CN112004945B - 用于结肠癌检测和治疗监控的方法 - Google Patents

用于结肠癌检测和治疗监控的方法 Download PDF

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CN112004945B
CN112004945B CN201980020784.5A CN201980020784A CN112004945B CN 112004945 B CN112004945 B CN 112004945B CN 201980020784 A CN201980020784 A CN 201980020784A CN 112004945 B CN112004945 B CN 112004945B
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biomarkers
therapy
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CN112004945A (zh
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I·M·莫林
M·基德
I·德罗斯多夫
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Liquid Biopsy Research LLC
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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CN201980020784.5A 2018-01-22 2019-01-22 用于结肠癌检测和治疗监控的方法 Active CN112004945B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862620015P 2018-01-22 2018-01-22
US62/620015 2018-01-22
PCT/US2019/014490 WO2019144099A1 (en) 2018-01-22 2019-01-22 Methods for colon cancer detection and treatment monitoring

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CN112004945B true CN112004945B (zh) 2025-02-14

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US (3) US11414707B2 (https=)
EP (1) EP3743534B1 (https=)
JP (1) JP7297770B2 (https=)
KR (1) KR20200113237A (https=)
CN (1) CN112004945B (https=)
AU (1) AU2019209436B2 (https=)
BR (1) BR112020014737A2 (https=)
CA (1) CA3088754A1 (https=)
DK (1) DK3743534T3 (https=)
ES (1) ES2917629T3 (https=)
IL (1) IL276089B2 (https=)
MX (1) MX2020007771A (https=)
PL (1) PL3743534T3 (https=)
SG (1) SG11202006974WA (https=)
WO (1) WO2019144099A1 (https=)

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PL3743534T3 (pl) 2018-01-22 2022-09-05 Liquid Biopsy Research LLC Sposoby wykrywania nowotworu okrężnicy i monitorowania leczenia
MX2022004372A (es) 2019-10-10 2022-07-27 Liquid Biopsy Res Llc Composiciones, métodos y kits para la estabilización de muestras biológicas y de arn.
US11809379B2 (en) * 2019-11-19 2023-11-07 International Business Machines Corporation Storage tiering for deduplicated storage environments
CN111157745A (zh) * 2020-01-17 2020-05-15 上海交通大学 人snrpa蛋白在肺癌复发或转移监测中的用途
CN115475247B (zh) * 2021-06-16 2024-02-20 厦门大学 β2-微球蛋白或其抑制剂的制药用途
KR102823777B1 (ko) * 2021-10-15 2025-06-23 한국과학기술원 인공지능을 이용하여 유전체 염기서열로 질환 진단 및 예측 방법, 그 시스템
CN113921079B (zh) * 2021-12-06 2022-03-18 四川省肿瘤医院 基于免疫相关基因的msi预测模型构建方法
CN121137146B (zh) * 2025-07-28 2026-04-07 首钢医院有限公司 检测基因组合物的试剂在制备预测结直肠癌患者远端切缘长度的产品中的应用

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EP2169078A1 (en) * 2008-09-26 2010-03-31 Fundacion Gaiker Methods and kits for the diagnosis and the staging of colorectal cancer

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CA3088754A1 (en) 2019-07-25
JP2021511057A (ja) 2021-05-06
EP3743534A1 (en) 2020-12-02
SG11202006974WA (en) 2020-08-28
IL276089A (en) 2020-08-31
IL276089B2 (en) 2024-07-01
AU2019209436B2 (en) 2025-06-05
AU2019209436A1 (en) 2020-08-06
DK3743534T3 (da) 2022-06-20
CN112004945A (zh) 2020-11-27
EP3743534B1 (en) 2022-03-23
KR20200113237A (ko) 2020-10-06
US20230220482A1 (en) 2023-07-13
PL3743534T3 (pl) 2022-09-05
WO2019144099A1 (en) 2019-07-25
MX2020007771A (es) 2020-09-03
IL276089B1 (en) 2024-03-01
US20250243553A1 (en) 2025-07-31
BR112020014737A2 (pt) 2020-12-08
JP7297770B2 (ja) 2023-06-26
US20190226030A1 (en) 2019-07-25
US11414707B2 (en) 2022-08-16
ES2917629T3 (es) 2022-07-11
US12305240B2 (en) 2025-05-20

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