CN111996101A - Full-automatic nucleic acid extraction instrument with reduced sample pollution probability - Google Patents
Full-automatic nucleic acid extraction instrument with reduced sample pollution probability Download PDFInfo
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- CN111996101A CN111996101A CN202010789509.4A CN202010789509A CN111996101A CN 111996101 A CN111996101 A CN 111996101A CN 202010789509 A CN202010789509 A CN 202010789509A CN 111996101 A CN111996101 A CN 111996101A
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- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 28
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 28
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 28
- 238000000605 extraction Methods 0.000 title claims abstract description 17
- 230000002829 reductive effect Effects 0.000 title abstract description 12
- 238000001514 detection method Methods 0.000 claims abstract description 61
- 238000007789 sealing Methods 0.000 claims abstract description 20
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 18
- 230000001681 protective effect Effects 0.000 claims abstract description 15
- 230000009467 reduction Effects 0.000 claims abstract description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 230000000149 penetrating effect Effects 0.000 claims description 5
- 239000000741 silica gel Substances 0.000 claims description 5
- 229910002027 silica gel Inorganic materials 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 4
- 210000003437 trachea Anatomy 0.000 claims description 4
- 239000000919 ceramic Substances 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 239000003566 sealing material Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- 239000007769 metal material Substances 0.000 claims description 2
- 125000003003 spiro group Chemical group 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 abstract description 4
- 238000000034 method Methods 0.000 description 6
- 238000001179 sorption measurement Methods 0.000 description 5
- 238000009423 ventilation Methods 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 230000000670 limiting effect Effects 0.000 description 4
- 230000003321 amplification Effects 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 241000252254 Catostomidae Species 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L9/00—Disinfection, sterilisation or deodorisation of air
- A61L9/16—Disinfection, sterilisation or deodorisation of air using physical phenomena
- A61L9/18—Radiation
- A61L9/20—Ultraviolet radiation
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Abstract
The invention discloses a full-automatic nucleic acid extractor with reduced sample pollution probability, which comprises a detection base, wherein one side of the detection base is fixedly connected with an instrument host, the outer sides of the detection base and the instrument host are fixedly connected with protective covers, accessory fixing blocks are uniformly arranged on the upper surface of the detection base, the front surface of the instrument host is fixedly connected with a control panel, one end of the instrument host, which is positioned in the protective cover, is fixedly connected with an extraction component, and the top end of the interior of the protective cover is fixedly connected with a sealing component. This full-automatic nucleic acid extraction appearance of sample pollution probability reduction is provided with anti-pollution component inside, and the disinfection component of anti-pollution component can remove between base and protection casing simultaneously to make things convenient for the staff to disinfect to the inside different positions of device, thereby prevent that the device is inside to breed the bacterium, lead to the sample to receive the problem of pollution easily.
Description
Technical Field
The invention relates to the technical field of nucleic acid detection, in particular to a full-automatic nucleic acid extraction instrument with reduced sample pollution probability.
Background
Nucleic acid is a biopolymer, which is an indispensable constituent substance for all known life forms, is a general name of deoxyribonucleic acid and ribonucleic acid, consists of nucleotide, and consists of 5-carbon sugar, phosphate group and nitrogenous base.
Chinese patent discloses a full-automatic nucleic acid extraction amplification detector (publication number: CN111154641A), which comprises a work box body and an operation display screen, wherein a core device is arranged in the work box body and is electrically connected with the operation display screen, the core device comprises a nucleic acid extraction amplification detection device, a thermal circulation device, an adjustable light supplement lamp device and an optical detection device, and the optical detection device is arranged in the core device and is positioned above the nucleic acid extraction amplification detection device.
Present full-automatic nucleic acid extraction appearance is after long-time the use, and its inside dust that can pile up to breed the bacterium easily in the corner, if misoperation in the use, then can cause the pollution to the sample, lead to the quality reduction that detects, and current device is inside comparatively closed, lead to internal environment to suffer the pollution easily, and current device does not possess ventilation function or ventilation function singleness, causes secondary pollution to the device is inside easily when ventilating.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a full-automatic nucleic acid extractor with reduced sample pollution probability, which solves the problems that after the existing full-automatic nucleic acid extractor is used for a long time, dust can be accumulated in the nucleic acid extractor, bacteria can be easily bred in corners, if the operation is wrong in the using process, the sample can be polluted, the detection quality is reduced, the interior of the existing device is closed, the internal environment is easily polluted, the existing device does not have a ventilation function or has a single ventilation function, and secondary pollution is easily caused to the interior of the device during ventilation.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: a full-automatic nucleic acid extractor with reduced sample pollution probability comprises a detection base, wherein one side of the detection base is fixedly connected with an instrument host, the outer sides of the detection base and the instrument host are fixedly connected with a protective cover, accessory fixing blocks are uniformly arranged on the upper surface of the detection base, a control panel is fixedly connected to the front surface of the instrument host, one end, positioned inside the protective cover, of the instrument host is fixedly connected with an extraction component, the top end inside the protective cover is fixedly connected with a sealing component, sliding grooves are uniformly formed in the side surface, close to the accessory fixing blocks, of the upper surface of the detection base, a communication hole is formed between two sets of accessory fixing blocks, the middle part of the upper surface of the detection base is fixedly connected with driving equipment, and the top end inside the detection base is rotatably connected with a shielding component connected with the output end of, the anti-pollution component that detects the inside fixedly connected with of base and run through inside the spout, and detect inside one side fixedly connected with air-out equipment of base, the inside opposite side fixedly connected with air inlet equipment of detection base, air inlet equipment's gas outlet and shelter from to be connected with between the component and be connected with the trachea.
Preferably, the accessory fixed block is the component of an L type, and four of accessory fixed block are a set of and become the rectangle and distribute, and is a set of the sunken position of accessory fixed block is internal and the corner position is outwards, detect the equal fixedly connected with sucking disc in one side that the base upper surface is close to accessory fixed block sunken position.
Preferably, the anti-pollution component includes the connecting plate, fixedly connected with second electric telescopic handle between the middle part of connecting plate lower surface and the detection base, and equal fixedly connected with gag lever post between connecting plate lower surface both ends and the detection base, the gag lever post has two sets of mutual sliding connection's column component to constitute, the last fixed surface of connecting plate is connected with the ultraviolet ray disinfection lamp that runs through the spout.
Preferably, the sealing member includes and detects base fixed connection's first electric telescopic handle, first electric telescopic handle's bottom fixedly connected with adsorbs the component, the outside cover that adsorbs the component bottom is equipped with sealed piece, and the bottom embedding that adsorbs the component is connected with the permanent magnet, sealed piece includes the body of silica gel material, and the upper surface embedding of silica gel body is connected with the carriage of metal material and adsorbs with adsorbing the component and be connected.
Preferably, the connecting air pipe comprises a vertical pipe, the vertical pipe penetrates through the anti-pollution member and is fixedly connected with an air outlet of the air inlet device, one end of the vertical pipe is fixedly connected with a spiral pipe, and the spiral pipe penetrates through the ultraviolet disinfection lamp.
Preferably, the one end that vertical pipe was kept away from to the spiral pipe is rotated and is connected with communicating pipe, the air outlet of communicating pipe with shelter from the component intercommunication, the bottom fixedly connected with bracing piece of spiral pipe, the bottom of bracing piece and the inner wall spiro union that detects the base.
Preferably, the shielding component comprises a rotary disc, a shielding plate is fixedly connected to the side face of the rotary disc, a communicating plate is fixedly arranged on one side, close to the shielding plate, of the side face of the rotary disc, air outlet holes are formed in the upper surface of the communicating plate, the air outlet holes are the same as the communicating holes in number and are in one-to-one correspondence with the communicating holes in the vertical direction, and the air outlet holes, the communicating plate, the rotary disc and the connecting air pipes are communicated with one another.
Preferably, the air inlet of the air inlet device and the air outlet of the air outlet device are both connected with a filter box in a threaded manner, the filter box is filled with a microporous ceramic filter plate, an activated carbon plate and a polyester fiber layer in sequence, and the part of the filter box connected with the detection base is filled with a sealing material.
(III) advantageous effects
The invention provides a full-automatic nucleic acid extractor with reduced sample pollution probability. The method has the following beneficial effects:
(1) the full-automatic nucleic acid extractor with the reduced sample pollution probability is characterized in that sliding grooves are uniformly formed in the side face, close to an accessory fixing block, of the upper surface of a detection base, anti-pollution components penetrating through the sliding grooves are fixedly connected inside the detection base and comprise connecting plates, a second electric telescopic rod is fixedly connected between the middle part of the lower surface of each connecting plate and the detection base, limiting rods are fixedly connected between the two ends of the lower surface of each connecting plate and the detection base and comprise two groups of columnar components in mutual sliding connection, an ultraviolet disinfection lamp penetrating through the sliding grooves is fixedly connected to the upper surface of each connecting plate, the device is internally provided with the anti-pollution components, and meanwhile, the disinfection components of the anti-pollution components can move between the base and a protective cover, so that workers can disinfect different positions inside the device conveniently, and bacteria breeding inside, the sample is easy to be polluted, and the device has a simple structure and is convenient to control.
(2) The full-automatic nucleic acid extraction instrument with the reduced sample pollution probability is characterized in that an air outlet device is fixedly connected with one side in a detection base, an air inlet device is fixedly connected with the other side in the detection base, a connecting air pipe is connected between an air outlet of the air inlet device and a shielding component, the connecting air pipe comprises a vertical pipe, the vertical pipe penetrates through the anti-pollution component and is fixedly connected with an air outlet of the air inlet device, one end of the vertical pipe is fixedly connected with a spiral pipe, the spiral pipe penetrates through an ultraviolet disinfection lamp, one end of the spiral pipe, far away from the vertical pipe, is rotatably connected with a communicating pipe, the air outlet of the communicating pipe is communicated with the shielding component, a supporting rod is fixedly connected with the bottom end of the spiral pipe, the bottom end of the supporting rod is in threaded connection with the inner wall of the detection base, the, when the air passes through, the sterilizing component can be started to sterilize the air, so that the pollution of the outside air to the inside of the device can be prevented.
(3) The full-automatic nucleic acid extractor with reduced sample pollution probability is characterized in that sealing components are fixedly connected with the top end inside the protective cover, the top end inside the detection base is rotatably connected with a shielding component connected with the output end of the driving device, the shielding component comprises a rotary disc, the side surface of the rotary disc is fixedly connected with a shielding plate, and one side of the side surface of the rotary disc close to the shielding plate is fixed with a communicating plate, the upper surface of the communicating plate is provided with air outlet holes, the number of the air outlet holes and the number of the communicating holes are the same, the air outlet holes and the communicating holes are in one-to-one correspondence in the vertical direction, the air outlet holes, the communicating plate, the rotary disc and the connecting air pipe are communicated with each other, the device can separate the space between the base and the protective cover through the shielding component, the shielding component is convenient to control and can be conveniently adjusted, and the sealing component can seal the kit when the kit is static, so that the probability of sample contamination can be further prevented.
Drawings
FIG. 1 is a front view of the present invention;
FIG. 2 is a partial cross-sectional view of the present invention;
FIG. 3 is a top view of the detection base of the present invention;
FIG. 4 is a cross-sectional view of a detection base according to the present invention;
FIG. 5 is a top view of the blocking member according to the present invention;
fig. 6 is an enlarged view of a portion a of fig. 4 according to the present invention.
In the figure, 1, a detection base; 2. a protective cover; 3. an instrument host; 4. a control panel; 5. an extraction means; 6. a sealing member; 7. an accessory fixing block; 8. a chute; 9. an anti-contamination member; 10. a shielding member; 11. air outlet equipment; 12. an air intake device; 13. connecting an air pipe; 14. a drive device; 61. a first electric telescopic rod; 62. an adsorption member; 63. a sealing block; 71. a suction cup; 72. a communicating hole; 91. a connecting plate; 92. an ultraviolet disinfection lamp; 93. a limiting rod; 94. a second electric telescopic rod; 131. a vertical tube; 132. a spiral tube; 133. a communicating pipe; 134. a support bar; 101. a turntable; 102. a shielding plate; 103. A communication plate; 104. and an air outlet.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-2, an embodiment of the present invention provides a technical solution: a full-automatic nucleic acid extractor with reduced sample pollution probability comprises a detection base 1, wherein the detection base comprises a moving part at the upper side and a driving part at the lower side, the detection base except a driving component is all arranged in the moving part, one side of the detection base 1 is fixedly connected with an instrument host 3, the outer sides of the detection base 1 and the instrument host 3 are both fixedly connected with a protective cover 2, accessory fixing blocks 7 are uniformly arranged on the upper surface of the detection base 1, the front surface of the instrument host 3 is fixedly connected with a control panel 4, one end of the instrument host 3, which is positioned in the protective cover 2, is fixedly connected with an extraction component 5, the top end of the inner part of the protective cover 2 is fixedly connected with a sealing component 6, the accessory fixing blocks 7 are L-shaped components, four accessory fixing blocks 7 are distributed in a group and form a rectangle, the concave parts of the accessory fixing blocks 7 in the, the side, close to the concave part of the accessory fixing block 7, of the upper surface of the detection base 1 is fixedly connected with suckers 71, the side, close to the accessory fixing block 7, of the upper surface of the detection base 1 is uniformly provided with sliding grooves 8, communication holes 72 are formed between the upper surface of the detection base 1 and the two sets of accessory fixing blocks 7, the middle part of the upper surface of the detection base 1 is fixedly connected with a driving device 14, the driving device 14 is 40W-90 type, the driving device 14 is provided with a locking structure and a speed reducing structure, the top end of the interior of the detection base 1 is rotatably connected with a shielding component 10 connected with the output end of the driving device 14, an anti-pollution component 9 penetrating through the sliding grooves 8 is fixedly connected inside the detection base 1, an air outlet device 11 is fixedly connected to one side of the interior of the, a connecting air pipe 13 is connected between the air outlet of the air intake device 12 and the shielding member 10, and the details not described in the present specification belong to the prior art known to those skilled in the art, on the other hand, each electrical component in the present device is electrically connected to an external controller, and the working logic and the working sequence between each electrical component can be controlled by programming and manual work.
When the kit is used, the sealing door of the protective cover 2 is opened, a sample, MCP lysate, MCP washing liquid I, MCP lysate II and MCP eluent are sequentially placed in different sets of accessory fixing blocks 7, the kit sets are fixed through the sucking discs 71 by pressing forcefully during placement, then the sealing door is closed, then the sealing members 6 on the upper sides of the kit sets are started, the first electric telescopic rods 61 in the sealing members 6 drive the adsorption members 62 to descend, the kit sets can be sealed through the sealing blocks 63, the kit sets are prevented from being polluted, then the extraction members 5 are started, extraction can be carried out, the driving members in the detection base 1 drive the moving parts to rotate, so that different kit sets are moved to the lower sides of the extraction members 5, when the moving parts of the detection base 1 move, the sealing members 6 are withdrawn from the kit sets, after the movement is completed, the sealing member 6 is then actuated to seal the cartridge.
Referring to fig. 3-6, the anti-pollution member 9 includes a connection plate 91, a second electric telescopic rod 94 is fixedly connected between the middle portion of the lower surface of the connection plate 91 and the detection base 1, and a limiting rod 93 is fixedly connected between both ends of the lower surface of the connection plate 91 and the detection base 1, the limiting rod 93 is composed of two groups of columnar members slidably connected with each other, an ultraviolet disinfection lamp 92 penetrating through the chute 8 is fixedly connected to the upper surface of the connection plate 91, the sealing member 6 includes a first electric telescopic rod 61 fixedly connected with the detection base 1, the bottom end of the first electric telescopic rod 61 is fixedly connected with the adsorption member 62, a sealing block 63 is sleeved outside the bottom end of the adsorption member 62, a permanent magnet is embedded and connected to the bottom end of the adsorption member 62, the sealing block 63 includes a body made of silica gel, a connection frame made of metal is embedded and connected to the upper, the connecting air pipe 13 comprises a vertical pipe 131, the vertical pipe 131 penetrates through the anti-pollution member 9 and is fixedly connected with an air outlet of the air intake device 12, one end of the vertical pipe 131 is fixedly connected with a spiral pipe 132, the spiral pipe 132 penetrates through the ultraviolet disinfection lamp 92, one end, far away from the vertical pipe 131, of the spiral pipe 132 is rotatably connected with a communicating pipe 133, the air outlet of the communicating pipe 133 is communicated with the shielding member 10, the bottom end of the spiral pipe 132 is fixedly connected with a supporting rod 134, the bottom end of the supporting rod 134 is in threaded connection with the inner wall of the detection base 1, the shielding member 10 comprises a rotary disc 101, a shielding plate 102 is fixedly connected to the side surface of the rotary disc 101, a communicating plate 103 is fixed to one side, close to the shielding plate 102, of the side surface of the rotary disc 101, air outlet holes 104 are formed in the upper, The turntable 101 and the connecting air pipe 13 are communicated with each other, the air inlet of the air inlet device 12 and the air outlet of the air outlet device 11 are both in threaded connection with a filter box, the filter box is filled with a microporous ceramic filter plate, an activated carbon plate and a polyester fiber layer in sequence, and the part of the filter box connected with the detection base 1 is filled with a sealing material.
Start second electric telescopic handle 94 in anti-pollution component 9, second electric telescopic handle 94 drives connecting plate 91 and ultraviolet ray disinfection lamp 92 and rises, when connecting plate 91 removes, can remain stable through gag lever post 93, after the ascending one end distance of ultraviolet ray disinfection lamp 92, can pass the inside of spout 8 entering protection casing 2, start ultraviolet ray disinfection lamp 92 afterwards and can disinfect, when ultraviolet ray disinfection lamp 92 is inside detecting base 1, can disinfect the inside that detects base 1, can start drive arrangement 14 simultaneously, drive arrangement 14 drives sheltering from the component 10 and rotates, baffle plate 102 in sheltering from the component 10 leaves from the downside of intercommunicating pore 72, and after the venthole 104 of intercommunication board 103 aligns with intercommunicating pore 72, can be with the inside intercommunication of detecting base 1 with protection casing 2, start air inlet equipment 12, air inlet equipment 12 filters outside air along connecting trachea 13 from the play gas in sheltering from component 10 after the filter box, along connecting trachea 13 The holes 104 are discharged, the ultraviolet disinfection lamp 92 can be started at the same time, when the air passes through the spiral pipe 132 in the connecting air pipe 13, the sterilization can be carried out under the action of the ultraviolet disinfection lamp 92, and the air outlet device 11 can discharge the air inside the device from another group of filter boxes when working.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The utility model provides a full-automatic nucleic acid extraction appearance of sample pollution probability reduction, is including detecting base (1), one side fixedly connected with instrument host (3) of detecting base (1), and the equal fixedly connected with protection casing (2) in the outside of detecting base (1) and instrument host (3), the last surface that detects base (1) evenly installs accessory fixed block (7), the preceding fixed surface of instrument host (3) is connected with control panel (4), instrument host (3) are located the inside one end fixedly connected with of protection casing (2) and draw component (5), its characterized in that: the top end inside the protective cover (2) is fixedly connected with a sealing component (6), the side surface of the upper surface of the detection base (1) close to the accessory fixing blocks (7) is uniformly provided with a sliding groove (8), a communication hole (72) is formed between the upper surface of the detection base (1) close to the two accessory fixing blocks (7), the middle part of the upper surface of the detection base (1) is fixedly connected with a driving device (14), the top end inside the detection base (1) is rotatably connected with a shielding component (10) connected with the output end of the driving device (14), the inside of the detection base (1) is fixedly connected with an anti-pollution component (9) penetrating through the sliding groove (8), one side inside the detection base (1) is fixedly connected with an air outlet device (11), and the other side inside the detection base (1) is fixedly connected with an air inlet device (12, and a connecting air pipe (13) is connected between the air outlet of the air inlet device (12) and the shielding component (10).
2. The apparatus according to claim 1, wherein the nucleic acid extractor comprises: accessory fixed block (7) are the component of an L type, and four of accessory fixed block (7) are a set of and become the rectangle and distribute, and is a set of the internal and corner position of concave part of accessory fixed block (7) is outwards, detect equal fixedly connected with sucking disc (71) in one side that base (1) upper surface is close to accessory fixed block (7) concave part.
3. The apparatus according to claim 1, wherein the nucleic acid extractor comprises: anti-pollution component (9) are including connecting plate (91), fixedly connected with second electric telescopic handle (94) between the middle part of connecting plate (91) lower surface and detection base (1), and connecting plate (91) lower surface both ends and detect equal fixedly connected with gag lever post (93) between base (1), gag lever post (93) have two sets of mutual sliding connection's column component to constitute, the last fixed surface of connecting plate (91) is connected with ultraviolet ray disinfection lamp (92) that run through spout (8).
4. The apparatus according to claim 1, wherein the nucleic acid extractor comprises: sealing member (6) include with detection base (1) fixed connection's first electric telescopic handle (61), the bottom fixedly connected with of first electric telescopic handle (61) adsorbs component (62), the outside cover that adsorbs component (62) bottom is equipped with sealed piece (63), and the bottom embedding that adsorbs component (62) is connected with the permanent magnet, sealed piece (63) include the body of silica gel material, and the upper surface embedding of silica gel body is connected with the carriage of metal material and adsorbs with adsorbing component (62) and is connected.
5. The apparatus according to claim 3, wherein the nucleic acid extractor comprises: connect trachea (13) including vertical pipe (131), air outlet fixed connection of anti-pollution component (9) and air inlet equipment (12) is run through to vertical pipe (131), the one end fixedly connected with spiral pipe (132) of vertical pipe (131), spiral pipe (132) pass from between ultraviolet ray disinfection lamp (92).
6. The apparatus according to claim 5, wherein the nucleic acid extractor comprises: the one end that vertical pipe (131) was kept away from in spiral pipe (132) rotates and is connected with communicating pipe (133), the air outlet and the component (10) intercommunication of sheltering from of communicating pipe (133), the bottom fixedly connected with bracing piece (134) of spiral pipe (132), the bottom of bracing piece (134) and the inner wall spiro union that detects base (1).
7. The apparatus according to claim 1, wherein the nucleic acid extractor comprises: the shielding component (10) comprises a rotary disc (101), a shielding plate (102) is fixedly connected to the side face of the rotary disc (101), a communicating plate (103) is fixedly arranged on one side, close to the shielding plate (102), of the side face of the rotary disc (101), air outlet holes (104) are formed in the upper surface of the communicating plate (103), the air outlet holes (104) are the same as the communicating holes (72) in number and are in one-to-one correspondence with the communicating holes in the vertical direction, and the air outlet holes (104), the communicating plate (103), the rotary disc (101) and the connecting air pipes (13) are communicated with one another.
8. The apparatus according to claim 1, wherein the nucleic acid extractor comprises: the air inlet of the air inlet device (12) and the air outlet of the air outlet device (11) are respectively in threaded connection with a filter box, the filter box is filled with a microporous ceramic filter plate, an activated carbon plate and a polyester fiber layer in sequence, and the part of the filter box connected with the detection base (1) is filled with a sealing material.
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| CN202010789509.4A CN111996101A (en) | 2020-08-07 | 2020-08-07 | Full-automatic nucleic acid extraction instrument with reduced sample pollution probability |
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| CN202010789509.4A CN111996101A (en) | 2020-08-07 | 2020-08-07 | Full-automatic nucleic acid extraction instrument with reduced sample pollution probability |
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