CN102960739A - Composition for improving asthenopia and its preparation method - Google Patents
Composition for improving asthenopia and its preparation method Download PDFInfo
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- CN102960739A CN102960739A CN2011102570966A CN201110257096A CN102960739A CN 102960739 A CN102960739 A CN 102960739A CN 2011102570966 A CN2011102570966 A CN 2011102570966A CN 201110257096 A CN201110257096 A CN 201110257096A CN 102960739 A CN102960739 A CN 102960739A
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Abstract
The invention relates to a composition for improving asthenopia and its preparation method. The composition consists of the following components by weight: 0.1-0.5 part of vitamin A, 30-50 parts of a chrysanthemum extract, 5-15 parts of a green tea extract, and 10-100 parts of an auxiliary material. The composition provided in the invention contains a variety of nutrients and anti-radiation components. Besides providing the nutrients required by eyes, the composition can reduce the harm of fluorescent screen X rays of visual media on eyes, repair tissue damage, and improve asthenopia.
Description
Technical field
The present invention relates to a kind of health product, relate to particularly a kind of alimentation composition be used to improving eye fatigue.
Background technology
Since the progress of society, the high speed development of modernization science and technology, electrification has entered huge numbers of families, and people's work, study, life style change.The modern uses and faces the visual media such as computer, TV for a long time, closely look thing, force a ciliary muscle to be in the contraction tense situation, thereby make crystal become protruding in adapting to near-sighted thing, eyes are long-term in tension and can not get having a rest, eyes are tired easily, and then cause that aqueous humor operation is obstructed, more easily cause glaucoma, simultaneously, xerophthalmia, cataract, ulcer of the cornea and retina peel off etc., and eyesight also descends rapidly.
Simultaneously, the Long Term Contact computer is except touching electromagnetic radiation, and flashing of computer fluorescent screen also has stronger spread effect to eyes, allows the malaise symptoms such as shedding tears appears in the people, hypopsia, dizziness.
Chrysanthemum is the dry capitulum of feverfew chrysanthemum (Chrystanthemum mor if olium Ramat).Most areas has cultivation in China, and the main place of production is Zhejiang, Anhui, Henan, Shandong, Sichuan Province etc.Chrysanthemum is a kind of industrial crops of medicine-food two-purpose, and its flavor property is sweet, hardship, and cold enters lung, Liver Channel.Pharmaceutical research shows that chrysanthemum has the antipathogen effect, can strengthen capillary resistance, and antiinflammatory action is arranged.Chrysanthemum extract has protective effect to biomembranous ultra-oxygen anion free radical damage, can be anti-ageing.Chrysanthemum contains volatile oil, choline, amino acid, chrysanthemum glucoside, vitamin A and B family vitamin etc., smell delicate fragrance, cool and comfortable.
Be rich in the compositions such as Tea Polyphenols (50%) and lipopolysaccharides in the green tea, can remove body interior free radical, absorption and seizure radioactive substance and external in conjunction with rear eliminating with it.Catechin is the chief component of Tea Polyphenols.Epigallo-catechin gallate (EGCG) (EpigalloCatechin Gallate, EGCG) be the chief component composition of Green Tea Polyphenols, it also is the main component of green tea catechins class, be the functional component that activity is the highest in the catechin, content is maximum, general content is counted the 30-50 milligram with every gram green tea.In catechin, a kind of catechin that EGCG is the removing free radical, oxidation resistance is the strongest.Contain the Antioxidant Enzyme Systems of a large amount of aldehydes matters in not only can protective in the tea, but also can promote its activity, thus the lipid peroxidation in the Cell protection film.Phenolic compound in green tea mainly is flavonoids, comprises flavones, flavanones and anthocyanidin etc.The report Tea Polyphenols such as Ceng Lei have multiple function, wherein can be used for radiation proof and (once build Zhang Yujun, the functional characteristic of Tea Polyphenols and application, 2003 (1): 43-46).
Vitamin A can be protected all part tissue of eye, is the raw material that consists of photoactive substance in the cellula visualis, vitamin A energy enhancing development, and the protection night vision can increase premunition and antitumaous effect.
Chinese patent application CN200810051653.7 discloses the health food of the anti-radiation eyesight protective that is comprised of green tea, cassia seed, the fruit of Chinese wolfberry, mulberry leaf, feverfew.
Chinese patent application CN200910086220.X discloses a kind of traditional Chinese medicine health care product for alleviating asthenopia and preparation method thereof, and this traditional Chinese medicine health care product is to be prepared from by certain weight ratio by deep sea fish oil, chrysanthemum, whortle, ginkgo leaf, vitamin C.Chinese patent application CN200810201679.5 discloses a kind of blueberry chrysanthemum capsules, forms (mass percent) by following component: blueberry powder: 15-30%; Chrysanthemum powder: 25-35%; Vitamin C: 2-5%; Starch: 35-50%.Component powders is mixed, in the empty pocket body of the hard shell capsules of packing into, cover capsule capsule cap, obtain described blueberry chrysanthemum capsules.The present invention is raw materials used to be natural blueberry and chrysanthemum, combines two kinds of natural materials that contain anthocyanidin and lutein, and cooperates vitamin C, allow to replenish simultaneously two kinds of natural colouring matters that eyes are required, play mutual synergy, can prevent teenager's eyesight, alleviate and use kopiopia.
Have not yet to see the relevant report that chrysanthemum, green tea (or Tea Polyphenols), vitamin A three medicines share.
Summary of the invention
The object of the present invention is to provide the asthenopic composition of a kind of improvement.
Another object of the present invention is to provide a kind of method for the preparation of improving asthenopic composition.
Another object of the present invention provides the application of said composition.
The asthenopic composition of a kind of improvement provided by the invention is grouped into by the one-tenth of following weight portion: 0.1～0.5 part of vitamin A, 30～50 parts of chrysanthemum extracts, 5～15 parts of green-tea extracts, 10～100 parts of auxiliary materials.
Preferably, said composition is grouped into by the one-tenth of following weight portion: 0.1～0.3 part of vitamin A, 30～40 parts of chrysanthemum extracts, 8～12 parts of green-tea extracts, 20～80 parts of auxiliary materials.
Further preferred, said composition is grouped into by the one-tenth of following weight portion: 0.2 part of vitamin A, 35 parts of chrysanthemum extracts, 10 parts of green-tea extracts, 50 parts of auxiliary materials.
In the above-mentioned composition:
Described weight portion can be the known unit of weights of field of medicaments such as μ g, mg, g, kg, and the perhaps multiple of above-mentioned known unit is such as 0.1kg, 10g, 100mg etc.;
Described chrysanthemum extract is the water extract of chrysanthemum, and its Content of Chlorogenic Acid is no less than 0.20%.
Described green-tea extract is the compound that extracts from green tea, and the content of EGCG is not less than 70%.
Described auxiliary material is that acceptable auxiliary material gets final product in the food industry, is selected from isomaltoketose, dextrin, white granulated sugar, citric acid, cane sugar powder, lactose or the honey one or more.
The asthenopic composition of improvement provided by the invention is oral formulations, is tablet, capsule, granule, pill, pulvis or oral liquid, also can be other acceptable edible formulations.
The present invention also provides a kind of method of improving asthenopic composition for preparing, and may further comprise the steps: supplementary material is sieved, stir according to the equivalent method of progressively increasing, then make preparation.
Composition of the present invention has the visual fatigue of improvement, vision protection or radiation-resistant effect.
Vitamin A has the physiological function that promotes growth of animal and breeding, keeps epithelial tissue and twenty-twenty vision.
Chrysanthemum is a kind of industrial crops of medicine-food two-purpose, and its flavor property is sweet, bitter, cool, enters lung, Liver Channel.Extract has protective effect to biomembranous ultra-oxygen anion free radical damage, can be anti-ageing.Chrysanthemum contains volatile oil, choline, amino acid, chrysanthemum glucoside, vitamin A and B family vitamin etc., smell delicate fragrance, cool and comfortable.Chlorogenic acid is a kind of effective phenolic antioxidant, and its oxidation resistance is better than caffeic acid, forulic acid, syringic acid, butylated hydroxy anisole (BHA) and tocopherol.Chlorogenic acid is Wheat Protein why, is because it contains a certain amount of R-OH base, can form the hydroperoxyl radical with antioxidation, and with the activity of the free radicals such as elimination hydroxyl radical free radical and superoxide anion, thereby protective tissue is avoided the infringement of oxidation.Chlorogenic acid is to effectively removing interior free yl, keeping the normal 26S Proteasome Structure and Function of body cell, prevent and delay the important function that has of tumour sudden change and the phenomenons such as old and feeble.
Be rich in the compositions such as Tea Polyphenols (50%) and lipopolysaccharides in the green tea, can remove body interior free radical, absorption and seizure radioactive substance and external in conjunction with rear eliminating with it.Epigallo-catechin gallate (EGCG) EpigalloCatechin Gallate (being called for short EGCG) is the chief component composition of Green Tea Polyphenols, it also is the main component of green tea catechins class, be the functional component that activity is the highest in the catechin, content is maximum, general content is counted the 30-50 milligram with every gram green tea.In catechin, a kind of catechin that EGCG is the removing free radical, oxidation resistance is the strongest.Contain the Antioxidant Enzyme Systems of a large amount of aldehydes matters in not only can protective in the tea, but also can promote its activity, thus the lipid peroxidation in the Cell protection film.Phenolic compound in green tea mainly is flavonoids, comprises flavones, flavanones and anthocyanidin etc.The content of EGCG is not less than 70% in the green-tea extract.
Composition provided by the invention has the following advantages:
1, the present composition contains multiple nutritional components and radioresistance composition, except providing eyes required nutritional labeling, can reduce the fluorescent screen X ray of visual medium to the injury of eyes, the damage of repair tissue, improve visual fatigue, be particularly suitable for often using the working clan of computer to take.
2, vitamin A, chrysanthemum extract and green-tea extract share, and have synergy.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Chrysanthemum extract described in the following embodiment available from the biological Co., Ltd of Shaanxi Rui Kang or in prosperous biotechnology Co., Ltd, be the water extract of chrysanthemum, its Content of Chlorogenic Acid is no less than 0.20%;
Described green-tea extract is available from Chengdu China high biological products Co., Ltd, or the auspicious enlightening biotinylated biomolecule in Xi'an Science and Technology Ltd., and its EGCG (Epigallo-catechin gallate (EGCG)) is not less than 70%,
Vitamin A is available from Guangxi remittance Kang Yuan medicine Co., Ltd.
Embodiment 1: improve asthenopic pulvis
1, prescription: vitamin A 0.1kg, chrysanthemum extract 50kg, green-tea extract 5kg, citric acid 10kg, white granulated sugar 20kg, dextrin 5g.
2, preparation method:
1) vitamin A, chrysanthemum extract, green-tea extract, citric acid, white granulated sugar, dextrin are crossed respectively 40 mesh sieves, for subsequent use;
2) with former, auxiliary material according to the equivalent method of progressively increasing, stir packing, every bag of 10g.
Embodiment 2: improve asthenopic granule
1, prescription: vitamin A 0.2kg, chrysanthemum extract 35kg, green-tea extract 10kg, cane sugar powder 50kg.
2, preparation method:
1) vitamin A, chrysanthemum extract, green-tea extract cane sugar powder are crossed respectively 40 mesh sieves, for subsequent use;
2) with former, auxiliary material according to the equivalent method of progressively increasing; stir; then use 50% ethanol as adhesive, softwood processed is with the oscillating granulator granulation of above-mentioned softwood with 14 eye mesh screens; particle is inserted in the multi-functional boiling drier; about 40 minutes of 50 ℃ of fluidized dryings, control pellet moisture be 5%, then whole grain; packing, every bag of 10g.
Embodiment 3: improve asthenopic oral liquid
1, prescription: vitamin A 0.5kg, chrysanthemum extract 30kg, green-tea extract 8kg, honey 10kg, white granulated sugar 8kg, citric acid 8kg.
2, preparation method:
1) take by weighing respectively vitamin A, chrysanthemum extract, green-tea extract, white granulated sugar, citric acid, cross 40 mesh sieves, for subsequent use;
2) above former, auxiliary material except honey mixed according to the equivalent method of progressively increasing, then be dissolved in the 30kg water, add honey and stir, be sub-packed in the aseptic bottle every bottle of 20ml.
Experimental example: on visual fatigue, eyesight and radiation-resistant impact
1, improves visual fatigue, vision protection
100 crowds that often use computer work of random selection, age 26-35 year, mean age 31.2 ± 0.6, be divided at random four groups, taking the product that embodiment 2 makes among the present invention is experimental group, takes separately that vitamin A, chrysanthemum extract, green-tea extract organize 1 in contrast, control group 2, control group 3.
Took continuously for 4 weeks, the result is as shown in table 1.
Table 1: on the impact of visual fatigue and eyesight
| Group | Visual fatigue doing well,improving rate (%) | Poor sight improvement rate (%) |
| The blank group | 0 | 0 |
| Control group 1 | 29.21* | 12.56* |
| Control group 2 | 25.38* | 25.21* |
| Control group 3 | 22.13* | 17.13* |
| Experimental group | 87.22*** ☆#※ | 64.34*** ☆#※ |
Compare * P＜0.05, * * * P＜0.001 with the blank group; Compare with control group 1,
☆P＜0.05; Compare with control group 2,
#P＜0.05; Compare with control group 3,
※P＜0.05
As can be seen from Table 1, compare with the blank group, control group 1-3 visual fatigue and eyesight are obviously improved (P＜0.05), take the effect of experimental group and have improved extremely significantly visual fatigue and eyesight (P＜0.001); 1-3 compares respectively with control group, the effect of experimental group be better than three and blank group difference and, namely visual fatigue and eyesight improve the aspect, vitamin A, chrysanthemum extract and green-tea extract share has synergy.
2, radiation protection
2.1 animal used as test: cleaning level Kunming mouse, 18～22g;
2.2 Experimental agents: chrysanthemum extract is available from the biological Co., Ltd of Shaanxi Rui Kang; Described green-tea extract is available from Chengdu China high biological products Co., Ltd; Vitamin A is available from Guangxi remittance Kang Yuan medicine Co., Ltd.2.3 test method and grouping:
Get one bag in embodiment 2 prepared samples, press vitamin A, chrysanthemum extract, the content ratio of green-tea extract in embodiment 2, take by weighing respectively vitamin A 0.2g, chrysanthemum extract 3.6g, green-tea extract 1.0g, add respectively the water-soluble solution of 20ml.Fill with every day and feed mouse 5ml, continuous irrigation was fed 30 days.
Get 100 mouse, be divided into 5 groups, 20 every group: the 1st group (blank group) do not make irradiation with radiation, gavages physiological saline; After all the other group groups are accepted respectively the 60Co gamma-rays full-body exposure of single 7.5Gy (lethal dose), second group (model group) gavages physiological saline, the 3rd group, the 4th group, the 5th group, the 6th group gavages respectively embodiment 2 (called after experimental group), vitamin A (control group 1), chrysanthemum extract (control group 2), green-tea extract (control group 3), fill with to feed dosage and be every day 1 time, the each filling fed 5ml, continuous 30 days.
2.4 experimental result:
Survival rate is that 1-6 group is respectively 100%, 0.48%, 79%, 25%, 22%, 23%, the experimental group effect be better than control group 1-3 effect and.
2.5 conclusion: product of the present invention has radiation-resistant effect, vitamin A, chrysanthemum extract, green-tea extract share effect be better than independent result of use and, namely the three share and has synergy.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvement to it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. one kind is improved asthenopic composition, it is characterized in that said composition is grouped into by the one-tenth of following weight portion: 0.1～0.5 part of vitamin A, 30～50 parts of chrysanthemum extracts, 5～15 parts of green-tea extracts, 10～100 parts of auxiliary materials.
2. composition according to claim 1 is characterized in that, said composition is grouped into by the one-tenth of following weight portion: 20～80 parts of 0.1～0.3 part of vitamin A, 30～40 parts of chrysanthemum extracts, 8～12 parts of green-tea extracts and auxiliary materials.
3. composition according to claim 1 is characterized in that, said composition is grouped into by the one-tenth of following weight portion: 0.2 part of vitamin A, 35 parts of chrysanthemum extracts, 10 parts of green-tea extracts, 50 parts of auxiliary materials.
4. each described composition is characterized in that according to claim 1-3, and described chrysanthemum extract is the water extract of chrysanthemum, and its Content of Chlorogenic Acid is no less than 0.20%.
5. each described composition is characterized in that according to claim 1-3, and described green-tea extract is the compound that extracts from green tea, and the content of EGCG is not less than 70%.
6. composition according to claim 1 is characterized in that, described auxiliary material is acceptable auxiliary material in the food industry.
7. composition according to claim 1 is characterized in that, described auxiliary material is selected from one or more in isomaltoketose, dextrin, white granulated sugar, citric acid, cane sugar powder, lactose or the honey.
8. composition according to claim 1 is characterized in that, said composition is oral formulations, is sheet, capsule, particle, ball, pulvis or oral liquid.
9. a method for preparing each described composition of claim 1-8 is characterized in that the method may further comprise the steps: supplementary material is sieved, stir according to the equivalent method of progressively increasing, then make preparation.
10. each described composition of claim 1-8 improves application in visual fatigue, vision protection or radiation-resistant health products or the medicine in preparation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108210640A (en) * | 2018-04-09 | 2018-06-29 | 成都图径生物科技有限公司 | Alleviation visual fatigue composition containing tea extract |
| CN108669333A (en) * | 2018-04-17 | 2018-10-19 | 佛山市雷米高动物营养保健科技有限公司 | Except pet tear stains composition, except pet tear stains product and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108210640A (en) * | 2018-04-09 | 2018-06-29 | 成都图径生物科技有限公司 | Alleviation visual fatigue composition containing tea extract |
| CN108669333A (en) * | 2018-04-17 | 2018-10-19 | 佛山市雷米高动物营养保健科技有限公司 | Except pet tear stains composition, except pet tear stains product and preparation method thereof |
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Application publication date: 20130313 |