CN112022750B - Compound essential oil, preparation method thereof and application of compound essential oil in anti-allergy acne-removing cosmetics - Google Patents
Compound essential oil, preparation method thereof and application of compound essential oil in anti-allergy acne-removing cosmetics Download PDFInfo
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- CN112022750B CN112022750B CN202011046497.2A CN202011046497A CN112022750B CN 112022750 B CN112022750 B CN 112022750B CN 202011046497 A CN202011046497 A CN 202011046497A CN 112022750 B CN112022750 B CN 112022750B
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- 239000000341 volatile oil Substances 0.000 title claims abstract description 160
- 150000001875 compounds Chemical class 0.000 title claims abstract description 69
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 47
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 44
- 206010000496 acne Diseases 0.000 title claims abstract description 44
- 239000002537 cosmetic Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000002088 nanocapsule Substances 0.000 claims abstract description 35
- 241000471262 Ardisia japonica Species 0.000 claims abstract description 25
- 240000002629 Pelargonium odoratissimum Species 0.000 claims abstract description 13
- 235000006151 Pelargonium odoratissimum Nutrition 0.000 claims abstract description 13
- 241000938542 Oenanthe aquatica Species 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000005354 coacervation Methods 0.000 claims abstract description 3
- 238000000605 extraction Methods 0.000 claims description 43
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
- 239000000463 material Substances 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 18
- 238000001816 cooling Methods 0.000 claims description 16
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 238000007873 sieving Methods 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 6
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- 235000019322 gelatine Nutrition 0.000 claims description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 5
- 239000003921 oil Substances 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 108010059892 Cellulase Proteins 0.000 claims description 4
- 240000007371 Cuscuta campestris Species 0.000 claims description 4
- 244000211187 Lepidium sativum Species 0.000 claims description 4
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- 241000212324 Oenanthe <angiosperm> Species 0.000 claims description 4
- 108010059820 Polygalacturonase Proteins 0.000 claims description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 4
- 229940106157 cellulase Drugs 0.000 claims description 4
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- 238000005086 pumping Methods 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 238000005187 foaming Methods 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 2
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- 239000000661 sodium alginate Substances 0.000 claims description 2
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- RSWGJHLUYNHPMX-ONCXSQPRSA-N abietic acid Chemical compound C([C@@H]12)CC(C(C)C)=CC1=CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(O)=O RSWGJHLUYNHPMX-ONCXSQPRSA-N 0.000 claims 1
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 28
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- 208000026935 allergic disease Diseases 0.000 abstract description 9
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- 231100000021 irritant Toxicity 0.000 abstract 1
- 230000002045 lasting effect Effects 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 8
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- 230000003020 moisturizing effect Effects 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000003385 bacteriostatic effect Effects 0.000 description 5
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 230000036564 melanin content Effects 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 235000019483 Peanut oil Nutrition 0.000 description 3
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- 239000000312 peanut oil Substances 0.000 description 3
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- 238000010998 test method Methods 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 108010003272 Hyaluronate lyase Proteins 0.000 description 2
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- IGKMJWPWSFSLDV-UHFFFAOYSA-N 1,4-dimethylcyclohexa-2,4-diene-1-carbaldehyde Chemical compound CC1=CCC(C)(C=O)C=C1 IGKMJWPWSFSLDV-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
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- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
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- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
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- 150000002212 flavone derivatives Chemical class 0.000 description 1
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 230000024181 negative regulation of developmental pigmentation Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
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- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to compound essential oil, a preparation method thereof and application thereof in anti-allergy acne-removing cosmetics. The compound essential oil is prepared from pelargonium odoratissimum essential oil, water fennel essential oil and Japanese ardisia essential oil according to the weight ratio of 5-6: 3-4: 5-6, preparing into nanocapsules containing 25% of compound essential oil by complex coacervation method, and adding into anti-allergic acne-removing cosmetic in an amount of 15-20%. The compound essential oil is prepared from natural plants, can inhibit bacteria, resist allergy and inhibit melanin from being deposited, the prepared nanocapsule can inhibit the volatilization of the essential oil and maintain the stability of the effective components of the essential oil, and the compound essential oil can achieve the effects of resisting allergy and removing acnes when added into cosmetics, is non-toxic and non-irritant, and has lasting effect without rebounding.
Description
Technical Field
The invention relates to compound essential oil, in particular to compound essential oil consisting of pelargonium odoratissimum, water fennel essential oil and Japanese ardisia herb essential oil, a preparation method of the compound essential oil and application of the compound essential oil in anti-allergy acne-removing daily cosmetics.
Background
In recent years, the cosmetic industry in China is rapidly developed, wherein the acne-removing cosmetics are added with antibiotics, so that the acne-removing cosmetics can play a role in diminishing inflammation when being used locally for a short time, but cannot be used radically; the long-term use of the medicine can cause drug resistance and even rotten face!
Plant essential oil as a natural raw material ingredient has a positive influence in the cosmetic industry. The essential oil has the characteristics of bacteriostasis, antivirus, antioxidation, safety, no toxicity, no pollution and the like, so the essential oil is applied to the cosmetic industry and is a safe, efficient and mild cosmetic raw material.
However, due to the defects of easy volatilization, low extraction efficiency and the like of the plant essential oil, the absorption rate of active ingredients of the essential oil to skin is low due to the loss of easy volatilization of the plant essential oil in the direct use process. Aiming at the defects of the plant essential oil, the compound essential oil nanocapsule is prepared by optimizing an extraction process and an advanced nanocapsule coating technology and is added into daily cosmetic formulations such as water, milk, face cream and the like, and the process has the advantages of protecting the active ingredients of the plant essential oil from the influence of moisture, oxygen and ultraviolet rays in the environment; the release of the active ingredients of the plant essential oil is controlled, so that the plant essential oil slowly and durably exerts curative effect; covering or reducing the bad smell of the plant essential oil increases the user's perception of the product, thereby increasing the economic benefit.
The original products of Bumper incense are good and prosperous in Africa, Europe and southwest Asia, and then are introduced into China. It belongs to a bush-shaped perennial herb plant with multiple branches, the whole plant is covered with fine white villi, the fleshy leaves are alternately opposite, the stem is thin and thin, and the small flower is white.
Oenanthe stolonifera is distributed in various places of China. It belongs to an umbelliferae perennial herb plant, has erect stem or creeping base, basal leaves with handles and base with leaf sheath; the leaf contour is triangle, the complex umbrella-shaped inflorescence grows from the top, the umbrella spokes are not equal in length and are upright and unfolded; the flower pillar is conical, vertical or divided at two sides.
Japanese ardisia herb is produced in various places of Hunan province. Its commodity is dry whole plant of Ardisia japonica belonging to family Ardisia, evergreen shrub, creeping-like transverse basal part, dark red, and slender adventitious root. The stem is usually single, cylindrical, purple brown in surface and short glandular hair.
Through research and experiments of a large amount of formula ratios, the inventor finally obtains the compound essential oil with the optimal ratio, proves the positive effect of the compound essential oil in the anti-allergy acne-removing cosmetics, and thus completes the invention. The invention provides compound essential oil and a nanocapsule prepared from the compound essential oil, which can be added into cosmetics to achieve the effects of inhibiting bacteria, resisting allergy and inhibiting melanin deposition, thereby achieving the effects of resisting allergy and removing acne.
Disclosure of Invention
The first purpose of the invention is to provide the compound essential oil which has simple extraction method and has the functions of resisting allergy, inhibiting bacteria, inhibiting melanin pigmentation and the like.
The second purpose of the invention is to provide a preparation method of the compound essential oil.
The third purpose of the invention is to provide the application of the compound essential oil in preparing anti-allergy acne-removing cosmetics.
The invention provides compound essential oil which is prepared from essential oil of pelargonium odoratissimum, essential oil of water fennel and essential oil of Japanese ardisia according to the weight ratio of 5-6: 3-4: 5-6.
The proportion of the essential oil for the compound essential oil is 5:3: 5.
Preferably, the preparation method of the essential oil of the dodder in the compound essential oil comprises the following steps:
taking the fresh leaves of the pelargonium odoratissimum, cutting into small pieces, placing the small pieces in a material basket in an extraction tank, then opening a pressure pump to convey deionized water into a preheater with the initial temperature of 100 ℃ at the speed of 20mL/min, continuously raising the temperature to 150 ℃ by a continuous program at the speed of 2 ℃/min, and then conveying hot deionized water into the extraction tank at the speed of 20 mL/min; extracting under 5MPa and 150 deg.C for 15min, cooling the extractive solution in a cooler from the bottom of the extraction tank, cooling to room temperature, adding 0.1g NaCl, extracting with petroleum ether, standing, separating organic layer, drying with anhydrous sodium sulfate, and removing organic solvent with rotary evaporator under vacuum to obtain the final product.
The preparation method of the cress essential oil in the compound essential oil comprises the following steps:
collecting fresh stem and leaf of herba Apii Graveolentis, drying, pulverizing, sieving, and adding supercritical CO2In the extraction kettle, the entrainer ethanol is used for extraction with the solid-liquid ratio of 1.5mL/mg, and the extraction conditions are as follows: the extraction pressure is 45MPa, the extraction temperature is 50 ℃, the extraction time is 3.5h, and CO is added2The flow rate was 25 kg/h. Filtering the extractive solution, recovering ethanol with rotary evaporator, and volatilizing to obtain herba Oenanthes Javanicae essential oil.
The preparation method of the ardisia japonica essential oil in the compound essential oil comprises the following steps:
pulverizing whole Japanese ardisia herb, sieving, placing in a round bottom flask, adding 20 times of distilled water, adjusting pH to 5.0 with hydrochloric acid, adding 0.5% complex enzyme (cellulase and pectinase mixed at a ratio of 2: 1), placing in a water bath kettle, performing enzymolysis at 45 deg.C for 35min, transferring into a material barrel of microwave dynamic extraction equipment, setting microwave power at 850W, performing microwave radiation for 40min, connecting a volatile oil separator to the microwave extraction equipment, and collecting distilled essential oil to obtain Japanese ardisia herb essential oil.
The invention also provides a preferable preparation method of the compound essential oil, which comprises the following steps:
(1) preparation of essential oil of Bumper oil
Taking the fresh leaves of the pelargonium odoratissimum, cutting into small pieces, placing the small pieces in a material basket in an extraction tank, then opening a pressure pump to convey deionized water into a preheater with the initial temperature of 100 ℃ at the speed of 20mL/min, continuously raising the temperature to 150 ℃ by a continuous program at the speed of 2 ℃/min, and then conveying hot deionized water into the extraction tank at the speed of 20 mL/min; extracting under 5MPa and 150 deg.C for 15min, cooling the extractive solution in a cooler from the bottom of the extraction tank, cooling to room temperature, adding 0.1g NaCl, extracting with petroleum ether, standing, separating organic layer, drying with anhydrous sodium sulfate, and removing organic solvent with rotary evaporator under vacuum to obtain the final product.
(2) Preparation method of water fennel essential oil
Collecting fresh stem and leaf of herba Apii Graveolentis, drying, pulverizing, sieving, and adding supercritical CO2In the extraction kettle, the entrainer ethanol is used for extraction with the solid-liquid ratio of 1.5mL/mg, and the extraction conditions are as follows: the extraction pressure is 45MPa, the extraction temperature is 50 ℃, the extraction time is 3.5h, and CO is added2The flow rate was 25 kg/h. Filtering the extractive solution, recovering ethanol with rotary evaporator, and volatilizing to obtain herba Oenanthes Javanicae essential oil.
(3) Preparation of Japanese ardisia herb essential oil
Pulverizing whole Japanese ardisia herb, sieving, placing in a round bottom flask, adding 20 times of distilled water, adjusting pH to 5.0 with hydrochloric acid, adding 0.5% complex enzyme (cellulase and pectinase mixed at a ratio of 2: 1), placing in a water bath kettle, performing enzymolysis at 45 deg.C for 35min, transferring into a material barrel of microwave dynamic extraction equipment, setting microwave power at 850W, performing microwave radiation for 40min, connecting a volatile oil separator to the microwave extraction equipment, and collecting distilled essential oil to obtain Japanese ardisia herb essential oil.
(4) Selecting and uniformly mixing the essential oil of the dodder, the essential oil of the water fennel and the essential oil of the Japanese ardisia according to the proportion to obtain the product.
The compound essential oil for the anti-allergy acne-removing cosmetic is prepared into nanocapsules containing 25% of compound essential oil according to a complex coacervation method, and the nanocapsules are added into the anti-allergy acne-removing cosmetic according to a proportion of 15-20%.
The anti-allergy acne-removing cosmetic has no special limitation on the selection of the formulation and the substrate, and can be prepared into anti-allergy acne-removing moisturizing lotion, anti-allergy acne-removing emulsion, anti-allergy acne-removing cream and the like.
The invention also comprises the application of the compound essential oil in the field of anti-allergy acne-removing cosmetics.
The compound essential oil has the following beneficial effects in the field of anti-allergy acne-removing cosmetics:
1. the compound essential oil is derived from natural plants, is low in price and easy to obtain, has a simple process, can enrich effective active ingredients, can play a role durably and stably, does not rebound, has no toxic or side effect, and is suitable for short-term anti-allergy and long-term acne and acne mark removal.
2. The invention originally combines the essential oil of the dodder, the essential oil of the water fennel and the essential oil of the Japanese ardisia herb, and determines the dosage proportion among the components through a large number of experiments, so that the compound essential oil has obvious synergistic effect, is prepared into the essential oil nanocapsule, inhibits the volatilization of the essential oil, maintains the stability of the effective components of the essential oil, is added into daily cosmetics, has no toxicity and irritation, can effectively inhibit bacteria, resist allergy and inhibit the deposition of melanin, and can stably, effectively and continuously play the functions of resisting allergy and removing acnes.
Detailed Description
The technical solution of the present invention is further described with reference to the following specific examples.
Example 1 preparation of anti-allergic acne-removing series cosmetics
The first step is as follows: preparation of various essential oils
The preparation method of the essential oil of the bumper is as follows:
taking the fresh leaves of the pelargonium odoratissimum, cutting into small pieces, placing the small pieces in a material basket in an extraction tank, then opening a pressure pump to convey deionized water into a preheater with the initial temperature of 100 ℃ at the speed of 20mL/min, continuously raising the temperature to 150 ℃ by a continuous program at the speed of 2 ℃/min, and then conveying hot deionized water into the extraction tank at the speed of 20 mL/min; extracting under 5MPa and 150 deg.C for 15min, cooling the extractive solution in a cooler from the bottom of the extraction tank, cooling to room temperature, adding 0.1g NaCl, extracting with petroleum ether, standing, separating organic layer, drying with anhydrous sodium sulfate, and removing organic solvent with rotary evaporator under vacuum to obtain the final product.
The preparation method of the cress essential oil comprises the following steps:
collecting fresh stem and leaf of herba Apii Graveolentis, drying, pulverizing, sieving, and adding supercritical CO2In the extraction kettle, the entrainer ethanol is used for extraction with the solid-liquid ratio of 1.5mL/mg, and the extraction conditions are as follows: the extraction pressure is 45MPa, the extraction temperature is 50 ℃, the extraction time is 3.5h, and CO is added2The flow rate was 25 kg/h. Filtering the extractive solution, recovering ethanol with rotary evaporator, and volatilizing to obtain herba Oenanthes Javanicae essential oil.
The preparation method of the ardisia japonica essential oil comprises the following steps:
pulverizing whole Japanese ardisia herb, sieving, placing in a round bottom flask, adding 20 times of distilled water, adjusting pH to 5.0 with hydrochloric acid, adding 0.5% complex enzyme (cellulase and pectinase mixed at a ratio of 2: 1), placing in a water bath kettle, performing enzymolysis at 45 deg.C for 35min, transferring into a material barrel of microwave dynamic extraction equipment, setting microwave power at 850W, performing microwave radiation for 40min, connecting a volatile oil separator to the microwave extraction equipment, and collecting distilled essential oil to obtain Japanese ardisia herb essential oil.
The second step is that: preparation of compound essential oil nanocapsules
Adding 10mL of water into 1g of gelatin, foaming overnight, dissolving in a water bath, adding 23mL of water to prepare a gelatin solution, and adjusting the pH value to 8; weighing 2g of sodium alginate, adding 33mL of water for dissolving, adding 1mL of compound essential oil, and grinding into primary emulsion; adding gelatin solution under high speed dispersion condition of 1000r/min, stirring continuously to mix well, adjusting pH to 4, stirring continuously for 10min, adding 60mL cold water, stirring continuously, and cooling to 30 deg.C; adding ice and cooling to below 10 ℃; stirring, adding 2mL of 37% formaldehyde, solidifying, stirring for 60min, stopping stirring, standing, precipitating completely, removing supernatant, adding anhydrous ethanol into the precipitated solid, pumping to semi-dry, and repeating for 5 times. And finally, drying the solid until the weight is unchanged, and collecting the solid to obtain the compound essential oil nanocapsule.
The third step: the compound essential oil nanocapsule is added into daily cosmetics to prepare anti-allergy acne moisturizing lotion, anti-allergy acne cream and anti-allergy acne cream.
The invention provides an application of the compound essential oil nanocapsule in an anti-allergy acne-removing cosmetic, and preferably the compound essential oil nanocapsule is added in the anti-allergy acne-removing cosmetic in an amount of 15-20% by mass.
The anti-allergy acne-removing cosmetic has no special limitation on the selection of the formulation and the substrate, and can be prepared into anti-allergy acne-removing moisturizing lotion, anti-allergy acne cream and the like.
Preparing anti-allergy acne moisturizing lotion:
the raw material components and contents of the anti-allergy acne-removing moisturizing lotion are shown in table 1.
TABLE 1 anti-allergic acne-removing moisturizing lotion formula
The preparation process comprises the following steps:
adding the compound essential oil nanocapsule into medium molecular hyaluronic acid, and uniformly mixing the medium molecular hyaluronic acid mixture and high molecular hyaluronic acid to obtain a mixed material A; and adding the mixed material A and the rest of the components into deionized water, and uniformly mixing to obtain the anti-allergy acne moisturizing lotion.
Preparing anti-allergy acne lotion:
the raw material components and the content of the anti-allergy acne lotion are shown in table 2.
TABLE 2 anti-allergic acne lotion formula
The preparation process comprises the following steps:
heating oleum Olivarum, vitamin E acetate, propyl p-hydroxybenzoate, polyethylene glycol (6) spermaceti stearate, glyceryl monostearate, and cetyl alcohol as oil phase to 55 deg.C, stirring, and keeping the temperature for 25 min; mixing glycerol, amino acids, and vitamin B2Heating cetyl alcohol and deionized water as water phase to 55 deg.C, stirring, and keeping the temperature for 25 min; adding the oil phase into an emulsifying pot, maintaining the temperature at 55 deg.C, starting homogenizing and stirring at 25r/min, pumping the water phase into the emulsifying pot, homogenizing for 5min, and stirring for 20 min; cooling to 35 deg.CAdding the compound essential oil nanocapsule, stirring and mixing uniformly, and cooling to room temperature to obtain the anti-allergy acne lotion.
Preparing anti-allergy acne cream:
the raw material components and the content of the anti-allergy acne cream are shown in table 3.
TABLE 3 anti-allergic acne cream formula
The preparation process comprises the following steps:
uniformly mixing sodium hyaluronate and nanocapsules to obtain a mixed material A; placing medical vaseline and glycerol on a water bath kettle, heating to 75 ℃ and dissolving to obtain a mixed material B; when the temperature of the mixed material B is reduced to 38 ℃, adding amino acid, sodium lactate, flavone, polyacrylamide and vitamin B2Uniformly stirring the vitamin E and the mixed material A, adding deionized water, and adjusting the pH value to 5.5-6 to obtain the anti-allergy acne cream.
The compound essential oil has the effects of resisting allergy, inhibiting bacteria and inhibiting melanin pigmentation and can be used for preparing anti-allergy acne series cosmetics.
Test example 1
The research on the in-vitro anti-allergic activity of the compound essential oil comprises the following steps:
1. materials and methods
1.1 test materials
The essential oil of the pelargonium odoratissimum, the essential oil of the water fennel and the essential oil of the Japanese ardisia herb are respectively prepared according to the embodiment. Preparing compound essential oil of the pelargonium odoratissimum essential oil and the water fennel essential oil according to the formula proportion (the composition 1, the Japanese ardisia herb essential oil is replaced by peanut oil with equal proportion); a compound essential oil of water fennel essential oil and Japanese ardisia essential oil (composition 2, the essential oil of the Bumper oil is replaced by peanut oil in equal proportion); a compound essential oil of the pelargonium odoratissimum and the essential oil of the Japanese ardisia herb (composition 3, the essential oil of the cress is replaced by peanut oil with equal proportion); the invention is compounded with essential oil (composition 4); the invention relates to a compound essential oil nanocapsule (a nanocapsule prepared by a composition 4).
1.2 test methods
(1) Adding 25% DMSO and 500U/mL hyaluronidase into 0.1mol/L acetate buffer solution, adding 0.25mL of compound essential oil with different concentrations, 1g of compound essential oil nanocapsule and 2.5mmol/L CaCl2Incubate at 37 ℃ for 20 min.
(2) After 20min, hyaluronic acid (1.2mg/mL, 5mL) was added and the mixture was incubated at 37 ℃ for 40 min. Then 0.4mol/L NaOH1mL was added and the reaction was stopped by cooling on ice.
(3) After 10min, 3mL of 800mM sodium borate buffer was added, and the mixture was incubated at 100 ℃ for 3min and cooled on ice. 15mL of a color developer (1g of p-dimethylbenzaldehyde dissolved in 100mL of an acetic acid solution containing 1.25mL of concentrated hydrochloric acid) was added. The mixture was then incubated at 37 ℃ for 20 min. The absorbance was measured at 540nm, and the hyaluronidase inhibitory activity (%) was calculated according to the following formula.
In the formula: a: OD value of the control solution; b: OD value of control blank solution (enzyme inactivated, distilled water instead of sample); c: OD value of the sample solution; d: OD value of the sample was not added.
2. Results and analysis
The hyaluronic acid inhibition rate of each composition is shown in table 4.
TABLE 4 hyaluronic acid inhibition test results for each composition
Comparison with composition 1. P<0.01; comparison with composition 2, # P<0.01; in comparison with the composition 3, the composition,△P<0.01; in comparison with the composition 4, the composition,▲P<0.01。
as can be seen from Table 4, each of the compositions exhibited anti-allergic effects, and composition 5 exhibited the highest anti-allergic activity. Compared with the compositions 1, 2 and 3 respectively, the anti-allergic activity of the composition 4 is obviously improved, which shows that the anti-allergic activity of the combination of 3 natural plant essential oils is improved, and the activity of the combination is reduced if any one of the natural plant essential oils is absent. The composition 4 is prepared into nanocapsules, the hyaluronic acid inhibition rate of the nanocapsules is obviously higher than that of the composition 4, the essential oil in the compositions 1-4 is volatile and has short action time, and the prepared nanocapsules can overcome the defect and improve the anti-allergy activity of the nanocapsules.
3. And (4) conclusion: the compound essential oil and the nanocapsules thereof have high hyaluronic acid inhibition rate, show high anti-allergy activity and play a role in quickly resisting allergy and maintaining stability of damaged skin.
Test example 2
The compound essential oil of the invention has in vitro inhibitory activity on staphylococcus and propionibacterium acnes:
1. materials and methods
1.1 test materials
The preparation method of each composition was the same as in test example 1.
1.2 test methods
(1) Preparing strain liquid: 2 strains of staphylococcus and propionibacterium acnes are taken, are respectively cultured for about 24 hours at 37 ℃ on a broth agar inclined plane, and are shaken and stirred uniformly to be used as strain liquid.
(2) Preparing a culture medium plate containing bacteria: cooling the BS culture medium sterilized by high-pressure steam to 45-50 ℃, and respectively adding 105-106And (3) fully shaking and uniformly mixing the CFU/mL staphylococcus and propionibacterium acnes, pouring the mixture into a sterilized culture dish, and cooling to obtain the bacterium-containing culture medium plate.
(3) And (3) measuring the inhibition zone: after the BS culture medium containing staphylococcus and propionibacterium acnes is solidified, a hole puncher with the diameter of 7mm is used for punching, four holes can be punched in each culture dish, 20 mu L of compound essential oil and 80 mu g of compound essential oil nanocapsules are added into each hole, and the holes are cultured in an incubator at 37 ℃ for 24 hours, and then the diameter of the inhibition zone is measured. Each composition was tested 10 times and the mean and standard deviation calculated.
2. Results and analysis
The bacteriostatic activity of each composition against staphylococci and propionibacterium acnes is shown in table 5.
TABLE 5 results of bacteriostatic tests on Staphylococcus and Propionibacterium acnes for each composition
Comparison with composition 1. P<0.01; comparison with composition 2, # P<0.01; in comparison with the composition 3, the composition,△P<0.01; in comparison with the composition 4, the composition,▲P<0.01。
as can be seen from Table 5, each of the compositions had inhibitory effects against Staphylococcus and Propionibacterium acnes, and composition 5 had the best bacteriostatic effect. Compared with the compositions 1, 2 and 3, the bacteriostatic activity of the composition 4 is obviously improved, which shows that the bacteriostatic activity of the combination of the 3 natural plant essential oils is improved, and the activity of the combination is reduced if any one of the natural plant essential oils is absent. The composition 1-4 cannot play the best antibacterial effect because the essential oil is volatile, and the compound essential oil is prepared into the nanocapsule, so that the exertion of the essential oil is reduced, and the antibacterial effect can be exerted durably and stably.
3. And (4) conclusion: the compound essential oil nanocapsule can effectively inhibit staphylococcus and propionibacterium acnes, so that the effect of removing acnes for a long time is achieved.
Test example 3
The compound essential oil of the invention has the following inhibiting effect on melanin pigmentation:
1. materials and methods
1.1 test materials
The preparation method of each composition was the same as in test example 1.
1.2 test methods
(1) Culturing of B16 cells: b16 cells at 95% humidity, CO2The culture was carried out in air at a concentration of 5% in DMEM containing 10% FBS at 37 ℃.
(2) Determination of melanin content: b16 cells at 5X 10 per well4The density of the seed is inoculated inAfter culturing for 24h on a 24-pore plate, removing the culture medium on the upper layer after the cells are completely attached to the wall, adding 500 mu L of each composition containing medicine for culturing, setting a normal group and a positive control group, continuously culturing for 48h, removing the supernatant, washing for 5 times by PBS (phosphate buffer solution), digesting the cells by trypsin, collecting the cells into a centrifuge tube, centrifuging for 10min at 10000r/min, removing the supernatant, dissolving melanin by 150 mu L of 2mol/L NaOH of 10% DMSO (sodium hydroxide), preserving the melanin in water bath at 80 ℃ for 2h, finally sucking 100 mu L of the dissolved solution, transferring the dissolved solution into a 96-pore plate, measuring the content of the melanin by the absorbance of the supernatant of each pore at the wavelength of 405nm, wherein the smaller the content is represented by the percentage relative to the absorbance of a blank control, and the stronger the inhibition effect of the sample on melanin pigmentation is proved.
2. Results and analysis
The inhibitory effect of each composition on melanin pigmentation is shown in table 6.
TABLE 6 inhibitory Effect of the compositions on melanin pigmentation
Comparison with composition 1. P<0.01; comparison with composition 2, # P<0.01; in comparison with the composition 3, the composition,△P<0.01; in comparison with the composition 4, the composition,▲P<0.01。
as can be seen from table 6, each composition had an inhibitory effect on melanin pigmentation, and No. 5 had the best effect on the inhibition of pigmentation. The lowest melanin content of composition 4 compared to compositions 1, 2, and 3, respectively, indicates that the melanin content is significantly reduced in the combination of 3 natural plant essential oils, and the inhibition is reduced in the absence of any one. The composition 1-4 has higher melanin content than composition 5 due to volatile essential oil, and can reduce volatilization of essential oil and inhibit melanin pigmentation.
Claims (5)
1. The compound essential oil is characterized by being prepared from pelargonium odoratissimum essential oil, water fennel essential oil and Japanese ardisia herb essential oil in a ratio of 5-6: 3-4: 5-6;
the preparation method of the essential oil of the pelargonium odoratissimum comprises the following steps:
taking the fresh leaves of the pelargonium odoratissimum, cutting into small pieces, placing the small pieces in a material basket in an extraction tank, then opening a pressure pump to convey deionized water into a preheater with the initial temperature of 100 ℃ at the speed of 20mL/min, continuously raising the temperature to 150 ℃ by a continuous program at the speed of 2 ℃/min, and then conveying hot deionized water into the extraction tank at the speed of 20 mL/min; extracting under 5MPa and 150 deg.C for 15min, cooling the extractive solution from the bottom of the extraction tank to room temperature, adding 0.1g NaCl, extracting with petroleum ether, standing, separating organic layer, drying with anhydrous sodium sulfate, and removing organic solvent with rotary evaporator under vacuum to obtain Colophonium oil;
the preparation method of the cress essential oil comprises the following steps:
collecting fresh stem and leaf of herba Apii Graveolentis, drying, pulverizing, sieving, and adding supercritical CO2In the extraction kettle, the entrainer ethanol is used for extraction with the solid-liquid ratio of 1.5mL/mg, and the extraction conditions are as follows: the extraction pressure is 45MPa, the extraction temperature is 50 ℃, the extraction time is 3.5h, and CO is added2The flow rate was 25 kg/h. Filtering the extractive solution, recovering ethanol with rotary evaporator, and volatilizing to obtain herba Oenanthes Javanicae essential oil;
the preparation method of the ardisia japonica essential oil comprises the following steps:
taking whole Japanese ardisia herb, crushing, sieving, placing in a round-bottom flask, adding 20 times of distilled water, adjusting pH to 5.0 with hydrochloric acid, and adding 0.5% of complex enzyme into a container, wherein the complex enzyme is obtained by mixing cellulase and pectinase according to a ratio of 2: 1; placing in a water bath pan at 45 deg.C for enzymolysis for 35min, transferring into a material barrel of microwave dynamic extraction equipment, setting microwave power at 850W, microwave radiating for 40min, connecting volatile oil separator to the microwave extraction equipment, and collecting distilled essential oil to obtain herba Ardisiae Japonicae essential oil;
selecting the essential oil of the dodder, the essential oil of the water fennel and the essential oil of the Japanese ardisia according to the proportion, and uniformly mixing to obtain the compound essential oil.
2. The compound essential oil of claim 1, wherein the proportion of the essential oil of the pelargonium odoratissimum, the essential oil of the water fennel and the essential oil of the Japanese ardisia herb is 5:3: 5.
3. A compound essential oil nanocapsule, which is characterized in that the compound essential oil of claim 1 is prepared into a nanocapsule containing 25% of the compound essential oil by a complex coacervation method.
4. The compound essential oil nanocapsule of claim 3, wherein the preparation method of the compound essential oil nanocapsule comprises:
adding 10mL of water into 1g of gelatin, foaming overnight, dissolving in a water bath, adding 23mL of water to prepare a gelatin solution, and adjusting the pH value to 8; weighing 2g of sodium alginate, adding 33mL of water for dissolving, adding 1mL of compound essential oil, and grinding into primary emulsion; adding gelatin solution under high speed dispersion condition of 1000r/min, stirring continuously to mix well, adjusting pH to 4, stirring continuously for 10min, adding 60mL cold water, stirring continuously, and cooling to 30 deg.C; adding ice and cooling to below 10 ℃; stirring, adding 2mL of 37% formaldehyde, solidifying, stirring for 60min, stopping stirring, standing, precipitating completely, removing supernatant, adding anhydrous ethanol into the precipitated solid, pumping to semi-dry, and repeating for 5 times. And finally, drying the solid until the weight is unchanged, and collecting the solid to obtain the compound essential oil nanocapsule.
5. The application of the compound essential oil nanocapsule is characterized in that the compound essential oil nanocapsule of claim 3 is added into an anti-allergy acne-removing cosmetic according to the mass of the compound essential oil nanocapsule accounting for 15-20% of the mass of the anti-allergy acne-removing cosmetic.
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| FR2504551A1 (en) * | 1981-04-24 | 1982-10-29 | Dehais Claude | Compsn. for treating skin, e.g. burns, eczema or acne - contains essential oils from Labiatae and other plant families |
| CN105287906A (en) * | 2014-07-28 | 2016-02-03 | 叶远青 | External application liquid cream with plant essence |
| CN104327952A (en) * | 2014-10-27 | 2015-02-04 | 山西大学 | Pelargonium odoratissimum essential oil and extraction method and application of essential oil |
| CN108938440A (en) * | 2018-09-28 | 2018-12-07 | 袁浩卿 | composite essential oil |
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| JP2013006814A (en) * | 2011-06-23 | 2013-01-10 | Bioland Ltd | Skincare composition for external use for preventing/ameliorating wrinkle |
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Effective date of registration: 20231024 Address after: 835000 Plant 4, Phase III, 1000000m2, Khorgos City, Ili Kazak Autonomous Prefecture, Xinjiang Uygur Autonomous Region Patentee after: Xinjiang Liaojing Biotechnology Engineering Co.,Ltd. Address before: G2-169, 6th Floor, Shenya Building, No. 47 Guomao Road, Longhua District, Haikou City, Hainan Province, 570100 Patentee before: Hainan Liaojing Consulting Management Co.,Ltd. Patentee before: Yingkou Wenying Investment Consulting Co.,Ltd. Effective date of registration: 20231024 Address after: G2-169, 6th Floor, Shenya Building, No. 47 Guomao Road, Longhua District, Haikou City, Hainan Province, 570100 Patentee after: Hainan Liaojing Consulting Management Co.,Ltd. Patentee after: Yingkou Wenying Investment Consulting Co.,Ltd. Address before: 266000 Songling Road, Laoshan District, Qingdao, Shandong Province, No. 99 Patentee before: QINGDAO University OF SCIENCE AND TECHNOLOGY |