CN112147356A - Quantitative liquid taking mechanism and microfluidic device - Google Patents

Quantitative liquid taking mechanism and microfluidic device Download PDF

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Publication number
CN112147356A
CN112147356A CN202011028336.0A CN202011028336A CN112147356A CN 112147356 A CN112147356 A CN 112147356A CN 202011028336 A CN202011028336 A CN 202011028336A CN 112147356 A CN112147356 A CN 112147356A
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China
Prior art keywords
liquid
channel
cavity
communication port
port
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Pending
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CN202011028336.0A
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Chinese (zh)
Inventor
梁品洪
周昭瑞
刘成
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Shenzhen Helai Biotechnology Co ltd
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Shenzhen Helai Biotechnology Co ltd
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Publication of CN112147356A publication Critical patent/CN112147356A/en
Priority to PCT/CN2021/105627 priority Critical patent/WO2022012445A1/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/029—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type provided with electric controlling means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid

Abstract

The application discloses liquid mechanism is got to ration includes: the liquid carrying rod is provided with a channel and is used for quantitatively measuring and conveying target liquid; the cavity channel is sleeved on the liquid carrying rod and provided with a first communicating port, a second communicating port and a third communicating port, and the third communicating port is positioned between the second communicating port and the bottom of the cavity channel; the air passage is used for communicating the second communication port with the third communication port; and a flow channel for receiving the target liquid flowing in from the first communication port and outputting the target liquid. The utility model provides a liquid mechanism is got to ration promotes the accuracy nature of liquid feeding on the basis that reduces structure complexity and manufacturing cost. The application also discloses a micro-fluidic device comprising the quantitative liquid taking mechanism.

Description

Quantitative liquid taking mechanism and microfluidic device
Technical Field
The application relates to the technical field of liquid measuring. And more particularly, to a quantitative liquid extraction mechanism and a microfluidic device.
Background
In vitro diagnostic tests, the accuracy of quantitative sample addition of sample liquid directly affects the accuracy and reliability of the final detection result. The liquid adding mode in the clinical diagnosis at the present stage mainly comprises the following two modes:
one of the methods is to realize liquid adding by devices such as an injection pump or a peristaltic pump, and the like, and the method mainly controls the sample adding amount by controlling the displacement of mechanical parts, and the devices cannot obtain ideal results on the precision of the liquid adding measuring range due to the structural characteristics of the devices.
The other method is to add liquid by a pipette or a dropper, which also has a few defects, mainly including that: the liquid adding precision of the liquid transfer device is high, but the price is high, and in contrast to the liquid transfer device, the price of the dropper is low, but the precision is difficult to guarantee.
Disclosure of Invention
As mentioned above, in the process of liquid sample application, the accuracy of quantitative liquid application, the complexity and the cost price of the liquid application instrument are important factors that cannot be ignored, and how to design an instrument device that can be compatible with the above requirements is an important problem for those skilled in the art.
In view of the above problems, in the present application, the inventor combines the mechanical principle of piston motion and the driving action principle of air pressure difference, invents a quantitative liquid adding mechanism and a corresponding device, and solves the aforementioned problems. The application can be widely applied to in-vitro diagnostic tests, in particular to the technical field of microfluidics.
In summary, an object of the present invention is to provide a quantitative liquid taking mechanism, which improves the accuracy of liquid feeding on the basis of reducing the complexity of the structure and the manufacturing cost.
In addition, on the basis of the above, the present application has another object to provide at least a microfluidic device including the above quantitative liquid taking mechanism.
Specifically, the method is realized through the following technical scheme:
first aspect of the present application
A first aspect provides a quantitative liquid taking mechanism, comprising:
the liquid carrying rod is provided with a channel and is used for quantitatively measuring and conveying target liquid;
the cavity channel is sleeved on the liquid carrying rod and provided with a first communicating port, a second communicating port and a third communicating port, and the third communicating port is positioned between the second communicating port and the bottom of the cavity channel;
the air passage is used for communicating the second communication port with the third communication port; and
and the flow channel is used for receiving the target liquid flowing in from the first communication port and outputting the target liquid.
In some embodiments, the channels are linear channels.
In some embodiments, the flow direction of the channel is perpendicular to the length direction of the carrier rod.
In some embodiments, the first communicating port and the second communicating port are symmetrically disposed on two sides of the cavity.
In some aspects, the bottom of the channel is recessed toward the cavity to form a recessed region.
In some embodiments, the channel, the airway, and the flow channel are provided by a single base.
In some technical schemes, the quantitative liquid taking mechanism further comprises a balance hole and a liquid adding hole, wherein the balance hole and the liquid adding hole are respectively communicated with the cavity channel and are arranged in the areas among the first communicating port, the second communicating port and the inlet of the cavity channel;
when the channel reaches a second preset position, two ends of the channel are respectively communicated with the balance hole and the liquid adding hole.
In some technical schemes, the balance hole and the liquid feeding hole are symmetrically arranged on two sides of the cavity.
Second aspect of the present application
A second aspect provides a microfluidic device comprising:
the quantitative liquid taking mechanism of the first aspect; and
and (4) a micro-fluidic chip.
The technical effects of the embodiments of the present application at least include:
in some embodiments, the quantitative liquid taking mechanism completes sample sampling work of accurately taking liquid through a liquid loading rod, a cavity channel, an air channel and a flow channel by a simple structure; meanwhile, the structure design is simple, the production and the manufacture are easy, and the production cost is convenient to control; in addition, the liquid carrying rod, the cavity channel, the air channel, the flow channel and other structures are arranged on one base, so that the structural design is further simplified.
In some embodiments, the quantitative liquid taking mechanism further comprises a balance hole and a liquid adding hole, and the balance hole and the liquid adding hole are used for adding liquid into the channel, so that the accuracy of liquid adding work is further improved.
Additional advantages, objects, and features of the application will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the application.
Drawings
FIG. 1 is a schematic diagram of the quantitative liquid extraction mechanism in some embodiments of the present application;
FIG. 2 is a schematic illustration of the liquid carrying rod in some embodiments of the present application;
FIG. 3 is another schematic view of the quantitative liquid withdrawal mechanism in some embodiments of the present application;
fig. 4 is a further schematic view of the quantitative liquid extraction mechanism in some embodiments of the present application.
Reference numerals:
10. a quantitative liquid taking mechanism; 100. a liquid carrying rod; 110. a channel; 200. a base; 210. a lumen; 211. a first communication port; 212. a second communication port; 213. a third communication port; 220. an airway; 230. a flow channel; 240. a balance hole; 250. a liquid adding hole; 260. a recessed region.
Detailed Description
The present application will now be described in further detail with reference to the accompanying drawings, whereby one skilled in the art can, with reference to the description, make an implementation.
The terms "first", "second" and "third" in the embodiments of the present application are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," or "third" may explicitly or implicitly include at least one of the feature. Further, the orientations and positional relationships indicated by the terms "upper", "lower", "top", "bottom", "inner", "outer", and the like are based on the orientations and positional relationships shown in the drawings, are merely for convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or apparatus referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present application. Furthermore, the terms "include" and "provided," as well as any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those steps or elements listed, but may alternatively include other steps or elements not listed, or inherent to such process, method, article, or apparatus.
In addition to the foregoing, it should be emphasized that reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
< means for quantitatively taking liquid >
As shown in fig. 1 to 4, a first aspect provides a quantitative liquid taking mechanism 10, including:
the liquid carrying rod 100 is provided with a channel 110, and the channel 110 is used for quantitatively measuring and conveying target liquid;
the channel 210 is sleeved on the liquid carrying rod 100, a first communicating port 211, a second communicating port 212 and a third communicating port 213 are arranged on the channel 210, and the third communicating port 213 is located between the second communicating port 212 and the bottom of the channel 210, wherein when the liquid carrying rod 100 moves to a preset position in the channel 210, the channel 110 communicates the first communicating port 211 with the second communicating port 212;
an air passage 220, the air passage 220 communicating the second communication port 212 with the third communication port 213; and
and a flow channel 230 for receiving the target liquid flowing from the first communication port 211 and outputting the target liquid.
In particular, as shown in fig. 1, the channels 110 are configured as straight channels 110, and in some other embodiments, may be designed in other shapes, such as curved shapes; furthermore, the size of the channel 110 can be designed by those skilled in the art according to the actual required range, that is, the channel 110 at least has one function of precisely measuring the target liquid; furthermore, for design convenience, the flow direction of the channel 110 may be perpendicular to the length direction of the liquid carrying rod 100, but in some other embodiments, the flow direction may also be non-perpendicular; in addition, both ends of the channel 110 are respectively communicated with the outside of the liquid carrying rod 100.
The shape of chamber way 210 and the size of inner space all with carry liquid pole 100 phase-match carry liquid pole 100 sliding connection in back in the chamber way 210, carry the outer wall of liquid pole 100 with the conflict of chamber way 210 inner wall meets, prevents that the target liquid of getting in the passageway 110 is followed carry the outer wall of liquid pole 100 with flow out in the gap that probably forms between the chamber way 210 inner wall.
In addition, in order to facilitate the target liquid in the channel 110 of the liquid carrying rod 100 to be delivered according to a predetermined schedule, the first communication port 211, the second communication port 212 and the third communication port 213 are provided in the channel 210.
As shown in fig. 2, for design convenience, the first communication port 211 and the second communication port 212 are symmetrically disposed on both sides of the cavity 210, but may be asymmetrically disposed in some other embodiments, and one skilled in the art may design the communication ports according to actual needs.
More specifically, the relationship among the first communication port 211, the second communication port 212, and the channel 210 is set to: when the channel 110 moves to a predetermined position, that is, between the first communication port 211 and the second communication port 212, one end of the channel 110 is communicated with the first communication port 211, and the other end is communicated with the second communication port 212, as shown in fig. 4, so that the gas is pushed in from the second communication port 212, and the target liquid in the channel 110 is pushed in the first communication port 211 under the action of the pressure difference.
In addition, as shown in fig. 2, the third communication port 213 is continuously provided between the second communication port 212 and the bottom of the chamber 210, and then one end of the air passage 220 is communicated with the second communication port 212 and the other end is communicated with the third communication port 213.
When the quantitative liquid taking mechanism 10 is actually used, the liquid carrying rod 100 is pushed to slide from the inlet of the cavity 210 to the bottom, so as to press the gas in the cavity 210, and the gas flows to the second communication port 212 through the third communication port 213, resulting in a gas pressure difference between the second communication port 212 and the first communication port 211. On this basis, the liquid carrying rod 100 is continuously pushed until the second communication port 212 and the first communication port 211 are simultaneously communicated with the channel 110, so that the target liquid in the channel 110 can be pushed into the flow channel 230 through the first communication port 211 under the action of the above-mentioned air pressure difference.
Therefore, the quantitative liquid taking mechanism 10 provided by the first aspect completes the sampling work of accurately taking a sample of liquid through the simple structures of the liquid loading rod 100, the cavity channel 210, the air channel 220 and the flow channel 230; meanwhile, the structure design is simple, the production and the manufacture are easy, and the production cost is convenient to control; in addition, the carrier liquid bar 100, the cavity 210, the air passage 220, the flow passage 230, etc. are disposed on one base 200, further simplifying the structural design.
Further, in some embodiments, continuing with fig. 1, the channel 210, the air channel 220, and the flow passage 230 may be provided by a single base 200.
Further, in some embodiments, as shown in fig. 2, the bottom of the channel 210 is recessed toward the cavity to form a recessed area 260, and specifically, the recessed area 260 is recessed toward the entrance of the channel 210. When the liquid-carrying rod slides in the channel 210, the concave area is limited to a certain area, so that a certain space is always kept between the liquid-carrying rod 100 and the bottom of the channel 210, as shown in fig. 4. The recessed area 260 is used for maintaining the communication between the channel 210 and the air passage 220 during the process that the liquid carrying rod 100 moves to the bottom of the channel 210, so as to prevent the liquid carrying rod 100 from being blocked in the channel 210. The compressed gas in the channel 210 generates positive pressure, and can be released continuously through the air channel 220, and pushes the liquid in the air channel 220 or the flow channel 230 to flow into the subsequent space structure.
Further, in some embodiments, as shown in fig. 1, 3, and 4, the quantitative liquid taking mechanism 10 further includes a balance hole 240 and a liquid adding hole 250, wherein the balance hole 240 and the liquid adding hole 250 are respectively communicated with the channel 210 and are disposed in an area between the first communication port 211, the second communication port 212, and the inlet of the channel 210, that is, when the liquid carrying rod 100 slides from the inlet of the channel 210 to the bottom, the liquid carrying rod passes through the balance hole 240 and the liquid adding hole 250, and then passes through the first communication port 211 and the second communication port 212;
when the channel 110 reaches a second predetermined position, two ends of the channel 110 are respectively communicated with the balance hole 240 and the liquid adding hole 250, that is, one end of the channel 110 is communicated with the balance hole 240, and the other end is communicated with the liquid adding hole 250, as shown in fig. 3.
The balance hole 240 and the liquid adding hole 250 are mainly used for accurately adding liquid into the channel 110, and the specific operation can be as follows: after a sufficient amount of liquid is added into the liquid adding hole 250, the liquid flows from the liquid adding hole 250 to the balance hole 240 under the action of gravity and capillary siphon, and when the liquid stored at the two sides of the liquid adding hole 250 and the balance hole 240 is balanced, the channel 110 can be filled with the liquid which is measured and taken out, so that accurate liquid adding work is realized.
It should be noted that the balancing hole 240 and the filling hole 250 may also be disposed on the base 200.
Further, in some embodiments, the balancing holes 240 and the filling holes 250 are symmetrically disposed on both sides of the channel 210.
< second aspect: micro-fluidic device
A second aspect provides a microfluidic device comprising:
the quantitative liquid taking mechanism 10 described in the embodiments of the first aspect; and
the microfluidic chip can be realized by the prior art.
Since the microfluidic chip has a high requirement on the accuracy of the sample liquid, the quantitative liquid taking mechanism 10 in the embodiments of the first aspect can achieve a very good practical effect in quantitative liquid adding operation when used in combination with the microfluidic chip.
While the embodiments of the present application have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in a variety of fields suitable for this application, and further modifications may readily occur to those skilled in the art, and it is therefore not intended to be limited to the details shown and described herein without departing from the general concept defined by the appended claims and their equivalents.

Claims (9)

1. Liquid mechanism is got to ration, its characterized in that includes:
the liquid carrying rod is provided with a channel and is used for quantitatively measuring and conveying target liquid;
the cavity channel is sleeved on the liquid carrying rod and provided with a first communicating port, a second communicating port and a third communicating port, and the third communicating port is positioned between the second communicating port and the bottom of the cavity channel;
the air passage is used for communicating the second communication port with the third communication port; and
and the flow channel is used for receiving the target liquid flowing in from the first communication port and outputting the target liquid.
2. The metered dose dispensing mechanism of claim 1, wherein said passageway is a linear passageway.
3. The quantitative liquid extraction mechanism of claim 1, wherein the flow direction of the channel is perpendicular to the length direction of the carrier rod.
4. The quantitative liquid taking mechanism according to claim 1, wherein the first communicating port and the second communicating port are symmetrically arranged on two sides of the cavity.
5. The quantitative liquid taking mechanism according to claim 1, wherein the bottom of the cavity is recessed towards the cavity to form a recessed area.
6. The quantitative liquid extraction mechanism of claim 1, wherein the cavity, the air channel and the flow channel are provided by one base.
7. The quantitative liquid taking mechanism according to any one of claims 1 to 6, further comprising a balance hole and a liquid adding hole, wherein the balance hole and the liquid adding hole are respectively communicated with the cavity and are arranged in the area between the first communication port, the second communication port and the inlet of the cavity;
when the channel reaches a second preset position, two ends of the channel are respectively communicated with the balance hole and the liquid adding hole.
8. The quantitative liquid taking mechanism as claimed in claim 7, wherein the balancing hole and the liquid adding hole are symmetrically arranged on two sides of the cavity.
9. A microfluidic device, comprising:
a dosing mechanism as claimed in any one of claims 1 to 8; and
and (4) a micro-fluidic chip.
CN202011028336.0A 2020-07-11 2020-09-26 Quantitative liquid taking mechanism and microfluidic device Pending CN112147356A (en)

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Application Number Priority Date Filing Date Title
PCT/CN2021/105627 WO2022012445A1 (en) 2020-07-11 2021-07-10 Quantitative liquid-taking mechanism and micro-fluidic device

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Application Number Priority Date Filing Date Title
CN202021370424 2020-07-11
CN2020213704244 2020-07-11

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CN112147356A true CN112147356A (en) 2020-12-29

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113007436A (en) * 2021-03-02 2021-06-22 深圳市和来生物技术有限公司 Power conveying mechanism with multiple power channels and micro-fluidic chip
CN113522123A (en) * 2021-08-02 2021-10-22 深圳市和来生物技术有限公司 Device for diluting liquid and microfluidic chip
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