CN112040987A - 用于改进的免疫疗法的基因调控组合物和方法 - Google Patents
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- CN112040987A CN112040987A CN201980019421.XA CN201980019421A CN112040987A CN 112040987 A CN112040987 A CN 112040987A CN 201980019421 A CN201980019421 A CN 201980019421A CN 112040987 A CN112040987 A CN 112040987A
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US201862643597P | 2018-03-15 | 2018-03-15 | |
US201862643598P | 2018-03-15 | 2018-03-15 | |
US201862643578P | 2018-03-15 | 2018-03-15 | |
US201862643587P | 2018-03-15 | 2018-03-15 | |
US62/643,587 | 2018-03-15 | ||
US62/643,578 | 2018-03-15 | ||
US62/643,598 | 2018-03-15 | ||
US62/643,597 | 2018-03-15 | ||
US201862692019P | 2018-06-29 | 2018-06-29 | |
US201862692010P | 2018-06-29 | 2018-06-29 | |
US201862692100P | 2018-06-29 | 2018-06-29 | |
US62/692,010 | 2018-06-29 | ||
US62/692,100 | 2018-06-29 | ||
US62/692,019 | 2018-06-29 | ||
US201862768443P | 2018-11-16 | 2018-11-16 | |
US201862768448P | 2018-11-16 | 2018-11-16 | |
US201862768458P | 2018-11-16 | 2018-11-16 | |
US201862768428P | 2018-11-16 | 2018-11-16 | |
US62/768,458 | 2018-11-16 | ||
US62/768,428 | 2018-11-16 | ||
US62/768,443 | 2018-11-16 | ||
US62/768,448 | 2018-11-16 | ||
US201962804265P | 2019-02-12 | 2019-02-12 | |
US62/804,265 | 2019-02-12 | ||
PCT/US2019/022365 WO2019178421A1 (en) | 2018-03-15 | 2019-03-14 | Gene-regulating compositions and methods for improved immunotherapy |
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CN112040987A true CN112040987A (zh) | 2020-12-04 |
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KR (1) | KR20200130826A (ja) |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113750218A (zh) * | 2021-08-10 | 2021-12-07 | 南通市肿瘤医院 | 多肽zc3h12a及其突变体在制备抗肝癌药物中的应用 |
WO2022242700A1 (en) * | 2021-05-20 | 2022-11-24 | Wuxi Biologics (Shanghai) Co., Ltd. | Genetically modified nk cells and uses thereof |
WO2023082640A1 (zh) * | 2021-11-10 | 2023-05-19 | 清华大学 | 增强免疫细胞持久性的方法 |
WO2023143515A1 (zh) * | 2022-01-29 | 2023-08-03 | 苏州沙砾生物科技有限公司 | 一种修饰的肿瘤浸润淋巴细胞及其用途 |
WO2024011335A1 (zh) * | 2022-07-10 | 2024-01-18 | 清华大学 | 经修饰的免疫细胞 |
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CA3162272A1 (en) * | 2019-11-25 | 2021-06-03 | KSQ Therapeutics, Inc. | Methods for activation and expansion of tumor infiltrating lymphocytes |
CN110777147A (zh) * | 2019-11-29 | 2020-02-11 | 上海科技大学 | 一种ikzf3基因沉默的t细胞及其应用 |
AU2021347907A1 (en) | 2020-09-23 | 2023-04-20 | Crispr Therapeutics Ag | Genetically engineered t cells with regnase-1 and/or tgfbrii disruption have improved functionality and persistence |
EP4281188A2 (en) * | 2021-01-19 | 2023-11-29 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Gene activation targets for enhanced human t cell function |
WO2023011433A1 (zh) * | 2021-08-03 | 2023-02-09 | 苏州沙砾生物科技有限公司 | 一种修饰的肿瘤浸润淋巴细胞及其用途 |
WO2023225665A1 (en) * | 2022-05-19 | 2023-11-23 | Lyell Immunopharma, Inc. | Polynucleotides targeting nr4a3 and uses thereof |
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WO2024011335A1 (zh) * | 2022-07-10 | 2024-01-18 | 清华大学 | 经修饰的免疫细胞 |
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KR20200130826A (ko) | 2020-11-20 |
WO2019178421A1 (en) | 2019-09-19 |
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