CN112137930B

CN112137930B - Skin allergy-relieving solid spray and preparation method thereof

Info

Publication number: CN112137930B
Application number: CN202011128252.4A
Authority: CN
Inventors: 徐国风; 曾珍; 韦铭; 劳巾婷
Original assignee: Guangzhou Yanzhibao Cosmetics Co ltd
Current assignee: Guangzhou Yanzhibao Cosmetics Co ltd
Priority date: 2020-10-21
Filing date: 2020-10-21
Publication date: 2021-06-01
Anticipated expiration: 2040-10-21
Also published as: CN112137930A

Abstract

The invention relates to the technical field of cosmetics, and particularly relates to a skin allergy-relieving solid spray and a preparation method thereof, wherein the skin allergy-relieving solid spray comprises the following components in parts by weight: 10-20 parts of wild chrysanthemum whole plant, 15-30 parts of wild ivy stems/leaves, 5-8 parts of witch hazel stems/leaves, 14-20 parts of chamomile flowers/leaves, 3-6 parts of golden camellia leaves and 6-12 parts of fallen rhizomes/leaves. The invention has the advantages of high stability, obvious allergy relieving effect and simple preparation process.

Description

Skin allergy-relieving solid spray and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, and particularly relates to a skin allergy-relieving solid spray and a preparation method thereof.

Background

Facial skin allergy is a common allergic form and is a common frequently-occurring disease in dermatology, and the incidence rate of the facial skin allergy tends to rise year by year along with environmental pollution and wide use of cosmetics. The face skin is allergic and has pruritus, and simultaneously, symptoms such as red swelling, dry scraps, blisters, even exudation, scabbing and the like can be caused; there may also be a sensation of tightness, numbness, swelling of the skin; some patients also have symptoms such as sneezing, watery nose, and lacrimation.

The existing commonly used medicines for face skin allergy are corticoid medicines, mainly have the effects of inhibiting the immune response of a human body, inhibiting the abnormal immune response which causes allergy, inhibiting the normal immune response and reducing the resistance of skin cells, thereby inducing the adverse reactions of non-allergic dermatitis, skin tumor, melanin deposition, abnormal skin growth and the like, and if the medicines are applied for a long time, the medicines can generate medicine dependence. In addition, non-hormonal treatment can be used, such as tacrolimus cream and the like, moisturizing cream and the like, but the price is high, the effect of the non-hormonal cream on removing inflammatory reaction is not better than that of hormone cream, the curative effect of each patient is different, the disease condition is easy to repeat, the duration is prolonged, the work, life and learning of the patient are influenced, and huge psychological pressure is caused.

There are many ways to prevent and treat skin allergy, and the general methods can be divided into the following categories.

Far from allergens: allergy is an immune abnormality and immune regulation disorder caused by a person with an allergic constitution after contacting with an allergen. It is important to prevent skin allergy to avoid contact with the substance causing allergy as much as possible. Allergens are necessary conditions for the occurrence of allergic reactions, and the occurrence of allergy can be avoided if the allergens are separated from the allergens, but the allergens of different human bodies are greatly different, so that the allergens do not have effects on all allergic patients.

Use of an antihistamine: antihistamines are antagonistic to the biological effects of histamine on humans, i.e. the use of antihistamine substances. The antihistaminic substance can inhibit mast cells from releasing allergic substances such as histamine, and inhibit division of eosinophilic cells and mast cells, thereby preventing the cells from aggregating at inflammation parts, relieving inflammation reaction, and achieving the purpose of treatment. However, most of the antihistamine substances are medicinal ingredients and are not allowed to be used in cosmetics.

Scavenging free radicals: recent studies have shown that the formation of allergic constitutions, as well as the onset of allergy, are associated with an excessive accumulation of free radicals in the body. The increasing environmental pollution, chemical abuse and radiation problems can directly cause the accumulation of free radicals in the body. The allergic constitution can be gradually improved by eliminating free radicals and regulating the immunity of the organism, but the required time is long and the short-term effect is not obvious.

Relieving itching and resisting stimulation: skin itch is a common complication of sensitive skin, and causes of skin itch are many, mainly due to dry skin. The treatment of cutaneous pruritus is on the one hand based on drugs, but more importantly, the patient is careful to care for the skin, and scratch is controlled, which leads to a vicious circle of more and more itching, which further aggravates the symptoms. The chemicals usually damage the cell membrane first, reducing cell tolerance, and promoting the secretion of various inflammatory factors by the cell, thereby causing inflammation. Therefore, by improving cell tolerance, protecting cell membranes is one of effective ways to prevent and treat skin allergy.

Enhancing skin barrier function: the abnormality of the skin lipid barrier not only reduces the water storage and moisturizing function of the skin, but also directly affects the growth and differentiation regulation of keratinocytes and the formation of healthy stratum corneum, which is the core part of the skin's physical barrier structure, and repairing or enhancing the skin's barrier function is an effective way to reduce skin sensitivity.

In recent years, researches at home and abroad find that extracts of some plants have a relieving effect on skin allergy, but have some problems, such as complex extraction process, single anti-allergy effect or single anti-allergy effect of some extracts and other side effects.

Chinese patent application CN104721098A discloses a skin allergy relieving liquid and a preparation method and application thereof, wherein the skin allergy relieving liquid in the invention takes six plants of wild chrysanthemum whole plant, wild ivy stem/leaf, witch hazel stem/leaf, camomile/leaf, golden camellia tea leaf and groundcherry rhizome/leaf as raw materials, and refined compound extracting solution is obtained by the steps of cleaning, crushing, hot water leaching, kaolin adsorption, standing, pressure filtration, ultrafiltration and the like. The skin allergy relieving liquid is a pure plant preparation, has a unique formula, can better regulate the immunologic function of a human body, improve the microcirculation of skin, diminish inflammation, relieve itching and promote skin metabolism under the synergistic effect of multiple beneficial factors in 6 plant raw materials, thereby inhibiting and eliminating a sensitization source and relieving anaphylactic reaction. However, the skin allergy-relieving liquid has instability, a small amount of precipitate exists, the preparation time is long, and the allergy-relieving effect is required to be further improved.

Therefore, it is necessary to develop a skin-soothing solid spray and a method for preparing the same, which can solve the above technical problems.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide the skin allergy-relieving solid spray which has high stability, obvious allergy-relieving effect and simple preparation process and the preparation method thereof.

The invention is realized by the following technical scheme:

the skin allergy-relieving solid spray comprises the following components in parts by weight: 10-20 parts of wild chrysanthemum whole plant, 15-30 parts of wild ivy stems/leaves, 5-8 parts of witch hazel stems/leaves, 14-20 parts of chamomile flowers/leaves, 3-6 parts of golden camellia leaves and 6-12 parts of fallen rhizomes/leaves.

The invention also relates to a preparation method of the skin allergy-relieving solid spray, which comprises the following steps:

1) weighing the raw materials according to the parts by weight, cleaning and cutting;

2) adding the cleaned and cut raw materials into water for leaching, filtering, and collecting an extracting solution;

3) adding an auxiliary agent into the extracting solution, and standing;

4) filtering the solid-liquid mixture formed after standing, and performing ultrafiltration on the obtained filtrate by using an ultrafiltration membrane to obtain skin allergy-relieving liquid;

5) mixing the skin allergy relieving liquid and the gel, heating to be transparent, and standing to room temperature to obtain the skin allergy relieving solid spray.

Preferably, the auxiliary agent in step 3) is at least one of diatomite, kaolin and polyacrylamide.

More preferably, the auxiliary agent is a mixture of diatomite and polyacrylamide with the mass ratio of the diatomite to the polyacrylamide being 1-2: 1.

Preferably, the amount of the water in the step 2) is 500-1500 parts by weight.

Preferably, the specific leaching process in step 2) is as follows: heating to 80-90 deg.C, maintaining the temperature, stirring, leaching for 3-6h, and cooling to below 50 deg.C.

More preferably, the temperature rising rate in the step 2) is 1-2 ℃/min, and the temperature reducing rate is 2-4 ℃/min.

More preferably, the step 2) includes the steps of:

adding the cleaned and cut raw materials into 1500 parts of water for leaching, firstly heating to 80-90 ℃, heating at the rate of 1-2 ℃/min, keeping the temperature, stirring and leaching for 3-6h, then cooling to below 50 ℃, cooling at the rate of 2-4 ℃/min, filtering, and collecting the extract.

Preferably, the mass of the auxiliary agent in the step 3) is 5-10% of the mass of the extracting solution.

Preferably, the auxiliary agent is added in the step 3), stirred for 0.5-1.5h and then kept stand for 6-10 h.

More preferably, the step 3) includes the steps of:

adding 5-10% of adjuvant into the extractive solution, stirring for 0.5-1.5 hr, and standing for 6-10 hr.

Preferably, the gel in the step 5) is a mixture of agarose, carrageenan and natto gum, and the weight ratio of the agarose, the carrageenan and the natto gum is 2-4:1-3: 1.

Preferably, the dosage of the gel in the step 5) is 0.5-3% of the mass of the skin allergy-relieving liquid.

Preferably, 0.1-1.5% of sodium carboxymethyl cellulose is added before heating in step 5), i.e. the sodium carboxymethyl cellulose accounts for 0.1-1.5% of the mass of the skin allergy-relieving liquid.

Preferably, in the step 5), the skin allergy-relieving liquid and the gel are mixed, the temperature is raised to 75-85 ℃, the mixture is stirred until the mixture is transparent, the temperature is reduced to 40-50 ℃, the stirring is stopped, and the mixture is kept stand to room temperature, so that the skin allergy-relieving solid spray is obtained.

More preferably, the temperature is raised and lowered by adopting a program in the step 5), wherein the temperature raising rate is 2-15 ℃/min, and the temperature lowering rate is 2-8 ℃/min.

More preferably, the step 5) includes the steps of:

mixing the skin allergy relieving liquid with 0.5-3% of gel, adding 0.1-1.5% of sodium carboxymethylcellulose, heating to 75-85 deg.C at a heating rate of 2-15 deg.C/min, stirring to transparent, cooling to 40-50 deg.C at a cooling rate of 2-8 deg.C/min, stopping stirring, and standing to room temperature to obtain skin allergy relieving solid spray.

The invention has the beneficial effects that:

according to the invention, the allergy-relieving effect is improved by further optimizing the dosage and the proportion of the raw materials, and the prepared skin allergy-relieving liquid has higher stability and is not easy to generate precipitates.

The invention further optimizes the heating and cooling rate of the extraction in the raw material extraction process, optimizes the composition of the auxiliary agent, is beneficial to adsorbing impurities, fully exerts the allergy relieving effect and shortens the extraction time.

The skin allergy-relieving liquid is prepared into a solid spray form, so that the stability of the skin allergy-relieving liquid is further improved, and the precipitation is avoided.

The invention optimizes the composition of the gel, is beneficial to stabilizing a system, has the functions of suspended particles and air, and can keep the suspended phase in a uniform state all the time. The gel of the invention is compatible with active ingredients and other functional ingredients of skin allergy relieving liquid, is suitable for various products for local application, and is beneficial to the active ingredients to play a role.

The solid spray has long retention time after being attached to the face, is beneficial to the transmission of active ingredients on the skin, improves the allergy relieving effect, avoids the liquid flowing of the common spray and reduces the burden of allergic skin.

The sodium carboxymethyl cellulose is added, so that the stability and the acting time of the product are further improved, and the active ingredients are favorably exerted.

The invention optimizes the heating and cooling rates in the gel forming process, and the formed gel has higher strength, is beneficial to stabilizing a system and simultaneously improves the atomization performance.

Detailed Description

The invention will be further described with reference to specific embodiments, and the advantages and features of the invention will become apparent as the description proceeds. These examples are illustrative only and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.

Example 1

A skin allergy-relieving solid spray is prepared by the following steps:

1) weighing 10 parts of whole wild chrysanthemum plants (roots, stems, leaves and flowers), 15 parts of wild ivy stems/leaves, 5 parts of witch hazel stems/leaves, 14 parts of chamomile flowers/leaves, 3 parts of golden camellia leaves and 6 parts of fallen rhizomes/leaves, cleaning and cutting;

2) adding the cleaned and cut raw materials into 500 parts of water for leaching, heating to 80 ℃ under stirring at the heating rate of 1 ℃/min, preserving heat, stirring, leaching for 3 hours, cooling to below 50 ℃ at the cooling rate of 2 ℃/min, filtering, and collecting the extract;

3) adding 5% of auxiliary agent into the extracting solution, stirring for 0.5h, and then standing for 6 h; the auxiliary agent is a mixture of diatomite and polyacrylamide with the mass ratio of 1: 1;

4) filtering the solid-liquid mixture formed after standing by using a plate-and-frame filter press, and performing ultrafiltration on the obtained filtrate by using a ceramic ultrafiltration membrane to obtain skin allergy relieving liquid;

5) mixing the skin allergy relieving liquid with 0.5% of a gelling agent, wherein the gelling agent is a mixture of agarose, carrageenan and natto gum, the weight ratio of the agarose, the carrageenan and the natto gum is 2:1:1, adding 0.1% of sodium carboxymethylcellulose, heating to 75 ℃, the heating rate is 2 ℃/min, stirring until the mixture is transparent, cooling to 40 ℃, the cooling rate is 2 ℃/min, stopping stirring, standing to room temperature, filling into a spray bottle, and slowly forming gel to obtain the skin allergy relieving solid spray.

Example 2

A skin allergy-relieving solid spray is prepared by the following steps:

1) weighing 20 parts of whole wild chrysanthemum plants (roots, stems, leaves and flowers), 30 parts of wild ivy stems/leaves, 8 parts of witch hazel stems/leaves, 20 parts of chamomile flowers/leaves, 6 parts of golden camellia leaves and 12 parts of fallen rhizomes/leaves, cleaning and cutting;

2) adding the cleaned and cut raw materials into 1500 parts of water for leaching, heating to 90 ℃ under stirring at a heating rate of 2 ℃/min, preserving heat, stirring, leaching for 6 hours, cooling to below 50 ℃ at a cooling rate of 4 ℃/min, filtering, and collecting an extracting solution;

3) adding 10% of auxiliary agent into the extracting solution, stirring for 1.5h, and then standing for 10 h; the auxiliary agent is a mixture of diatomite and polyacrylamide with the mass ratio of 2: 1;

4) filtering the solid-liquid mixture formed after standing by using a plate-and-frame filter press, and performing ultrafiltration on the obtained filtrate by using a stainless steel tubular ultrafiltration membrane to obtain skin allergy relieving liquid;

5) mixing the skin allergy relieving liquid with 3% of a gel agent, wherein the gel agent is a mixture of agarose, carrageenan and natto gum, the weight ratio of the agarose, the carrageenan and the natto gum is 4:3:1, adding 1.5% of sodium carboxymethylcellulose, heating to 85 ℃, the heating rate is 15 ℃/min, stirring until the mixture is transparent, cooling to 50 ℃, the cooling rate is 8 ℃/min, stopping stirring, standing to room temperature, filling the mixture into a spray bottle, and slowly forming gel to obtain the skin allergy relieving solid spray.

Example 3

A skin allergy-relieving solid spray is prepared by the following steps:

1) weighing 15 parts of whole wild chrysanthemum plants (roots, stems, leaves and flowers), 25 parts of wild ivy stems/leaves, 6 parts of witch hazel stems/leaves, 17 parts of chamomile flowers/leaves, 4 parts of golden camellia leaves and 9 parts of fallen rhizomes/leaves, cleaning and cutting;

2) adding the cleaned and cut raw materials into 1000 parts of water for leaching, heating to 85 ℃ under stirring at the heating rate of 1.5 ℃/min, preserving heat, stirring, leaching for 4 hours, cooling to below 50 ℃ at the cooling rate of 3 ℃/min, filtering, and collecting the extract;

3) adding 7% of auxiliary agent into the extracting solution, stirring for 1h, and then standing for 8 h; the auxiliary agent is a mixture of diatomite and polyacrylamide with the mass ratio of 2: 1;

5) mixing the skin allergy-relieving liquid with 1.5% of a gel agent, wherein the gel agent is a mixture of agarose, carrageenan and natto gum, the weight ratio of the agarose, the carrageenan and the natto gum is 3:2:1, adding 1% of sodium carboxymethylcellulose, heating to 80 ℃, the heating rate is 8 ℃/min, stirring until the mixture is transparent, cooling to 45 ℃, the cooling rate is 5 ℃/min, stopping stirring, standing to room temperature, filling the mixture into a spray bottle, and slowly forming gel to obtain the skin allergy-relieving solid spray.

Comparative example 1

The difference from the embodiment 3 is only that the raw materials in the step 1) have different dosage ratios, and the other conditions are the same, specifically as follows: 15 parts of wild chrysanthemum whole plant (root, stem, leaf and flower), 15 parts of wild ivy stem/leaf, 12 parts of witch hazel stem/leaf, 15 parts of chamomile flower/leaf, 6 parts of golden camellia leaf and 11 parts of fallen rhizomes/leaf.

Comparative example 2

The difference from the example 3 is only that the temperature rising and reducing rates in the leaching process in the step 2) are different, and the rest conditions are the same, and are as follows:

2) adding the cleaned and cut raw materials into 1000 parts of water for leaching, heating to 85 ℃ under stirring at the heating rate of 4 ℃/min, preserving heat, stirring, leaching for 4h, cooling to below 50 ℃ at the cooling rate of 6 ℃/min, filtering, and collecting the extract.

Comparative example 3

2) adding the cleaned and cut raw materials into 1000 parts of water for leaching, heating to 85 ℃ under stirring at the heating rate of 0.5 ℃/min, preserving heat, stirring, leaching for 4 hours, cooling to below 50 ℃ at the cooling rate of 1 ℃/min, filtering, and collecting the extract.

Comparative example 4

The difference from example 3 is only that in step 3) the auxiliary agent is kaolin of equal mass, and the other conditions are the same.

Comparative example 5

The difference from the example 3 is only that the dosage of the gel agent in the step 5) is not changed, the gel agent consists of a mixture of agarose, carrageenan and pectin, the weight ratio of the agarose, the carrageenan and the pectin is 3:2:1, and the rest conditions are the same.

Comparative example 6

The difference from the embodiment 3 is only that the dosage of the gel agent in the step 5) is not changed, the gel agent is composed of a mixture of agarose, carrageenan and natto gum, the weight ratio of the agarose, the carrageenan and the natto gum is 1:2:3, and the rest conditions are the same.

Comparative example 7

The only difference from example 3 is that the sodium carboxymethylcellulose in step 5) is replaced by an equal mass of hydroxymethylcellulose, and the other conditions are the same.

Comparative example 8

The difference from example 3 is only that the temperature reduction rate in step 5) is 1 ℃/min, and the rest of the conditions are the same.

Comparative example 9

The difference from example 3 is only that the temperature reduction rate in step 5) is 10 ℃/min, and the rest of the conditions are the same.

Test example 1

Skin allergy-relieving solid spray stability test: the sample was left at 45 ℃ for 24h and then at-15 ℃ for 24h, thus one cycle, without interruption between cycles, and after 8 cycles the appearance of the sample was observed, with the results shown in table 1.

TABLE 1

Sample (I)	8 circulation
		Example 1	Without obvious change
Example 2	Without obvious change
		Example 3	Without obvious change
Comparative example 5	Collapse of solid gel and little liquid separation
		Comparative example 6	The solid gel did not collapse, but a small amount of liquid separated out
Comparative example 7	Collapse of solid gel and precipitation of trace amount of liquid
		Comparative example 8	Collapse of solid gel and precipitation of trace amount of liquid
Comparative example 9	Collapse of solid gel and precipitation of trace amount of liquid

In addition, the stability test of the skin allergy relieving solutions of example 3 and comparative example 1 is performed by the method, after 8 cycles, the skin allergy relieving solution of example 3 has a trace amount of precipitate, the skin allergy relieving solution of comparative example 1 has a small amount of precipitate, and the precipitate amount is obviously increased compared with the skin allergy relieving solution of example 3.

Test example 2

And (3) testing the sensitivity-relieving performance: 105 female volunteers (aged 20-50 years) were enrolled to use the product of example 3 and comparative examples 1-6, and 15 people in each group were sprayed 1 time each day, morning and evening, at 2 pumps (about 0.2g pump down) to atomize the product for even distribution on the skin surface. Observations were made after 7 days, and the results are shown in table 2.

Allergic symptoms of 150 volunteers were: different degrees of facial redness and swelling, itching, peeling and dryness.

TABLE 2

The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.

Claims

1. A preparation method of a skin allergy-relieving solid spray is characterized by comprising the following steps:

3) adding an auxiliary agent into the extracting solution, and standing;

5) mixing the skin allergy relieving liquid with the gel, heating to 75-85 deg.C, stirring to transparent, cooling to 40-50 deg.C, stopping stirring, and standing to room temperature to obtain skin allergy relieving solid spray; the gel is a mixture of agarose, carrageenan and natto gum, and the weight ratio of the agarose to the carrageenan is 2-4:1-3: 1; the dosage of the gel is 0.5-3% of the mass of the skin allergy-relieving liquid;

the skin allergy-relieving solid spray comprises the following raw materials in parts by weight: 10-20 parts of wild chrysanthemum whole plant, 15-30 parts of wild ivy stems/leaves, 5-8 parts of witch hazel stems/leaves, 14-20 parts of chamomile flowers/leaves, 3-6 parts of golden camellia leaves and 6-12 parts of fallen rhizomes/leaves;

in the step 2), the amount of the water is 500-1500 parts by weight; the specific leaching process comprises the following steps: heating to 80-90 deg.C, maintaining the temperature, stirring, leaching for 3-6h, and cooling to below 50 deg.C; the rate of temperature rise is 1-2 ℃/min, and the rate of temperature reduction is 2-4 ℃/min;

the mass of the auxiliary agent in the step 3) is 5-10% of that of the extracting solution, the auxiliary agent is added, stirred for 0.5-1.5h and then kept stand for 6-10 h; the auxiliary agent is a mixture of diatomite and polyacrylamide with the mass ratio of 1-2: 1;

adding sodium carboxymethylcellulose which accounts for 0.1-1.5% of the mass of the skin allergy-relieving liquid before heating in the step 5); and (5) adopting a program to heat and cool, wherein the heating rate is 2-15 ℃/min, and the cooling rate is 2-8 ℃/min.