CN112168889A - Anti-acne freeze-dried excipient and preparation method thereof - Google Patents

Anti-acne freeze-dried excipient and preparation method thereof Download PDF

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Publication number
CN112168889A
CN112168889A CN201910600420.6A CN201910600420A CN112168889A CN 112168889 A CN112168889 A CN 112168889A CN 201910600420 A CN201910600420 A CN 201910600420A CN 112168889 A CN112168889 A CN 112168889A
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China
Prior art keywords
freeze
binder
preparation
dried
solution
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CN201910600420.6A
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Chinese (zh)
Inventor
李和伟
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Changzhou Weibo Haitai Bio Tech Co ltd
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Changzhou Weibo Haitai Bio Tech Co ltd
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Priority to CN201910600420.6A priority Critical patent/CN112168889A/en
Publication of CN112168889A publication Critical patent/CN112168889A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying

Abstract

The invention relates to an anti-acne freeze-dried excipient and a preparation method thereof, in particular to a freeze-dried excipient prepared by a formula of active ingredients containing centella asiatica leaf extract, Australia pepper extract, salicylic acid and derivatives thereof and a binding agent and a preparation method thereof.

Description

Anti-acne freeze-dried excipient and preparation method thereof
Technical Field
The invention relates to an anti-acne freeze-dried excipient and a preparation method thereof, in particular to a freeze-dried excipient prepared by a formula of active ingredients containing centella asiatica leaf extract, Australia pepper extract, salicylic acid and derivatives thereof and a binding agent and a preparation method thereof.
Background
The freeze-drying excipient technology is a technology of adding a skeleton supporting agent and a binding agent into a flowable liquid, semisolid or solid active ingredient, or the flowable liquid, semisolid or solid contains the binding agent and the skeleton supporting agent, then pouring the flowable liquid, semisolid or solid into a forming mold, and forming the flowable liquid, semisolid or solid by a freeze-drying process, wherein a preparation prepared by the freeze-drying excipient technology is called a freeze-drying excipient.
The preparation adopts a freeze drying process, can protect unstable active ingredients from being damaged, generates a large number of micropores and pore passages through water sublimation, and can be quickly disintegrated and dissolved, so the preparation is widely applied and can be applied to a plurality of fields of orally disintegrating tablets, quick-release tablets, chewable tablets, special cosmetics, medical appliances, health care products and the like.
At present, acne-removing essence products on the market are mainly in a smearing type, and because acne-removing functional components are unstable, a large amount of additives are required to be added, and the addition of the additives can stimulate the skin, so that the acne-removing effect is greatly reduced.
In addition, the wet tissue for removing acne is also available in the market, the effective components are in a liquid state and are soaked in the base cloth, and additives are required to be added to prevent the oxidation or the breeding of bacteria, so that various discomforts, such as stabbing pain, red swelling, pruritus or other allergic phenomena, can occur when consumers use the wet tissue.
Disclosure of Invention
An anti-acne freeze-dried excipient is characterized by comprising an active ingredient and a binder.
The active ingredients are selected from one or more of centella asiatica leaf extract, macadamia japonica extract, pepper extract, salicylic acid and derivatives thereof, and the mass percentage of the active ingredients is 0.01-99%, preferably 0.01-50%, 0.1-30%, 0.1-10%, 0.5-50%, 0.5-30%, 0.5-10%, 0.5-5%, 1-50%, 1-30%, 1-10%, and most preferably 0.5-50%.
The binder can be a freeze-dried binder or a combination of the freeze-dried binder and a low-temperature binder.
The freeze-drying binder is artificial or natural high molecular polymer, inorganic substance gel, cellulose ethers, modified starch, hyaluronic acid, albumin, dextran, chitosan and products with different molecular weights thereof, sodium alginate, PVP, PVA, polyethylene glycol, agar, polyamino acid, glycan or a combination of the sodium alginate, the PVP, the PVA, the polyethylene glycol, the agar, the polyamino acid and the glycan; the low-temperature binder is one or a combination of more of C1-C16 alcohol, grease, surfactant and high molecular polymer.
The C1-C6 alcohol is selected from one or more of propylene glycol, butanediol, glycerol, 1, 2-butanediol, 1, 2-propanediol, 1, 3-butanediol, pentanediol, polyethylene glycol, polyglycerol, diglycerol and the like.
The oil and fat is selected from one or more of polydimethylsiloxane, polyglycerol-6 octastearate, caprylic/capric triglyceride, glycerol tri (ethyl hexanoate), diisostearyl malate, polyglycerol-2 triisostearate, dipentaerythritol tri-hydroxystearate, phytosterol oleate, petrolatum, xanthan gum, glycerol tri (behenic acid/isostearic acid/eicosanedioic acid) ester, lecithin, hydrogenated polydecene, ethylhexyl methoxycinnamate, butter, mink oil, goose oil, shark liver oil, almond oil, olive oil, sesame oil, tea seed oil, ethylhexyl palmitate, shea butter, hexyl laurate, dioctyl carbonate, GTCC, propylheptyl caprylate, oleyl alcohol or triglyceride and the like.
The surfactant is one or more selected from Tween component, span component, PEG-20 glycerol triisostearate, polyglycerol-10 distearate, polyglycerol-2 oleate, potassium cocoyl glycinate, and potassium lauroyl glycinate.
The high molecular polymer is one or more of sodium alginate, lanolin, agar, polyvinyl alcohol methyl acrylate graft copolymer, carbomer resin, sodium hyaluronate, hyaluronic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol, polyethylene oxide, modified paraffin, polyacrylamide, sodium polyacrylate, polyacrylic acid and derivatives thereof.
The inorganic gel is one or more of diatomite, bentonite, montmorillonite, hectorite and silica gel.
The glue binder is one or more of collagen, gelatin, hydrolyzed gelatin, arabic gum, xanthan gum, soybean protein gum, sclerotium rolfsii gum, biological sugar gum, carrageenan, guar gum, gellan gum, pectin, konjac gum, carrageenan, locust bean gum, locust bean gum, etc.
The cellulose ether binder is one or more of microcrystalline cellulose, carboxymethyl cellulose, carboxyethyl cellulose, hydroxyethyl methyl cellulose, hydroxypropyl methyl cellulose and the like.
The modified starch binder is selected from one or more of sodium polyacrylate grafted starch, pullulan, hydroxypropyl starch, hydroxypropyl methyl starch, pregelatinized starch, amylose, carboxymethyl starch, hydroxyethyl starch, hydroxypropyl starch and the like.
The polyamino acid is selected from one or more of polyglutamic acid, polyalanine, polyaspartic acid, polylysine and the like.
The polysaccharide is selected from one or more of fucoidan, inulin, dextran, etc.
The formula can be further added with other auxiliary materials, and the auxiliary materials are selected from one or more of a skeleton supporting agent, a skin feeling modifying agent, an antioxidant, a flavoring agent, essence, a trans-mucous membrane, a transdermal absorption enhancer and a pH regulator.
The skeleton agent is selected from one or more of sugar (such as maltose, trehalose, etc.), sugar alcohol (such as mannitol, sorbitol), amino acid with 2-12 carbon atoms (such as glycine, alanine, glutamic acid, etc.), and inorganic salt (such as sodium phosphate, aluminum silicate, etc.).
The skin feeling improver is one or more selected from polymethyl silsesquioxane, tapioca starch, di-C12-13 alcohol malate, di-myristyl tartrate, PPG-15 stearyl alcohol ether, nylon-12, and Vaccinium myrtillus seed oil.
The antioxidant is selected from one or more of vitamin C, vitamin E, anthocyanin, resveratrol, glutathione, superoxide dismutase, yeast/rice fermentation product filtrate, plant extract, Beauveria bassiana extract, Armillaria matsutake extract, fruit and vegetable extract, plant-derived polyphenol compounds, and the like with antioxidant effect.
The flavoring agent and essence are selected from essence with mint flavor, chocolate flavor, fruit and vegetable flavor, flower and grass flavor, plant flavor, vanilla flavor, coffee flavor, tea flavor, corn flavor, lemon flavor, milk flavor, etc., or mixture of more than one of the above flavors.
The trans-mucosal or transdermal absorption enhancer is selected from one or more of lecithin, tween and span.
The pH regulator is selected from one or more of citric acid, sorbic acid, tartaric acid, lactic acid, malic acid, sodium bicarbonate, sodium carbonate, disodium hydrogen phosphate, calcium phosphate, potassium phosphate, and magnesium phosphate.
The preparation method of the freeze-dried excipient comprises the following steps:
A. method 1
a) Fixing the volume of solution, emulsion or suspension formed by water, active ingredients and auxiliary materials, and degassing;
b) injecting a) into a quantitative molding die by using a quantitative filling pump, and degassing;
c) freeze-drying b), removing solvent to obtain stable lyophilized preparation containing active oil and stabilizer, and packaging the lyophilized preparation in mold.
B. Method 2
a) Preparation of a soft ice mixture:
mixing the active ingredients and the auxiliary materials with the solvent completely or partially, and freezing to obtain a soft ice mixture 1;
b) mixing the rest active ingredients and adjuvants with solvent part, and freezing and pulverizing at low temperature or spraying at low temperature to obtain ice powder 2;
c) the rest of active ingredients and auxiliary materials are used as dry powder 3;
d) mixing one or more of a), b) and c) to obtain all soft ice mixtures;
e) shaping by using a certain mould to obtain a shaped mixture 4, and demoulding;
f) the mixture 4 was freeze-dried to obtain a freeze-dried preparation.
C. Method 3
a) Fixing the volume of solution, emulsion or suspension formed by water, active ingredients and auxiliary materials, and degassing;
b) drip-filling the solution in the cabin body with the internal temperature below the eutectic point of the solution by using a quantitative filling pump, so that the solution is quickly frozen when dripping;
c) freeze-drying the frozen solution to obtain a stable lyophilized preparation containing active oil and stabilizer.
The freeze-dried excipient can be in any shape, and can be in the shape of tablets, capsules, soft capsules, spheres, ellipsoids or various characters, animals, plants, food, graphic marks or cartoon images.
The freeze-dried excipient product can be applied to the fields of daily chemicals, medicines, health products, foods and medical appliances.
Detailed Description
The present invention is further illustrated by the following examples, but the present invention is not limited thereto.
Example 1
2% of sodium hyaluronate, 2.0% of asiatic centella leaf extract, 5.3% of pullulan and 803.5% of tween-803, adding water to a constant volume of 1L, degassing to obtain a mixed solution, pouring the mixed solution into a sheet-shaped mold by using a liquid transfer gun, degassing, pre-freezing, freeze-drying, and removing a solvent to obtain the asiatic centella external acne-removing freeze-drying excipient.
Example 2
4.0% of mannitol, 1.0% of tremella sporophore extract, 2.5% of carbomer, 0.05% of triethanolamine and 5.0% of macadamia ternifolia extract are added with water to be constant volume to 1L and degassed to obtain a mixed solution, a peristaltic pump is used for instilling in a cabin body with the internal temperature below the eutectic point of the solution, the mixed solution is rapidly frozen when being dripped, and the frozen solution is freeze-dried to obtain the external acne-removing freeze-dried excipient for pepper.
Example 3
Dissolving trehalose 8%, salicylic acid 0.94%, glycerol 15% and resveratrol 2.15% in water to obtain a mixed solution, and freezing the mixed solution at-10 deg.C to obtain a soft ice mixture; filling the soft ice mixture into a precooled spherical mold by using a quantitative filling pump for quantification; a liquid nitrogen circulating cooling mode is adopted to ensure that the quantitative components are separated from the die at the temperature of minus 205 ℃; and (4) freeze-drying the components separated from the mould to obtain the salicylic acid external acne-removing freeze-dried excipient.
Example 4
Dissolving 20% of salicylate silanol, 15% of hydroxyethyl urea, 0.5% of dextran and 0.05% of sodium bicarbonate in water uniformly to form a mixed solution, and freezing the liquid at-7 ℃ to form a soft ice mixture; taking 15% of modified cassava starch as dry powder, adding the soft ice mixture, and uniformly mixing; filling the mixed soft ice mixture into a pre-cooled spherical mold by using a quantitative filling pump for quantifying; a liquid nitrogen circulating cooling mode is adopted to ensure that the quantitative components are separated from the die at the temperature of minus 205 ℃; and (4) freeze-drying the components separated from the mould to obtain the salicylic acid acne-removing freeze-dried excipient.
Example 5
35% of pepper extract, 4.8% of mannitol, 4.8% of pullulan, 1.3% of polyglutamic acid, 0.5% of Taikui agave leaf extract, adding water to a constant volume of 2L, degassing to obtain a mixed solution, filling the mixed solution into a sheet-shaped mould by using a liquid transfer gun, degassing, pre-freezing, freeze-drying, and removing a solvent to obtain the pepper acne-removing freeze-drying excipient.
Example 6
Dissolving 3% of pepper extract, 5.0% of asiatic pennywort herb leaf extract, 0.85% of tremella fruiting body extract and 4.0% of vitamin C in water uniformly to form a mixed solution, and preparing ice powder by low-temperature crushing; dissolving 15% of modified cassava starch, 0.2% of guar gum and 15% of glycerol in water uniformly to form a mixed solution, and freezing the liquid at-7 ℃ to form a soft ice mixture; mixing ice powder with the soft ice mixture, and uniformly stirring; filling the mixed soft ice mixture into a pre-cooled spherical mold by using a quantitative filling pump for quantifying; a liquid nitrogen circulating cooling mode is adopted to ensure that the quantitative components are separated from the die at the temperature of minus 205 ℃; and (4) freeze-drying the components separated from the mould to obtain the compound acne-removing freeze-dried excipient.
The composition, form and preparation method of the components of the present invention are not limited to the forms shown in the examples, which are only preferred examples of the present invention and are not intended to limit the scope of protection. All changes and modifications which come within the meaning and range of equivalency of the claims are to be embraced within their scope.

Claims (9)

1. An anti-acne freeze-dried excipient is characterized by consisting of an anti-acne active component and a binder.
2. The lyophilized excipient of claim 1, wherein the active ingredient is selected from one or more of centella asiatica leaf extract, piper australis extract, zanthoxylum bungeanum extract, salicylic acid and derivatives thereof, and the mass percentage of the active ingredient is 0.01-99%; the binder can be a freeze-dried binder or a combination of the freeze-dried binder and a low-temperature binder.
3. The lyophilized excipient of claims 1-2, wherein the lyophilized binder is an artificial or natural polymeric polymer, an inorganic gelling agent, a cellulose ether, a modified starch, a hyaluronic acid, an albumin, a dextran, chitosan and its different molecular weight products, sodium alginate, PVP, PVA, polyethylene glycol, agar, a polyamino acid, a polysaccharide, or a combination thereof; the low-temperature binder is one or a combination of more of C1-C16 alcohol, grease, surfactant and high molecular polymer.
4. The formula of claims 1-3, wherein the formula further comprises other adjuvants selected from one or more of skeleton support agent, skin feel modifier, antioxidant, correctant, essence, trans-mucosa agent, transdermal absorption enhancer and pH regulator.
5. The method according to claim 1, wherein the following method is used:
A. method 1
a) Fixing the volume of solution, emulsion or suspension formed by water, active ingredients and auxiliary materials, and degassing;
b) injecting a) into a quantitative molding die by using a quantitative filling pump, and degassing;
c) freeze-drying b), removing solvent to obtain stable lyophilized preparation containing active oil and stabilizer, and packaging the lyophilized preparation in mold.
B. Method 2
a) Preparation of a soft ice mixture:
mixing the active ingredients and the auxiliary materials with the solvent completely or partially, and freezing to obtain a soft ice mixture 1;
b) mixing the rest active ingredients and adjuvants with solvent part, and freezing and pulverizing at low temperature or spraying at low temperature to obtain ice powder 2;
c) the rest of active ingredients and auxiliary materials are used as dry powder 3;
d) mixing one or more of a), b) and c) to obtain all soft ice mixtures;
e) shaping by using a certain mould to obtain a shaped mixture 4, and demoulding;
f) the mixture 4 was freeze-dried to obtain a freeze-dried preparation.
C. Method 3
a) Fixing the volume of solution, emulsion or suspension formed by water, active ingredients and auxiliary materials, and degassing;
b) drip-filling the solution in the cabin body with the internal temperature below the eutectic point of the solution by using a quantitative filling pump, so that the solution is quickly frozen when dripping;
c) freeze-drying the frozen solution to obtain a stable lyophilized preparation containing active oil and stabilizer.
6. The product obtained by the formulation and/or the preparation method according to any one of claims 1 to 5.
7. Product according to claim 6, characterized in that it is of arbitrary shape.
8. The product according to claim 7, characterized in that it is in the form of tablets, capsules, soft capsules, spheres, ellipsoids or various figures, animals, plants, food, graphic signs or cartoon figures.
9. The product according to claims 1-8, which can be used in the field of daily chemicals, pharmaceuticals, nutraceuticals, foods, and medical devices.
CN201910600420.6A 2019-07-04 2019-07-04 Anti-acne freeze-dried excipient and preparation method thereof Withdrawn CN112168889A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111214522A (en) * 2018-11-23 2020-06-02 山东坦途农业科技有限公司 Freeze-dried excipient containing pseudo-ginseng and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468528A (en) * 2016-06-07 2017-12-15 董玲 A kind of lyophilized formulations and preparation method thereof
CN108567745A (en) * 2017-03-10 2018-09-25 常州柚盾实业投资有限公司 A kind of lyophilized excipient and preparation method thereof containing active constituent
CN108619522A (en) * 2017-03-15 2018-10-09 常州柚盾实业投资有限公司 A kind of lyophilized excipient and preparation method thereof containing phenolic acid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468528A (en) * 2016-06-07 2017-12-15 董玲 A kind of lyophilized formulations and preparation method thereof
CN108567745A (en) * 2017-03-10 2018-09-25 常州柚盾实业投资有限公司 A kind of lyophilized excipient and preparation method thereof containing active constituent
CN108619522A (en) * 2017-03-15 2018-10-09 常州柚盾实业投资有限公司 A kind of lyophilized excipient and preparation method thereof containing phenolic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111214522A (en) * 2018-11-23 2020-06-02 山东坦途农业科技有限公司 Freeze-dried excipient containing pseudo-ginseng and preparation method thereof

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Application publication date: 20210105

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