CN112138120A - Capsule based on acer truncatum fruit shell extract and processing equipment thereof - Google Patents

Capsule based on acer truncatum fruit shell extract and processing equipment thereof Download PDF

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Publication number
CN112138120A
CN112138120A CN202011072543.6A CN202011072543A CN112138120A CN 112138120 A CN112138120 A CN 112138120A CN 202011072543 A CN202011072543 A CN 202011072543A CN 112138120 A CN112138120 A CN 112138120A
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capsule
parts
shell
extract
edible
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桑柳波
唐毅
孙浩然
陈春霖
游世文
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Mingtong Chongqing Agricultural Technology Development Co ltd
Zhongke Guanghua Chongqing New Material Research Institute Co ltd
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Mingtong Chongqing Agricultural Technology Development Co ltd
Zhongke Guanghua Chongqing New Material Research Institute Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/20—Aceraceae (Maple family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/074—Filling capsules; Related operations
    • A—HUMAN NECESSITIES
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    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
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    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
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    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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Abstract

The invention discloses a capsule based on acer truncatum fruit shell extract and processing equipment thereof, relating to the technical field of medicine processing, and comprising a capsule shell and medicinal powder filled in the capsule shell, wherein the medicinal powder comprises 4-14 parts of acer truncatum fruit shell tannin, 5-12 parts of grape skin extract, 4-12 parts of persimmon leaf extract, 3-8 parts of honeysuckle extract, 5-12 parts of kiwi fruit root extract, 4-10 parts of turmeric extract and 1-3 parts of chitosan oligosaccharide chelated copper; the capsule shell comprises 2-10 parts of edible chitosan, 1-5 parts of sodium alginate, 2-10 parts of soybean protein isolate, 10-20 parts of hydroxypropyl methylcellulose, 2-6 parts of nano edible montmorillonite, 0.5-2 parts of calcium hydrophosphate, 0.5-2 parts of talcum powder, 1-5 parts of maltitol, 1-3 parts of porous starch, 0.5-1 part of edible pigment and 60-90 parts of 10% tartaric acid aqueous solution. The capsule disclosed by the invention has the effects of enhancing immunity, resisting oxidation, resisting aging, resisting tumors and the like, can fully exert the effect of acer truncatum fruit shell tannin, promotes the development and utilization of the acer truncatum fruit shell tannin, and provides a high-quality and low-price anticancer medicine for human beings.

Description

Capsule based on acer truncatum fruit shell extract and processing equipment thereof
Technical Field
The invention relates to the technical field of medicine processing, in particular to a capsule based on acer truncatum fruit shell extract and processing equipment thereof.
Background
Acer truncatum is a special tree species in China and belongs to Aceraceae deciduous tree. Is distributed in Heilongjiang, Liaoning, Beijing, inner Mongolia, Jilin, Hebei, Henan, Shandong, Shanxi, Yunnan, Gansu, Ningxia, etc. of China. The acer truncatum leaves contain rich effective components such as flavone and chlorogenic acid, and the inner seed coats of the acer truncatum contain 60% of high-quality condensed tannin. Tannin, commonly known as tannin, is a polyphenol compound with the characteristic of precipitating protein, is soluble in water, ethanol and acetone, and is insoluble in chloroform or diethyl ether. The toxicological and pharmacodynamical research results show that the tannin has the obvious effects of inhibiting bacteria in vitro, resisting lipid oxidation, reducing blood sugar, resisting tumors, resisting canceration and the like. Tannin contains phenolic hydroxyl group, can be used as scavenger of various free radicals, and has effects of resisting aging and enhancing immunity. Along with the improvement of living standard, the health consciousness of people is also continuously improved, and the health food has wide market because of meeting the health requirements of people. Therefore, the development of products meeting the market demand by utilizing the bioactive components of tannin in acer truncatum has become a research hotspot of a plurality of researchers. The capsule has a capsule shell and is filled with the medicine, so that the capsule has the advantages of preventing the medicine from directly contacting with the outside, improving the stability of the medicine, covering the bad smell of the medicine and the like. In addition, the preparation has the effects of slow release, controlled release and positioning release by changing the property of the capsule shell. Therefore, the tannin capsule in the acer truncatum is developed, so that the natural and healthy health-care product can be improved for human beings, and the development and utilization of the acer truncatum can be improved.
In the production of capsule medicines, a capsule filling machine is usually adopted to fill the raw materials of the medicines into capsules, but the existing capsule filling machine has a complex structure and high input cost, and is not suitable for small-scale production and processing; the traditional manual preparation of capsules has low efficiency and poor sanitary conditions, the waste of the medicinal raw materials and the moisture absorption are serious in the filling process, the medicinal powder in each capsule cannot ensure the uniform filling, the particle weight is not uniform, and the requirement of the medicine quality is not met.
Disclosure of Invention
In view of the above, the present invention provides a capsule based on acer truncatum fruit shell extract and a processing device thereof, so that acer truncatum fruit shell tannin is combined with various medicinal materials to prepare a non-toxic and harmless anticancer medicine with high quality and low price, so as to fully exert the efficacy of the acer truncatum fruit shell tannin, promote the development and utilization of the acer truncatum fruit shell tannin, and prepare the acer truncatum fruit shell tannin into the capsule by using a small semi-automatic device, thereby improving the utilization rate of tannin and the medicine quality.
The invention solves the technical problems by the following technical means:
a capsule based on acer truncatum fruit shell extract comprises a capsule shell and medicinal powder filled in the capsule shell, wherein the medicinal powder comprises the following raw materials in parts by weight: 4-14 parts of acer truncatum fruit shell tannin, 5-12 parts of grape skin extract, 4-12 parts of persimmon leaf extract, 3-8 parts of honeysuckle extract, 5-12 parts of kiwi fruit root extract, 4-10 parts of turmeric extract and 1-3 parts of chitosan oligosaccharide chelated copper;
it should be noted that:
the grape skin is rich in resveratrol, procyanidin, grape seed oil, etc., and resveratrol is a non-flavonoid polyphenol compound, contains stilbene structure, and has highest content in grape skin, especially grape skin. Has pharmacological effects of resisting cancer, oxidation, free radical, preventing heart disease, etc., has multiple activities, and has no toxicity and multiple functions.
The folium kaki is rich in various pharmacologically active substances such as flavone, triterpene, vitamins and microelements, and has effects of resisting oxidation, resisting cancer, stopping bleeding, sterilizing, and regulating immunity. The flavonoid compound serving as one of the most main active ingredients in the persimmon leaves has remarkable functions in the aspects of oxidation resistance, antibiosis, aging resistance, blood pressure regulation and the like, and has high nutritional and health-care values.
The honeysuckle has the effects of clearing away heat and toxic materials and dispelling wind and heat. Modern pharmacological studies show that honeysuckle has the effects of resisting inflammation, tumors, viruses, aging, oxidation and the like. The honeysuckle has good therapeutic effect on various cancers such as gastric cancer, lung cancer, colon cancer, breast cancer, leukemia and the like.
Alkaloids, flavonoids, triterpenes, anthraquinones, phenylpropanoids and other components are extracted from the Chinese gooseberry root, so that the Chinese gooseberry root has a good treatment effect on malignant tumors of a digestive system and a respiratory system (such as esophageal cancer, gastric cancer, lung cancer and the like), has a good effect on breast cancer, and has wide anticancer cell activity.
The turmeric is rich in curcumin compounds, which mainly comprise 3 curcumin, demethoxycurcumin and bisdemethoxycurcumin, and the content ratio is about 77%, 18% and 5% respectively. A large number of researches show that the curcumin compounds have remarkable biological activities, including anti-inflammation, antioxidation, antivirus, antitumor, lipid lowering and the like.
The chitosan oligosaccharide is the product of chitosan degradation, and has a molecular formula of (C)6H11O4N)nN is 2-10, and is oligosaccharide formed by connecting 2-10 glucosamine structural units through beta-1, 4-glycosidic bonds. The chitosan oligosaccharide has good physiological activity of chitosan, low relative molecular mass and good water solubility, and is easy to be absorbed by organisms. Recent researches prove that the chitosan oligosaccharide is nontoxic, can improve the immunity of a human body, has anticancer and antioxidant effects, and has obvious effects on reducing blood pressure and blood sugar, promoting the absorption of calcium and other trace elements and the like. Copper is a trace element necessary for human bodies and can influence the generation of cell factors in macrophages, and the chitosan oligosaccharide chelated copper (COS-Cu) can improve the anticancer, immune and inflammatory reactions of organisms, can also be used as a copper supplement agent for preventing, treating or assisting in treating diseases caused by copper deficiency, improves the copper absorption rate of the organisms, reduces the toxicity of copper and further improves the guiding performance of capsule shells.
The capsule shell comprises the following raw materials in parts by weight: 2-10 parts of edible chitosan, 1-5 parts of sodium alginate, 2-10 parts of soybean protein isolate, 10-20 parts of hydroxypropyl methylcellulose, 2-6 parts of nano edible montmorillonite, 0.5-2 parts of calcium hydrophosphate, 0.5-2 parts of talcum powder, 1-5 parts of maltitol, 1-3 parts of porous starch, 0.5-1 part of edible pigment and 60-90 parts of 10% tartaric acid aqueous solution.
At present, the medicinal capsule shells on the market are mainly animal capsule shells, the main component of the medicinal capsule shells is animal gelatin, and the animal gelatin capsule shells are prepared by mixing with auxiliary materials after being refined, wherein the proportion of the animal gelatin capsule shells in the capsule shells in China exceeds 95 percent. The physical and chemical properties of the gelatin are complex, and the source is difficult to control, so that the gelatin capsule shell has a plurality of defects. The gelatin capsule shell is easy to dehydrate in a dry environment and further hardened and easily fragile; the water absorption is easy to occur in a humid environment, and the water is further softened; the cross-linking reaction is easy to occur when the aldehyde substances are encountered, the requirement on the storage environment is high, and the property is unstable. The plant type capsule shell has the advantages of high inertia, stable property, wide applicability, high safety and the like. The medicinal capsule shell which is developed by compounding the edible chitosan, the soybean protein isolate and the hypromellose can completely overcome the defects and limitations of gelatin capsules, has stronger viscosity, gel property and film-forming property, good reproducibility, biodegradability, non-antigenicity, mechanical property and low price, is novel modified starch with a honeycomb structure and large specific surface area, is used as an economic biodegradable adsorbent, can fully adsorb edible pigment, and improves the color stability and uniformity of the capsules.
Further, the processing method of the capsule shell comprises the following steps:
s1, dissolving edible chitosan, soy protein isolate, nano edible montmorillonite, calcium hydrogen phosphate, talcum powder, maltitol, sodium alginate, hydroxypropyl methylcellulose and edible pigment in 10% tartaric acid aqueous solution, and fully stirring and mixing at 50 ℃ to obtain colloidal liquid;
s2, obtaining colloidal liquid from S1, and processing the colloidal liquid by a glue dipping method or a pressing method to obtain a capsule shell;
s3, placing the capsule shell obtained in the step S2 into 10% of CaCl2Calcifying in the solution for 10-15s, soaking in clear water for 5-10s, and oven drying at 30-45 deg.C.
Further, the preparation method of the chitosan oligosaccharide chelated copper comprises the following steps:
respectively weighing chitosan oligosaccharide and copper chloride dihydrate according to the mass ratio of 15:8, uniformly mixing, grinding at room temperature for about 3 hours to enable the chitosan oligosaccharide and the copper chloride to fully react, then adding absolute ethyl alcohol according to the material ratio of 1:3, stirring at the rotating speed of 400r/min for 10 minutes, filtering to remove filtrate, washing filter residues with the absolute ethyl alcohol for a plurality of times, and then drying in an oven at 60 ℃ for 4 hours to obtain the chitosan oligosaccharide chelated copper.
Furthermore, the nano edible montmorillonite is loaded with tea polyphenol, and the preparation method comprises the following steps:
adding 20% ethanol solution by volume into nano edible montmorillonite at a material ratio of 1:20, stirring for 20h, adding 3 wt% tea polyphenol into the nano edible montmorillonite, dispersing for 30min under 90KW ultrasound to obtain suspension, and distilling the suspension under reduced pressure to remove solvent to obtain the tea polyphenol-loaded nano edible montmorillonite. The tea polyphenol-loaded nano edible montmorillonite can improve the mechanical property, water resistance, water vapor barrier property and oxidation resistance of the capsule shell, and can inhibit gas exchange inside and outside the capsule shell, thereby preventing the medicinal powder from absorbing moisture.
In addition, the invention also provides a processing device of capsules based on acer truncatum fruit shell extracts, which is used for filling medicinal powder into capsule shells and comprises a machine body shell, wherein horizontal supporting plates are symmetrically arranged at two sides of the lower part of the machine body shell, a capsule placing plate is placed on the horizontal supporting plates, capsule placing holes are uniformly distributed on the capsule placing plate, air cylinders I are symmetrically arranged at two sides of the bottom of the machine body shell, an air cylinder shaft of the air cylinder I is connected with the bottom surface of the capsule placing plate, an ejecting plate is arranged below the capsule placing plate, an ejecting rod matched with the capsule placing holes is arranged on the top surface of the ejecting plate, an air cylinder II is arranged in the middle of the bottom of the machine body shell, an air cylinder shaft of the air cylinder II is connected with the bottom surface of the ejecting plate, horizontal sliding grooves are symmetrically arranged at two sides of the middle part of the machine body shell, capsule cap placing plates are placed in the horizontal sliding grooves, the capsule cap placing hole corresponds to the capsule placing hole, the capsule placing hole and the capsule cap placing hole are both provided with elastic clamping layers, a partition plate is arranged above the capsule cap placing plate, the partition plate is provided with an ejecting hole corresponding to the capsule cap placing hole, the partition plate and the upper part of the machine body shell form a capsule collecting cavity, a powder filling box is vertically arranged between the capsule placing plate and the capsule cap placing plate, the bottom of the powder filling box is provided with a filling opening, the bottom of the powder filling box is in clearance contact with the capsule placing plate, a third air cylinder is arranged in the machine body shell, an air cylinder shaft of the third air cylinder is connected with the side surface of the powder filling box, the side surface of the machine body shell is provided with a powder filling box containing cavity, the bottom surface of the powder filling box containing cavity is level with the placing capsule plate, the length of the ejecting rod is larger than the sum of the thicknesses of the capsule placing plate, the capsule cap placing plate and the partition plate, the machine body shell is provided with, the outer side wall of the machine body shell is provided with a control panel.
This processing equipment can realize the semi-automatic operation of capsule filling, and equipment structure is simpler, and holistic filling performance is simple perfect more, and the stability ability of the holistic work of better guarantee and structure, the flexibility is higher, and performance and practicality have all obtained higher promotion to can avoid the waste of powder in the filling in-process, improve the quality of the capsule of processing.
Further, powder filling box comprises outer box and interior box, and the cylinder axle of cylinder three links to each other with the side of outer box, and the bilateral symmetry of outer box is provided with fixed slot, and interior box detachably shelves in the fixed slot of outer box, and the bottom of outer box is equipped with the elasticity sealing washer. Through the cooperation design of outer box and interior box, more convenient in the filling of powder and the washing of powder filling box, firstly improve the use convenience and the sanitary condition of powder filling box, secondly the switching of the powder of being convenient for can be applicable to the filling of different powder, improve equipment application range. Elastic sealing ring can further prevent that powder from breaking away from powder filling box and scattering, accumulation on the board is placed to the utricule, avoids the waste of powder.
Further, a push plate is vertically arranged on the partition plate, a cylinder IV is arranged in the machine body shell, a cylinder shaft of the cylinder IV is connected with the side face of the push plate, when the cylinder IV is in a contraction state, the push plate is located on one side of the machine body shell, and a capsule outlet is formed in the other side of the machine body shell. Four work of cylinder through control panel control, the cylinder promotes the push pedal and slides to capsule export one side, can export the capsule propelling movement to the capsule on the baffle to from the capsule export processing equipment of seeing off and collect.
Furthermore, a circle of elastic bulges are arranged in the ejection hole, and the width formed between the elastic bulges is slightly smaller than the diameter of the capsule cap. The elastic bulge firstly exerts certain main force on the capsule cap in the process of ejecting the capsule by the ejector rod, so that the capsule body and the capsule cap can be tightly matched, and secondly, the capsule ejected to the upper surface of the partition plate is prevented from falling into the capsule cap placing plate from the ejection hole.
Further, the outer box and the inner box of the powder filling box are both made of stainless steel, and a heater is arranged in a fixing clamping groove of the outer box. The medicine powder in the medicine powder filling box can be prevented from absorbing moisture by heating the heater; firstly, avoid powder because of the moisture absorption caking, guarantee that powder can normally fill to the utricule, secondly control the powder water content of filling to the utricule, guarantee the shelf life of powder, avoid the moisture absorption rotten.
Furthermore, the top of the ejection rod is of a concave structure matched with the bottom of the bag body. The design of concave surface structure can increase the area of contact of ejector pin at the in-process of ejecting capsule and utricule bottom, reduces the local atress of utricule bottom, prevents to warp because of the too big capsule that leads to of local atress at ejecting in-process.
The invention has the beneficial effects that:
1. the capsule containing acer truncatum fruit shell tannin has the effects of enhancing immunity, resisting oxidation, resisting aging, resisting tumors and the like, can fully exert the effect of the acer truncatum fruit shell tannin, promotes the development and utilization of the acer truncatum fruit shell tannin, and provides a cheap and good-quality anticancer medicine for human beings.
2. The capsule shell prepared by the method has excellent mechanical property, water resistance, water vapor barrier property and oxidation resistance, can inhibit gas exchange inside and outside the capsule shell, thereby preventing the medicinal powder from absorbing moisture, has good reproducibility, biodegradability, non-antigenicity, good mechanical property and low price, is novel modified starch with a honeycomb structure and large specific surface area by porous starch, can fully adsorb edible pigment as an economic biodegradable adsorbent, and improves the color stability and uniformity of the capsule; in addition, the chitosan oligosaccharide chelated copper is added into the capsule shell, so that the anticancer, immune and inflammatory reactions of organisms can be improved, the capsule shell can be used as a copper supplement agent for preventing, treating or assisting in treating diseases caused by copper deficiency, the absorption rate of the organisms on copper is improved, the toxicity of copper is reduced, and the guiding performance of the capsule shell is further improved.
3. The processing equipment can realize semi-automatic operation of capsule filling, has a simpler equipment structure, has simpler and more complete integral filling performance, better guarantees integral work and structural stability, has higher flexibility, and can better improve the service performance and the practicability, avoid waste of medicinal powder in the filling process, prevent the medicinal powder from absorbing moisture in the filling process, and improve the quality of processed capsules.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a side view of the present invention;
FIG. 3 is an enlarged view of a portion of FIG. 1 at A;
wherein, the organism shell 1, horizontal support plate 2, board 3 is placed to the utricule, hole 4 is placed to the utricule, cylinder 5, knock-out plate 6, knock-out pole 7, cylinder two 8, horizontal spout 9, board 10 is placed to the capsule cap, hole 11 is placed to the capsule cap, elasticity chucking layer 12, baffle 13, ejection hole 14, capsule collection chamber 15, powder filling box 16, outer box 161, interior box 162, fixed slot 163, filling opening 17, cylinder three 18, powder filling box accomodates chamber 19, opening 20, control panel 21, elasticity sealing washer 22, push pedal 23, cylinder four 24, capsule export 25, elastic bulge 26, heater 27.
Detailed Description
The invention will be described in detail below with reference to the following drawings:
example one
The preparation method of the chitosan oligosaccharide chelated copper comprises the following steps:
respectively weighing 1500g of chitosan oligosaccharide and 800g of copper chloride dihydrate, uniformly mixing, grinding at room temperature for about 3h to ensure that the chitosan oligosaccharide and the copper chloride react fully, then adding 6.9L of absolute ethyl alcohol, stirring at the rotating speed of 400r/min for 10min, filtering to remove filtrate, washing filter residues with the absolute ethyl alcohol for several times, and then drying in an oven at 60 ℃ for 4h to obtain 1903g of chitosan oligosaccharide chelated copper.
The preparation method of the tea polyphenol-loaded nano edible montmorillonite comprises the following steps:
adding 100g of nano edible montmorillonite into 2L of 20% ethanol solution by volume fraction, stirring for 20h, adding 3g of tea polyphenol into the nano edible montmorillonite, dispersing for 30min under 90KW ultrasound to obtain suspension, and distilling the suspension under reduced pressure to remove the solvent to obtain 102.8g of tea polyphenol-loaded nano edible montmorillonite.
Example two
On the basis of the first embodiment, the capsule based on the acer truncatum fruit shell extract comprises a capsule shell and medicinal powder filled in the capsule shell, wherein the medicinal powder comprises 40g of acer truncatum fruit shell tannin, 50g of grape skin extract, 40g of persimmon leaf extract, 30g of honeysuckle extract, 50g of kiwi root extract, 40g of turmeric extract and 10g of chitosan oligosaccharide chelated copper; the capsule shell comprises 20g of edible chitosan, 10g of sodium alginate, 20g of soybean protein isolate, 100g of hydroxypropyl methylcellulose, 20g of tea polyphenol-loaded nano edible montmorillonite, 5g of calcium hydrophosphate, 5g of talcum powder, 10g of maltitol, 10g of porous starch, 5g of edible pigment and 600g of 10% tartaric acid aqueous solution. The preparation method of the capsule shell comprises the following steps: dissolving edible chitosan, soybean protein isolate, nano edible montmorillonite, calcium hydrogen phosphate, talcum powder, maltitol, sodium alginate, hydroxypropyl methylcellulose and edible pigment in 10% tartaric acid aqueous solution, and stirring and mixing at 50 deg.C to obtain colloidal liquid; processing the obtained colloidal liquid by a glue dipping method or a pressing method to obtain a capsule shell; placing the obtained capsule shell in 10% CaCl2Calcifying in the solution for 10s, soaking in clear water for 5s, and oven drying at 30 deg.C.
EXAMPLE III
On the basis of the first embodiment, the capsule based on the acer truncatum bunge shell extract comprises a capsule shell and medicinal powder filled in the capsule shell, wherein the medicinal powder comprises 80g of acer truncatum bunge shell tannin, 70g of grape skin extract, 100g of persimmon leaf extract, 50g of honeysuckle extract, 70g of kiwi fruit root extract, 80g of turmeric extract and 20g of chitosan oligosaccharide chelated copper; the capsule shell comprises 40g of edible chitosan, 30g of sodium alginate, 60g of soybean protein isolate, 150g of hydroxypropyl methylcellulose, 30g of tea polyphenol-loaded nano edible montmorillonite, 10g of calcium hydrophosphate, 7g of talcum powder, 30g of maltitol, 20g of porous starch, 8g of edible pigment and 700g of 10% tartaric acid aqueous solution. The preparation method of the capsule shell comprises the following steps: dissolving edible chitosan, soybean protein isolate, nano edible montmorillonite, calcium hydrogen phosphate, pulvis Talci, maltitol, sodium alginate, hydroxypropyl methylcellulose and edible pigment in 10% tartaric acid water solution, stirring and mixing at 50 deg.CObtaining colloidal liquid; processing the obtained colloidal liquid by a glue dipping method or a pressing method to obtain a capsule shell; placing the obtained capsule shell in 10% CaCl2Calcifying 13s in the solution, then soaking in clear water for 7s, and drying at the constant temperature of 40 ℃.
Example four
On the basis of the first embodiment, the capsule based on the acer truncatum bunge shell extract comprises a capsule shell and medicinal powder filled in the capsule shell, wherein the medicinal powder comprises 140g of acer truncatum bunge shell tannin, 120g of grape skin extract, 120g of persimmon leaf extract, 80g of honeysuckle extract, 120g of kiwi fruit root extract, 100g of turmeric extract and 30g of chitosan oligosaccharide chelated copper; the capsule shell comprises 100g of edible chitosan, 50g of sodium alginate, 100g of soybean protein isolate, 200g of hydroxypropyl methylcellulose, 60g of tea polyphenol-loaded nano edible montmorillonite, 20g of calcium hydrophosphate, 20g of talcum powder, 50g of maltitol, 30g of porous starch, 10g of edible pigment and 900g of 10% tartaric acid aqueous solution. The preparation method of the capsule shell comprises the following steps: dissolving edible chitosan, soybean protein isolate, nano edible montmorillonite, calcium hydrogen phosphate, talcum powder, maltitol, sodium alginate, hydroxypropyl methylcellulose and edible pigment in 10% tartaric acid aqueous solution, and stirring and mixing at 50 deg.C to obtain colloidal liquid; processing the obtained colloidal liquid by a glue dipping method or a pressing method to obtain a capsule shell; placing the obtained capsule shell in 10% CaCl2Calcifying in the solution for 15s, soaking in clear water for 10s, and oven drying at 45 deg.C.
The capsule powder prepared in the second to fourth examples is taken and subjected to acute toxicity test and long-term toxicity test respectively.
First, acute toxicity test
Preparation of a test sample: and (3) adding water into the capsule powder prepared in the second to fourth embodiments respectively to prepare 30% (g/v) powder suspension.
1. Half lethal dose (LD50) determination:
one-time oral administration is carried out by filling the drug powder suspension into mice according to the dose of 6.1-15g/kg, no mice die within seven days, and no toxic reaction of the mice is observed after administration. The test failed to detect LD50 in mice that were orally administered with the drug powder suspension of the present invention by a single gavage, since the administration concentration was 30% and the administration volume (1.0 ml/mouse) was maximized.
2. Maximum tolerated dose determination: mice were gavaged three times over 24 hours, each time animals received a maximum volume (1ml/20g) dose (15g/kg) at a maximum concentration (30%), 7 hours apart, and none of the mice died and had a toxic response within seven days.
Second, Long term toxicity test
1. Animal grouping: wistar germ line healthy white rats with 60 animals and half animals are selected and randomly divided into three groups, wherein each group comprises 20 animals and 10 animals.
2. Dose, route:
low dose group: 2.4g/kg dose;
high dose group: 4.8g/kg dose;
blank control group: 0g/kg dose;
the suspension of the capsule powder prepared in the second to fourth examples is respectively infused into the stomach of the white rat once a day according to the dosage, the concentration of the suspension of the powder is 24% (g/v), and the dosage is 2mL/100g of body weight, and the suspension of the powder is continuously infused for 4 weeks.
3. And (4) checking results: at 24 hours after the last administration, half of the animals in each group were killed, the organs of the animals were fixed with 10% formalin, covered with paraffin, sliced, and HE-stained, and the pathological histological examination of the blank control group and the high dose group was performed with an optical microscope, and the results showed that the organs of the heart, liver, spleen, lung, kidney, stomach, brain, adrenal gland, testis, ovary, small intestine, etc. of the high dose group did not show toxic pathological changes compared with the blank control group. Although the low dose group had stored the material, no histological examination was performed since no abnormal lesion was found at the high dose.
According to the experimental results of acute toxicity tests and long-term toxicity tests, the capsule prepared by the invention has no toxic or side effect on mice, and can ensure the safe use of human bodies.
EXAMPLE five
As shown in figures 1-3, a processing device of capsule based on acer truncatum fruit shell extract comprises a machine body shell 1, wherein horizontal supporting plates 2 are symmetrically arranged on two sides of the lower portion of the machine body shell 1, a capsule placing plate 3 is placed on the horizontal supporting plates 2, capsule placing holes 4 are uniformly distributed on the capsule placing plate 3, cylinders 5 are symmetrically arranged on two sides of the bottom of the machine body shell 1, cylinder shafts of the cylinders 5 are connected with the bottom surface of the capsule placing plate 3, an ejector plate 6 is arranged below the capsule placing plate 3, ejector rods 7 matched with the capsule placing holes 4 are arranged on the top surface of the ejector plate 6, a cylinder II 8 is arranged in the middle of the bottom of the machine body shell 1, cylinder shafts of the cylinder II 8 are connected with the bottom surface of the ejector plate 6, horizontal sliding grooves 9 are symmetrically arranged on two sides of the middle portion of the machine body shell 1, a capsule cap placing plate 10 is placed in the horizontal sliding grooves 9, and capsule cap placing holes 11 are uniformly distributed on the capsule cap, the capsule cap placing hole 11 corresponds to the capsule placing hole 4, the capsule placing hole 4 and the capsule cap placing hole 11 are both provided with an elastic clamping layer 12, a partition plate 13 is arranged above the capsule cap placing plate 10, the partition plate 13 is provided with an ejection hole 14 corresponding to the capsule cap placing hole 11, the partition plate 13 and the upper part of the machine body shell 1 form a capsule collecting cavity 15, a medicinal powder filling box 16 is vertically arranged between the capsule cap placing plate 3 and the capsule cap placing plate 10, the bottom of the medicinal powder filling box 16 is provided with a filling opening 17, the bottom of the medicinal powder filling box 16 is in clearance contact with the capsule placing plate 3, a third air cylinder 18 is arranged in the machine body shell 1, the air cylinder shaft of the third air cylinder 18 is connected with the side surface of the medicinal powder filling box 16, the side surface of the machine body shell 1 is provided with a medicinal powder filling box containing cavity 19, the bottom surface of the medicinal powder filling box containing cavity 19 is level with the capsule placing plate 3, the length of the ejector rod 7 is greater than the sum of, the body shell 1 is equipped with the opening 20 in the position that board 3, capsule cap placed board 10, powder filling box accomodate the chamber 19 and correspond is placed to the utricule, is equipped with control panel 21 on the lateral wall of body shell 1.
The medicine powder filling box 16 is composed of an outer box 161 and an inner box 162, the cylinder shafts of the three cylinders 18 are connected with the side surface of the outer box 161, the two sides of the outer box 161 are symmetrically provided with fixing clamping grooves 163, the inner box 162 is detachably placed in the fixing clamping grooves 163 of the outer box 161, and the bottom of the outer box 161 is provided with an elastic sealing ring 22.
The baffle 13 is vertically provided with a push plate 23, the body shell 1 is internally provided with a cylinder four 24, the cylinder shaft of the cylinder four 24 is connected with the side surface of the push plate 23, when the cylinder four 24 is in a contraction state, the push plate 23 is positioned at one side of the body shell 1, and the other side of the body shell 1 is provided with a capsule outlet 25.
A ring of elastic protrusions 26 is provided in the ejection hole 14, and the width formed between the elastic protrusions 26 is slightly smaller than the diameter of the capsule cap.
The outer box 161 and the inner box 162 of the medicine powder filling box 16 are both made of stainless steel, and a heater 27 is arranged in a fixing clamping groove 163 of the outer box 161.
The top of the ejection rod 7 is a concave structure matched with the bottom of the capsule body.
The using method of the invention is as follows:
before using, pack into the utricule and place the utricule on board 3 and place in the hole 4, pack into the capsule cap and place the capsule cap on board 10 and place in the hole 11, under the effect of elasticity chucking layer 12, utricule and capsule shell are blocked respectively in the utricule is placed in hole 4 and capsule cap and is placed in the hole 11, then place board 3 and capsule cap with the utricule respectively and place board 10 and insert in organism shell 1 from opening 20 on organism shell 1, and the utricule opening upwards, capsule cap opening is downwards. When the medicine powder filling device is used, the control panel 21 controls the third air cylinder 18 to work periodically, the third air cylinder 18 drives the medicine powder filling box 16 to slide back and forth on the capsule body placing plate 3, and medicine powder leaks from the filling opening 17 and is filled into the capsule body in the sliding process; when the bag body is filled, the control panel 21 controls the third air cylinder 18 to stop working, and the medicine powder filling box 16 is accommodated into the medicine powder filling box accommodating cavity 19 under the action of the third air cylinder 18; then, the control panel 21 controls the first air cylinder 5 to work, and the first air cylinder 5 drives the capsule placing plate 3 to move upwards and finally to be in close contact with the capsule cap placing plate 10; the control panel 21 controls the second air cylinder 8 to work, the second air cylinder 8 drives the ejector plate 6 to move upwards, the ejector plate 6 is in the upward movement process, the ejector rod 7 is inserted from the capsule placing hole 4 and pushes the capsule to move upwards, the capsule cap is gradually inserted in the capsule upward movement process and is tightly matched with the capsule cap into a whole, the ejector plate 6 continues to move upwards, the ejector rod 7 pushes the capsule formed by the capsule and the capsule cap to enter the ejector hole 14 along the capsule cap placing hole 11 and finally pushes the capsule ejector hole 14 into the partition plate 13 to form a capsule collecting cavity 15 with the upper part of the machine body shell 1, the control panel 21 controls the fourth air cylinder 24 to work, the fourth air cylinder 24 pushes the push plate 23 to slide towards one side of the capsule outlet 25, the capsule on the partition plate 13 can be pushed to the capsule outlet 25 and is sent out of the processing equipment from the capsule outlet 25 to be collected, and then the second air cylinder 8 is sequentially controlled by the control panel 21, And finishing one filling after the cylinder 5 stops working. And then repeating the above operations.
Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims. The techniques, shapes, and configurations not described in detail in the present invention are all known techniques.

Claims (10)

1. A capsule based on Acer truncatum Bunge shell extract comprises a capsule shell and medicinal powder filled in the capsule shell, and is characterized in that the medicinal powder comprises the following raw materials in parts by weight: 4-14 parts of acer truncatum fruit shell tannin, 5-12 parts of grape skin extract, 4-12 parts of persimmon leaf extract, 3-8 parts of honeysuckle extract, 5-12 parts of kiwi fruit root extract, 4-10 parts of turmeric extract and 1-3 parts of chitosan oligosaccharide chelated copper;
the capsule shell comprises the following raw materials in parts by weight: 2-10 parts of edible chitosan, 1-5 parts of sodium alginate, 2-10 parts of soybean protein isolate, 10-20 parts of hydroxypropyl methylcellulose, 2-6 parts of nano edible montmorillonite, 0.5-2 parts of calcium hydrophosphate, 0.5-2 parts of talcum powder, 1-5 parts of maltitol, 1-3 parts of porous starch, 0.5-1 part of edible pigment and 60-90 parts of 10% tartaric acid aqueous solution.
2. The capsule based on Acer truncatum husk extract as claimed in claim 1, wherein the processing method of the capsule shell is as follows:
s1, dissolving edible chitosan, soy protein isolate, nano edible montmorillonite, calcium hydrogen phosphate, talcum powder, maltitol, sodium alginate, hydroxypropyl methylcellulose and edible pigment in 10% tartaric acid aqueous solution, and fully stirring and mixing at 50 ℃ to obtain colloidal liquid;
s2, obtaining colloidal liquid from S1, and processing the colloidal liquid by a glue dipping method or a pressing method to obtain a capsule shell;
s3, placing the capsule shell obtained in the step S2 into 10% of CaCl2Calcifying in the solution for 10-15s, soaking in clear water for 5-10s, and oven drying at 30-45 deg.C.
3. The capsule based on Acer truncatum husk extract as claimed in claim 2, wherein the preparation method of the chitosan oligosaccharide chelated copper is as follows:
respectively weighing chitosan oligosaccharide and copper chloride dihydrate according to the mass ratio of 15:8, uniformly mixing, grinding at room temperature for about 3 hours to enable the chitosan oligosaccharide and the copper chloride to fully react, then adding absolute ethyl alcohol according to the material ratio of 1:3, stirring at the rotating speed of 400r/min for 10 minutes, filtering to remove filtrate, washing filter residues with the absolute ethyl alcohol for a plurality of times, and then drying in an oven at 60 ℃ for 4 hours to obtain the chitosan oligosaccharide chelated copper.
4. The capsule based on Acer truncatum husk extract as claimed in claim 3, wherein the edible nano-montmorillonite is loaded with tea polyphenol, and the preparation method is as follows:
adding 20% ethanol solution by volume into nano edible montmorillonite at a material ratio of 1:20, stirring for 20h, adding 3 wt% tea polyphenol into the nano edible montmorillonite, dispersing for 30min under 90KW ultrasound to obtain suspension, and distilling the suspension under reduced pressure to remove solvent to obtain the tea polyphenol-loaded nano edible montmorillonite.
5. The processing equipment of the acer truncatum fruit shell extract-based capsule according to claim 4, which comprises a machine body shell, wherein horizontal supporting plates are symmetrically arranged on two sides of the lower portion of the machine body shell, a capsule placing plate is placed on the horizontal supporting plates, capsule placing holes are uniformly distributed on the capsule placing plate, first air cylinders are symmetrically arranged on two sides of the bottom of the machine body shell, air cylinder shafts of the first air cylinders are connected with the bottom surface of the capsule placing plate, an ejector plate is arranged below the capsule placing plate, ejector rods matched with the capsule placing holes are arranged on the top surface of the ejector plate, second air cylinders are arranged in the middle of the bottom of the machine body shell, air cylinder shafts of the second air cylinders are connected with the bottom surface of the ejector plate, horizontal sliding grooves are symmetrically arranged on two sides of the middle of the machine body shell, and capsule cap placing plates are placed in the horizontal sliding grooves, the capsule filling machine is characterized in that capsule cap placing holes are uniformly distributed in the capsule cap placing plate and correspond to the capsule body placing holes, elastic clamping layers are arranged in the capsule body placing holes and the capsule cap placing holes, a partition plate is arranged above the capsule cap placing plate and provided with ejection holes corresponding to the capsule cap placing holes, a capsule collecting cavity is formed between the partition plate and the upper portion of the machine body shell, a medicine powder filling box is vertically arranged between the capsule body placing plate and the capsule cap placing plate, a filling opening is formed in the bottom of the medicine powder filling box, the bottom of the medicine powder filling box is in gap contact with the capsule body placing plate, a third air cylinder is arranged in the machine body shell, an air cylinder shaft of the third air cylinder is connected with the side face of the medicine powder filling box, a medicine powder filling box containing cavity is arranged on the side face of the machine body shell, the bottom face of the medicine powder filling box containing cavity is level to the capsule body placing plate, and the length, The capsule cap placing plate and the partition plate are equal in thickness, openings are formed in the positions, corresponding to the capsule body placing plate, the capsule cap placing plate and the powder filling box containing cavity, of the machine body shell, and a control panel is arranged on the outer side wall of the machine body shell.
6. The apparatus for processing the acer truncatum fruit shell extract-based capsule as claimed in claim 5, wherein the powder filling box is composed of an outer box and an inner box, the cylinder shaft of the cylinder III is connected with the side surface of the outer box, the two sides of the outer box are symmetrically provided with fixing clamping grooves, the inner box is detachably placed in the fixing clamping grooves of the outer box, and the bottom of the outer box is provided with an elastic sealing ring.
7. The apparatus for processing the capsule based on the acer truncatum fruit shell extract as recited in claim 6, wherein the separator is vertically provided with a push plate, the housing is provided with a cylinder IV, the cylinder IV has a cylinder shaft connected with the side surface of the push plate, when the cylinder IV is in a contracted state, the push plate is positioned at one side of the housing, and the other side of the housing is provided with a capsule outlet.
8. The apparatus for processing Acer truncatum fruit shell extract-based capsules as claimed in claim 7, wherein a circle of elastic protrusions is arranged in the ejection holes, and the width formed between the elastic protrusions is slightly smaller than the diameter of the capsule cap.
9. The apparatus for processing the acer truncatum fruit shell extract based capsule as claimed in claim 8, wherein the outer box and the inner box of the powder filling box are both made of stainless steel, and a heater is arranged in the fixing clamping groove of the outer box.
10. The apparatus for processing Acer truncatum husk extract-based capsules as claimed in any one of claims 5 to 9, wherein the top of the ejector rod has a concave structure matching the bottom of the capsule body.
CN202011072543.6A 2020-10-09 2020-10-09 Capsule based on acer truncatum fruit shell extract and processing equipment thereof Pending CN112138120A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101032267A (en) * 2007-01-13 2007-09-12 吴建生 Tea for dispelling the alcoholic intoxication
CN101724094A (en) * 2008-10-13 2010-06-09 辽宁师范大学 Chitosan oligosaccharide chelated copper and preparation method thereof
CN103190616A (en) * 2013-04-03 2013-07-10 上海春芝堂生物制品有限公司 Pseudo-ginseng and grape seed capsules and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101032267A (en) * 2007-01-13 2007-09-12 吴建生 Tea for dispelling the alcoholic intoxication
CN101724094A (en) * 2008-10-13 2010-06-09 辽宁师范大学 Chitosan oligosaccharide chelated copper and preparation method thereof
CN103190616A (en) * 2013-04-03 2013-07-10 上海春芝堂生物制品有限公司 Pseudo-ginseng and grape seed capsules and preparation method thereof

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