CN112089763A - Medical mint gel eye protection patch and preparation method thereof - Google Patents
Medical mint gel eye protection patch and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Abstract
The invention provides a medical mint gel eye protection patch and a preparation method thereof, wherein the medical mint gel eye protection patch comprises the following raw materials in parts by weight: 10-15 parts of medical grade polyvinyl alcohol, 5-10 parts of mint extract, 0.25-0.5 part of rose essential oil, 0.1-0.3 part of clove oil, 0.3-0.5 part of carrageenan, 0.15-0.25 part of sodium alginate and 90-100 parts of water; the preparation method of the medical mint gel eye protection patch comprises the following steps: s1, preparing raw materials; s2, mixing water, mint extract, carrageenan and sodium alginate to obtain a mixture A; s3, mixing the rose essential oil and the clove oil, and performing vacuum defoaming, injection molding, freezing and thawing treatment and irradiation sterilization to obtain the medical mint gel eye-protecting patch. The medical mint gel eye protection patch provided by the invention has excellent moisturizing effect and antibacterial performance, and can effectively reduce the occurrence probability of exposed keratitis in the general anesthesia process.
Description
Technical Field
The invention relates to the technical field of medical auxiliary materials, in particular to a medical mint gel eye protection patch and a preparation method thereof.
Background
General anesthesia is a common operation anesthesia mode in clinic, when general anesthesia is carried out, the eyelids are loosened due to the action of an anesthetic drug muscle relaxant, so that the eyelids cannot be normally closed, the eye cornea is exposed, when oxygen is supplied to the mask, the mask is not tightly contacted with the mouth scratching nose, a large amount of oxygen can laterally leak, and the eye cornea exposed outside is impacted, so that the occurrence of exposed keratitis is induced. In order to reduce the probability of occurrence of the exposed keratitis in the general anesthesia process, the currently common treatment method is to perform moisture preservation treatment on the eyes of a patient during the general anesthesia, but the common saline gauze covering mode has short moisture preservation time, frequent gauze replacement and easy saline inflow to the eyes to cause bad feeling. Therefore, in recent years, more and more novel gel eye protection patches for clinical experiments replace a saline gauze covering mode, and the use feeling and operation of patients are obviously improved compared with the saline gauze covering mode, but the conventional gel eye protection patches have unsatisfactory moisturizing effect, are easy to breed bacteria and cause secondary damage to eyes. Based on the above, the invention provides a medical mint gel eye protection patch and a preparation method thereof.
Disclosure of Invention
The invention aims to solve the problems that the existing gel eye protection patch is not ideal in moisturizing effect and easy to breed bacteria, and provides a medical mint gel eye protection patch and a preparation method thereof.
In order to achieve the purpose, the invention is realized by the following technical scheme:
a medical mint gel eye protection patch comprises the following raw materials in parts by weight: 10-15 parts of medical grade polyvinyl alcohol, 5-10 parts of mint extract, 0.25-0.5 part of rose essential oil, 0.1-0.3 part of clove oil, 0.3-0.5 part of carrageenan, 0.15-0.25 part of sodium alginate and 90-100 parts of water.
Preferably, the medical mint gel eye protection patch comprises the following raw materials in parts by weight: 11-14 parts of medical grade polyvinyl alcohol, 6-9 parts of mint extract, 0.3-0.45 part of rose essential oil, 0.15-0.25 part of clove oil, 0.35-0.45 part of carrageenan, 0.18-0.22 part of sodium alginate and 92-98 parts of water.
Preferably, the medical mint gel eye protection patch comprises the following raw materials in parts by weight: 12 parts of medical grade polyvinyl alcohol, 8 parts of mint extract, 0.4 part of rose essential oil, 0.2 part of clove oil, 0.4 part of carrageenan, 0.2 part of sodium alginate and 95 parts of water.
Preferably, the mass ratio of the mint extract to the rose essential oil is 13-30: 1, further preferably, the mass ratio of the mint extract to the rose essential oil is 20: 1.
preferably, the mint extract is extracted by the following method: cleaning fresh mint, drying, kneading or cutting to obtain crushed mint, weighing the crushed mint, placing the crushed mint in a reactor, adding petroleum ether which is 3-5 times of the weight of the weighed crushed mint, performing reflux extraction for 40-60 min, adding ethanol which is 3-5 times of the weight of the weighed crushed mint and 1, 3-stearic acid-2-lauric glyceride which is 0.1-0.2% of the weight of the weighed crushed mint, continuing reflux extraction for 1-2 h, concentrating under reduced pressure, and cooling to room temperature to obtain a mint extract
The invention also provides a preparation method of the medical mint gel eye protection patch, which is characterized by comprising the following steps:
s1, weighing the raw materials according to 10-15 parts of medical grade polyvinyl alcohol, 5-10 parts of mint extract, 0.25-0.5 part of rose essential oil, 0.1-0.3 part of clove oil, 0.3-0.5 part of carrageenan, 0.15-0.25 part of sodium alginate and 90-100 parts of water for later use;
s2, heating the water weighed in the step S1 to 60-70 ℃, adding the mint extract weighed in the step S1, mechanically stirring at the speed of 200-400 r/min for 30-40 min, cooling to 40 ℃, adding the carrageenan weighed in the step S1 and sodium alginate, continuously stirring for 30min, and cooling to room temperature to obtain a mixture A;
s3, adding the rose essential oil and the clove oil weighed in the step S1 into the mixture A prepared in the step S2, stirring for 10-15 min, removing bubbles in vacuum, performing injection molding to obtain a semi-finished gel eye protection paste, performing freeze thawing treatment for 2 times, and performing irradiation sterilization to obtain the medical mint gel eye protection paste.
Preferably, the freeze thawing method comprises the following specific operations: and (3) freezing the semi-finished product of the gel eye-protecting patch in a freezing chamber at the temperature of-20 to-18 ℃ for 7 to 8 hours, vacuumizing for 30 minutes, unfreezing for 2 to 4 hours at the temperature of 25 to 30 ℃, and introducing inert gas for 30 minutes to finish the treatment by a freezing and unfreezing method.
Preferably, the inert gas is nitrogen or argon, and the flow rate of the inert gas is 0.1L/30 s.
Compared with the prior art, the gel eye-protecting patch provided by the invention has the advantages that:
the gel eye protection patch provided by the invention is reasonable in formula, uses a water level medium, uses medical-grade polyvinyl alcohol as a main component, improves the formability and the comfort degree of the gel eye protection patch by adding carrageenan and sodium alginate, and improves the moisturizing and bacteriostatic effects of the gel eye protection patch by adding the mint extract, the rose essential oil and the clove oil in a reasonable proportion.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Example 1
The invention provides a medical mint gel eye protection patch which comprises the following raw materials in parts by weight: 10 parts of medical grade polyvinyl alcohol, 10 parts of mint extract, 0.25 part of rose essential oil, 0.3 part of clove oil, 0.3 part of carrageenan, 0.15 part of sodium alginate and 90 parts of water;
the mint extract is extracted by the following method: cleaning fresh mint, drying, cutting to obtain crushed mint, weighing the crushed mint, putting the crushed mint into a reactor, adding petroleum ether with the mass 3 times that of the weighed crushed mint, performing reflux extraction for 60min, adding ethanol with the mass 3 times that of the weighed crushed mint and 1, 3-stearic acid-2-lauric glyceride with the mass 0.2% that of the weighed crushed mint, continuing reflux extraction for 2h, performing reduced pressure concentration, and cooling to room temperature to obtain a mint extract;
a preparation method of a medical mint gel eye patch comprises the following steps:
s1, weighing the raw materials according to 10 parts of medical grade polyvinyl alcohol, 10 parts of mint extract, 0.25 part of rose essential oil, 0.3 part of clove oil, 0.3 part of carrageenan, 0.15 part of sodium alginate and 90 parts of water for later use;
s2, heating the water weighed in the step S1 to 60 ℃, adding the mint extract weighed in the step S1, mechanically stirring at the speed of 400r/min for 30min, cooling to 40 ℃, adding the carrageenan weighed in the step S1 and sodium alginate, continuously stirring for 30min, and cooling to room temperature to obtain a mixture A;
s3, adding the rose essential oil and the clove oil weighed in the step S1 into the mixture A prepared in the step S2, stirring for 10min, removing bubbles in vacuum, performing injection molding to obtain a semi-finished product of the gel eye protection paste, performing freeze thawing treatment for 2 times, and performing irradiation sterilization to obtain the medical mint gel eye protection paste.
The specific operation of the freezing and thawing method treatment is as follows: and (3) freezing the semi-finished product of the gel eye-protecting patch in a freezing chamber at the temperature of-20 ℃ for 8h, vacuumizing for 30min, unfreezing for 4h at the temperature of 25 ℃, introducing inert gas for 30min, wherein the inert gas is nitrogen, the flow of the inert gas is 0.1L/30s, and finishing the treatment by a freezing and unfreezing method after the introduction of the inert gas is finished.
Example 2
The invention provides a medical mint gel eye protection patch which comprises the following raw materials in parts by weight: 12 parts of medical grade polyvinyl alcohol, 8 parts of mint extract, 0.4 part of rose essential oil, 0.2 part of clove oil, 0.4 part of carrageenan, 0.2 part of sodium alginate and 95 parts of water;
the mint extract is extracted by the following method: cleaning fresh mint, drying, kneading to obtain crushed mint, weighing the crushed mint, putting the crushed mint into a reactor, adding petroleum ether which is 4 times of the weight of the weighed crushed mint, performing reflux extraction for 50min, adding ethanol which is 4 times of the weight of the weighed crushed mint and 1, 3-stearic acid-2-lauric glyceride which is 0.15% of the weight of the weighed crushed mint, continuing reflux extraction for 1.5h, concentrating under reduced pressure, and cooling to room temperature to obtain a mint extract;
a preparation method of a medical mint gel eye patch comprises the following steps:
s1, weighing the raw materials according to 12 parts of medical grade polyvinyl alcohol, 8 parts of mint extract, 0.4 part of rose essential oil, 0.2 part of clove oil, 0.4 part of carrageenan, 0.2 part of sodium alginate and 95 parts of water for later use;
s2, heating the water weighed in the step S1 to 65 ℃, adding the mint extract weighed in the step S1, mechanically stirring at the speed of 300r/min for 40min, cooling to 40 ℃, adding the carrageenan weighed in the step S1 and sodium alginate, continuously stirring for 30min, and cooling to room temperature to obtain a mixture A;
s3, adding the rose essential oil and the clove oil weighed in the step S1 into the mixture A prepared in the step S2, stirring for 15min, removing bubbles in vacuum, performing injection molding to obtain a semi-finished product of the gel eye protection paste, performing freeze thawing treatment for 2 times, and performing irradiation sterilization to obtain the medical mint gel eye protection paste.
The specific operation of the freezing and thawing method treatment is as follows: freezing the semi-finished product of the gel eye-protecting patch in a freezing chamber at the temperature of-20 ℃ for 8h, vacuumizing for 30min, unfreezing for 3h at the temperature of 30 ℃, introducing inert gas for 30min, wherein the inert gas is nitrogen, the flow of the inert gas is 0.1L/30s, and finishing the treatment by a freezing and unfreezing method after the inert gas is introduced.
Example 3
The invention provides a medical mint gel eye protection patch which comprises the following raw materials in parts by weight: 15 parts of medical grade polyvinyl alcohol, 5 parts of mint extract, 0.5 part of rose essential oil, 0.1 part of clove oil, 0.5 part of carrageenan, 0.25 part of sodium alginate and 100 parts of water;
the mint extract is extracted by the following method: cleaning fresh mint, drying, kneading to obtain crushed mint, weighing the crushed mint, putting the crushed mint into a reactor, adding petroleum ether which is 5 times of the weight of the weighed crushed mint, performing reflux extraction for 40min, adding ethanol which is 5 times of the weight of the weighed crushed mint and 1, 3-stearic acid-2-lauric glyceride which is 0.1% of the weight of the weighed crushed mint, continuing reflux extraction for 1h, concentrating under reduced pressure, and cooling to room temperature to obtain a mint extract;
a preparation method of a medical mint gel eye patch comprises the following steps:
s1, weighing the raw materials according to 15 parts of medical grade polyvinyl alcohol, 5 parts of mint extract, 0.5 part of rose essential oil, 0.1 part of clove oil, 0.5 part of carrageenan, 0.25 part of sodium alginate and 100 parts of water for later use;
s2, heating the water weighed in the step S1 to 70 ℃, adding the mint extract weighed in the step S1, mechanically stirring at the speed of 200r/min for 40min, cooling to 40 ℃, adding the carrageenan weighed in the step S1 and sodium alginate, continuously stirring for 30min, and cooling to room temperature to obtain a mixture A;
s3, adding the rose essential oil and the clove oil weighed in the step S1 into the mixture A prepared in the step S2, stirring for 15min, removing bubbles in vacuum, performing injection molding to obtain a semi-finished product of the gel eye protection paste, performing freeze thawing treatment for 2 times, and performing irradiation sterilization to obtain the medical mint gel eye protection paste.
The specific operation of the freezing and thawing method treatment is as follows: freezing the semi-finished product of the gel eye-protecting patch in a freezing chamber at the temperature of-18 ℃ for 7h, vacuumizing for 30min, unfreezing for 2h at the temperature of 30 ℃, introducing inert gas for 30min, wherein the inert gas is argon, the flow of the inert gas is 0.1L/30s, and finishing the treatment by a freezing and unfreezing method after the introduction of the inert gas is finished.
Comparative example 1
The medical mint gel eye protection patch comprises the following raw materials in parts by weight: 10 parts of medical grade polyvinyl alcohol, 10 parts of mint extract, 0.25 part of rose essential oil, 0.3 part of clove oil, 0.3 part of carrageenan, 0.15 part of sodium alginate and 90 parts of water;
the mint extract is extracted by the following method: cleaning fresh mint, drying, cutting to obtain crushed mint, weighing the crushed mint, putting the crushed mint into a reactor, adding petroleum ether with the mass 3 times of that of the weighed crushed mint, performing reflux extraction for 60min, adding ethanol with the mass 3 times of that of the weighed crushed mint, continuously performing reflux extraction for 2h, performing reduced pressure concentration, and cooling to room temperature to obtain a mint extract;
a preparation method of a medical mint gel eye patch comprises the following steps:
s1, weighing the raw materials according to 10 parts of medical grade polyvinyl alcohol, 10 parts of mint extract, 0.25 part of rose essential oil, 0.3 part of clove oil, 0.3 part of carrageenan, 0.15 part of sodium alginate and 90 parts of water for later use;
s2, heating the water weighed in the step S1 to 60 ℃, adding the mint extract weighed in the step S1, mechanically stirring at the speed of 400r/min for 30min, cooling to 40 ℃, adding the carrageenan weighed in the step S1 and sodium alginate, continuously stirring for 30min, and cooling to room temperature to obtain a mixture A;
s3, adding the rose essential oil and the clove oil weighed in the step S1 into the mixture A prepared in the step S2, stirring for 10min, removing bubbles in vacuum, performing injection molding to obtain a semi-finished product of the gel eye protection paste, performing freeze thawing treatment for 2 times, and performing irradiation sterilization to obtain the medical mint gel eye protection paste.
The specific operation of the freezing and thawing method treatment is as follows: and (3) freezing the semi-finished product of the gel eye-protecting patch in a freezing chamber at the temperature of-20 ℃ for 8h, vacuumizing for 30min, unfreezing for 4h at the temperature of 25 ℃, introducing inert gas for 30min, wherein the inert gas is nitrogen, the flow of the inert gas is 0.1L/30s, and finishing the treatment by a freezing and unfreezing method after the introduction of the inert gas is finished.
Comparative example 2
The invention provides a medical mint gel eye protection patch which comprises the following raw materials in parts by weight: 10 parts of medical grade polyvinyl alcohol, 10 parts of mint extract, 0.3 part of clove oil, 0.3 part of carrageenan, 0.15 part of sodium alginate and 90 parts of water;
the mint extract is extracted by the following method: cleaning fresh mint, drying, cutting to obtain crushed mint, weighing the crushed mint, putting the crushed mint into a reactor, adding petroleum ether with the mass 3 times that of the weighed crushed mint, performing reflux extraction for 60min, adding ethanol with the mass 3 times that of the weighed crushed mint and 1, 3-stearic acid-2-lauric glyceride with the mass 0.2% that of the weighed crushed mint, continuing reflux extraction for 2h, performing reduced pressure concentration, and cooling to room temperature to obtain a mint extract;
a preparation method of a medical mint gel eye patch comprises the following steps:
s1, weighing the raw materials according to 10 parts of medical grade polyvinyl alcohol, 10 parts of mint extract, 0.3 part of clove oil, 0.3 part of carrageenan, 0.15 part of sodium alginate and 90 parts of water for later use;
s2, heating the water weighed in the step S1 to 60 ℃, adding the mint extract weighed in the step S1, mechanically stirring at the speed of 400r/min for 30min, cooling to 40 ℃, adding the carrageenan weighed in the step S1 and sodium alginate, continuously stirring for 30min, and cooling to room temperature to obtain a mixture A;
s3, adding the clove oil weighed in the step S1 into the mixture A prepared in the step S2, stirring for 10min, removing bubbles in vacuum, injecting to obtain a semi-finished product of the gel eye-protecting patch, treating for 2 times by adopting a freezing and thawing method, and performing irradiation sterilization to obtain the medical mint gel eye-protecting patch.
The specific operation of the freezing and thawing method treatment is as follows: and (3) freezing the semi-finished product of the gel eye-protecting patch in a freezing chamber at the temperature of-20 ℃ for 8h, vacuumizing for 30min, unfreezing for 4h at the temperature of 25 ℃, introducing inert gas for 30min, wherein the inert gas is nitrogen, the flow of the inert gas is 0.1L/30s, and finishing the treatment by a freezing and unfreezing method after the introduction of the inert gas is finished.
The gel eye-protection patches prepared in the above examples 1 to 3 and comparative examples 1 to 2 were subjected to a moisture retention test, the test method being: corresponding gel eye-protecting patches were placed in a constant temperature test chamber (temperature 25 ℃. + -. 1 ℃ C., relative humidity 50%. + -. 2%) and the relative humidity in the constant temperature test chamber was tested at 30min, 1h, 2h, 4h, 6h, 8h, 10h, and the results are shown in Table 1.
Table 1:
test results show that the gel eye protection patches prepared in the embodiments 1-3 of the invention have far better moisture retention performance than comparative examples, can ensure that the surrounding use environment reaches more than 90% when used for 30 min-10 h, and can be completely suitable for clinical experiments of general anesthesia surgeries.
The gel eye-protecting patch prepared in the embodiment 1-3 is tested for bacteriostasis, and the test result shows that the bacteriostasis rate of staphylococcus aureus and bacillus subtilis in the embodiment 1-3 can reach more than 90 percent
Clinical trials were conducted on the gel eye patch prepared in example 1, and the gel eye patch prepared in example was used clinically in 30 cases of general anesthesia, and the incidence of keratitis after surgery was followed, which showed that none of the 30 cases of eyes had symptoms of keratitis such as hyperemia, edema, pain, photophobia, and the like.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. The medical mint gel eye protection patch is characterized by comprising the following raw materials in parts by weight: 10-15 parts of medical grade polyvinyl alcohol, 5-10 parts of mint extract, 0.25-0.5 part of rose essential oil, 0.1-0.3 part of clove oil, 0.3-0.5 part of carrageenan, 0.15-0.25 part of sodium alginate and 90-100 parts of water.
2. The medical mint gel eye protection patch according to claim 1, wherein the medical mint gel eye protection patch comprises the following raw materials in parts by weight: 11-14 parts of medical grade polyvinyl alcohol, 6-9 parts of mint extract, 0.3-0.45 part of rose essential oil, 0.15-0.25 part of clove oil, 0.35-0.45 part of carrageenan, 0.18-0.22 part of sodium alginate and 92-98 parts of water.
3. The medical mint gel eye patch according to claim 1 or 2, wherein the medical mint gel eye patch comprises the following raw materials in parts by weight: 12 parts of medical grade polyvinyl alcohol, 8 parts of mint extract, 0.4 part of rose essential oil, 0.2 part of clove oil, 0.4 part of carrageenan, 0.2 part of sodium alginate and 95 parts of water.
4. The medical mint gel eye patch as claimed in claim 1 or 2, wherein the weight ratio of the mint extract to the rose essential oil is 13-30: 1.
5. the medical mint gel eye patch as claimed in claim 3, wherein the mint extract is extracted by the following method: cleaning fresh mint, drying, kneading or chopping to obtain chopped mint, weighing the chopped mint, placing the chopped mint in a reactor, adding petroleum ether which is 3-5 times of the mass of the weighed chopped mint, carrying out reflux extraction for 40-60 min, adding ethanol which is 3-5 times of the mass of the weighed chopped mint and 1, 3-stearic acid-2-lauric glyceride which is 0.1-0.2% of the mass of the weighed chopped mint, continuing reflux extraction for 1-2 h, concentrating under reduced pressure, and cooling to room temperature to obtain the mint extract.
6. A preparation method of a medical mint gel eye protection patch is characterized by comprising the following steps:
s1, weighing the raw materials according to 10-15 parts of medical grade polyvinyl alcohol, 5-10 parts of mint extract, 0.25-0.5 part of rose essential oil, 0.1-0.3 part of clove oil, 0.3-0.5 part of carrageenan, 0.15-0.25 part of sodium alginate and 90-100 parts of water for later use;
s2, heating the water weighed in the step S1 to 60-70 ℃, adding the mint extract weighed in the step S1, mechanically stirring at the speed of 200-400 r/min for 30-40 min, cooling to 40 ℃, adding the carrageenan weighed in the step S1 and sodium alginate, continuously stirring for 30min, and cooling to room temperature to obtain a mixture A;
s3, adding the rose essential oil and the clove oil weighed in the step S1 into the mixture A prepared in the step S2, stirring for 10-15 min, removing bubbles in vacuum, performing injection molding to obtain a semi-finished gel eye protection paste, performing freeze thawing treatment for 2 times, and performing irradiation sterilization to obtain the medical mint gel eye protection paste.
7. The preparation method of the medical peppermint gel eye patch according to claim 6, wherein the freezing and thawing method comprises the following specific steps: and (3) freezing the semi-finished product of the gel eye-protecting patch in a freezing chamber at the temperature of-20 to-18 ℃ for 7 to 8 hours, vacuumizing for 30 minutes, unfreezing for 2 to 4 hours at the temperature of 25 to 30 ℃, and introducing inert gas for 30 minutes to finish the treatment by a freezing and unfreezing method.
8. The method for preparing a medical peppermint gel eye patch according to claim 7, wherein the inert gas is nitrogen or argon, and the flow rate of the inert gas is 0.1L/30 s.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112826811A (en) * | 2021-02-01 | 2021-05-25 | 湖北兵兵药业(集团)有限公司 | Medical cold compress gel eye patch and preparation method thereof |
| WO2023216066A1 (en) * | 2022-05-09 | 2023-11-16 | 台北科技大学 | Polysaccharide composition and method for reducing protein adsorption |
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| WO2023216066A1 (en) * | 2022-05-09 | 2023-11-16 | 台北科技大学 | Polysaccharide composition and method for reducing protein adsorption |
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