CN112105721A - 内皮细胞因子及其方法 - Google Patents
内皮细胞因子及其方法 Download PDFInfo
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- CN112105721A CN112105721A CN201980020598.1A CN201980020598A CN112105721A CN 112105721 A CN112105721 A CN 112105721A CN 201980020598 A CN201980020598 A CN 201980020598A CN 112105721 A CN112105721 A CN 112105721A
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1171—Haematopoietic stem cells
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- C12N2502/28—Vascular endothelial cells
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- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
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- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862647433P | 2018-03-23 | 2018-03-23 | |
| US62/647,433 | 2018-03-23 | ||
| PCT/US2019/023637 WO2019183508A1 (en) | 2018-03-23 | 2019-03-22 | Endothelial cell factors and methods thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112105721A true CN112105721A (zh) | 2020-12-18 |
Family
ID=67987596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980020598.1A Pending CN112105721A (zh) | 2018-03-23 | 2019-03-22 | 内皮细胞因子及其方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12146165B2 (https=) |
| EP (1) | EP3768282A4 (https=) |
| JP (2) | JP7455067B2 (https=) |
| CN (1) | CN112105721A (https=) |
| CA (1) | CA3094837A1 (https=) |
| WO (1) | WO2019183508A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118834915A (zh) * | 2024-08-15 | 2024-10-25 | 扬州大学 | 一种在羊毛乳头细胞中稳定过表达的sox18慢病毒重组标签载体的构建及应用 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025096798A2 (en) * | 2023-10-31 | 2025-05-08 | The Children's Medical Center Corporation | Endothelial cell factors and methods thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050227352A1 (en) * | 2004-04-09 | 2005-10-13 | Stowers Institute For Medical Research | Use of BMP (BAM) signaling to control stem cell fate determination |
| US20120207744A1 (en) * | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
| US20130243736A1 (en) * | 2012-01-27 | 2013-09-19 | Sapporo Medical University | Replacement of bone marrow niche cells for treatment of various diseases |
| US20140162366A1 (en) * | 2012-08-31 | 2014-06-12 | Salk Institute For Biological Studies | Generation of vascular progenitor cells |
| WO2016201133A2 (en) * | 2015-06-09 | 2016-12-15 | The Regents Of The University Of California | Hematopoietic cells and methods of using and generating the same |
| WO2017015245A1 (en) * | 2015-07-20 | 2017-01-26 | Angiocrine Bioscience, Inc. | Methods and compositions for stem cell transplantation |
| CN107249607A (zh) * | 2014-12-19 | 2017-10-13 | 安吉克莱茵生物科学有限公司 | 包括工程化内皮细胞的生物相容性植入物 |
| US20180010124A1 (en) * | 2012-10-22 | 2018-01-11 | Wisconsin Alumni Research Foundation | Induction of Hemogenic Endothelium from Pluripotent Stem Cells by Forced Expression of Transcription Factors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009042910A2 (en) | 2007-09-26 | 2009-04-02 | University Of South Florida | Ship inhibition to direct hematopoietic stem cells and induce extramedullary hematopoiesis |
| JP5139271B2 (ja) | 2005-05-24 | 2013-02-06 | ホワイトヘッド インスティチュート フォー バイオメディカル リサーチ | 培養した造血幹細胞を拡大しかつ分析する方法 |
| GB201212111D0 (en) * | 2012-07-06 | 2012-08-22 | Gmbh | Vascular bed-specific endothelial cells |
| JP6581906B2 (ja) * | 2013-01-15 | 2019-09-25 | コーネル ユニヴァーシティー | 確定因子によるヒト内皮の造血性多系列前駆細胞へのリプログラミング |
| CN108291196B (zh) * | 2015-07-20 | 2021-08-27 | 安吉克莱茵生物科学有限公司 | 表达ets转录因子的工程化的内皮细胞 |
-
2019
- 2019-03-22 EP EP19772190.5A patent/EP3768282A4/en active Pending
- 2019-03-22 CN CN201980020598.1A patent/CN112105721A/zh active Pending
- 2019-03-22 US US17/040,421 patent/US12146165B2/en active Active
- 2019-03-22 CA CA3094837A patent/CA3094837A1/en active Pending
- 2019-03-22 JP JP2020550792A patent/JP7455067B2/ja active Active
- 2019-03-22 WO PCT/US2019/023637 patent/WO2019183508A1/en not_active Ceased
-
2024
- 2024-03-12 JP JP2024037742A patent/JP7683068B2/ja active Active
- 2024-09-04 US US18/824,457 patent/US20240417695A1/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050227352A1 (en) * | 2004-04-09 | 2005-10-13 | Stowers Institute For Medical Research | Use of BMP (BAM) signaling to control stem cell fate determination |
| US20120207744A1 (en) * | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
| US20130243736A1 (en) * | 2012-01-27 | 2013-09-19 | Sapporo Medical University | Replacement of bone marrow niche cells for treatment of various diseases |
| US20140162366A1 (en) * | 2012-08-31 | 2014-06-12 | Salk Institute For Biological Studies | Generation of vascular progenitor cells |
| US20180010124A1 (en) * | 2012-10-22 | 2018-01-11 | Wisconsin Alumni Research Foundation | Induction of Hemogenic Endothelium from Pluripotent Stem Cells by Forced Expression of Transcription Factors |
| CN107249607A (zh) * | 2014-12-19 | 2017-10-13 | 安吉克莱茵生物科学有限公司 | 包括工程化内皮细胞的生物相容性植入物 |
| WO2016201133A2 (en) * | 2015-06-09 | 2016-12-15 | The Regents Of The University Of California | Hematopoietic cells and methods of using and generating the same |
| WO2017015245A1 (en) * | 2015-07-20 | 2017-01-26 | Angiocrine Bioscience, Inc. | Methods and compositions for stem cell transplantation |
Non-Patent Citations (7)
| Title |
|---|
| HAGEDORN, ELLIOTT J.等: "Defining the Transcriptional Code That Specifies Sinusoidal Endothelial Cells in the HSPC Niche", 《BLOOD》, vol. 130, pages 1 - 2 * |
| MAESTRE, INÉS FERNÁNDEZ: "Elucidating the Transcriptional Program Specifying Endothelial Cells in the Zebrafish Blood Stem Cell Niche", MASTER THESIS OF UNIVERSITY OF APPLIED SCIENCES TECHNIKUM WIEN, pages 1 - 132 * |
| PARK C等: "Transcriptional regulation of endothelial cell and vascular development", 《CIRC RES》, vol. 112, no. 10, pages 1380 - 1400, XP055547751, DOI: 10.1161/CIRCRESAHA.113.301078 * |
| PERLIN, J.R.等: "Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment", 《J MOL MED》, vol. 95, pages 809 - 819, XP036279062, DOI: 10.1007/s00109-017-1559-8 * |
| YOU LR等: "Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity", 《NATURE》, vol. 435, no. 7038, pages 98 - 104 * |
| 张开滋等: "《骨髓纤维化中西医结合治疗》", vol. 2014, 湖南科学技术出版社, pages: 781 - 785 * |
| 杜华等: "骨髓微环境对造血干细胞命运的调控", 《中国组织工程研究》, vol. 19, no. 14, pages 2283 - 2290 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118834915A (zh) * | 2024-08-15 | 2024-10-25 | 扬州大学 | 一种在羊毛乳头细胞中稳定过表达的sox18慢病毒重组标签载体的构建及应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024075624A (ja) | 2024-06-04 |
| JP7683068B2 (ja) | 2025-05-26 |
| US20240417695A1 (en) | 2024-12-19 |
| JP2021518143A (ja) | 2021-08-02 |
| JP7455067B2 (ja) | 2024-03-25 |
| WO2019183508A1 (en) | 2019-09-26 |
| EP3768282A1 (en) | 2021-01-27 |
| CA3094837A1 (en) | 2019-09-26 |
| US12146165B2 (en) | 2024-11-19 |
| US20210079343A1 (en) | 2021-03-18 |
| EP3768282A4 (en) | 2021-12-08 |
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