GB201212111D0 - Vascular bed-specific endothelial cells - Google Patents
Vascular bed-specific endothelial cellsInfo
- Publication number
- GB201212111D0 GB201212111D0 GB201212111A GB201212111A GB201212111D0 GB 201212111 D0 GB201212111 D0 GB 201212111D0 GB 201212111 A GB201212111 A GB 201212111A GB 201212111 A GB201212111 A GB 201212111A GB 201212111 D0 GB201212111 D0 GB 201212111D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- specific
- vascular bed
- endothelial cells
- generation
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Vascular Medicine (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
Abstract
This invention relates to methods for the generation and subsequent validation of vascular bed-specific endothelial cells with specific genetic and functional signatures starting from cellular precursors and use thereof. These vascular bed-specific endothelial cells with specific genetic and functional signatures from cellular precursors of the endothelial lineage of the present invention are in a particular embodiment of present invention used for the generation of in vitro bioengineered tissue culture equivalents. These in vitro bioengineered tissue culture equivalents are in an additional embodiment used for drug toxicity testing or for the generation of bioengineered vessel conduits for in vivo transplantation. In yet another embodiment these cells generated by present invention are used for treatment of vascular bed-specific diseases affecting the brain (e.g., stroke), the liver (e.g., sinusoidal obstruction syndrome), the heart (myocardial ischemia), the extremities (e.g., peripheral vascular disease), amongst others.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201212111A GB201212111D0 (en) | 2012-07-06 | 2012-07-06 | Vascular bed-specific endothelial cells |
PCT/EP2013/064410 WO2014006228A1 (en) | 2012-07-06 | 2013-07-08 | Vascular bed-specific endothelial cells |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201212111A GB201212111D0 (en) | 2012-07-06 | 2012-07-06 | Vascular bed-specific endothelial cells |
Publications (1)
Publication Number | Publication Date |
---|---|
GB201212111D0 true GB201212111D0 (en) | 2012-08-22 |
Family
ID=46766308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB201212111A Ceased GB201212111D0 (en) | 2012-07-06 | 2012-07-06 | Vascular bed-specific endothelial cells |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB201212111D0 (en) |
WO (1) | WO2014006228A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160289757A1 (en) * | 2015-04-01 | 2016-10-06 | Institute Of Environmental Science And Research Limited | Methods and materials for detecting rna sequences |
US20210079343A1 (en) * | 2018-03-23 | 2021-03-18 | The Children's Medical Center Corporation | Endothelial cell factors and methods thereof |
CN110577967A (en) * | 2018-05-22 | 2019-12-17 | 中国人民解放军军事科学院军事医学研究院 | induced pluripotent stem cell and preparation method thereof |
WO2020079107A1 (en) * | 2018-10-19 | 2020-04-23 | F. Hoffmann-La Roche Ag | Synergistic transcription factors to induce high resistance transendothelial barrier |
JP2023516484A (en) | 2020-03-11 | 2023-04-19 | ビット バイオ リミテッド | Hepatocyte production method |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001048150A1 (en) * | 1999-12-28 | 2001-07-05 | Kyowa Hakko Kogyo Co., Ltd. | Cells capable of differentiating into heart muscle cells |
KR20110024660A (en) * | 2009-09-03 | 2011-03-09 | 차의과학대학교 산학협력단 | Serum-free, xeno-free method for differentiation of human embryonic stem cells or human induced pluripotent stem cells into endothelial cells |
-
2012
- 2012-07-06 GB GB201212111A patent/GB201212111D0/en not_active Ceased
-
2013
- 2013-07-08 WO PCT/EP2013/064410 patent/WO2014006228A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2014006228A1 (en) | 2014-01-09 |
WO2014006228A9 (en) | 2014-04-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AT | Applications terminated before publication under section 16(1) |