CN102552549A - Composition for improving visual fatigue and preparation method and application thereof - Google Patents
Composition for improving visual fatigue and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to composition for improving visual fatigue and a preparation method and application thereof. The composition comprises following materials by weight part: 20 parts to 50 parts of huckleberry extractives, 10 parts to 30 parts of ginkgo leaf extractives, 5 parts to 15 parts of xanthophylls, 5 parts to 15 parts of green tea extractives and 0.1 parts to 0.5 parts of vitamin. The composition comprises various nutrition constituents and radiation resistant constituents, thereby being capable of providing the nutrition constituents for eyes, reducing harm of X-ray of a visual media fluorescent screen on eyes, repairing tissue damage and improving eye fatigue.
Description
Technical field
The present invention relates to a kind of health promoting product, relate to a kind of tired alimentation composition of easing eyes that is used for particularly.
Background technology
Since the progress of society, modernized high-speed development of science and technology, electrification has got into huge numbers of families, and people's work, study, life style change.Modern's life-time service and in the face of visual media such as computers, TV is closely looked thing, forces a ciliary muscle to be in the contraction tense situation; Thereby make crystal become protruding in adapting to near-sighted thing, eyes are long-term in tension and can not get having a rest the eyes easy fatigue; And then cause that aqueous humor operation is obstructed, be prone to cause glaucoma, simultaneously; Xerophthalmia, cataract, corneal ulcer and retina peel off etc., and vision also descends rapidly.
Simultaneously, contact computer for a long time except touching electromagnetic radiation, fluoroscopic the flashing of computer also has stronger stimulation to eyes, lets malaise symptoms such as shedding tears appears in the people, visual deterioration, dizziness.
Pericarpium Citri tangerinae is blue berry again, belongs to ericad, is the fruit of European Pericarpium Citri tangerinae.The flavone compound kind is many in the Pericarpium Citri tangerinae, content is high, mainly contains anthocyanidin, flavonol, preceding anthocyanidin and Quercetin composition, is the main active of this platymiscium.Wherein the research of anthocyan material the earliest.Finding now has about more than 30 kinds of anthocyanin, and wherein common has 15 kinds.Its coloring matter has five kinds of glycocides: anthocyanidin (is also claimed anthocyanidin; Anthocyanidin), delphinidin (is claimed delphinidin again; Delphindin), enidin (is claimed malvidin again; Malvidin), Radix Paeoniae florigen (peonidin), petunidin (are claimed 3-first delphinidin again, petunidin).Three kinds of sugar are arranged: glucose, galactose and arabinose.These five kinds of glycocides and three kinds of monosaccharide to three glucosides that glycosyl is formed are topmost anthocyanin.
Be rich in compositions such as tea polyphenols (50%) and lipopolysaccharide in the green tea, can remove intravital free radical, absorption and seizure radioactive substance and with get rid of after it combines external.Catechin is the main composition of tea polyphenols.Epigallocatechin gallate (EGCG) (EpigalloCatechin Gallate; EGCG) be the main constituent of green tea tea polyphenols; It also is the main component of green tea catechins class; Be the functional component that activity is the highest in the catechin, content is maximum, general content is counted the 30-50 milligram with every gram green tea.In catechin, a kind of catechin that EGCG is the removing free radical, oxidation resistance is the strongest.Contain a large amount of aldehydes matters in the tea and not only can protect intravital antioxidase system, but also can promote its activity, thus the lipid peroxidation in the protection cell membrane.Phenolic compound in green tea mainly is a flavonoid, comprises flavone, flavanone and anthocyanidin etc.Report tea polyphenols such as Ceng Lei have multinomial function, wherein can be used for radioprotective and (once build Zhang Yujun, the functional characteristic of tea polyphenols and application, 2003 (1): 43-46).
Phylloxanthin and zeaxanthin all are the phylloxanthin classes that belong to carotenoid system.And phylloxanthin extensively is present in the blood plasma and organ of green plants and human body, can eliminate hydroxy radical, is the chain rupture antioxidant of lipid peroxidation reaction.For the prevention of human body diseases, bringing into play important effect.And the phylloxanthin apoplexy due to endogenous wind, zeaxanthin and phylloxanthin except having carotenoid likewise the physiologically active, still have unique eye-protecting function.
Folium Ginkgo is a kind of plant with very high medical value, and ginkgo is the ancient seeds of China, and it is the tree of the medical treatment of mystery, and clinical application range progressively enlarges.The dried leaves of Ginkgoaceae plant Ginkgo biloba.Astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.Be used for cough and asthma due to lung deficiency, coronary heart disease, angina pectoris, hyperlipidemia, anticoagulant is solid, and certain probability improving memory is arranged.Though Folium Ginkgo ability blood circulation promoting; Prevention of Cardiovascular is sick; But can not take other simultaneously and control cardiovascular drugs (like aspirin), Semen Ginkgo extrac is the concentrated granular shape, has very strong removing free radical and antioxidation; The synthetic collagen protein composition of flavonoid glycoside in the Folium Ginkgo, aminoacid and aminoacid keeps skin gloss and elasticity to play no small effect to human body beauty treatment, the growth of inhibition melanin.In addition, according to modern clinical research, to the negative symptoms be main (as social withdrawal, sluggishness, thinking wholesale, symptom such as dull) chronic schizophrenia remarkable result is arranged, senile dementia is also had certain effect.
Vitamin A can be protected all part tissue of eye, is the raw material that constitutes photoactive substance in the optic cell, and vitamin A can promote growth promoter, and the protection night vision can increase premunition and antitumaous effect.
One Chinese patent application CN200910086220.X discloses a kind of Chinese medicine health care product that is used for alleviating asthenopia and preparation method thereof, and this Chinese medicine health care product is to be prepared from by certain weight ratio bathypelagic fish oil, Flos Chrysanthemi, European Pericarpium Citri tangerinae, Folium Ginkgo, vitamin C.Be rich in natural materials such as anthocyanidin, flavone, tea polyphenols during the present invention is raw materials used, and cooperate vitamin A, make and to replenish two kinds of nutritional labelings that eyes are required simultaneously, play mutual synergism, can prevent the teenager vision, alleviate and use the eyestrain.
One Chinese patent application is mainly processed by the material of following parts by weight: European Pericarpium Citri tangerinae extract: 30～90 parts number for the application for a patent for invention file of CN200910236323.X discloses a kind of compositions with asthenopia releasing function; Folium Ginkgo extract: 20～60 parts; Fructus Lycii extract: 25～75 parts; DHA powder: 17.5～52.5 parts; Vitamin A, vitamin C are primary raw material, and said composition can be improved symptoms such as eye is dry and astringent, fatigue.
One Chinese patent application number discloses a kind of pharmaceutical composition with asthenopia releasing function and preparation method thereof for the application for a patent for invention file of CN200910237243.6.This pharmaceutical composition is to be prepared from according to a certain weight ratio Pericarpium Citri tangerinae extract, phylloxanthin, vitamin A.
Do not see at present the relevant report that Pericarpium Citri tangerinae extract, Semen Ginkgo extrac, phylloxanthin, green tea extract, vitamin A share as yet.
Summary of the invention
The object of the present invention is to provide the asthenopic compositions of a kind of improvement.
The asthenopic compositions of a kind of improvement provided by the invention, it contains the composition of following weight portion: 20～50 parts of Pericarpium Citri tangerinae extracts, 10～30 parts of Folium Ginkgo extract, 5～15 parts of phylloxanthins, 5～15 parts of green tea extracts, 0.1～0.5 part of vitamin A.
Preferably, said composition contains the composition of following weight portion: 30～40 parts of Pericarpium Citri tangerinae extracts, 15～25 parts of Folium Ginkgo extract, 8～12 parts of phylloxanthins, 8～12 parts of green tea extracts, 0.2～0.4 part of vitamin A.
Further preferably, said composition contains the composition of following weight portion: 35 parts of Pericarpium Citri tangerinae extracts, 20 parts of Folium Ginkgo extract, 10 parts of phylloxanthins, 10 parts of green tea extracts, 0.3 part of vitamin A.
Compositions provided by the invention also comprises closes 300～500 parts adjuvant, is preferably 200～400 parts, more preferably 300 parts.
In the above-mentioned composition:
Said weight portion can be the known unit of weights of field of medicaments such as μ g, mg, g, kg, and the perhaps multiple of above-mentioned known unit is like 0.1kg, 10g, 100mg etc.
Said Pericarpium Citri tangerinae extract is the water extract of Pericarpium Citri tangerinae, and wherein anthocyanidin content is no less than 20%;
Said Folium Ginkgo extract is the ethanol extract of Folium Ginkgo, and general flavone content is not less than 24%;
Said phylloxanthin can directly be bought, and can be raw material with the marigold flower also, produces through steps such as dehydration pulverizing, solvent extraction, low-molecular-weight alcohol purification and vacuum concentration, and wherein lutein dipalmitate content is not less than 55%.
Said green tea extract is the complex that from green tea, extracts, and the content of epigallocatechin gallate (EGCG) is not less than 70%.Above-mentioned Pericarpium Citri tangerinae extract, Folium Ginkgo extract, green tea extract are the commercially available prod.
Said adjuvant is that acceptable auxiliary gets final product in the food industry, is selected from isomaltulose, dextrin, white sugar, citric acid, cane sugar powder, lactose or the Mel one or more.
The asthenopic compositions of improvement provided by the invention is acceptable tablet, capsule, granule, pill, powder, oral liquid or syrup clinically.
The present invention also provides the above-mentioned improvement of a kind of preparation asthenopic method for compositions, may further comprise the steps: supplementary material is sieved, stir according to the equivalent method of progressively increasing, promptly get.
The present invention also provides above-mentioned composition to improve the application in asthenopia, vision protection or radiation-resistant health product or the medicine in preparation.
Compositions of the present invention has the asthenopia of improvement, vision protection or radiation-resistant effect.
Anthocyanidin in the Pericarpium Citri tangerinae extract has stronger antioxidant action; Long-term edible can assist to remove toxic chemical substance, free radical etc. in the retina increase the retina C.I. Natural Red 8 and generate, and improve Infravision; The help eyes adapt to the variation of strong and weak light, take for a long time to make vision lasting.Pericarpium Citri tangerinae extract demonstrates the tangible help of eye, is through improving oxygen and the blood-transmitted ability to eye by inference.Many ocular disease comprise that the source of cataract formation and macular degeneration finally ascribes the injury of radical pair eye to.Pericarpium Citri tangerinae extract can protect eyes to avoid free radical injury as strong antioxidant.Existing discovering; Anthocyanidin can effectively improve human eye macula lutea recovery time especially in the dark situation identification of centering high spatial numeral more obvious; Thereby think that anthocyanidin can increase the microcirculatory blood in optical fundus; Acceleransstoff metabolism exchange and enhancing are to the protective effect of blood vessel; And then improve macula lutea recovery time and noctovision effect, and this possibly can promote that the regeneration of retinal stem cells vision rhodopsin is relevant with anthocyanidin, this also is one of the anthocyanidin reason that can effectively improve the computer terminal syndrome that causes because of the long-time operation computer.
Semen Ginkgo extrac is the concentrated granular shape; Have very strong removing free radical and antioxidation; The synthetic collagen protein composition of flavonoid glycoside in the Folium Ginkgo, aminoacid and aminoacid keeps skin gloss and elasticity to play no small effect to human body beauty treatment, the growth of inhibition melanin.
Be rich in compositions such as tea polyphenols (50%) and lipopolysaccharide in the green tea, can remove intravital free radical, absorption and seizure radioactive substance and with get rid of after it combines external.Epigallocatechin gallate (EGCG) EpigalloCatechin Gallate (being called for short EGCG) is the main constituent of green tea tea polyphenols; It also is the main component of green tea catechins class; Be the functional component that activity is the highest in the catechin, content is maximum, general content is counted the 30-50 milligram with every gram green tea.In catechin, a kind of catechin that EGCG is the removing free radical, oxidation resistance is the strongest.Contain a large amount of aldehydes matters in the tea and not only can protect intravital antioxidase system, but also can promote its activity, thus the lipid peroxidation in the protection cell membrane.Phenolic compound in green tea mainly is a flavonoid, comprises flavone, flavanone and anthocyanidin etc.The content of EGCG is not less than 70% in the green tea extract.
Phylloxanthin and zeaxanthin all are the phylloxanthin classes that belong to carotenoid system.And phylloxanthin extensively is present in the blood plasma and organ of green plants and human body, can eliminate hydroxy radical, is the chain rupture antioxidant of lipid peroxidation reaction.Vitamin A has the physiological function that promotes growth of animal and breeding, keeps epithelial tissue and twenty-twenty vision.
Compositions provided by the invention has the following advantages:
1, the present composition contains multiple nutritional components and radioprotective composition; Except providing eyes required nutritional labeling, can reduce of the injury of the fluorescent screen X ray of visual medium, the damage of repair tissue to eyes; Improve asthenopia, be particularly suitable for often using the working clan of computer to take.
2, compared with prior art, Pericarpium Citri tangerinae extract, Semen Ginkgo extrac, lutein ester, green tea extract, vitamin A share, and have synergy.
The specific embodiment
Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.Pericarpium Citri tangerinae extract and Folium Ginkgo extract are available from Shaanxi Sen Fu Bioisystech Co., Ltd, and wherein anthocyanidin content is no less than 20% in the Pericarpium Citri tangerinae extract, and in the Folium Ginkgo extract, general flavone content is not less than 24%; Said phylloxanthin is available from Shanxi Jiahe Plant Chemical Co., Ltd., and lutein dipalmitate content is not less than 55%.
Green tea extract is available from the high biological product company limited of Chengdu China, or the auspicious enlightening biotinylated biomolecule in Xi'an Science and Technology Ltd., and its EGCG (epigallocatechin gallate (EGCG)) is not less than 70%.
Vitamin A is available from Guangxi remittance Kang Yuan medicine company limited.
Embodiment 1: improve asthenopic powder
1, prescription: Pericarpium Citri tangerinae extract 35kg, Semen Ginkgo extrac 20kg, phylloxanthin 10kg, green tea extract 10kg, vitamin A 0.3kg, citric acid 100kg, white sugar 150kg, dextrin 50kg.
2, method for preparing:
1) Pericarpium Citri tangerinae extract, Semen Ginkgo extrac, phylloxanthin, green tea extract, vitamin A, citric acid, white sugar, dextrin are crossed 40 mesh sieves, subsequent use;
2) with former, adjuvant according to the equivalent method of progressively increasing, stir packing, every bag of 10g.
Embodiment 2: improve asthenopic granule
1, prescription: Pericarpium Citri tangerinae extract 20kg, Semen Ginkgo extrac 10kg, phylloxanthin 5kg, green tea extract 5kg, vitamin A 0.1kg, cane sugar powder 100kg.
2, method for preparing:
1) Pericarpium Citri tangerinae extract, Semen Ginkgo extrac, phylloxanthin, green tea extract, vitamin A, cane sugar powder are crossed 40 mesh sieves respectively, subsequent use;
2) with former, adjuvant according to the equivalent method of progressively increasing, stir, use 50% ethanol as binding agent then; The system soft material is processed granule with above-mentioned soft material with the granulator that waves of 14 eye mesh screens, and granule is inserted in the multi-functional boiling drier; About 40 minutes of 50 ℃ of airpillow-dry, control pellet moisture be 5%, then granulate; Packing, every bag of 10g.
Embodiment 3: improve asthenopic oral liquid
1, prescription: Pericarpium Citri tangerinae extract 50kg, Semen Ginkgo extrac 30kg, phylloxanthin 15kg, green tea extract 15kg, vitamin A 0.5kg, Mel 100kg, white sugar 300kg, citric acid 100kg.
2, method for preparing:
1) take by weighing Pericarpium Citri tangerinae extract, Semen Ginkgo extrac, phylloxanthin, green tea extract, vitamin A, white sugar, citric acid respectively, cross 40 mesh sieves, subsequent use;
2) with above former, adjuvant except that Mel according to the equivalent method mix homogeneously that progressively increases, be dissolved in then in the 400kg water, add Mel and stir, be sub-packed in the aseptic bottle every bottle of 20ml.
Experimental example: to asthenopia, vision and radiation-resistant influence
1, improves asthenopia, vision protection
1.1 140 of random selections often use the crowds of computer works, age 26-35 year, and the mean age 31.2 ± 0.6, be divided into seven groups at random, taking the product that embodiment 1-3 makes among the present invention is experimental group, takes Pericarpium Citri tangerinae extract separately as matched group 1.With the one Chinese patent application application number is that embodiment 1 prepared compositions in the CN200910086220.X patent document is that preferred composition that matched group 2, one Chinese patent application number provide for the patent of CN200910236323.X is that the preferred composition that matched group 3, one Chinese patent application number provide for the patent document of CN200910237243.6 is a matched group 4.
Took for 4 weeks continuously, the result is as shown in table 1.
Matched group 2 compositions and method for preparing are following:
Bathypelagic fish oil 1.36g, Flos Chrysanthemi 7g, European Pericarpium Citri tangerinae extract 0.5g, Folium Ginkgo 10.5g, vitamin C 0.75g.
With Pericarpium Citri tangerinae, 7 times of water gagings of adding of above-mentioned weight portion, heating extraction is 2 times under normal pressure, extracts 2 hours at every turn; Merge extractive liquid; Filter 2 times with 300 mesh sieves, be concentrated into relative density and be 1.33 thick paste, under 70 ℃, 0.07Mpa vacuum after the drying; Be ground into 120 order fine powders, get Pericarpium Citri tangerinae extract; With Flos Chrysanthemi, Folium Ginkgo, add 3 times of water gagings and extracted 2 hours, merge extractive liquid, concentrates, drying, powder gets dry extract; With Pericarpium Citri tangerinae extract, dried cream powder, fish oil and vitamin C mixing, be ground into fine powder, drying incapsulates, and promptly gets capsule.
Matched group 3 compositions and method for preparing are following:
European Pericarpium Citri tangerinae extract 60g, Folium Ginkgo extract 40g, Fructus Lycii extract 50g, DHA powder 35g, vitamin A 0.11g, vitamin C 14.5g.
Adjuvant: soybean salad oil 300.39g, gelatin 300g, glycerol 150g, purified water 270g.
With formula ratio through the European Pericarpium Citri tangerinae extract that is up to the standards (available from the natural pharmaceutcal corporation, Ltd of Hunan Xi Er; Anthocyanin) >=20.0%), Folium Ginkgo extract is (available from Beijing Jia Kang source development in science and technology company limited; Total flavones >=24%), Fructus Lycii extract is (available from limited the courting death of the natural Pharmaceutical of Hunan Xi Er; Crude polysaccharides >=20%), vitamin C (Beijing Jia Kang source development in science and technology company limited), DHA powder are (available from limited the courting death of Beijing Jia Kang source development in science and technology; DHA content >=10%) waves in three-dimensional and mix 30min in the mixer; Behind the mix homogeneously, put with soybean salad oil, the vitamin A (Beijing Jia Kang source development in science and technology company limited, content 1,000,000 IU/g) of formula ratio again and mix in the rustless steel beverage pot and stir.Mixed liquor process colloid mill 2～3 times is crossed 80 mesh sieves, and is for use:
1.2 preparation glue: it is subsequent use to take by weighing each material according to the formula proportion of glue.With changing glue (70 ℃) in load weighted purified water, glycerol, joining of the gelatin glue jar, evacuation (pressure 0.08Mpa), 80 eye mesh screens are filtered to insulation (holding temperature is 60 ℃) in the storage glue jar.
1.3 compacting soft gelatin capsule: the production environment temperature is that 21 ± 1 ℃, relative humidity are 30-40%, uses RJNJ-2 type encapsulating machine to suppress the soft capsule of device as 0.5g.
1.4 typing, preliminarily dried: baking temperature is 20-25 ℃, and relative humidity is 25%-30%, dry 24 hours.
1.5, thereby prepare soft capsule with the 95% concentration ethanol oil stain flush away that soft capsule is outer.
The composition and the method for preparing of matched group 4 are following:
Soft capsule content prescription: Pericarpium Citri tangerinae extract 51g, phylloxanthin 18g, retinol1 g, Cera Flava 21g, sorbitan mono-oleic acid ester 4g, soybean oil 405g.
Softgel shell prescription: gelatin 101g, glycerol 32g, sorbitol 11g, citric acid 6g, sodium benzoate 0.085g, purified water 100g.
The softgel shell method for preparing: gelatin, glycerol, sorbitol, citric acid, sodium benzoate, the purified water of above-mentioned recipe quantity are put in the appropriate vessel, and 70-80 ℃ of heating in vacuum stirs, and is mixed with gelatin solution, puts into and sprawls case, and be for use:
The soft capsule content method for preparing: Cera Flava is mixed with 1/3 soybean oil, 70 ℃ of heating in water bath dissolvings, colloid mill was pulverized 10 minutes, got mixed liquor 1; Pericarpium Citri tangerinae extract mixes with 1/3 soybean oil, joins in the mixed liquor 1, and colloid mill is pulverized and got mixed liquor 2 in 10 minutes; Then sorbitan mono-oleic acid ester, phylloxanthin, vitamin A are mixed with remaining 1/3 soybean oil, join in the mixed liquor 2, colloid mill was pulverized 10 minutes, got medicinal liquid.
Capsular preparation: medicinal liquid for preparing and gelatin solution are poured in the pellet processing machine, pelleting, typing, drying is washed ball, drying, packing makes soft capsule.
Table 1: to asthenopia and visual acuity affected
| Group | Asthenopia doing well,improving rate (%) | Poor sight improvement rate (%) |
| Matched group 1 | 36.87 | 21.32 |
| Matched group 2 | 62.13 | 45.46 # |
| Matched group 3 | 58.61 | 40.8 # |
| Matched group 4 | 63.22 | 51.68 # |
| Experimental group 1 | 88.25 ** | 60.37 **& |
| Experimental group 2 | 86.41 ** | 61.68 **& |
| Experimental group 3 | 87.39 ** | 64.52 **& |
* representes that matched group compares with experimental group, P＜0.01,
#Expression matched group 2,3,4 is compared P＜0.05 with matched group 1;
&The expression experimental group is compared P＜0.05 with matched group 2 or 3,4 groups
Can find out by table 1, after experiment finishes, experimental group and matched group asthenopia and vision by improve, experimental group is compared with matched group 1, has utmost point significant difference (P＜0.01), experimental group is compared with matched group 2 or 3,4 groups, has significant difference (P＜0.05).This explains that compositions of the present invention improving aspect asthenopia and the vision, is superior to single compositions-Pericarpium Citri tangerinae extract, also is superior to matched group simultaneously, has the effect of Synergistic.
2, radiation protection
2.1 laboratory animal: cleaning level Kunming mouse, 18～22g;
2.2 experiment medicine: Pericarpium Citri tangerinae extract is available from Shaanxi Sen Fu Bioisystech Co., Ltd
2.3 test method and grouping:
Get 180 mices, be divided into 9 groups, 20 every group: the 1st group (blank group) do not made irradiation with radiation, irritates the clothes normal saline; After all the other groups are accepted the 60Co gamma-rays total irradiation of single 7.5Gy (lethal dose) respectively; Second group (model group) irritated the clothes normal saline; Irritate clothes matched group 1, matched group 2, matched group 3, matched group 4,1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment respectively for the 3rd group, the 4th group, the 5th group, the 6th group, the 7th group, the 8th group, the 9th group; Irritate to feed dosage and be every day 1 time, the each filling fed 5ml, continuous 30 days.
2.4 experimental result:
Survival rate is that the 1-9 group is respectively 100%, 0.43%, 62%, 68%, 65%, 70%, 80%, 83%, 81%, and the effect of taking the embodiment group is superior to the effect of matched group.
2.5 conclusion: product of the present invention has radiation-resistant effect, and Pericarpium Citri tangerinae extract, Semen Ginkgo extrac, phylloxanthin, green tea extract, vitamin A share the effect that effect is superior to using separately Pericarpium Citri tangerinae extract, promptly share to have synergy.
Though, used general explanation, the specific embodiment and test in the preceding text, the present invention has been done detailed description, on basis of the present invention, can make some modifications or improvement to it, this will be apparent to those skilled in the art.Therefore, these modifications or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (9)
1. one kind is improved asthenopic compositions; It is characterized in that said composition contains the composition of following weight portion: 20～50 parts of Pericarpium Citri tangerinae extracts, 10～30 parts of Folium Ginkgo extract, 5～15 parts of phylloxanthins, 5～15 parts of green tea extracts, 0.1～0.5 part of vitamin A.
2. compositions according to claim 1; It is characterized in that said composition contains the composition of following weight portion: 30～40 parts of Pericarpium Citri tangerinae extracts, 15～25 parts of Folium Ginkgo extract, 8～12 parts of phylloxanthins, 8～12 parts of green tea extracts, 0.2～0.4 part of vitamin A.
3. compositions according to claim 1 is characterized in that, said composition contains the composition of following weight portion: 35 parts of Pericarpium Citri tangerinae extracts, 20 parts of Folium Ginkgo extract, 10 parts of phylloxanthins, 10 parts of green tea extracts, 0.3 part of vitamin A.
4. according to each described compositions among the claim 1-3, it is characterized in that said Pericarpium Citri tangerinae extract is the water extract of Pericarpium Citri tangerinae, wherein anthocyanidin content is no less than 20%; Said Folium Ginkgo extract is the ethanol extract of Folium Ginkgo, and general flavone content is not less than 24%; Dipalmitate content is not less than 55% in the said phylloxanthin; Said green tea extract is the complex that from green tea, extracts, and the content of epigallocatechin gallate (EGCG) is not less than 70%.
5. according to each described compositions among the claim 1-4, it is characterized in that said compositions also comprises the adjuvant of 300～500 weight portions, be preferably 200～400 weight portions, more preferably 300 weight portions.
6. compositions according to claim 5 is characterized in that said adjuvant is selected from one or more in isomaltulose, dextrin, white sugar, citric acid, cane sugar powder, lactose or the Mel.
7. according to each described compositions among the claim 1-6, it is characterized in that said composition is tablet, capsule, granule, pill, powder, oral liquid or syrup.
8. one kind prepares each said method for compositions among the claim 1-7, it is characterized in that this method may further comprise the steps: supplementary material is sieved, stir according to the equivalent method of progressively increasing, promptly get.
9. each described compositions is improved the application in asthenopia, vision protection or radiation-resistant health product or the medicine in preparation among the claim 1-8.
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| CN109875049A (en) * | 2019-03-11 | 2019-06-14 | 昆明七彩云花生物科技有限公司 | A kind of lozenge and its processing method for protecting eyes |
| CN112273495A (en) * | 2020-10-23 | 2021-01-29 | 西安陈锦济生物科技有限公司 | Tea composition for quickly recovering eyesight by clearly seeing far |
| CN113475652A (en) * | 2021-07-19 | 2021-10-08 | 广东轻工职业技术学院 | Preparation method of plant beverage with asthenopia relieving effect |
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| CN103892164A (en) * | 2012-12-30 | 2014-07-02 | 保龄宝生物股份有限公司 | Eyesight-improving eye-protecting anti-radiation erythritol chewable tablets and preparation method thereof |
| CN103892164B (en) * | 2012-12-30 | 2015-07-15 | 保龄宝生物股份有限公司 | Eyesight-improving eye-protecting anti-radiation erythritol chewable tablets and preparation method thereof |
| CN103734712A (en) * | 2013-12-02 | 2014-04-23 | 中国农业大学 | Eye-protecting blueberry-raspberry functional food |
| CN103734712B (en) * | 2013-12-02 | 2015-02-18 | 中国农业大学 | Eye-protecting blueberry-raspberry functional food |
| CN104474018A (en) * | 2014-12-22 | 2015-04-01 | 威海百合生物技术股份有限公司 | Health-care soft capsule for relieving asthenopia |
| CN105876785A (en) * | 2016-04-12 | 2016-08-24 | 郝明强 | Eyesight-protecting and electromagnetic-radiation-preventing food as well as preparation method thereof |
| CN108095112A (en) * | 2017-12-18 | 2018-06-01 | 苏州诺衡生命科技有限公司 | One kind contributes to health food for relieving visual fatigues of health food and preparation method |
| CN108210640A (en) * | 2018-04-09 | 2018-06-29 | 成都图径生物科技有限公司 | Alleviation visual fatigue composition containing tea extract |
| CN109875049A (en) * | 2019-03-11 | 2019-06-14 | 昆明七彩云花生物科技有限公司 | A kind of lozenge and its processing method for protecting eyes |
| CN112273495A (en) * | 2020-10-23 | 2021-01-29 | 西安陈锦济生物科技有限公司 | Tea composition for quickly recovering eyesight by clearly seeing far |
| CN113475652A (en) * | 2021-07-19 | 2021-10-08 | 广东轻工职业技术学院 | Preparation method of plant beverage with asthenopia relieving effect |
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