CN112138045B

CN112138045B - Pharmaceutical composition for preventing or treating sepsis, preparation method thereof and traditional Chinese medicine processing equipment

Info

Publication number: CN112138045B
Application number: CN202011091655.6A
Authority: CN
Inventors: 张伟
Original assignee: Affiliated Hospital of Zunyi Medical University
Current assignee: Affiliated Hospital of Zunyi Medical University
Priority date: 2020-10-13
Filing date: 2020-10-13
Publication date: 2022-09-09
Anticipated expiration: 2040-10-13
Also published as: CN112138045A

Abstract

The invention discloses a pharmaceutical composition for preventing or treating sepsis, a preparation method thereof and traditional Chinese medicine processing equipment, wherein the pharmaceutical composition comprises rhubarb horsetails, honey-fried forsythia, gypsum, root of red rooted saliva, honeysuckle flower and giant knotweed rhizome; the traditional Chinese medicine composition comprises, by weight, 10-20 parts of ginger and rhubarb, 5-15 parts of honey-fried fructus forsythiae, 1-2 parts of gypsum, 3-10 parts of salvia miltiorrhiza, 5-10 parts of honeysuckle and 3-5 parts of polygonum cuspidatum. Solves the technical problems that the traditional Chinese medicine and western medicine have relatively limited action surfaces for treating sepsis in the prior art, and the common traditional Chinese medicine adopts a plurality of original medicinal materials, so that the traditional Chinese medicine has large toxic and side effects and the drug effect is difficult to effectively exert.

Description

Pharmaceutical composition for preventing or treating sepsis, preparation method thereof and traditional Chinese medicine processing equipment

Technical Field

The invention relates to the technical field of related medicines for sepsis, in particular to a medicine composition for preventing or treating sepsis and a preparation method thereof.

Background

Sepsis (sepsis) refers to the Systemic Inflammatory Response Syndrome (SIRS) caused by infection with clinically proven presence of bacteria or highly suspicious foci of infection. Although sepsis is caused by infection, once it occurs, its development follows its own pathological course and laws, so it is essentially the body's response to infectious agents.

In recent years, despite the great progress of anti-infective therapy and organ function support technologies, sepsis still has a mortality rate as high as 30-70%, and due to its high data cost and large medical resource consumption, it seriously harms human health.

However, the traditional western medicines are usually targeted for treatment according to the actual conditions of patients, the treatment mode is too limited, and the onset of sepsis is closely related to the change of multiple systems and multiple organs of the body.

Although there are related traditional Chinese medicine preparations in the prior art, the traditional Chinese medicine preparation is often not only of a large variety of medicinal materials, but also adopts raw medicinal materials which are mostly not further processed, and on the basis, because the traditional Chinese medicine also has certain toxic and side effects, the mode further brings certain burden to the viscera of a patient, such as the liver.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition for preventing or treating sepsis and a preparation method thereof, and aims to solve the technical problems that the sepsis treatment effect of traditional Chinese medicines and western medicines in the prior art is relatively limited, and common traditional Chinese medicines adopt various original medicinal materials, so that the toxic and side effects are large, and the drug effect is difficult to effectively exert.

In order to solve the technical problems, the invention specifically provides the following technical scheme:

a pharmaceutical composition for preventing or treating sepsis comprises radix et rhizoma Rhei, fructus forsythiae processed with Mel, Gypsum Fibrosum, Saviae Miltiorrhizae radix, flos Lonicerae and rhizoma Polygoni Cuspidati; wherein the content of the first and second substances,

the traditional Chinese medicine composition comprises, by weight, 10-20 parts of rheum officinale, 5-15 parts of honey-fried fructus forsythiae, 1-2 parts of gypsum, 3-10 parts of salvia miltiorrhiza, 5-10 parts of honeysuckle and 3-5 parts of polygonum cuspidatum.

In order to solve the technical problems, the invention further provides the following technical scheme:

a process for the preparation of a pharmaceutical composition as described above, comprising:

s100, processing ginger and rhubarb: parching radix Et rhizoma Rhei yellow wine, moistening with succus Zingiberis recens, adding rhizoma Zingiberis recens, and steaming to obtain radix Et rhizoma Rhei;

s200, processing honey-fried fructus forsythiae: parching fructus forsythiae, adding Mel solution, parching, spreading and air drying to obtain Mel processed fructus forsythiae;

s300, extracting ginger, rhubarb and honey-fried forsythia: leaching radix et rhizoma Rhei and Mel processed fructus forsythiae in yellow wine, and concentrating the obtained leaching solution to obtain radix et rhizoma Rhei and Mel processed fructus forsythiae extract;

s400, decocting gypsum, salvia miltiorrhiza, honeysuckle and polygonum cuspidatum with water: decocting Gypsum Fibrosum, Saviae Miltiorrhizae radix, flos Lonicerae and rhizoma Polygoni Cuspidati with water, and filtering to obtain water decoction;

s500, adding honey into the water decoction, decocting into paste, adding the curcuma longa rhubarb and the honey-fried forsythia suspense extract, and mixing to obtain the pharmaceutical composition.

As a preferred embodiment of the present invention, step S100 specifically includes:

s101, drying and grinding raw rhubarb, and spraying clear water for wetting;

s102, repeatedly screening the wetted raw rhubarb particles for multiple times, and spraying yellow wine into the particles in each screening process;

s103, stewing the raw rhubarb sprayed with the yellow wine at the temperature of 60-70 ℃, and stir-frying to obtain wine-fried raw rhubarb;

s104, adding the wine-fried raw rhubarb into ginger juice for moistening, and then adding ginger slices for steaming; wherein the content of the first and second substances,

the step S104 includes:

s1041, adding water into the crushed ginger grains for several times, juicing, combining the ginger juices obtained by multiple times of squeezing, and dividing into two parts according to the proportion of 1: 1.5-2;

s1042, soaking the wine-fried raw rhubarb into a first part of ginger juice, and mixing and moistening for the first time;

s1043, taking out the rhubarb which is subjected to the first moistening, and frying;

s1044 spreading the fried rhubarb, respectively placing ginger slices on the upper layer and the lower layer to enable the rhubarb to be positioned between the two layers of ginger slices, pouring a second part of ginger juice into the rhubarb, and steaming.

As a preferred embodiment of the present invention, step S300 specifically includes:

s301, freezing and conveying the obtained ginger-rhubarb in a vacuum environment, and intermittently stirring and crushing the frozen ginger-rhubarb in the conveying process to form frozen powder;

s302, heating and conveying the obtained honey-fried forsythia in a gradual heating environment in a nitrogen atmosphere, and alternately performing needling and extrusion in the heating and conveying process;

and S303, mixing the ginger-rhubarb processed in the step S301 and the honey-fried forsythia suspense, placing the mixture into yellow wine for leaching, and concentrating to obtain ginger-rhubarb and honey-fried forsythia suspense extracts.

In order to solve the above technical problems, the present invention further provides the following technical solutions:

the traditional Chinese medicine processing equipment for the preparation method comprises a first transmission channel and a second transmission channel which are arranged in parallel, wherein the inlet end of the first transmission channel is communicated with a screening and spraying device, the outlet ends of the first transmission channel and the second transmission channel are connected to form a same opening, and the opening is communicated with a mixing device; wherein, the first and the second end of the pipe are connected with each other,

the first transmission channel comprises a first transmission roller, a first shell, a vacuum pump and a refrigerator, wherein the first shell is arranged around the first transmission roller and provided with an inlet and an outlet, the vacuum pump is used for vacuumizing the first shell, the refrigerator is used for providing a refrigeration environment for the interior of the first shell, the inlet and the outlet of the first shell can be opened or closed and are provided with sealing baffles, and a crushing piece used for being matched with the first transmission roller to perform extrusion crushing is arranged on the inner wall of the first shell;

second transmission passageway includes second transmission roller, encloses to close the second transmission roller sets up and sets up the second casing of feed inlet and discharge gate, be used for to let in nitrogen gas in the second casing and lead to the nitrogen gas structure, and be used for to the inside heating element who provides heat energy of second casing, just heating element follows the extending direction of second casing is formed with a plurality of heating intervals, be provided with on the inner wall of second casing and be used for the cooperation the second transmission roller carries out acupuncture in turn and extruded acupuncture stripper plate.

As a preferred scheme of the present invention, a side plate is formed by extending upward a side wall of the first conveying roller along a conveying direction, and the first conveying roller is movably connected with a vibration structure for driving the conveying roller to vibrate;

the crushing piece comprises a telescopic rod and a push plate and a crushing cutter roller, the telescopic rod is arranged on the inner wall of the first shell in a downward extending mode, the push plate and the crushing cutter roller are arranged in the telescopic rod in a mode of being far away from one end of the first shell in sequence along the transmission direction, and the end face of the push plate is higher than the end face of the crushing cutter roller.

As a preferable aspect of the present invention, an end surface of the push plate close to the first conveying roller is formed to be inclined toward the first conveying roller in the conveying direction to form an inclined surface, and one side of the cut inclined surface close to the first conveying roller is formed to be a saw-toothed blade;

the crushing knife roll is formed into a first knife roll part, a second knife roll part and a third knife roll part which are spirally wound by a blade from one end close to the first shell to one end far away from the first shell in sequence, and the radius of the first knife roll part, the radius of the third knife roll part and the radius of the second knife roll part are sequentially increased.

As a preferred scheme of the invention, the screening and spraying device comprises a plurality of layers of vibrating screens which are sequentially arranged from top to bottom, a horn-shaped spraying structure is arranged between two adjacent layers of vibrating screens, a spray head of the spraying structure is arranged around a gap between two adjacent vibrating screens along the horizontal direction, a bearing disc is further arranged below the vibrating screen at the lower end, and a suction screening structure is communicated with the bearing disc;

the sucking and screening structure is used for sucking the rheum officinale particles on the bearing disc to the position above the vibrating screen mesh on the uppermost layer.

As a preferable mode of the present invention, the bottom surface of the receiving tray is gradually reduced from a side away from the suction screening structure to a side close to the suction screening structure;

part of the pipeline connected with the bearing disc in the suction screening structure is inclined obliquely upwards;

a plurality of blanking hole channels are formed in the part, located above the vibrating screen, of the suction screening structure;

the sieve pores of the plurality of layers of the vibrating screens are sequentially reduced from top to bottom.

As a preferable scheme of the present invention, a discharging opening is openably or closably disposed on a bottom surface of one side of the receiving tray, which is close to the suction screening structure, the discharging opening is communicated with the first conveying channel through a receiving cavity, and the receiving cavity includes a material amount limiting plate and a material pushing structure for pushing material into the first conveying channel.

Compared with the prior art, the invention has the following beneficial effects:

1) the whole medicinal ingredients are relatively simple and the traditional Chinese medicines are adopted for compatibility, so that the toxic and side effects on a human body are reduced, the burden on visceral organs is reduced, the whole curative effect is further improved, the whole immune function is improved, and the damage to other organs is reduced;

2) based on the introduction of ginger and rhubarb, the rhubarb is further processed and the ginger is introduced, so that the rhubarb is cooperated to further play the roles of sterilization and inflammation diminishing, and the severity of other abnormal reactions caused by sepsis is reduced; meanwhile, honey roasting is carried out on the forsythia, and effective components such as forsythin, forsythiaside and the like are refined by effective honey;

3) on the basis, gypsum, the salvia miltiorrhiza, the honeysuckle and the giant knotweed rhizome are added, so that the traditional Chinese medicine composition can be used for synergistically treating epidemic febrile disease and hyperpyrexia, has a certain effect on heart, effectively relieves other various side reactions caused by sepsis, comprehensively relieves the problems of damp heat and the like, starts from multiple aspects, further improves the body function of a human body on the basis of treating the sepsis, and enhances the immunity.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary and that other implementation drawings may be derived from the provided drawings by those of ordinary skill in the art without inventive effort.

FIG. 1 is a flow chart of a method of preparation provided by an embodiment of the present invention;

FIG. 2 is a schematic diagram of a portion of a first transmission channel according to an embodiment of the present invention;

FIG. 3 is a partial structural view of the portion A in FIG. 2;

fig. 4 is a schematic partial structure diagram of a second transmission channel according to an embodiment of the present invention;

FIG. 5 is a partial structural view of the portion B in FIG. 4;

fig. 6 is a schematic partial structure diagram of a screening and spraying device provided by an embodiment of the invention.

The reference numerals in the drawings denote the following, respectively:

1-vibrating a screen; 2-a bearing plate; 3-suction screening structure; 4-a blanking duct;

51-a first transfer roller; 52-an inlet; 53-an outlet; 54-a first housing; 55-a crushing member; 56-side plate; 57-a vibrating structure;

551-telescopic rod; 552-pusher plate; 553-crushing knife roll; 554-serrated doctor blade; 555-a first roller section; 556 — second knife roll section; 557-third tri-roll knife section;

61-a second transport roller; 62-a feed port; 63-a discharge hole; 64-a second housing; 65-needling the extrusion plate;

651-connecting rod; 652-a needle; 653-ladder-like protrusions.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a pharmaceutical composition for preventing or treating sepsis, which comprises rhubarb horsetails, honey-fried forsythia, gypsum, root of red rooted saliva, honeysuckle flower and giant knotweed rhizome; wherein, the first and the second end of the pipe are connected with each other,

In a further preferred embodiment, the pharmaceutical composition is formed into an aqueous solution, a paste, granules or tablets by means of a carrier.

The whole medicine adopts the traditional Chinese medicine compound components, comprehensively improves the immunity of a human body through reasonable compatibility, has a certain regulating effect on organ injury and other side reactions caused by sepsis, effectively reduces the influence of the sepsis on the body function, and comprehensively reduces the death rate of the sepsis.

As shown in fig. 1, the present invention provides a method for preparing the above-mentioned pharmaceutical composition, comprising:

s100, processing of ginger and rhubarb: roasting the raw rhubarb wine, adding ginger juice for moistening, adding ginger slices into the ginger juice, and steaming to obtain ginger rhubarb;

In a further preferred embodiment, in order to more effectively process rhubarb and improve the processing effect of ginger on rhubarb, the effective components in rhubarb are better blended with ginger, and the synergistic effect between the two is further improved, the step S100 specifically includes:

s101, drying and grinding raw rhubarb, and spraying clear water for wetting;

s104, adding the wine-fried raw rhubarb into the ginger juice for moistening, and then adding the ginger slices for steaming.

In a further preferred embodiment, step S104 includes:

s1044 spreading the fried rhubarb, respectively placing ginger slices on the upper layer and the lower layer to ensure that the rhubarb is positioned between the two layers of ginger slices, pouring a second part of ginger juice into the rhubarb, and steaming.

In a more preferred embodiment of the present invention, in step S1044, before steaming, a second moistening step of the rhubarb added with the second part of ginger juice is further included; wherein, the first and the second end of the pipe are connected with each other,

the temperature of the first moistening is higher than that of the second moistening.

Except for the improvement of the processing process of the medicinal materials, the medicinal materials need to be further processed in the pretreatment of mixing the medicinal materials, and generally, the medicinal materials are crushed or smashed. However, in the present invention, based on the processing of rhubarb and forsythia suspensa per se, on this basis, the rhubarb and forsythia suspensa are further processed before being mixed, and specifically, the step S300 specifically includes:

s302, heating and transmitting the obtained honey-fried forsythia in a gradual change type heating environment in a nitrogen atmosphere, and alternately performing needling and extrusion in the heating and transmitting process;

s303, mixing the rhubarb processed in the step S301 and the step S302 with honey-fried forsythia, leaching the mixture in yellow wine, and concentrating to obtain the rhubarb extract and the honey-fried forsythia extract.

After wine roasting, the steamed rheum officinale is frozen in the transmission process and is subjected to intermittent beating and crushing, and as the gaps have steamed water, the water is changed into ice in a freezing mode, so that the supporting volume in the gaps is increased, certain extrusion and damage are performed on particles, on the basis, the intermittent beating and crushing mode is further adopted, the integral structure of the particles is effectively damaged, and effective components can be better extracted in the later treatment process; meanwhile, the honey-fried forsythia is heated in a gradual change type heating environment to be in a state of continuous contraction and relaxation, so that honey liquid can better permeate into medicinal materials, the permeation state of the medicinal materials is better matched in a mode of alternately operating needling and extrusion during the period, the adsorption of the honey liquid is effectively improved, and certain effective components can be better permeated and extracted.

In another embodiment of the present invention, according to the specific treatment manner, the present invention further provides a traditional Chinese medicine processing apparatus, which includes a first transmission channel and a second transmission channel which are arranged in parallel, wherein an inlet end of the first transmission channel is communicated with a screening and spraying device, outlet ends of the first transmission channel and the second transmission channel are connected to form a same opening, and the opening is communicated with a mixing device; wherein the content of the first and second substances,

the first conveying channel comprises a first conveying roller 51, a first shell 54 which surrounds the first conveying roller 51 and is provided with an inlet 52 and an outlet 53, a vacuum pump for vacuumizing the first shell 54, and a refrigerator for providing a freezing environment for the interior of the first shell 54, wherein the inlet 52 and the outlet 53 of the first shell 54 can be provided with sealing baffles in an opening or closing manner, and a crushing piece 55 for being matched with the first conveying roller 51 to crush is arranged on the inner wall of the first shell 54;

second transmission path includes second transmission roller 61, encloses to close second transmission roller 61 sets up and sets up the second casing 64 of feed inlet 62 and discharge gate 63, be used for to let in the nitrogen gas structure of leading to of nitrogen gas in the second casing 64, and be used for to the inside heating element who provides heat energy of second casing, just heating element follows the extending direction of second casing 64 is formed with a plurality of heating intervals, be provided with on the inner wall of second casing 64 and be used for the cooperation second transmission roller 61 carries out acupuncture in turn and extruded acupuncture stripper plate 65.

In a further preferred embodiment, a side plate 56 is formed by extending the first conveying roller 51 upwards along the side wall of the conveying direction, and a vibration structure 57 for driving the conveying roller to vibrate is movably connected to the first conveying roller 51;

the crushing member 55 includes a telescopic bar 551 extending downward from the inner wall of the first housing 54, and a push plate 552 and a crushing blade 553 arranged in the telescopic bar 551 at an end away from the first housing 54 in order in the conveying direction, wherein an end surface of the push plate 552 is higher than an end surface of the crushing blade 553.

Carry out the flat push through push pedal 552, after pushing away flat ginger rhubarb for the medicinal material is whole to be formed into relatively controllable thickness, and rethread broken rotor 553 carries out the breakage on this basis, more is favorable to holistic crushing effect and broken homogeneity.

In a further preferred embodiment, an end surface of the pushing plate 552 close to the first conveying roller 51 is formed as an inclined surface inclined toward the first conveying roller 51 in the conveying direction, and a side of the cut inclined surface close to the first conveying roller 51 is formed as a serrated blade 554;

the crushing cutter 553 is formed as a first cutter portion 555, a second cutter portion 556 and a third cutter portion 557 in which blades are spirally wound in order from one end close to the first housing 54 to one end far from the first housing 54, and the radius of the first cutter portion 555, the radius of the third cutter portion 557 and the radius of the second cutter portion 556 are sequentially increased.

The crushing rotor 553 is provided with the first rotor portion 555, the second rotor portion 556 and the third rotor portion 557 which are spirally wound from top to bottom in sequence, and the width of each rotor portion is set in a targeted manner, so that the gradient setting is realized, and the crushing efficiency and the crushing effect of the whole crushing rotor 553 are effectively improved.

It should be further noted that, the whole screening process is not simply screening particles, and yellow wine needs to be sprayed in the screening process to enable the yellow wine to be better soaked, specifically, the screening and spraying device comprises multiple layers of vibrating screens 1 which are sequentially arranged from top to bottom, a horn-shaped spraying structure is arranged between two adjacent layers of vibrating screens 1, a nozzle of the spraying structure is arranged around a gap between two adjacent vibrating screens 1 along the horizontal direction, a receiving disc 2 is further arranged below the lower vibrating screen 1, and a suction screening structure 3 is communicated with the receiving disc 2;

the suction screening structure 3 is used for sucking the rhubarb particles on the bearing disc 2 to the position above the vibrating screen mesh 1 on the uppermost layer.

The yellow wine is sprayed in the gaps screened layer by layer, so that the whole yellow wine is in a better dispersion state, and the spraying effect and the infiltration degree of the yellow wine are effectively improved based on the whole yellow wine.

Certainly, when the wettability reaches a certain degree, the weight of the whole particles becomes larger, the particles cannot be sucked away by the suction screening structure 3, and the stability of the wettability of the rhubarb particles which cannot be sucked in relative to the yellow wine is further ensured.

Meanwhile, further, the bottom surface of the receiving tray 2 gradually decreases from the side away from the suction screening structure 3 to the side close to the suction screening structure 3;

the part of the pipeline connected with the bearing disc 2 in the suction screening structure 3 is inclined obliquely upwards.

In a more preferred embodiment, a plurality of blanking openings 4 are formed in the portion of the suction screen structure 3 above the vibrating screen 1;

the sieve pores of the plurality of layers of the vibrating screen 1 are sequentially reduced from top to bottom.

In a further preferred embodiment, in order to enable the feeding amount to be controllable each time, a discharging hole can be arranged on the bottom surface of one side, close to the suction screening structure 3, of the receiving disc 2 in an opening or closing manner, the discharging hole is communicated with the first conveying channel through a receiving cavity, and the receiving cavity comprises a material amount limiting plate and a material pushing structure used for pushing materials into the first conveying channel. The limiting plate can be a height limiting plate, the whole amount of the limiting plate can be limited through height limitation under the condition that the bottom area is certain, and when the limited amount is reached, material pushing can be carried out through the material pushing structure to achieve feeding.

The needling extrusion plate 65 is connected through a telescopic connecting rod 651, the needling extrusion plate 65 comprises a plurality of groups of needling pieces and extrusion pieces which are alternately arranged along the transmission direction, a plurality of felting needles 652 are formed on the needling pieces, a plurality of rows of ladder-shaped protrusions 653 vertical to the transmission direction are formed on the extrusion pieces, and the tips of the ladder-shaped protrusions 653 face the second transmission roller 61.

Example 1

The traditional Chinese medicine processing equipment is adopted to prepare the traditional Chinese medicine according to the following preparation method:

s100, processing of ginger and rhubarb: drying radix et rhizoma Rhei, grinding, and spraying clear water for moistening; repeatedly sieving the wetted raw rhubarb particles for multiple times, and spraying yellow wine into the particles in each sieving process; stewing the yellow wine-sprayed raw rhubarb at the temperature of 60-70 ℃, and stir-frying to obtain wine-fried raw rhubarb; adding water into the crushed ginger grains for several times, juicing, combining the ginger juices obtained by multiple times of squeezing, and dividing into two parts according to the proportion of 1: 1.5-2; soaking radix et rhizoma Rhei processed with wine in the first part of succus Zingiberis recens, mixing, and moistening for the first time; taking out the rhubarb which is subjected to the first moistening, and frying; spreading the fried rhubarb, respectively placing ginger slices on the upper layer and the lower layer to ensure that the rhubarb is positioned between the two layers of ginger slices, pouring a second part of ginger juice into the rhubarb, and steaming;

s300, extracting ginger, rhubarb and honey-fried forsythia: freezing and conveying the obtained ginger-rhubarb in a vacuum environment, and intermittently beating and crushing the frozen ginger-rhubarb in the conveying process to form frozen powder; heating and transmitting the obtained honey-fried forsythia in a gradual heating environment in a nitrogen atmosphere, and performing alternate needling and extrusion operations in the heating and transmitting process; mixing the processed radix et rhizoma Rhei and Mel-processed fructus forsythiae, leaching in yellow wine, and concentrating to obtain radix et rhizoma Rhei extract and Mel-processed fructus forsythiae extract;

s500, adding honey into the water decoction, decocting into paste, adding the ginger-rhubarb and the honey-fried forsythia suspense extract, and mixing to obtain a medicinal composition A1.

Wherein the dosage of each raw material is as follows:

10-20 parts of ginger and rhubarb, 5-15 parts of honey-fried forsythia, 1-2 parts of gypsum, 3-10 parts of salvia miltiorrhiza, 5-10 parts of honeysuckle and 3-5 parts of polygonum cuspidatum.

Example 2

The preparation was carried out as in example 1, except that the amounts of the starting materials were as follows:

To obtain the medicinal composition A2.

Example 3

To obtain the medicinal composition A3.

Example 4

The preparation method is as in example 3, except that in step S300, rheum officinale and honey-fried forsythia suspense are directly leached in yellow wine and concentrated to obtain rheum officinale and honey-fried forsythia suspense extracts, and finally the pharmaceutical composition a4 is prepared.

Test example 1

Three groups of 20 mice are taken, each group is respectively set as a model group and a control group, 60 mice are taken for an experimental group (wherein 15 mice are used for medicaments A1, A2, A3 and A4), and 50mg/kg of endotoxin is injected once through tail vein respectively, wherein the mice in the model group are not treated by any medicament, the mice in the control group are treated by using a commercially available Xuebijing medicament, and the mice in the experimental group are treated by using a paste prepared by honey refining of the medicinal composition.

The results were observed after 7 days, in which,

19 mice in the model group die, and the death rate reaches 95 percent;

the control group of mice died 14 mice, and the death rate reached 70%;

the mice in the experimental group died 20 mice, and the mortality rate reached 33.3% (among them, 5 mice died by a1, 4 mice died by a2, 3 mice died by A3, and 8 mice died by a 4).

Therefore, the pharmaceutical composition provided by the invention can effectively reduce the death rate of sepsis. On the premise of adopting the formula and the mode of the pharmaceutical composition, the mortality rate of the pharmaceutical composition is even lower than that of a medicine prepared by simply adopting the formula of the pharmaceutical composition.

Test example 2

The medicine A3 is used as an experimental medicine and is applied to the phase I clinic after being approved by the drug administration according to the relevant requirements of the drug clinical experiment quality management standard and the approval is obtained.

20 patients with sepsis of similar age and similar degree of disease were selected from the cooperative hospital, parameters of abdominal pressure, intestinal dysfunction score (a score determination standard for gastrointestinal function in MODS score), inflammatory factor level and cardiac function index before and after treatment were obtained from the hospital database, and the average value was calculated. (mainly, the Xuebijing is adopted for treatment, and symptomatic treatment is carried out according to side effects and the like, and the control group in the table is corresponded)

After the beginning of phase I clinic, selecting patients with similar age and disease degree to the patients who suffer from sepsis from the same hospital, after obtaining patient consent and signing a clinic experiment informed book, treating with medicine A3, checking the parameters of abdominal pressure, intestinal dysfunction score, inflammatory factor level and cardiac function index before treatment, and detecting the index again after treatment is completed. The specific correspondence is to the observation groups in the table. The treatment scheme is that the ointment of the medicine A3 is taken once in the morning and at night, and symptomatic support treatment is given according to the disease condition.

TABLE 1

TABLE 2

TABLE 3

It can be seen from the above that the effect of the traditional Chinese medicine of the invention after being matched with symptomatic support treatment is obviously superior to that of the existing conventional treatment mode, and the traditional Chinese medicine can comprehensively improve the functions of all organs of the body, reduce the severity of side reactions caused to the body and comprehensively improve the treatment effect.

The above embodiments are only exemplary embodiments of the present application, and are not intended to limit the present application, and the protection scope of the present application is defined by the claims. Various modifications and equivalents may be made by those skilled in the art within the spirit and scope of the present application and such modifications and equivalents should also be considered to be within the scope of the present application.

Claims

1. A preparation method of a medicine composition for preventing or treating sepsis is characterized in that,

the medicine composition consists of 10 to 20 weight parts of rhubarb horsetails, 5 to 15 weight parts of honey-fried forsythia, 1 to 2 weight parts of gypsum, 3 to 10 weight parts of salvia miltiorrhiza, 5 to 10 weight parts of honeysuckle and 3 to 5 weight parts of giant knotweed;

the preparation method comprises the following steps:

s100, processing of ginger and rhubarb: parching radix Et rhizoma Rhei yellow wine, moistening with succus Zingiberis recens, adding rhizoma Zingiberis recens, and steaming to obtain radix Et rhizoma Rhei;

s300, extracting ginger, rhubarb and honey-fried forsythia: freezing and conveying the obtained ginger-rhubarb in a vacuum environment, and intermittently stirring and crushing the frozen ginger-rhubarb in the conveying process to form frozen powder; heating and transmitting the obtained honey-fried forsythia in a gradual heating environment in a nitrogen atmosphere, and performing alternate needling and extrusion operations in the heating and transmitting process; leaching the treated rhubarb horsetails and honey-fried forsythia in yellow wine, concentrating the leaching liquid to obtain rhubarb horsetails and honey-fried forsythia extract; s400, decocting gypsum, salvia miltiorrhiza, honeysuckle and polygonum cuspidatum with water: decocting Gypsum Fibrosum, Saviae Miltiorrhizae radix, flos Lonicerae and rhizoma Polygoni Cuspidati with water, and filtering to obtain water decoction;

2. The method according to claim 1, wherein step S100 specifically comprises:

s101, drying and grinding raw rhubarb, and spraying clear water for wetting;

step S104 includes:

3. The preparation method of claim 1 or 2, further comprising a traditional Chinese medicine processing device, wherein the traditional Chinese medicine processing device comprises a first conveying channel and a second conveying channel which are arranged in parallel, the inlet end of the first conveying channel is communicated with a screening and spraying device, the outlet ends of the first conveying channel and the second conveying channel are connected to form a same opening, and the opening is communicated with a mixing device; wherein the content of the first and second substances,

the first transmission channel comprises a first transmission roller (51), a first shell (54) which surrounds the first transmission roller (51) and is provided with an inlet (52) and an outlet (53), a vacuum pump for vacuumizing the first shell (54), and a refrigerator for providing a freezing environment for the interior of the first shell (54), the inlet (52) and the outlet (53) of the first shell (54) can be provided with sealing baffles in an opening or closing manner, and the inner wall of the first shell (54) is provided with a crushing piece (55) for extruding and crushing by matching with the first transmission roller (51);

second transmission path includes second transmission roller (61), encloses to close second transmission roller (61) set up and set up second casing (64) of feed inlet (62) and discharge gate (63), be used for to let in nitrogen gas's logical nitrogen gas structure in second casing (64), and be used for to the inside heating element who provides the heat energy of second casing, just heating element follows the extending direction of second casing (64) is formed with a plurality of heating intervals, be provided with on the inner wall of second casing (64) and be used for the cooperation second transmission roller (61) carry out acupuncture in turn and extruded acupuncture stripper plate (65).

4. A preparation method according to claim 3, wherein a side plate (56) is formed by extending the side wall of the first conveying roller (51) upwards along the conveying direction, and a vibration structure (57) for driving the conveying roller to vibrate is movably connected to the first conveying roller (51);

the crushing member (55) comprises a telescopic rod (551) extending downwards from the inner wall of the first shell (54), and a push plate (552) and a crushing cutter roller (553) which are arranged in the telescopic rod (551) and far away from one end of the first shell (54) in sequence along the transmission direction, wherein the end surface of the push plate (552) is higher than the end surface of the crushing cutter roller (553).

5. A manufacturing method according to claim 4, wherein an end surface of the pushing plate (552) near the first conveying roller (51) is formed as an inclined surface inclined toward the first conveying roller (51) in a conveying direction, and a side of the cut-off inclined surface near the first conveying roller (51) is formed as a saw-toothed blade (554);

the crushing cutter roller (553) is sequentially formed into a first cutter portion (555), a second cutter portion (556) and a third cutter portion (557) in which blades are spirally wound from one end close to the first shell (54) to one end far away from the first shell (54), and the radius of the first cutter portion (555) and the radius of the third cutter portion (557) and the radius of the second cutter portion (556) are sequentially increased.

6. The preparation method according to claim 3, characterized in that the screening and spraying device comprises a plurality of layers of vibrating screens (1) which are sequentially arranged from top to bottom, a horn-shaped spraying structure is arranged between two adjacent layers of the vibrating screens (1), a spray head of the spraying structure is arranged around a gap between two adjacent vibrating screens (1) along the horizontal direction, a bearing disc (2) is further arranged below the vibrating screen (1) at the lower end, and a suction screening structure (3) is communicated with the bearing disc (2);

the suction screening structure (3) is used for sucking the rheum officinale particles on the bearing disc (2) to the position above the vibrating screen (1) on the uppermost layer.

7. A preparation method as claimed in claim 6, characterized in that the bottom surface of said basin (2) is gradually lowered from the side remote from said suction screening structure (3) to the side close to said suction screening structure (3);

a part of pipelines connected with the bearing disc (2) in the suction screening structure (3) is inclined upwards;

a plurality of blanking hole channels (4) are formed in the part, located above the vibrating screen (1), of the suction screening structure (3);

the sieve pores of the multiple layers of the vibrating screens (1) are sequentially reduced from top to bottom.

8. A preparation method according to claim 6, characterized in that a discharge port is arranged on the bottom surface of the receiving disc (2) close to one side of the suction screening structure (3) in an openable or closable manner, the discharge port is communicated with the first conveying channel through a receiving cavity, and the receiving cavity comprises a material amount limiting plate and a material pushing structure for pushing materials into the first conveying channel;

the acupuncture stripper plate (65) is connected through a telescopic connecting rod (651), the acupuncture stripper plate (65) comprises a plurality of groups of acupuncture pieces and extrusion pieces which are alternately arranged along the transmission direction, a plurality of puncture needles (652) are formed on the acupuncture pieces, a plurality of rows of ladder-shaped protrusions (653) which are perpendicular to the transmission direction are formed on the extrusion pieces, and the tips of the ladder-shaped protrusions (653) face the second transmission roller (61).