through the blasting bead, but water molecules or oil molecules generally cannot pass through the blasting bead, so that volatile gas can be slowly released in the blasting bead if only the prior art is used.

Wherein the surfactant is sulfated castor oil or glyceryl monostearate or sucrose ester; the curing agent adopts aliphatic amine such as ethylenediamine, diethylenetriamine or triethylenetetramine; the emulsifier is sucrose fatty acid ester or monoglyceride or whey protein.

3) Preparing capsule shell glue solution: see table two for parts by weight of the examples of components and properties of the recoiled popping-bead "garment".

Preparing raw materials in parts by weight: 90-110 parts of gelatin, 130 parts of sorbitol solution 110-90 parts of glycerin, 4-6 parts of sucralose, 0.2-0.3 part of lemon yellow, 0.1-0.2 part of brilliant blue and 4-6 parts of acetate starch

Table two:

preparing gelatin, sorbitol solution, glycerin, sucralose, lemon yellow, brilliant blue and acetate starch according to the above embodiments; mixing acetate starch and partial glycerin, grinding by using a colloid grinder, and sieving by using a 300-mesh sieve to obtain a mixture of the acetate starch and the glycerin; putting the mixture of sorbitol solution, residual glycerin, sucralose, lemon yellow, brilliant blue and glycerin into a vacuum gelatin tank, starting a stirring paddle, heating to 60-70 ℃, putting gelatin, stirring while adding the gelatin to obtain a uniform gelatin solution, stopping stirring, standing, vacuumizing until the vacuum degree is-0.05-0.08 Mpa, degassing for 0.8-1.2 hours until the gelatin solution is free of bubbles, cooling to 58-60 ℃, discharging the gelatin, and placing in a 50 ℃ heat-preservation barrel for heat preservation to obtain the gelatin solution of the capsule shell.

The pore diameter is measured by a nanometer microscope, the pore diameter of the coat is measured by experiments to be 0.13-0.15nm, most of gas can not pass through when water or oil can not pass through under no pressure, the pore diameter is close to the pore diameter of the nanometer RO membrane, and water and gas can not pass through under no external pressure. After a plurality of essential oil popping beads are placed in the air for 5 hours, the weight of the essential oil popping beads is increased by 0.5 percent, which indicates that the popping bead 'coat' prepared by the capsule shell glue solution has certain water absorption. The coat formed by the raw material proportion of the capsule shell glue solution and the preparation process has very dense pores, prevents the volatilization of the components of the traditional Chinese medicine composition, and has better water absorption performance through a plurality of experiments, thereby realizing the function of drying the surrounding air. From the performance of the above embodiments, the first group of embodiments has the best relative performance, moderate thickness and minimum pore diameter, and belongs to the best embodiments. Especially when exploding the pearl and being used for the gauze mask product, people daily exhalation steam can produce the water smoke around the mouth nose because taking the gauze mask, and water smoke leads to bacterial growing easily, consequently the pearl of exploding of this application can also avoid bacterial growing, further avoids other diseases to produce. Furthermore, as the water around the bead is adsorbed, a part of water molecules can be adsorbed on the outer surface of the 'coat' of the bead explosion, and if the bead explosion is not used for a long time or stored, a layer of water film is formed due to the water absorption, so that the sealing performance of the bead explosion can be further improved.

By comparing table 1 and table 2 above, the pore size of the bead-blasting as-formed "underwear" is not as dense as the pore size of the "outerwear" that is wrapped, and thus the "outerwear" performs a good sealing function. However, it should be noted that although the "outer clothing" has dense holes, the "outer clothing" cannot be used to replace the "inner clothing", because the "outer clothing" is relatively brittle and has poor toughness and is easy to break and fracture, and the "inner clothing" has strong toughness and plays a good role in sincere skeletal work.

4) Drying and shaping: in the drying and shaping process, the recoiled blasting beads are placed in a rotating cage for shaping, the ambient temperature is 18-24 ℃, the humidity is 45-65%, and the shaping time is controlled to be 1-2 h.

The combined implementation effect of the shaping in the one step and the drying in the two steps is the best, if a certain mode is adopted independently, the drying and shaping can be realized, but the time is long, and the combined use effect is the best in order to improve the production efficiency.

The traditional Chinese medicine composition essential oil bead is particularly suitable for masks, sachets, fragrance products or cigarette products after preparation, the product is convenient to store, when in use, a cavity for placing the bead is designed in the application product, when in use, only the bead needs to be pinched and exploded, the traditional Chinese medicine essential oil component can be volatilized, and the bead is pinched and exploded or the bead is taken and put into the cavity after the bead is volatilized for a period of time. And various traditional Chinese medicine components can be prepared according to the requirements of customers, for example, the lianhuaqingwen is approved by most people to have resistance to new coronavirus, the lianhuaqingwen essential oil or the lianhuaqingwen extract essential oil can be prepared into blasting beads and placed in special positions of the mask, some masks are provided with inner cores, storage parts can be arranged on the inner cores, and the mask can be provided with the traditional Chinese medicine components by pinching and blasting.

Claims

1. A preparation method of an essential oil bead blasting containing a traditional Chinese medicine composition comprises a bead blasting forming liquid preparation process, a bead blasting initial forming process is carried out on the essential oil containing the traditional Chinese medicine composition and the bead blasting forming liquid by means of equipment, and a drying and shaping process is carried out on the formed bead blasting, and is characterized in that: adding a bead blasting recoating procedure after the bead blasting primary forming procedure and before the drying and shaping procedure, wherein the bead blasting recoating procedure is to put the primary formed bead blasting into a storage hopper of a pill press, convey capsule shell glue solution into a glue solution box of the pill press, start the pill press to press pills, and finish the recoating procedure, wherein the capsule shell thickness is controlled to be 0.2-1mm, the recoated bead blasting weight is 0.2-0.25g, the ambient temperature is 18-24 ℃, and the humidity is 45-65%;

b. mixing acetate starch and half of glycerol, grinding by using a colloid grinder, and sieving by using a 300-mesh sieve to obtain a mixture of the acetate starch and the glycerol for later use;

2. The method for preparing the essential oil beadlets containing the traditional Chinese medicine composition according to claim 1, which is characterized in that: in the step a, the following raw materials are prepared according to the parts by weight: 100 parts of gelatin, 120 parts of sorbitol solution, 80 parts of glycerin, 5 parts of sucralose, 0.25 part of lemon yellow, 0.125 part of brilliant blue and 5 parts of acetate starch.

3. The method for preparing the essential oil beadlets containing the traditional Chinese medicine composition according to claim 1, which is characterized in that: the preparation method of the bead blasting forming liquid comprises the following steps: mixing and stirring 70-80 parts of sodium alginate aqueous solution, 15-20 parts of glycerol, 5-8 parts of surfactant, 2-4 parts of curing agent and 3-5 parts of emulsifier uniformly at 35-40 ℃ to form emulsion molding liquid.

4. The method for preparing the essential oil beadlets containing the traditional Chinese medicine composition according to claim 1, which is characterized in that: the initial forming process of the exploded bead is to drop essential oil containing the traditional Chinese medicine composition into the forming liquid of the exploded bead by means of three-phase flow dropping pill equipment, and the forming is carried out when the thickness of the outer skin reaches 0.5-1 mm.

5. The method for preparing the essential oil beadlets containing the traditional Chinese medicine composition according to claim 1, which is characterized in that: in the drying and shaping process, the recoiled blasting beads are placed in a rotating cage for shaping, the ambient temperature is 18-24 ℃, the humidity is 45-65%, and the shaping time is controlled to be 1-2 h.

6. The method for preparing the essential oil beadlets containing the traditional Chinese medicine composition according to claim 5, which is characterized in that: the drying and shaping process also comprises the step of putting the recoiled exploded beads into a rotating cage for air drying, wherein the ambient temperature is 28-40 ℃, the humidity is less than or equal to 30%, and the drying time is controlled within 12-14 h.

7. The method for preparing the essential oil beadlets containing the traditional Chinese medicine composition according to claim 6, which is characterized in that: the drying and shaping process also comprises standing and drying, wherein standing and drying are carried out after air drying is finished, the environment temperature is 28-40 ℃, the humidity is less than or equal to 30%, and the standing time is controlled to be 1-2 h.

8. The use of an essential oil beading containing a Chinese medicinal composition on a mask according to claim 1.

9. The use of an essential oil beading containing a Chinese medicinal composition according to claim 1 in a sachet or fragrance product.

10. The use of the essential oil beadlets containing a traditional Chinese medicine composition in cigarettes according to claim 1.