CN104288428A - 一种治疗类风湿性关节炎的中药组合物 - Google Patents

一种治疗类风湿性关节炎的中药组合物 Download PDF

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CN104288428A
CN104288428A CN201410488019.5A CN201410488019A CN104288428A CN 104288428 A CN104288428 A CN 104288428A CN 201410488019 A CN201410488019 A CN 201410488019A CN 104288428 A CN104288428 A CN 104288428A
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彭阳
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Abstract

本发明公开了一种治疗类风湿性关节炎的中药组合物，属于中药领域。它是由下述重量份的原料药制成：制川乌8g，黄芪18g，桂枝8g，白芍15g，穿山龙18g，地龙18g，青风藤12g，多腺悬钩子18g，僵蚕12g，乌梢蛇15g，蜂房10g，甘草8g。本发明药物安全可靠，无副作用，能温经散寒，驱风除湿，通络扶正，有效治疗类风湿性关节炎且不易复发，有效率达94％。

Description

一种治疗类风湿性关节炎的中药组合物
技术领域
本发明属于中药领域，具体地说，尤其涉及一种治疗类风湿性关节炎的中药组合物。
背景技术
类风湿关节炎(RA)是一种病因未明的慢性、以炎性滑膜炎为主的系统性疾病。其特征是手、足小关节的多关节、对称性、侵袭性关节炎症，经常伴有关节外器官受累及血清类风湿因子阳性，可以导致关节畸形及功能丧失。RA的发病可能与遗传、感染、性激素等有关。RA的病理主要有滑膜衬里细胞增生、间质大量炎性细胞浸润，以及微血管的新生、血管翳的形成及软骨和骨组织的破坏等。常见发病人群为女性，发病率为男性的2～3倍。可发生于任何年龄，高发年龄为40～60岁。RA的症状为体重减轻、低热及疲乏感等，并可引起晨僵、关节受累、关节畸形等。
RA根据关节功能分级Ⅰ级：功能状态完好，能完成平常任务无碍，能自由活动；Ⅱ级：能从事正常活动，但有1个或多个关节活动受限或不适；Ⅲ级：只能胜任一般职业性任务或自理生活中的一部分；Ⅳ级：大部分或完全丧失活动能力，需要长期卧床或依赖轮椅，很少或不能生活自理。
目前，RA尚无根治方法。患者通过非药物、药物等综合治疗，减轻关节炎症反应，抑制病变发展及不可逆骨质破坏，尽可能保护关节和肌肉的功能，最终达到病情完全缓解或低疾病活动度的目标。
发明内容
本发明的目的在于克服上述缺陷，提供一种治疗类风湿性关节炎的中药组合物，该中药制剂能有效治疗类风湿性关节炎，疗效确切且不易复发。
所述的治疗类风湿性关节炎的中药组合物，由下述重量份的原料药制成：制川乌8g，黄芪18g，桂枝8g，白芍15g，穿山龙18g，地龙18g，青风藤12g，多腺悬钩子18g，僵蚕12g，乌梢蛇15g，蜂房10g，甘草8g。
配制及服用方法：先煎制川乌30分钟，后与其他中药混合煎制，每日一剂，分早晚两次饭后服用。
各中药的药理作用：
制川乌：辛、苦，热；有毒。归心、肝、肾、脾经。功效与主治：祛风除湿，温经止痛。用于风寒湿痹，乳房疼痛，胸部胀痛，关节疼痛，心腹冷痛，寒疝作痛，麻醉止痛。
黄芪：甘，微温。归脾经、肺经。功效与主治：补气固表,利尿消肿,托毒排脓。用于气虚乏力,表虚自汗,气虚水肿,内热消渴,小便不利及气虚不能摄血的便血、崩漏。
桂枝：辛、甘，温。归肺经、心经、膀胱经。功效与主治：散寒解表；温通经脉；促阳化气。用于风寒表证；寒湿痹痛；四肢厥冷；经闭痛经；癥瘕结块；胸痹；心悸；痰饮；小便不利。
白芍：苦、酸、微寒。归肝经、脾经。功效与主治：养血和宫、缓急止痛、敛阴平肝。用于崩漏、自汗、盗汗、胁肋脘腹疼痛、四肢挛痛、头痛、眩晕。
穿山龙：苦、辛，平。归肺经、肝经。功效与主治：祛风除湿，活血通络，化痰止咳。用于风湿痹痛，跌打损伤；咳嗽痰多；治疮肿，乳汁不下及经闭。
地龙：咸、寒。归肝经、肺经、膀胱经。功效与主治：清热熄风、平肝降压、洛络通痹、清肺平喘、利尿通淋。用于高热神昏、惊痫抽搐、眩晕头痛、肺热咳喘、热结尿闭、关节痹痛、肢体麻木、半身不遂、高血压症。
青风藤：苦、辛，平。归肝经、脾经。功效与主治：祛风湿、通经络、利小便。用于风湿痹痛、关节肿胀、麻痹瘙痒。
多腺悬钩子：辛，温。归肝经、肾经。功效与主治：祛风除湿、补肾壮阳。用于风湿痛，治疗肾虚、阳痿、月经不调诸症。
僵蚕：辛咸，平。归肝经、肺经、胃经。功效与主治：祛风解痉，化痰散结。用于中风失音、中风口嘴眼斜、惊痫抽搐、头风、喉风、咽喉肿痛、瘰疬、痄腮、风疹、疮毒喉痹、瘰疬结核、风疮瘾疹、丹毒、乳腺炎。
乌梢蛇：味甘、性平。归经肝、脾经。功效与主治：祛风湿、通经络、熄风止痉、止痒解毒。用于风湿顽痹、麻木拘挛、中风口眼歪斜、半身不遂、小儿惊风、抽搐痉挛、破伤风、麻风疥癣、瘰疬恶疮。
蜂房：甘、平。归胃经。功效与主治：祛风、攻毒、杀虫、止痛、抗过敏。用于龋齿牙痛、疮疡肿毒、乳痈、瘰疬、皮肤顽癣、鹅掌风、过敏性体质。
甘草：甘，平。归心经、肺经、脾经、胃经。功效与主治：益气补中，清热解毒，祛痰止咳，缓急止痛，调和药性。用于脾气虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，热毒疮疡，咽喉肿痛，药物、食物中毒。
与现有技术相比，本发明的有益效果是：
1、本发明所使用的中草药符合《中华人民共和国药典》规定，药物安全可靠，无副作用。
2、本方疗效确切，能温经散寒，驱风除湿，通络扶正，有效治疗类风湿性关节炎且不易复发，有效率达94％。
以下结合临床试验及典型病例对本发明进一步说明。
一、临床试验：
1、临床资料：随机选取25～66岁的类风湿性关节炎患者100例，随机分为治疗组和对照组两组，其中，治疗组50例，男性17例，女性33例，平均年龄为40.4岁；对照组50例，男性19例，女性31例，平均年龄为40.8岁。
2、诊断标准：
①轻型期：小发作，病型较轻，发病初期突然关节手脚酸痛2-3天，无肿块出现。
②中型期：每遇乱风下雨就会提前2-3天发作，局部性手脚关节肿痛，出现肿块、痛疼，甚至手脚会麻木2-3天，手脚感到麻痛，不方便、没力。
③重型期：大发作，不管有没有乱风下雨，病人会全身关节感到刺痛难忍，手脚脾痛甚至变型，运动不方便，全身不舒服，病人生活不能自理。
3、治疗方法：治疗组服用本发明药物，每天分两次饭后口服；对照组服用雷公藤多苷片，每日根据病人体重1mg/kg,分三次饭后服用。
4、疗效评定标准
治愈：晨僵症状及关节疼痛症状消失，关节肿胀消失，关节活动自如，各关节生理功能恢复正常。
显效：经给药治疗后，身体状况好转，间歇期延长，观察二年半内没有复发者。
好转：身体健康状况好转，间歇期相对延长。
无效：达不到好转标准者。
5、治疗结果：
治愈 显效 有效 无效 总有效率％
治疗组 22 19 6 3 94％
对照组 5 11 15 19 62％
具体实施方式
实施例
配比(单位：克)：制川乌8g，黄芪18g，桂枝8g，白芍15g，穿山龙18g，地龙18g，青风藤12g，多腺悬钩子18g，僵蚕12g，乌梢蛇15g，蜂房10g，甘草8g。
配制及服用方法：水煎服，先煎制川乌30分钟，后与其他中药混合煎制，每日一剂，分早晚两次饭后服用。

Claims (1)

1.一种治疗类风湿性关节炎的中药组合物，其特征在于：由下述重量份的原料药制成：制川乌8g，黄芪18g，桂枝8g，白芍15g，穿山龙18g，地龙18g，青风藤12g，多腺悬钩子18g，僵蚕12g，乌梢蛇15g，蜂房10g，甘草8g。
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN105496636A (zh) * 2015-11-26 2016-04-20 武汉武达博硕园科技有限公司 风湿病外治装置
GB2558275A (en) * 2016-12-23 2018-07-11 Naturex Sa Compositions

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CN1327841A (zh) * 2001-05-04 2001-12-26 刘玉福 治疗类风湿性关节炎的药物

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CN1327841A (zh) * 2001-05-04 2001-12-26 刘玉福 治疗类风湿性关节炎的药物

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105496636A (zh) * 2015-11-26 2016-04-20 武汉武达博硕园科技有限公司 风湿病外治装置
GB2558275A (en) * 2016-12-23 2018-07-11 Naturex Sa Compositions
US11219657B2 (en) 2016-12-23 2022-01-11 Naturex Sa Method for treating or preventing inflammation

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Application publication date: 20150121