GB201212111D0 - Vascular bed-specific endothelial cells - Google Patents

Vascular bed-specific endothelial cells

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Publication number
GB201212111D0
GB201212111D0 GB201212111A GB201212111A GB201212111D0 GB 201212111 D0 GB201212111 D0 GB 201212111D0 GB 201212111 A GB201212111 A GB 201212111A GB 201212111 A GB201212111 A GB 201212111A GB 201212111 D0 GB201212111 D0 GB 201212111D0
Authority
GB
United Kingdom
Prior art keywords
specific
vascular bed
endothelial cells
generation
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201212111A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Original Assignee
Katholieke Universiteit Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katholieke Universiteit Leuven filed Critical Katholieke Universiteit Leuven
Priority to GB201212111A priority Critical patent/GB201212111D0/en
Publication of GB201212111D0 publication Critical patent/GB201212111D0/en
Priority to PCT/EP2013/064410 priority patent/WO2014006228A1/en
Ceased legal-status Critical Current

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Vascular Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)

Abstract

This invention relates to methods for the generation and subsequent validation of vascular bed-specific endothelial cells with specific genetic and functional signatures starting from cellular precursors and use thereof. These vascular bed-specific endothelial cells with specific genetic and functional signatures from cellular precursors of the endothelial lineage of the present invention are in a particular embodiment of present invention used for the generation of in vitro bioengineered tissue culture equivalents. These in vitro bioengineered tissue culture equivalents are in an additional embodiment used for drug toxicity testing or for the generation of bioengineered vessel conduits for in vivo transplantation. In yet another embodiment these cells generated by present invention are used for treatment of vascular bed-specific diseases affecting the brain (e.g., stroke), the liver (e.g., sinusoidal obstruction syndrome), the heart (myocardial ischemia), the extremities (e.g., peripheral vascular disease), amongst others.
GB201212111A 2012-07-06 2012-07-06 Vascular bed-specific endothelial cells Ceased GB201212111D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB201212111A GB201212111D0 (en) 2012-07-06 2012-07-06 Vascular bed-specific endothelial cells
PCT/EP2013/064410 WO2014006228A1 (en) 2012-07-06 2013-07-08 Vascular bed-specific endothelial cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201212111A GB201212111D0 (en) 2012-07-06 2012-07-06 Vascular bed-specific endothelial cells

Publications (1)

Publication Number Publication Date
GB201212111D0 true GB201212111D0 (en) 2012-08-22

Family

ID=46766308

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201212111A Ceased GB201212111D0 (en) 2012-07-06 2012-07-06 Vascular bed-specific endothelial cells

Country Status (2)

Country Link
GB (1) GB201212111D0 (en)
WO (1) WO2014006228A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160289757A1 (en) * 2015-04-01 2016-10-06 Institute Of Environmental Science And Research Limited Methods and materials for detecting rna sequences
US20210079343A1 (en) * 2018-03-23 2021-03-18 The Children's Medical Center Corporation Endothelial cell factors and methods thereof
CN110577967A (en) * 2018-05-22 2019-12-17 中国人民解放军军事科学院军事医学研究院 induced pluripotent stem cell and preparation method thereof
WO2020079107A1 (en) * 2018-10-19 2020-04-23 F. Hoffmann-La Roche Ag Synergistic transcription factors to induce high resistance transendothelial barrier
JP2023516484A (en) 2020-03-11 2023-04-19 ビット バイオ リミテッド Hepatocyte production method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001048150A1 (en) * 1999-12-28 2001-07-05 Kyowa Hakko Kogyo Co., Ltd. Cells capable of differentiating into heart muscle cells
KR20110024660A (en) * 2009-09-03 2011-03-09 차의과학대학교 산학협력단 Serum-free, xeno-free method for differentiation of human embryonic stem cells or human induced pluripotent stem cells into endothelial cells

Also Published As

Publication number Publication date
WO2014006228A1 (en) 2014-01-09
WO2014006228A9 (en) 2014-04-03

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)