CN112004524B - 药物递送系统 - Google Patents

药物递送系统 Download PDF

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Publication number
CN112004524B
CN112004524B CN201980027345.7A CN201980027345A CN112004524B CN 112004524 B CN112004524 B CN 112004524B CN 201980027345 A CN201980027345 A CN 201980027345A CN 112004524 B CN112004524 B CN 112004524B
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formulation
csa
tacrolimus
plga
drug
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Chinese (zh)
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CN112004524A (zh
Inventor
S·贝妮塔
T·纳萨尔
莱斯利·雷比伯
阿米特·巴迪希
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Yissum Research Development Co of Hebrew University of Jerusalem
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Yissum Research Development Co of Hebrew University of Jerusalem
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    • A61K31/28Compounds containing heavy metals
    • A61K31/282Platinum compounds
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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  • Life Sciences & Earth Sciences (AREA)
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  • Epidemiology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980027345.7A 2018-02-26 2019-02-26 药物递送系统 Active CN112004524B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862635088P 2018-02-26 2018-02-26
US62/635,088 2018-02-26
PCT/IL2019/050217 WO2019162951A1 (en) 2018-02-26 2019-02-26 Drug delivery systems

Publications (2)

Publication Number Publication Date
CN112004524A CN112004524A (zh) 2020-11-27
CN112004524B true CN112004524B (zh) 2024-09-10

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US (1) US20210128534A1 (enExample)
EP (1) EP3758677A1 (enExample)
JP (1) JP7416430B2 (enExample)
KR (2) KR102717886B1 (enExample)
CN (1) CN112004524B (enExample)
AU (1) AU2019226051B2 (enExample)
CA (1) CA3092016A1 (enExample)
IL (1) IL276784B2 (enExample)
WO (1) WO2019162951A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140041505A (ko) 2011-04-29 2014-04-04 셀렉타 바이오사이언시즈, 인크. 조절 b 세포 유도를 위한 관용원성 합성 나노운반체
BR112015027291A8 (pt) 2013-05-03 2019-12-24 Selecta Biosciences Inc uso de um imunossupressor que têm uma vida eficaz farmacodinâmica especificada e composição compreendendo o referido imunossupressor
WO2016037164A1 (en) 2014-09-07 2016-03-10 Selecta Biosciences, Inc. Methods and compositions for attenuating gene expression modulating anti-viral transfer vector immune responses
KR102753928B1 (ko) 2017-03-11 2025-01-14 셀렉타 바이오사이언시즈, 인크. 항염증제, 및 면역억제제를 포함하는 합성 나노담체를 사용한 조합 치료와 관련된 방법 및 조성물
GB201810925D0 (en) * 2018-07-03 2018-08-15 Blueberry Therapeutics Ltd Compositions and methods of treatment
GB201810923D0 (en) * 2018-07-03 2018-08-15 Blueberry Therapeutics Ltd Compositions and method of treatment
EP3980784A1 (en) 2019-06-04 2022-04-13 Selecta Biosciences, Inc. Formulations and doses of pegylated uricase
BR112022010952A2 (pt) * 2019-12-05 2022-09-06 West Virginia Univ Board Of Governors On Behalf Of West Virginia Univ Nanosferas de plga carregadas de proteína
AU2021236234A1 (en) * 2020-03-11 2022-10-06 Selecta Biosciences, Inc. Methods and compositions related to synthetic nanocarriers
EP4167979A1 (en) * 2020-06-19 2023-04-26 Cannovex BV Pulmonary formulation comprising cannabinoids
KR20230047095A (ko) 2020-07-29 2023-04-06 카낙 테크놀로지스, 엘엘씨 치료용 친유성 활성물질의 개선된 전달을 위한 약제학적 조성물
CA3166084C (en) 2020-07-29 2025-06-10 Karnak Technologies, Llc Oral compositions of beneficial lipophilic, nutriceutical, and edible oil food supplements
EP4199906A1 (en) * 2020-08-20 2023-06-28 Bionanosim (BNS) Ltd Lipid delivery systems for delivery of oxaliplatin palmitate acetate
DK202070707A1 (en) 2020-10-26 2022-05-02 Jacob Holm & Sons Ag Dry CBD Delivery Fabric
US12605394B2 (en) 2024-07-25 2026-04-21 Visionary Assets, Llc Compositions containing cannabinoid nanoparticles

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014317A (zh) * 2004-11-09 2007-08-08 诺瓦加利制药公司 含有免疫抑制剂的眼用乳剂

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4851067B2 (ja) * 2004-01-28 2012-01-11 ホソカワミクロン株式会社 ナノ粒子含有組成物およびその製造方法
KR101319772B1 (ko) * 2004-11-09 2013-10-23 노바갈리 파르마 에스 에이 면역 억제제를 포함하는 안과용 유제
CN1903365A (zh) * 2005-07-28 2007-01-31 中国医学科学院生物医学工程研究所 载药纳米微粒及其制备方法和该微粒在制备抗血管再狭窄制剂中的应用
ES2425969T3 (es) * 2007-04-27 2013-10-18 Kyushu University, National University Corporation Agente para el tratamiento de enfermedades pulmonares
CN101810563B (zh) * 2009-09-25 2012-04-25 宋洪涛 他克莫司眼用在体凝胶制剂及其制备方法
US20140079642A1 (en) * 2011-01-24 2014-03-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Nanoparticles based for dermal and systemic delivery of drugs
US20170065533A1 (en) * 2011-01-24 2017-03-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nanoparticles for dermal and systemic delivery of drugs
US20150037422A1 (en) * 2012-02-22 2015-02-05 Trustees Of Tufts College Compositions and methods for ocular delivery of a therapeutic agent
US9724304B2 (en) * 2012-06-14 2017-08-08 Temple University—Of the Commonwealth System of Higher Education Nanospheres for therapeutic agent delivery
CN102772827B (zh) * 2012-07-13 2014-05-07 华南理工大学 Plga/羟基磷灰石/碳酸钙复合微球及其制备方法
KR101940888B1 (ko) * 2013-12-31 2019-01-21 피비앤비 에스에이 체형 복원 및 체형 관리용 제어 방출 지방산 조성물
EP3154524B1 (en) * 2014-06-12 2021-12-15 Adare Pharmaceuticals USA, Inc. Extended-release drug delivery compositions
GB201419540D0 (en) * 2014-11-03 2014-12-17 Nanomerics Ltd Delivery of drugs
CN105769821B (zh) * 2016-04-19 2019-06-14 浙江工业大学 他克莫司自组装聚合物纳米粒给药系统及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101014317A (zh) * 2004-11-09 2007-08-08 诺瓦加利制药公司 含有免疫抑制剂的眼用乳剂

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Cyclosporin A loadied PLGA nanoparticle:preparation, optimization, in0vitro characterization and stability studies;Sanyog Jain et al.;《Current Nanoscience》;第6卷(第4期);422-431 *

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