AR084333A1 - miRNA IN ARTICULAR DISEASES - Google Patents

miRNA IN ARTICULAR DISEASES

Info

Publication number
AR084333A1
AR084333A1 ARP110104736A ARP110104736A AR084333A1 AR 084333 A1 AR084333 A1 AR 084333A1 AR P110104736 A ARP110104736 A AR P110104736A AR P110104736 A ARP110104736 A AR P110104736A AR 084333 A1 AR084333 A1 AR 084333A1
Authority
AR
Argentina
Prior art keywords
mirna
disease
articular diseases
treatment
articular
Prior art date
Application number
ARP110104736A
Other languages
Spanish (es)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of AR084333A1 publication Critical patent/AR084333A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente solicitud se refiere a microARN (miARN), en particular mir-140, como un indicador del estado de un tejido o una enfermedad tal como osteoartritis (OA) y como molécula diana para el descubrimiento de una sustancia para el tratamiento de una enfermedad articular. También se proporcionan métodos y compuestos para investigación, análisis y/o tratamiento de una enfermedad articular, especialmente OA.The present application refers to microRNA (miRNA), in particular mir-140, as an indicator of the state of a tissue or a disease such as osteoarthritis (OA) and as a target molecule for the discovery of a substance for the treatment of a disease articulate. Methods and compounds for research, analysis and / or treatment of joint disease, especially OA, are also provided.

ARP110104736A 2010-12-17 2011-12-16 miRNA IN ARTICULAR DISEASES AR084333A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10306444 2010-12-17

Publications (1)

Publication Number Publication Date
AR084333A1 true AR084333A1 (en) 2013-05-08

Family

ID=45446007

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104736A AR084333A1 (en) 2010-12-17 2011-12-16 miRNA IN ARTICULAR DISEASES

Country Status (3)

Country Link
AR (1) AR084333A1 (en)
TW (1) TW201241179A (en)
WO (1) WO2012084709A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106119375B (en) * 2016-07-05 2019-12-06 四川大学华西医院 Medicine with regulating and controlling effect on articular cartilage degeneration and verification method
WO2022219404A1 (en) * 2021-04-13 2022-10-20 Oslo Universitetssykehus Hf Gene therapy for inflammatory conditions

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0281604B1 (en) 1986-09-02 1993-03-31 Enzon Labs Inc. Single polypeptide chain binding molecules
AU634186B2 (en) 1988-11-11 1993-02-18 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US5582981A (en) 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
EP0605522B1 (en) 1991-09-23 1999-06-23 Medical Research Council Methods for the production of humanized antibodies
ES2127948T3 (en) 1993-10-27 1999-05-01 Ribozyme Pharm Inc OLIGONUCLEOTIDES MODIFIED IN THE POSITION 2'-AMIDO AND 2'-PEPTIDE.
FR2739031B1 (en) 1995-09-27 1997-11-21 Lhd Lab Hygiene Dietetique TRANSDERMAL MATRIX SYSTEM FOR ADMINISTRATION OF AN ESTROGEN AND / OR A PROGESTIVE BASED ON STYRENE-ISOPRENE-STYRENE COPOLYMER, PREPARATION METHOD AND THERAPEUTIC USE
GB9602326D0 (en) 1996-02-06 1996-04-03 Cruachem Ltd Compounds
US5736154A (en) 1996-03-11 1998-04-07 Fuisz Technologies Ltd. Transdermal delivery system
AU728120B2 (en) 1996-03-25 2001-01-04 Lts Lohmann Therapie-Systeme Gmbh A Transdermal therapeutic system with small application thickness and high flexibility, as well as processes for its production
AUPO379596A0 (en) 1996-11-22 1996-12-19 Soltec Research Pty Ltd Percutaneous delivery system
WO1998037240A1 (en) 1997-02-24 1998-08-27 Tm Technologies, Inc. Anti-sense oligonucleotide pharmacological agents
KR20050115231A (en) * 2003-02-10 2005-12-07 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 Regulation of mammalian cells
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
WO2010108192A1 (en) * 2009-03-20 2010-09-23 The Research Foundation Of State University Of New York Mirnas as therapeutic targets in cancer

Also Published As

Publication number Publication date
WO2012084709A1 (en) 2012-06-28
TW201241179A (en) 2012-10-16

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal