CN112138127A - 一种治疗四肢关节的中药组合物及其制备方法 - Google Patents
一种治疗四肢关节的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明中药配方领域,涉及一种治疗四肢关节的中药组合物,包括下列重量份的中药原料:牧丹皮8‑12份、艾叶10‑15份、桑枝10‑13份、干姜6‑8份、赤芍10‑12份、川芎10‑13份、鸡血藤8‑12份、荆芥6‑10份、防风10‑14份、姜黄10‑12份、羌活10‑12份、桂枝6‑8份、泽泻10‑14份、桑寄生8‑12份、丹参10‑12份、牛膝10‑12份、威灵仙9‑12份、赤芍7‑12份、千年健10‑12份、伸筋草10‑12份、入地金牛6‑9份。本发明具有补肾阳祛风寒,通经络舒筋骨,温阳益气,止痛活血。适用于一切关节肿痛、腰椎疼痛、四肢麻木、老年退行性关节疼痛、腰肌劳损,及现代医学的类风湿性关节炎、风湿性关节炎、强制性脊柱炎、大骨节病、结核性关节炎、肢体关节疼痛、变形、骨质损害。
Description
技术领域
本发明涉及一种中药组合物,尤其涉及一种治疗四肢关节的中药组合物及其制备方法。
背景技术
关节炎(arthritis)泛指发生在人体关节及其周围组织,由炎症、感染、退化、创伤或其他因素引起的炎性疾病,可分为数十种。我国的关节炎患者有1亿以上,且人数在不断增加。临床表现为关节的红、肿、热、痛、功能障碍及关节畸形,严重者导致关节残疾、影响患者生活质量。据统计我国50岁以上人群中半数患骨关节炎,65岁以上人群中90%女性和80%男性患骨关节炎。我国的患病率为0.34%~0.36%,严重者寿命约缩短10~15年。
多数关节炎病程较长、缠绵难愈,治疗颇为棘手。关节疼痛是关节炎最主要的表现。不同类型的关节炎可表现出不同的疼痛特点。严重者还会出现关节功能障碍,关节周围组织水肿,周围肌肉的保护性痉挛和关节结构被破坏,导致关节活动受限。慢性关节炎患者由于长期关节活动受限,可能导致永久性关节功能丧失。
现在的治疗关节疼痛的过程中存在的问题主要有药效差,疗程长;生产效率低;使用不便。
发明内容
本发明所要解决的技术问题是提供一种治疗四肢关节的中药组合物及其制备方法。
为解决上述技术问题,本发明的技术方案是:
一种治疗四肢关节的中药组合物,,包括下列重量份的中药原料:
牧丹皮8-12份、艾叶10-15份、桑枝10-13份、
干姜6-8份、赤芍10-12份、川芎10-13份、
鸡血藤8-12份、荆芥6-10份、防风10-14份、
姜黄10-12份、羌活10-12份、桂枝6-8份、
泽泻10-14份、桑寄生8-12份、丹参10-12份、
牛膝10-12份、威灵仙9-12份、赤芍7-12份、
千年健10-12份、伸筋草10-12份、入地金牛6-9份。
作为优选的技术方案,包括下列重量份的中药原料:
牧丹皮8份、艾叶10份、桑枝10份、
干姜6份、赤芍10份、川芎10份、
鸡血藤8份、荆芥6份、防风10份、
姜黄10份、羌活10份、桂枝6份、
泽泻10份、桑寄生8份、丹参10份、
牛膝10份、威灵仙9份、赤芍7份、
千年健10份、伸筋草10份、入地金牛6份。
作为优选的技术方案,包括下列重量份的中药原料:
牧丹皮12份、艾叶15份、桑枝13份、
干姜8份、赤芍12份、川芎13份、
鸡血藤12份、荆芥10份、防风14份、
姜黄12份、羌活12份、桂枝8份、
泽泻14份、桑寄生12份、丹参12份、
牛膝12份、威灵仙12份、赤芍12份、
千年健12份、伸筋草12份、入地金牛9份。
作为优选的技术方案,包括下列重量份的中药原料:
牧丹皮10份、艾叶12.5份、桑枝11.5份、
干姜7份、赤芍11份、川芎11.5份、
鸡血藤10份、荆芥8份、防风12份、
姜黄11份、羌活11份、桂枝7份、
泽泻12份、桑寄生10份、丹参11份、
牛膝11份、威灵仙10.5份、赤芍9.5份、
千年健11份、伸筋草11份、入地金牛7.5份。
作为优选的技术方案,一种制备所述的治疗四肢关节的中药组合物的方法,包括步骤:
(1)将配方中的滋养类和根茎类组分按配比混合打碎,然后放入蒸锅蒸;
(2)将配方中其余组分按配比混合打碎,在滋养类和根茎类组分后放入步骤(1)中的蒸锅蒸,蒸熟后,冷却备用;
(3)在步骤(2)中蒸熟的药材中添加红曲作为催化剂发酵,发酵完成后晒干备用;
(4)将步骤(3)中晒干的药材用酒精浸泡一段时间后过滤去药渣得到滤液,减压蒸干到膏状植物提取物。
作为优选的技术方案,所述步骤(1)中组分打碎至20-60目大小,所述步骤(2)中牧丹皮、艾叶、桑枝、干姜、赤芍、川芎、鸡血藤、荆芥、防风、姜黄、羌活、桂枝、泽泻、桑寄生、丹参、牛膝、威灵仙、赤芍、千年健、伸筋草、入地金牛分为滋补类或根茎类成分先进行蒸。
作为优选的技术方案,所述步骤(3)中红曲添加的量为所述蒸熟的药材的重量的1/4到1/3,发酵温度在36-39度,所述红曲同三七粉一同加入。
作为优选的技术方案,所述步骤(3)中的酒精,包括没有发酵的浓度大于等于95%的酒精和发酵的浓度大于等于75%的酒精,所述浸泡为盖过浸泡,浸泡为4-8小时。
作为优选的技术方案,所述步骤(4)减压蒸干条件为负压0.08pa、温度55-60度。
作为优选的技术方案,还包括:
5)将4)中的膏状植物提取物按照常规工艺加入常规辅料制成临床接受的胶囊剂、片剂、颗粒剂、丸剂或口服液中的一种或多种。
本发明的有益效果:
由于采用了上述技术方案,:补肾阳祛风寒,通经络舒筋骨,温阳益气,止痛活血。治疗一切风、寒、湿痹症,适用于一切关节肿痛、腰椎疼痛、四肢麻木、老年退行性关节疼痛、腰肌劳损,及现代医学的类风湿性关节炎、风湿性关节炎、强制性脊柱炎、大骨节病、结核性关节炎、肢体关节疼痛、变形、骨质损害,也可使用于自身免疫性疾病的硬皮病、雷诺病、干燥综合症、外伤性肢体瘫痪、脑血管病的后遗症及长期服用激素产生依赖性和长期服用解热镇痛药伤胃的患者皆有一定疗效。
具体实施方式
一种治疗四肢关节的中药组合物,,包括下列重量份的中药原料:
牧丹皮8-12份、艾叶10-15份、桑枝10-13份、
干姜6-8份、赤芍10-12份、川芎10-13份、
鸡血藤8-12份、荆芥6-10份、防风10-14份、
姜黄10-12份、羌活10-12份、桂枝6-8份、
泽泻10-14份、桑寄生8-12份、丹参10-12份、
牛膝10-12份、威灵仙9-12份、赤芍7-12份、
千年健10-12份、伸筋草10-12份、入地金牛6-9份。
作为优选的技术方案,一种制备所述的治疗四肢关节的中药组合物的方法,包括步骤:
(1)将配方中的滋养类和根茎类组分按配比混合打碎,然后放入蒸锅蒸;
(2)将配方中其余组分按配比混合打碎,在滋养类和根茎类组分后放入步骤(1)中的蒸锅蒸,蒸熟后,冷却备用;
(3)在步骤(2)中蒸熟的药材中添加红曲作为催化剂发酵,发酵完成后晒干备用;
(4)将步骤(3)中晒干的药材用酒精浸泡一段时间后过滤去药渣得到滤液,减压蒸干到膏状植物提取物。
作为优选的技术方案,所述步骤(1)中组分打碎至20-60目大小,所述步骤(2)中牧丹皮、艾叶、桑枝、干姜、赤芍、川芎、鸡血藤、荆芥、防风、姜黄、羌活、桂枝、泽泻、桑寄生、丹参、牛膝、威灵仙、赤芍、千年健、伸筋草、入地金牛分为滋补类或根茎类成分先进行蒸。
作为优选的技术方案,所述步骤(3)中红曲添加的量为所述蒸熟的药材的重量的1/4到1/3,发酵温度在36-39度,所述红曲同三七粉一同加入。
作为优选的技术方案,所述步骤(3)中的酒精,包括没有发酵的浓度大于等于95%的酒精和发酵的浓度大于等于75%的酒精,所述浸泡为盖过浸泡,浸泡为4-8小时。
作为优选的技术方案,所述步骤(4)减压蒸干条件为负压0.08pa、温度55-60度。
作为优选的技术方案,还包括:
5)将4)中的膏状植物提取物按照常规工艺加入常规辅料制成临床接受的胶囊剂、片剂、颗粒剂、丸剂或口服液中的一种或多种。
实施例一:
作为优选的技术方案,包括下列重量份的中药原料:
牧丹皮8份、艾叶10份、桑枝10份、
干姜6份、赤芍10份、川芎10份、
鸡血藤8份、荆芥6份、防风10份、
姜黄10份、羌活10份、桂枝6份、
泽泻10份、桑寄生8份、丹参10份、
牛膝10份、威灵仙9份、赤芍7份、
千年健10份、伸筋草10份、入地金牛6份。
实施例二:
作为优选的技术方案,包括下列重量份的中药原料:
牧丹皮12份、艾叶15份、桑枝13份、
干姜8份、赤芍12份、川芎13份、
鸡血藤12份、荆芥10份、防风14份、
姜黄12份、羌活12份、桂枝8份、
泽泻14份、桑寄生12份、丹参12份、
牛膝12份、威灵仙12份、赤芍12份、
千年健12份、伸筋草12份、入地金牛9份。
实施例三:
作为优选的技术方案,包括下列重量份的中药原料:
牧丹皮10份、艾叶12.5份、桑枝11.5份、
干姜7份、赤芍11份、川芎11.5份、
鸡血藤10份、荆芥8份、防风12份、
姜黄11份、羌活11份、桂枝7份、
泽泻12份、桑寄生10份、丹参11份、
牛膝11份、威灵仙10.5份、赤芍9.5份、
千年健11份、伸筋草11份、入地金牛7.5份。
病例1
张某某,女,68岁,汉。山西绛县人,于2015年4月初诊。患者双膝关节疼痛3-4年,逐渐加重,近期双膝关节肿大伴腔内积液(左膝关节较重),两腿关节变形呈“O”型腿,行走、站立艰难,同时,腕、肘关节疼痛。化验:WBC:17.35,109/L;ESR:44.8mm/h;ASO:540u(1:80)。诊断为风湿性关节炎。按实施例2所述药方,即嘱:给蜜丸2粒/次,日三次,二周后疼痛缓解,肿胀消退,服用一个疗程后,生活自理,三个疗程后生活自理,并能做家务。
病例2
王某某,女,64岁,汉,山西绛县古坡人,2015年4月初诊。患者双膝关节疼痛2年,逐渐加重,遇天气变化更甚,近日双膝肿大,右膝更明显,活动受限,行走困难,夜间加重。MRI片:右膝膑上囊积液,退行性变;化验:13.9,109/L,ESR:34mm/h,确诊:风湿性关节炎,老年性关节退行性变。按实施例2所述药方,蜜丸2粒,日三次,白开水送服。两个疗程(一个月为一疗程),肿胀逐渐消退,活动自如,继续服用一个疗程巩固疗效,疗效颇佳。
病例3
王某某,男,62岁,农民,山西绛县冷口人,2016年7月24日初诊。患者腰痛2-3年,伴右下肢疼痛一年左右,近日夜间疼痛厉害。CT:L4/5椎间盘膨出,及椎间盘变形,L3-5椎体骨质增生,L5椎后小关节退变。按实施例2所述药方,蜜丸2粒,日三次,服用一个疗程后,疼痛消失,活动自如,能胜任一般劳动,两个疗程后基本痊愈(为巩固继续服用一疗程,症状完全消失)。
病例4
王某某,女,58岁,汉,退休工人,山西绛县古绛镇,于2016年9月22日初诊。患者腰痛2年左右,多服止痛药,近月余起床、平坐都较困难,遇天气变化加重,直站可以,不能弯腰,CT:L2-3-4椎间盘膨出。医院建议手术治疗,患者一是经济困难,而是怕手术后遗症,要求服本药。按实施例1所述药方,即嘱:服水丸55粒(约5克),日三次,每3-5天加5粒/次,加至半个月(半个疗程)80粒/次,后明显好转,活动自如,疼痛消失。以此量服用,一个疗程后完全康复。
病例5
患者张某某,女,65岁,汉族,农民。山西省太原市清徐县人。2017年6月22日初诊。该患者腰椎疼痛五年,诊断为腰椎间盘突出和骨刺,生活不便。日三次餐后白开水送服蜜丸2.5丸实施例2的中药组合三个疗程(一个疗程一个月),病痛程度明显好转,生活完全自理。
病例6
患者王某,男,48岁,汉族,农民,山西省朔州市怀仁县人。2017年3月28日初诊。该患者右膝关节疼痛,遇凉加重,得热方缓,运动后膝盖疼痛加剧。诊断为关节退行性病变,按风寒麻痹关节炎,日三次餐后白开水送服蜜丸1丸实施例3的中药组合一个疗程(一个疗程一个月),右膝疼痛发凉症状明显减轻。服用本发明的中药组合三个疗程,右膝疼痛发凉症状完全消失,患者恢复每日锻炼。
病例7
患者崔某,男,69岁,汉族,农民,山西省晋中市太谷县人。2017年2月24日初诊。该患者长期从事体力劳动,二年前偶有腰背部疼痛,后疼痛加剧,伴局部板涨不适。诊断为腰肌劳损。日三次餐后白开水送服水丸125粒实施例1的中药组合物十日后腰背部疼痛、板胀不适症状明显减轻。服用本发明的中药组合二个疗程患者述腰背部疼痛板胀不适症状已完全消失,查体无异常。
病例8
患者伍某,女,55岁,汉族,农民,山西省运城市闻喜县人。2017年8月19日初诊。该患者患雷诺病六年,间歇发作。双手每于受凉变为苍白色,继而转为青紫,伴麻木发凉及针刺样疼痛,得暖后恢复正常。夏天好转,入冬加重,手指溃疡。日三次餐后白开水送服水丸50粒实施例5的中药组合物三个疗程(一个疗程一个月),临床症状缓解,溃疡面愈合。
病例9
患者胡某,女,32岁,汉族,农民,山东省临沂市兰陵县人。2017年5月23日初诊。该患者十年前首次中风,后结合西医治疗开药维持。患者来诊时左侧全瘫无知觉,左手紧扣胸部不能动,嘴角稍歪,舌头歪,能语不顺。诊断为脑梗死后遗症。日三次餐后白开水送服水丸80粒实施例4的中药组合物六个疗程(一个疗程一个月),左手放松,舌正位,手脚已有知觉,肢体瘫痪有所缓解。。
以上显示和描述了本发明的基本原理、主要特征及本发明的优点。本行业的技术人员应该了解,本发明不受上述实施例的限制,上述实施例和说明书中描述的只是说明本发明的原理,在不脱离本发明精神和范围的前提下,本发明还会有各种变化和改进,这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。
Claims (10)
1.一种治疗四肢关节的中药组合物,其特征在于,包括下列重量份的中药原料:
牧丹皮8-12份、艾叶10-15份、桑枝10-13份、
干姜6-8份、赤芍10-12份、川芎10-13份、
鸡血藤8-12份、荆芥6-10份、防风10-14份、
姜黄10-12份、羌活10-12份、桂枝6-8份、
泽泻10-14份、桑寄生8-12份、丹参10-12份、
牛膝10-12份、威灵仙9-12份、赤芍7-12份、
千年健10-12份、伸筋草10-12份、入地金牛6-9份。
2.如权利要求1所述的一种治疗四肢关节的中药组合物,其特征在于,包括下列重量份的中药原料:
牧丹皮8份、艾叶10份、桑枝10份、
干姜6份、赤芍10份、川芎10份、
鸡血藤8份、荆芥6份、防风10份、
姜黄10份、羌活10份、桂枝6份、
泽泻10份、桑寄生8份、丹参10份、
牛膝10份、威灵仙9份、赤芍7份、
千年健10份、伸筋草10份、入地金牛6份。
3.如权利要求1所述的一种治疗四肢关节的中药组合物,其特征在于,包括下列重量份的中药原料:
牧丹皮12份、艾叶15份、桑枝13份、
干姜8份、赤芍12份、川芎13份、
鸡血藤12份、荆芥10份、防风14份、
姜黄12份、羌活12份、桂枝8份、
泽泻14份、桑寄生12份、丹参12份、
牛膝12份、威灵仙12份、赤芍12份、
千年健12份、伸筋草12份、入地金牛9份。
4.如权利要求1所述的一种治疗四肢关节的中药组合物,其特征在于,包括下列重量份的中药原料:
牧丹皮10份、艾叶12.5份、桑枝11.5份、
干姜7份、赤芍11份、川芎11.5份、
鸡血藤10份、荆芥8份、防风12份、
姜黄11份、羌活11份、桂枝7份、
泽泻12份、桑寄生10份、丹参11份、
牛膝11份、威灵仙10.5份、赤芍9.5份、
千年健11份、伸筋草11份、入地金牛7.5份。
5.一种制备1至4任一权利要求所述的治疗四肢关节的中药组合物的方法,其特征在于,包括步骤:
(1)将配方中的滋养类和根茎类组分按配比混合打碎,然后放入蒸锅蒸;
(2)将配方中其余组分按配比混合打碎,在滋养类和根茎类组分后放入步骤(1)中的蒸锅蒸,蒸熟后,冷却备用;
(3)在步骤(2)中蒸熟的药材中添加红曲作为催化剂发酵,发酵完成后晒干备用;
(4)将步骤(3)中晒干的药材用酒精浸泡一段时间后过滤去药渣得到滤液,减压蒸干到膏状植物提取物。
6.根据权利要求5所述的制备方法,其特征在于所述步骤(1)中组分打碎至20-60目大小,所述步骤(2)中牧丹皮、艾叶、桑枝、干姜、赤芍、川芎、鸡血藤、荆芥、防风、姜黄、羌活、桂枝、泽泻、桑寄生、丹参、牛膝、威灵仙、赤芍、千年健、伸筋草、入地金牛分为滋补类或根茎类成分先进行蒸。
7.根据权利要求5所述的制备方法,其特征在于所述步骤(3)中红曲添加的量为所述蒸熟的药材的重量的1/4到1/3,发酵温度在36-39度,所述红曲同三七粉一同加入。
8.根据权利要求5所述的制备方法,其特征在于所述步骤(3)中的酒精,包括没有发酵的浓度大于等于95%的酒精和发酵的浓度大于等于75%的酒精,所述浸泡为盖过浸泡,浸泡为4-8小时。
9.根据权利要求5所述的制备方法,其特征在于所述步骤(4)减压蒸干条件为负压0.08pa、温度55-60度。
10.如权利要求5所述的一种治疗四肢关节的中药组合物的制备方法,其特征在于,还包括:
5)将4)中的膏状植物提取物按照常规工艺加入常规辅料制成临床接受的胶囊剂、片剂、颗粒剂、丸剂或口服液中的一种或多种。
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