CN112089776A - 一种治疗赤游丹风火热毒证的中药软膏 - Google Patents
一种治疗赤游丹风火热毒证的中药软膏 Download PDFInfo
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Abstract
本发明公开了一种治疗赤游丹风火热毒证的中药软膏，涉及中医药领域，其特征在于：它由下列质量百分比的中药原料制成：浮萍11.11‑16.67％、桔梗11.11‑16.67％、佩兰13.34‑20.00％、杏仁11.11‑16.67％、绿萼梅10.00‑15.00％、紫草茸16.65‑25.00％、甘草6.65‑10.00％；其中各中药原料组分含量百分数之和等于100％；该中药软膏使用方便，对症性强，治疗效果好，治愈率98.11％，有效率100％。
Description
技术领域
本发明涉及中医药领域，尤其涉及一种治疗赤游丹风火热毒证的中药软膏。
背景技术
赤游丹，又名赤游风。是指以发病部位出现皮肤红肿，形如云片、色赤如丹、游走不定为主要表现的新生儿疾病。此病发病急骤，初起局部皮肤鲜红或片状，形似云彩，漫延迅速，灼热疼痛，稍高出皮肤，边缘清楚，游走不定，可伴恶寒高热等全身症状，患部可伴发水疱，偶有结毒化脓，皮肤溃烂，坏死，而致蛀骨。治疗不当可因邪毒入侵内脏，致高热、神昏、抽搐甚至死亡。现代中医学认为：赤游丹的发病原因，多由局部皮肤损伤、脐部疾患、臀部湿疹、虫咬、护理不善等，为歪风邪毒所侵，以致感染成病，邪毒入经脉，随气血流走全身，发于肌表，因而出现红肿、灼热、疼痛等风火热毒证候。目前，中医的治则是疏风散邪、泻火解毒、或凉血解毒、开窍熄风。但申请人认为，中医对该病的认识及治疗方法还有待完善，本人经多年研究及临床实践表明：因新生儿为稚阴稚阳之体，肺为娇脏，宣发肃降功能低下，随之皮肤的防御功能也低下，所以风热邪毒，易侵袭新生儿体表，入肺经；当风热邪毒侵袭患儿体表，易致体表气滞，营卫不调，气滞则湿郁，湿郁则化火，导致发热、恶寒；气滞致血瘀，发病部位皮肤可见红肿；再因手太阴肺经与手厥阴心包经相连，风热由肺经逆传至心包经，导致高热不退，神志昏迷。治疗宜轻宣肺脏透邪，健脾行气化滞祛瘀。
发明内容
本发明在于克服现有技术的不足，提供一种对症性强，显效快，治疗效果好，治愈率高，且治疗方便的一种治疗赤游丹风火热毒证的中药软膏。
为了达到以上目的，本发明所采取的技术方案是，该一种治疗赤游丹风火热毒证的中药软膏，其特征在于：它由下列质量百分比的中药原料制成：浮萍11.11-16.67％、桔梗11.11-16.67％、佩兰13.34-20.00％、杏仁11.11-16.67％、绿萼梅10.00-15.00％、紫草茸16.65-25.00％、甘草6.65-10.00％；其中各中药原料组分含量百分数之和等于100％。优化中药原料组方为：浮萍13.89％、桔梗13.89％、佩兰16.67％、杏仁13.89％、绿萼梅12.5％、紫草茸20.83％、甘草8.33％。一种治疗赤游丹风火热毒证的中药软膏由以下步骤制作：一、按浮萍11.11-16.67％、桔梗(挥发油)11.11-16.67％、绿萼梅(挥发油)10.00-15.00％、杏仁(挥发油)11.11-16.67％、佩兰(挥发油)13.34-20.00％、紫草茸16.65-25.00％、甘草(挥发油)6.65-10.00％的比例准确称取炮制好的各中药原料，在称取各中药原料时，将桔梗、绿萼梅、杏仁、佩兰、甘草混放在一起，将浮萍、紫草茸混放在一起；二、将混放在一起的桔梗、绿萼梅、杏仁、佩兰、甘草放入多功能提取罐，并向多能提取罐中加生活饮用水，搅拌，加水量为称好的中药原料桔梗、绿萼梅、杏仁、佩兰、甘草质量之和的6-8倍，浸泡30分钟，加热常压提取挥发油，提取时间为100分钟，提取完毕，取下挥发油冷藏备用；三、在提取挥发油进行70分钟时将混放在一起的浮萍、紫草茸放入煮药锅，并向煮药锅内加生活饮用水，加水量为浮萍、紫草茸质量之和的7-8倍，搅拌均匀，浸泡10分钟，武火加热至沸，改文火煎煮30分钟，停止加热，过滤，留渣，得一次药液；四、将提取罐中的药液混合物过滤，留渣，得过滤药液；五、将提取罐中的药渣并入煮药锅，加生活饮用水，加水量为浮萍、桔梗、绿萼梅、杏仁、佩兰、紫草茸、甘草质量之和的4-5倍，武火加热至沸，改文火煎煮30分钟，停止加热，过滤，留渣，得二次药液；六、将一次药液、二次药液，过滤药液都放入不锈钢筒混合得混合药液；向混合药液中加甲壳素，搅匀，甲壳素的添加量为混合药液质量的3/万，45℃保温12小时，取上清液；七、将上清液放入离心机，离心处理10分钟，转鼓转数9000-10000转/分钟，弃渣，得净化药液；八、将净化药液倒入煮药锅，加热浓缩，浓缩至每毫升药液中含1.5-2克中药原料的提取物时，停止加热，得浓缩药液；九、向浓缩药液中加入羧甲基纤维素钠、甘油、三氯叔丁醇；添加的量：每1000毫升浓缩药液加羧甲基纤维素钠60克，甘油150克，三氯叔丁醇5克；添加的方法：将羧甲基纤维素钠和甘油研匀，加入热浓缩药液，搅拌，降到自然温度时再加入三氯叔丁醇和备用的中药挥发油，搅拌均匀，装瓶，封盖，每瓶50毫升；即为一种治疗赤游丹风火热毒证的中药软膏。
组方中，君药浮萍、臣药桔梗、佐药佩兰、使药甘草；浮萍宣表疏风透邪，桔梗宣发肺气，佩兰化湿健脾，甘草健脾胃缓药性；紫草茸凉血解毒，破瘀行气止痛，助力浮萍；杏仁肃降肺气助力桔梗；绿萼梅理气化湿健脾助力佩兰。
该一种治疗赤游丹风火热毒证的中药软膏其组方药理为：宣肺降气、疏风解表透邪，凉血解毒，健脾化湿，行气化滞祛瘀。
其中：浮萍——味辛，性寒；归肺、膀胱经。具有发汗解表，止痒，透疹，利水消肿之功效。用于外感表证，发热无汗，较宜用于风热表证无汗者。浮萍为发散风热药，发散风热药性偏寒凉，味辛而多苦。辛散以祛风，苦寒则清热。
桔梗——味苦、辛，性微寒；归肺经。具有祛痰止咳，利咽，解毒排脓之功效。桔梗苦，长于降肺气；辛开宣肺气，以畅利胸中气机；性微寒而不盛，故应用广泛。
佩兰——味辛，性平；归脾、胃、肺经。具有化湿、解表之功效。本品气味芳香，其化湿醒脾作用与广藿香相似而力缓。又因本品药性平和，不偏温燥，故尤长于治疗脾经湿热阻中证。
杏仁——味苦，性温，有小毒；归肺大肠经。具有止咳平喘、润肠通便之功效。杏仁苦能降肺气，又略兼宣肺之功。
绿萼梅——味辛、涩，性平；归肝、胃、肺经。具有疏肝和胃、理气化痰之功效。本品芳香行气，既能疏肝解郁，又能理气和胃。且性平，寒热病症皆可用。
紫草茸——味苦，性平；归肺、肝经。具有清热，凉血，解毒，破瘀行气止痛之功效。《唐本草》：“主五脏邪气，带下，心痛，破积血，金疮生肉。”紫草茸既能解毒活血，又无作泻之患。
甘草——味甘，性微寒，归心、肺、脾、胃经。具有补心脾气，止咳、去痰、平喘，缓急止痛，清热解毒，调和药性之功效。本品长于补益心气，本品在许多方剂中都发挥调和药性的作用，通过解毒，可降低某些药中的毒性。
该一种治疗赤游丹风火热毒证的中药软膏的使用方法为：涂抹患处，涂抹面积大出红肿处1-2厘米，一日3次，7天为一个疗程。
服药禁忌：母乳喂养患儿的母亲在患儿用药期间忌食辛辣，膻腥甘厚之品。
本发明的有益效果在于：该一种治疗赤游丹风火热毒证的中药软膏使用方便，对症性强，治疗效果好，治愈率98.11％，有效率100％。
临床资料分析
一、诊断依据
依据中华人民共和国中医药行业标准-中医病证诊断疗效标准(ZY-T001.1-94)中医外科丹毒的诊断标准制定：
1、多发于新生儿。
2、局部皮肤红肿，形如云片，焮热疼痛，游走不定。
3、发热恶寒，烦躁多啼；舌红，苔黄或白；脉数。
4、血白细胞总数及中性粒细胞明显增高。
二、疗效评定
依据中华人民共和国中医药行业标准-中医病证诊断疗效标准(ZY-T001.1-94)中医外科丹毒的疗效标准制定。
1、治愈：全身及局部症状消退，血象正常。
2、好转：全身症状消退，局部症状未全消。
3、未愈：全身与局部症状未能控制。
三、疗效结果分析
自2010年1月至2018年12月，共确诊赤游丹风火热毒证患儿53例，其中，男性患儿28例，女性患儿25例，年龄最小的出生18天，最大的6个月，用该软膏外敷治疗1-2个疗程，治愈52例，治愈率为98.11％；好转1例，好转率1.89％；有效率100％。
具体实施例
实施例一
按浮萍13.89％、桔梗13.89％、佩兰16.67％、杏仁13.89％、绿萼梅12.5％、紫草茸20.83％、甘草8.33％的比例准确称取炮制好的中药原料共1000克，其中浮萍138.9克、桔梗138.9克、佩兰166.7克、杏仁138.9克、绿萼梅125克、紫草茸208.3克、甘草83.3克。
在称取各中药原料时，将桔梗、绿萼梅、杏仁、佩兰、甘草混放在一起，将浮萍、紫草茸混放在一起；将混放在一起的桔梗、绿萼梅、杏仁、佩兰、甘草放入多功能提取罐，并向多能提取罐中加生活饮用水，搅拌，加水量为称好的中药原料桔梗、绿萼梅、杏仁、佩兰、甘草质量之和的6-8倍，浸泡30分钟，加热常压提取挥发油，提取时间为100分钟，提取完毕，取下挥发油冷藏备用；在提取挥发油进行70分钟时将混放在一起的浮萍、紫草茸放入煮药锅，并向煮药锅内加生活饮用水，加水量为浮萍、紫草茸质量之和的7-8倍，搅拌均匀，浸泡10分钟，武火加热至沸，改文火煎煮30分钟，停止加热，过滤，留渣，得一次药液；四、将提取罐中的药液混合物过滤，留渣，得过滤药液；将提取罐中的药渣并入煮药锅，加生活用水，加水量为浮萍、桔梗、绿萼梅、杏仁、佩兰、紫草茸、甘草质量之和的4-5倍，武火加热至沸，改文火煎煮30分钟，停止加热，过滤，留渣，得二次药液；将一次药液、二次药液，过滤药液都放入不锈钢筒混合得混合药液；向混合药液中加甲壳素，搅匀，甲壳素的添加量为混合药液质量的3/万，45℃保温12小时，取上清液；将上清液放入离心机，离心处理10分钟，转鼓转数9000-10000转/分钟，弃渣，得净化药液；将净化药液倒入煮药锅，加热浓缩，浓缩至每毫升药液中含1.6克中药原料的提取物时，停止加热，得浓缩药液625毫升；准确称取羧甲基纤维素钠37.5克，甘油93.75克、三氯叔丁醇3.13克；将称好的羧甲基纤维素钠和甘油研匀，加入热浓缩药液，搅拌，降到自然温度时再加入称好的三氯叔丁醇和备用的中药挥发油，搅拌均匀，装瓶，封盖，每瓶50毫升；即为一种治疗赤游丹风火热毒证的中药软膏。
用该软膏治疗赤游丹风火热毒证患儿21例，治愈21例，治愈率100％。
典型病例
李某，女，出生23天，莱芜区苗山镇人，2011年4月27日由家长带到我处就诊。家长述：自昨日下午患儿多烦躁啼哭，夜间发热，无流涕、咳嗽症状，今早发现腹部小片红斑，形如片云，游走不定，经医务室介绍前来就诊。诊见：局部红肿，略高出正常皮肤，压之褪色，舌红，苔薄黄，脉数；患儿体温37.6℃，血常规检验白细胞18×109/L，中性粒细胞百分比为85；诊断为新生儿赤游丹，让其涂抹该一种治疗赤游丹风火热毒证的中药软膏，每日三次，治疗5天好转，一个疗程全身及局部症状消失，血象正常。随访半年，无复发。
实施例2
按浮萍12.50％、桔梗14.50％、佩兰17.00％、杏仁13.50％、绿萼梅12.50％、紫草茸22.50％、甘草7.50％的比例准确称取炮制好的中药原料共1000克，其中浮萍125克、桔梗145克、佩兰170克、杏仁135克、绿萼梅125克、紫草茸225克、甘草75克。
制作方法同实施例1。
用该软膏治疗赤游丹风火热毒证患儿17例，治愈16例，治愈率94.12％；好转1例，好转率5.88％，有效率100％。
典型病例
刘某，男，出生25天，莱芜区茶业口镇人，2015年10月12日由家长带到我处就诊，家长述：患儿自今天凌晨焦躁啼哭不停，发热，继而面部出现稍微突出皮肤表面的红斑，形如片云，无其他感冒症状，也不知孩子得的什么病，所以前来就诊。诊见：红斑炘红灼热，舌红，苔白，脉洪数；患儿体温38.1℃，血常规检验白细胞18.6×109/L，中性粒细胞百分比为86.7；诊断为新生儿赤游丹，让其涂抹该一种治疗赤游丹风火热毒证的中药软膏，每日三次，用药一个疗程，病情大有好转，又用一个疗程，全身及局部症状消失，血象正常。随访半年，无复发。
实施例3
按浮萍15.50％、桔梗12.50％、佩兰15.00％、杏仁15.50％、绿萼梅13.50％、紫草茸19.50％、甘草8.50％的比例准确称取炮制好的中药原料共1000克，其中浮萍155克、桔梗125克、佩兰150克、杏仁155克、绿萼梅135克、紫草茸195克、甘草85克。
制作方法同实施例1。
用该软膏治疗赤游丹风火热毒证患儿15例，治愈15例，治愈率100％。
典型病例
张某，男，2个月11天。莱芜区羊里镇人，2018年8月5日由家长带到我处就诊。家长述：患儿自昨日下午发热，烦躁啼哭不停，右下肢皮肤红肿，形如云片，高出皮肤，游走不定，无流涕、咳嗽症状，到镇医院去，医生说不像感冒，介绍到我处就诊。诊见：红斑焮热，舌红，苔黄，脉数；患儿体温37.8℃，血常规检验白细胞18.3×109/L，中性粒细胞百分比为85.5；诊断为新生儿赤游丹，让其涂抹该一种治疗赤游丹风火热毒证的中药软膏，每日三次，用药一个疗程，全身症状消退，局部症状末全消，又用一个疗程，全身及局部症状消失，血象正常。随访半年，无复发。
Claims (3)
1.一种治疗赤游丹风火热毒证的中药软膏，其特征在于：它由下列质量百分比的中药原料制成：浮萍11.11-16.67％、桔梗11.11-16.67％、佩兰13.34-20.00％、杏仁11.11-16.67％、绿萼梅10.00-15.00％、紫草茸16.65-25.00％、甘草6.65-10.00％；其中各中药原料组分含量百分数之和等于100％。
2.根据权利要求1所述的一种治疗赤游丹风火热毒证的中药软膏，其特征在于：优化中药原料组方为：浮萍13.89％、桔梗13.89％、佩兰16.67％、杏仁13.89％、绿萼梅12.5％、紫草茸20.83％、甘草8.33％。
3.根据权利要求1所述的一种治疗赤游丹风火热毒证的中药软膏，其特征在于：由以下步骤制作：一、按浮萍11.11-16.67％、桔梗(挥发油)11.11-16.67％、绿萼梅(挥发油)10.00-15.00％、杏仁(挥发油)11.11-16.67％、佩兰(挥发油)13.34-20.00％、紫草茸16.65-25.00％、甘草(挥发油)6.65-10.00％的比例准确称取炮制好的各中药原料，在称取各中药原料时，将桔梗、绿萼梅、杏仁、佩兰、甘草混放在一起，将浮萍、紫草茸混放在一起；二、将混放在一起的桔梗、绿萼梅、杏仁、佩兰、甘草放入多功能提取罐，并向多能提取罐中加生活饮用水，搅拌，加水量为称好的中药原料桔梗、绿萼梅、杏仁、佩兰、甘草质量之和的6-8倍，浸泡30分钟，加热常压提取挥发油，提取时间为100分钟，提取完毕，取下挥发油冷藏备用；三、在提取挥发油进行70分钟时将混放在一起的浮萍、紫草茸放入煮药锅，并向煮药锅内加生活饮用水，加水量为浮萍、紫草茸质量之和的7-8倍，搅拌均匀，浸泡10分钟，武火加热至沸，改文火煎煮30分钟，停止加热，过滤，留渣，得一次药液；四、将提取罐中的药液混合物过滤，留渣，得过滤药液；五、将提取罐中的药渣并入煮药锅，加生活饮用水，加水量为浮萍、桔梗、绿萼梅、杏仁、佩兰、紫草茸、甘草质量之和的4-5倍，武火加热至沸，改文火煎煮30分钟，停止加热，过滤，留渣，得二次药液；六、将一次药液、二次药液，过滤药液都放入不锈钢筒混合得混合药液；向混合药液中加甲壳素，搅匀，甲壳素的添加量为混合药液质量的3/万，45℃保温12小时，取上清液；七、将上清液放入离心机，离心处理10分钟，转鼓转数9000-10000转/分钟，弃渣，得净化药液；八、将净化药液倒入煮药锅，加热浓缩，浓缩至每毫升药液中含1.5-2克中药原料的提取物时，停止加热，得浓缩药液；九、向浓缩药液中加入羧甲基纤维素钠、甘油、三氯叔丁醇；添加的量：每1000毫升浓缩药液加羧甲基纤维素钠60克，甘油150克，三氯叔丁醇5克；添加的方法：将羧甲基纤维素钠和甘油研匀，加入热浓缩药液，搅拌，降到自然温度时再加入三氯叔丁醇和备用的中药挥发油，搅拌均匀，装瓶，封盖，每瓶50毫升；即为一种治疗赤游丹风火热毒证的中药软膏。
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