CN112089794A - Traditional Chinese medicine hemostatic formula and preparation method thereof - Google Patents
Traditional Chinese medicine hemostatic formula and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine formula and the technical field of preparation thereof, in particular to a traditional Chinese medicine formula for stopping bleeding, which comprises radix angelicae pubescentis, pseudo-ginseng, bletilla striata, prepared frankincense, ligusticum wallichii, cimicifuga foetida, notopterygium root, angelica sinensis and safflower, and the traditional Chinese medicine formula comprises the following components in parts by weight: 10-12 parts of radix angelicae pubescentis, 5-8 parts of pseudo-ginseng, 5-8 parts of bletilla striata, 5-8 parts of prepared frankincense, 3-5 parts of ligusticum wallichii, 3-5 parts of cimicifuga foetida, 2-4 parts of notopterygium root, 2-3 parts of angelica and 1-3 parts of safflower. The radix angelicae pubescentis contained in the formula can inhibit bacteria, and the bletilla striata can astringe to stop bleeding, relieve swelling and promote tissue regeneration. The ligusticum wallichii can stop bleeding, remove stasis, relieve swelling and pain; the prepared frankincense can relax tendons, activate collaterals and promote qi circulation; notoginseng radix has hemostatic, blood stasis dispelling, antiinflammatory, and analgesic effects; the cimicifugae foetidae is capable of relieving exterior syndrome and promoting eruption, and clearing heat and removing toxicity, and meanwhile, the formula is an external medicine, so that the formula is safe, small in side effect, strong in usability and more suitable for large-scale popularization and use.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine formulas and preparation thereof, in particular to a traditional Chinese medicine hemostatic formula and a preparation method thereof.
Background
The application of hemostatics is significant, and the hemostatics can stop bleeding by promoting blood coagulation, and is called hemostatics, which can promote blood coagulation to stop bleeding mainly by enhancing or inhibiting coagulation factors in vivo to achieve the purpose of hemostasis. Under the action of blood coagulation factors, prothrombin is changed into thrombin, the thrombin changes fibrinogen into fibrin, blood clots are generated, bleeding stops, and hemostatics such as vitamin K, prothrombin, haemostasis and the like can affect certain factors and promote or restore the blood coagulation process to stop bleeding. Vitamin K is an essential substance for synthesizing prothrombin in liver, when the prothrombin is lack in blood, the coagulation of blood can be retarded, the liver can be promoted to synthesize prothrombin by the vitamin K, the hemostatic effect is achieved, the haemostasis can promote the increase of platelets, the platelet function and the platelet adhesive force are enhanced, the coagulation process is accelerated, the capillary permeability is reduced, and the prothrombin can be changed into thrombin to promote the coagulation process; the fibrinolysis system existing in the body can dissolve formed fibrin (blood clots), so that the fibrinolysis system is blocked, the blood coagulation can be prolonged, and the hemostasis is facilitated, wherein the medicines comprise 6-aminocaproic acid, hemostasis aromatic acid, hemostasis naphthenic acid and the like; drugs that reduce capillary permeability such as adrenal chromazone (Anluo blood) are also commonly used as hemostatic drugs; in addition, the hypophysis posterior lobe essence (acting on vascular smooth muscle to shrink arteriole, venule and capillary vessel), xingeling and the like, Chinese herbal medicine hemostatic, Yunnan white drug powder and the like also have good hemostatic effects, and the absorbable gelatin sponge and hemostatic cotton (sponge-like objects prepared by tightly disinfecting the Anluo blood, medicinal gelatin, disodium etalate, formaldehyde and the like) have good hemostatic effects and are suitable for emergency treatment of various traumatic hemorrhage, but a traditional Chinese medicine hemostatic wound patch or spray is lacked for local application of the patch or the spray for treating incised wound hemorrhage, blood stasis and swelling pain, skin burn and scald, thereby meeting the daily requirements of people in life.
In conclusion, the invention solves the existing problems by designing a traditional Chinese medicine hemostasis formula and a preparation method thereof.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine hemostatic formula and a preparation method thereof, and aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a traditional Chinese medicine hemostasis formula comprises radix angelicae pubescentis, pseudo-ginseng, bletilla striata, prepared frankincense, ligusticum wallichii, cimicifuga foetida, notopterygium root, angelica sinensis and safflower, and the traditional Chinese medicine hemostasis formula comprises the following components in parts by weight: 10-12 parts of radix angelicae pubescentis, 5-8 parts of pseudo-ginseng, 5-8 parts of bletilla striata, 5-8 parts of prepared frankincense, 3-5 parts of ligusticum wallichii, 3-5 parts of cimicifuga foetida, 2-4 parts of notopterygium root, 2-3 parts of angelica sinensis and 1-3 parts of safflower.
Preferably, the radix angelicae pubescentis, the pseudo-ginseng, the bletilla striata, the prepared frankincense, the ligusticum wallichii, the cimicifuga foetida, the notopterygium root, the angelica and the safflower comprise the following components in parts by weight: 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of cimicifuga foetida, 3 parts of notopterygium root, 2 parts of angelica and 1 part of safflower.
Preferably, the specific steps are as follows:
s1, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the materials into a reaction kettle respectively, adding deionized water according to a ratio of 1: 4-6, and stirring for 30-40 min to obtain a mixed solution A;
and S11, heating the mixed solution A in the step S1 to 50-60 ℃ for 1-2 hours, extracting, filtering by a 100-300-mesh filtering device after heating, finally, vacuum concentrating the filtered liquid at 40-60 ℃, and preparing the concentrated liquid into a wound plaster dosage form.
Preferably, the specific steps are as follows:
s2, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the materials into a reaction kettle respectively, adding deionized water according to the ratio of 1: 4-6, stirring for 30-40 min to obtain a mixed solution A,
s21, heating the mixed solution A in the step S1 to 50-60 ℃, continuously heating for 1-2 hours, extracting, and filtering through a 100-300-mesh filtering device after heating to obtain a liquid medicine which is prepared into a spray formulation.
Preferably, the stirring speed in S1 is the same as the stirring speed in S2, and the stirring speeds are all 200-300 rpm/min.
Compared with the prior art, the invention has the beneficial effects that:
1. in the invention, the traditional Chinese medicine hemostatic formula is designed for local application of incised wound bleeding, blood stasis swelling and pain and skin burn and scald, the radix angelicae pubescentis contained in the formula can inhibit bacteria, the bletilla striata can astringe to stop bleeding, relieve swelling and promote tissue regeneration, and the ligusticum wallichii can stop bleeding, remove blood stasis, relieve swelling and alleviate pain; the prepared frankincense can relax tendons, activate collaterals and promote qi circulation; notoginseng radix has hemostatic, blood stasis dispelling, antiinflammatory, and analgesic effects; the cimicifugae foetidae is capable of relieving exterior syndrome and promoting eruption, and clearing heat and removing toxicity, and meanwhile, the formula is an external medicine, so that the formula is safe, small in side effect, strong in usability and more suitable for large-scale popularization and use.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.
The invention provides a technical scheme that:
a traditional Chinese medicine hemostasis formula comprises radix angelicae pubescentis, pseudo-ginseng, bletilla striata, prepared frankincense, ligusticum wallichii, cimicifuga foetida, notopterygium root, angelica sinensis and safflower, and the traditional Chinese medicine hemostasis formula comprises the following components in parts by weight: 10-12 parts of radix angelicae pubescentis, 5-8 parts of pseudo-ginseng, 5-8 parts of bletilla striata, 5-8 parts of prepared frankincense, 3-5 parts of ligusticum wallichii, 3-5 parts of cimicifuga foetida, 2-4 parts of notopterygium root, 2-3 parts of angelica sinensis and 1-3 parts of safflower.
Further, the radix angelicae pubescentis, the pseudo-ginseng, the bletilla striata, the prepared frankincense, the ligusticum wallichii, the cimicifuga foetida, the notopterygium root, the angelica and the safflower comprise the following components in parts by weight: 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of cimicifuga foetida, 3 parts of notopterygium root, 2 parts of angelica and 1 part of safflower.
Further, the method comprises the following specific steps:
s1, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the materials into a reaction kettle respectively, adding deionized water according to a ratio of 1: 4-6, and stirring for 30-40 min to obtain a mixed solution A;
and S11, heating the mixed solution A in the step S1 to 50-60 ℃ for 1-2 hours, extracting, filtering by a 100-300-mesh filtering device after heating, finally, vacuum concentrating the filtered liquid at 40-60 ℃, and preparing the concentrated liquid into a wound plaster dosage form.
Further, the method comprises the following specific steps:
s2, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the materials into a reaction kettle respectively, adding deionized water according to the ratio of 1: 4-6, stirring for 30-40 min to obtain a mixed solution A,
s21, heating the mixed solution A in the step S1 to 50-60 ℃, continuously heating for 1-2 hours, extracting, and filtering through a 100-300-mesh filtering device after heating to obtain a liquid medicine which is prepared into a spray formulation.
Further, the stirring speed in the S1 is the same as that in the S2, and the stirring speed is 200-300 rpm/min.
Detailed description of the preferred embodiments
Example 1:
step 1, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the components into a reaction kettle respectively, adding deionized water according to a ratio of 1:6, and stirring for 30-40 min to obtain a mixed solution A;
and 11, heating the mixed liquid A obtained in the step 1 to 60 ℃ for 1-2 hours, extracting, filtering by using a 300-mesh filtering device after heating is finished, and finally, vacuum-concentrating the filtered liquid at 60 ℃ to prepare the concentrated liquid into a wound plaster dosage form.
Example 2:
step 2, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the components into a reaction kettle respectively, adding deionized water according to a ratio of 1:4, stirring for 30-40 min to obtain a mixed solution A,
and step 21, heating the mixed solution A obtained in the step 1 to 60 ℃ for 1-2 hours, extracting, and filtering the mixture through a 300-mesh filtering device after heating to obtain a liquid medicine which is prepared into a spray formulation.
Example 3:
step 1, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the components into a reaction kettle respectively, adding deionized water according to a ratio of 1:5, and stirring for 30-40 min to obtain a mixed solution A;
and 11, heating the mixed solution A obtained in the step 1 to 55 ℃ for 1-2 hours, extracting, filtering by using a 100-300-mesh filtering device after heating is finished, and finally, vacuum-concentrating the filtered liquid at 60 ℃ to prepare the concentrated liquid into a wound plaster dosage form.
Example 4:
step 2, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the materials into a reaction kettle respectively, adding deionized water according to a ratio of 1:4.5, and stirring for 30-40 min to obtain a mixed solution A;
and step 21, heating the mixed solution A obtained in the step 1 to 55 ℃ for 1-2 hours, extracting, and filtering by a 1300-mesh filtering device after heating to obtain a liquid medicine which is prepared into a spray formulation.
In conclusion, the wound patch and the finished spray of the components are analyzed by a chromatograph and act on the skin local parts such as knife wounds, skin burns and the like, the traditional Chinese medicine hemostatic formula designed by the invention is used for local application of knife wound bleeding, blood stasis and gall, skin burns and scalds, the pubescent angelica root contained in the formula can inhibit bacteria, and the bletilla striata can astringe to stop bleeding, relieve swelling and promote tissue regeneration. The ligusticum wallichii can stop bleeding, remove stasis, relieve swelling and pain; the prepared frankincense can relax tendons, activate collaterals and promote qi circulation; notoginseng radix has hemostatic, blood stasis dispelling, antiinflammatory, and analgesic effects; the cimicifugae foetidae is capable of relieving exterior syndrome and promoting eruption, and clearing heat and removing toxicity, and meanwhile, the formula is an external medicine, so that the formula is safe, small in side effect, strong in usability and more suitable for large-scale popularization and use.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (5)
1. A traditional Chinese medicine hemostasis formula comprises radix angelicae pubescentis, pseudo-ginseng, bletilla striata, prepared frankincense, ligusticum wallichii, cimicifuga foetida, notopterygium root, angelica sinensis and safflower, and the traditional Chinese medicine hemostasis formula comprises the following components in parts by weight: 10-12 parts of radix angelicae pubescentis, 5-8 parts of pseudo-ginseng, 5-8 parts of bletilla striata, 5-8 parts of prepared frankincense, 3-5 parts of ligusticum wallichii, 3-5 parts of cimicifuga foetida, 2-4 parts of notopterygium root, 2-3 parts of angelica sinensis and 1-3 parts of safflower.
2. The traditional Chinese medicine hemostatic formula according to claim 1, wherein the radix angelicae pubescentis, the pseudo-ginseng, the bletilla striata, the prepared frankincense, the ligusticum wallichii, the cimicifuga foetida, the notopterygium root, the angelica sinensis and the safflower are prepared from the following components in parts by weight: 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of cimicifuga foetida, 3 parts of notopterygium root, 2 parts of angelica and 1 part of safflower.
3. The preparation method of hemostasis by using traditional Chinese medicine according to claim 2 comprises the following specific steps:
s1, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the materials into a reaction kettle respectively, adding deionized water according to a ratio of 1: 4-6, and stirring for 30-40 min to obtain a mixed solution A;
and S11, heating the mixed solution A in the step S1 to 50-60 ℃ for 1-2 hours, extracting, filtering by a 100-300-mesh filtering device after heating, finally, vacuum concentrating the filtered liquid at 40-60 ℃, and preparing the concentrated liquid into a wound plaster dosage form.
4. The preparation method of hemostasis by using traditional Chinese medicine according to claim 2 comprises the following specific steps:
s2, taking 10 parts of radix angelicae pubescentis, 8 parts of pseudo-ginseng, 5 parts of bletilla striata, 5 parts of prepared frankincense, 3 parts of ligusticum wallichii, 3 parts of rhizoma cimicifugae, 3 parts of notopterygium root, 2 parts of angelica sinensis and 1 part of safflower, sequentially adding the materials into a reaction kettle respectively, adding deionized water according to the ratio of 1: 4-6, stirring for 30-40 min to obtain a mixed solution A,
s21, heating the mixed solution A in the step S1 to 50-60 ℃, continuously heating for 1-2 hours, extracting, and filtering through a 100-300-mesh filtering device after heating to obtain a liquid medicine which is prepared into a spray formulation.
5. The method for preparing a traditional Chinese medicine for hemostasis as claimed in claim 3 or 4, wherein the stirring speed in S1 is the same as the stirring speed in S2 and the stirring speed is 200-300 rpm/min.
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Application publication date: 20201218 |
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