CN111973489A

CN111973489A - Sheep placenta extract freeze-dried powder and preparation method thereof

Info

Publication number: CN111973489A
Application number: CN202010913497.1A
Authority: CN
Inventors: 简经红
Original assignee: Hunan Benmei Bio Tech Co ltd
Current assignee: Hunan Benmei Bio Tech Co ltd
Priority date: 2020-09-03
Filing date: 2020-09-03
Publication date: 2020-11-24
Anticipated expiration: 2040-09-03
Also published as: CN111973489B

Abstract

The invention provides a sheep placenta extract freeze-dried powder and a preparation method thereof, belonging to the technical field of freeze-dried powder preparation. The freeze-dried powder comprises a phase A component and a phase B component, wherein the phase A component comprises: oat beta-glucan, cordyceps militaris extract and sodium hyaluronate; the phase B component comprises: the temperature and time of each step and the content and the proportion of various components, particularly the oligopeptide-1, the oligopeptide-3, the hydrolyzed placenta (sheep) extract and other components are strictly controlled in the preparation process, so that the wall-hanging phenomenon of the freeze-dried powder in the preparation process is reduced to be within 2 percent, the production loss of products is greatly reduced, the quality of the freeze-dried powder is improved, the factor bioactivity of the product is obviously improved on the basis of keeping moisture of the prepared freeze-dried powder, the sebaceous membrane can be effectively healthy, the cell regeneration is activated, and the skin tissue metabolism is normal.

Description

Sheep placenta extract freeze-dried powder and preparation method thereof

Technical Field

The invention belongs to the technical field of freeze-dried powder preparation, and particularly relates to sheep placenta freeze-dried powder and a preparation method thereof.

Background

The freeze-dried powder is solid sterile powder which is prepared by freezing liquid medicine under the vacuum condition through an ultralow temperature freezing process, has the function of beautifying and repairing, and is a skin care product which is gradually developed in recent years. The preparation of the freeze-dried powder is a process of quickly freezing a dried substance at a low temperature and then directly sublimating frozen water molecules into water vapor to escape in a proper vacuum environment. The product obtained by freeze-drying is called lyophilisate and the process is called lyophilisation. The substance is always in a low-temperature frozen state before being dried, and the ice crystals are uniformly distributed in the substance, so that the concentration phenomenon caused by dehydration can not occur in the sublimation process, and the side effects of foam, oxidation and the like generated by water vapor are avoided.

The preparation of the product into lyophilized powder mainly has the following advantages: (1) the biological activity is completely reserved; (2) the volatilization loss of the effective components is extremely low; (3) the retention trait is not changed; (4) the structure and the volume are unchanged; (5) the original state can be quickly recovered when meeting water; (6) the oxygen-free environment is not easy to oxidize and (7)99.9 percent of dehydration is not deteriorated for a long time. Due to the advantages, freeze-dried powder and the like are widely accepted by people and are greatly developed.

However, the existing freeze-dried powder still has various problems, for example, although most of the freeze-dried powder has a moisturizing effect, the problem of sensitive skin cannot be improved, the immunity resistance of the skin is difficult to increase, a sebum membrane is thickened, and the metabolism of skin tissues is normal, and meanwhile, most of the freeze-dried powder preparation processes are complex, and the quality of products obtained by a simpler method can be influenced to a certain extent.

For example, Chinese patent application 201910658495.X discloses a formula for preparing oligopeptide-1-containing freeze-dried powder, which comprises the following components in percentage by weight: water: 80-92 percent; oligopeptide-1: 3 to 10 percent; mannitol: 5 to 10 percent. The invention also discloses a method for preparing the oligopeptide-1-containing freeze-dried powder, which comprises the following steps: the method comprises the following steps: mixing water and mannitol, heating to 75-80 ℃, stirring and mixing uniformly, and cooling to obtain a mixed material body; cooling the mixed material body to 40-45 ℃, adding oligopeptide-1, stirring and mixing uniformly, and continuously cooling; and after the temperature of the material is reduced to 30-35 ℃, filling the material body into a glass bottle, and taking the material out of the pot after freezing and sublimation. The oligopeptide-1-containing freeze-dried powder disclosed by the invention is simple in formula structure, reasonable in proportion, good in forming effect and remarkable in repairing effect. However, the freeze-dried powder prepared by the application has a low improvement effect on sensitive muscles, and the problem of wall hanging of the product is not concerned in the application.

Sensitive skin is a problem skin, and there may be sensitive skin in any skin type. As is well known, the pathological change of sensitive skin is the thinning of the horny layer and the red reticular shape of the face after the blood stasis after the subcutaneous capillary vessel dilation, and the Chinese patent application 201810260596.7 discloses a repair freeze-dried powder compounded by a plurality of polypeptides, which is composed of the following raw materials in percentage by mass: mannitol 4.5-5.5%, disodium hydrogen phosphate 0.01-0.03%, oligopeptide-10.8-1.2%, oligopeptide-20.3-0.7%, oligopeptide-31.5-2.5%, oligopeptide-42.5-3.5%, oligopeptide-52.5-3.5%, glutathione 1.5-2.5%, acetyl hexapeptide-80.03-0.07%, tripeptide-1 copper 0.03-0.07%, acetyl tetrapeptide-50.08-0.12%, and water in balance. Dissolving mannitol, oligopeptide-1, oligopeptide-2, oligopeptide-3, oligopeptide-4, oligopeptide-5, glutathione, acetyl hexapeptide-8, tripeptide-1 copper and acetyl tetrapeptide-5 in water, sterilizing, adding disodium hydrogen phosphate, filtering, standing, bottling, freeze drying, and packaging. The skin repairing and growing promoting agent can promote skin repairing and growing, repair sensitive damaged skin, red blood, red swelling after sun exposure, skin damage after micro-finishing and the like, achieve the effects of resisting aging, tendering skin and whitening, safely and effectively improve a plurality of skin problems such as pockmarks, acne marks, weak and damaged cuticle and the like.

Aiming at the problems of incomplete or weaker functions and shorter quality guarantee time of products such as freeze-dried powder and the like in the prior art, the development of the freeze-dried powder which can preserve moisture, enhance the immunity and physical resistance of skin, thicken a sebum membrane and ensure normal metabolism of skin tissues is urgently needed, and the quality of the products can be ensured while the preparation process is optimized.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide the sheep placenta extract freeze-dried powder and the preparation method thereof, the oligopeptide-1, the oligopeptide-3, the hydrolyzed placenta (sheep) extract and other components are added into the freeze-dried powder, and the components are interacted by controlling the content and the proportion of the components, so that the immunity and the resistance of the skin can be enhanced, the sebaceous membrane can be thickened, and the metabolism of skin tissues can be normal on the basis of original moisture preservation of the freeze-dried powder.

The purpose of the invention is realized by the following technical scheme:

a lyophilized powder of ovine placenta extract comprises phase A component and phase B component;

the phase A component comprises the following components in parts by weight: 8-15 parts of oat beta-glucan, 5-10 parts of CORDYCEPS MILITARIS (CORDYCEPS MILITARIS) extract and 3-8 parts of sodium hyaluronate;

the phase B component comprises the following components in parts by weight: 13-10 parts of oligopeptide-33-10 parts of oligopeptide, 8-15 parts of hydrolyzed placenta (sheep) extract and 3-8 parts of serum albumin.

Preferably, the phase A component comprises the following components in parts by weight: 9-12 parts of oat beta-glucan, 6-9 parts of CORDYCEPS MILITARIS (CORDYCEPS MILITARIS) extract and 4-7 parts of sodium hyaluronate;

the phase B component comprises the following components in parts by weight: 15-8 parts of oligopeptide-35-8 parts of oligopeptide, 9-12 parts of hydrolyzed placenta (sheep) extract and 4-6 parts of serum albumin.

Further preferably, the phase A component comprises the following components in parts by weight: 10 parts of oat beta-glucan, 8 parts of CORDYCEPS MILITARIS (CORDYCEPS MILITARIS) extract and 5 parts of sodium hyaluronate;

the phase B component comprises the following components in parts by weight: oligopeptide-16 parts, oligopeptide-36 parts, hydrolyzed placenta (sheep) extract 10 parts and serum albumin 5 parts.

Wherein the phase B component also contains 1-3 parts of snail mucus extract; preferably 2 parts.

In the implementation process, the invention unexpectedly discovers that the ratio of the parts by weight of the serum albumin to the parts by weight of the snail mucus extract is controlled to be 1-8: 1, the biological activity of the factors of the obtained product can be obviously improved, the skin lipid membrane can be effectively healthily kept, the cell regeneration is activated, and the appearance of the produced freeze-dried powder is better.

In some preferred embodiments, the ratio of the parts by weight of the serum albumin to the snail mucus extract is 2-7: 1;

preferably, the ratio of the serum albumin to the snail mucus extract in parts by weight is 2-5: 1;

preferably, the ratio of the serum albumin to the snail mucus extract in parts by weight is 2.5: 1. in the implementation process, the invention unexpectedly discovers that the weight ratio of oligopeptide-1 to oligopeptide-3 to the hydrolyzed placenta (sheep) extract is controlled to be 1: 1: when the freeze-dried powder prepared at 0.8-5 hours is compounded with an active agent, the activity of the biological protein can be effectively activated, and the quality of the freeze-dried powder is improved.

In some preferred embodiments, the weight ratio of oligopeptide-1, oligopeptide-3 and hydrolyzed placenta (ovine) extract is 1: 1: 1-5;

more preferably, the weight part ratio of the oligopeptide-1, the oligopeptide-3 and the hydrolyzed placenta (sheep) extract is 1: 1: 1-3;

further preferably, the weight ratio of oligopeptide-1, oligopeptide-3 and hydrolyzed placenta (sheep) extract is 3: 3: 5.

the invention also provides a preparation process of the sheep placenta extract freeze-dried powder, which comprises the following steps:

(1) uniformly mixing the phase A components according to the formula dosage, and then carrying out high-pressure sterilization to obtain a mixture A for later use;

(2) filtering the mixture A obtained in the step (1), adding the mixture A into the phase B component with the formula dosage, and uniformly mixing to obtain a mixture B;

(3) and (3) filling the mixture B obtained in the step (2) into a freeze dryer, and carrying out pre-freezing, sublimation drying and re-drying to obtain the freeze-dried powder.

Further, the autoclaving in the step (1) is performed at 121 ℃ for 30 minutes under a pressure of 0.12 MPa.

Further, the pore size of the filtration in the step (2) is 0.22m²/g。

Further, the pre-freezing temperature in the step (3) is-10 ℃ and the time is 120 minutes.

Further, the sublimation drying temperature in the step (3) is 20 ℃ and the time is 120 minutes.

Further, the re-drying in the step (3) is carried out at 35 ℃ for 300 minutes.

A preparation process of the sheep placenta extract freeze-dried powder specifically comprises the following steps:

(1) uniformly mixing the phase A components according to the formula dosage, and sterilizing for 30 minutes at the temperature of 121 ℃ and under the pressure of 0.12MPa to obtain a mixture A for later use;

(2) subjecting the mixture A obtained in step (1) to 0.22m²Filtering with a filter membrane with a pore diameter of/g, adding the filtered solution into the phase B component with the formula dosage, and uniformly mixing to obtain a mixture B;

(3) and (3) filling the mixture B obtained in the step (2) into a freeze dryer, pre-freezing for 120 minutes at-10 ℃, sublimation-drying for 120 minutes at 20 ℃, and re-drying for 300 minutes at 35 ℃ to obtain the freeze-dried powder.

According to the invention, the temperature and time of each step and the content and the proportion of various components, especially oligopeptide-1, oligopeptide-3, hydrolyzed placenta (sheep) extract and the like are strictly controlled in the preparation process, so that the wall-hanging phenomenon of the freeze-dried powder in the preparation process is reduced to be within 2%, the production loss of products is greatly reduced, and the quality of the freeze-dried powder is improved.

In the present invention:

oligopeptide-1 is a synthetic peptide consisting of 3 amino acids of glycine, histidine and lysine, and can promote epidermal regeneration, stimulate the synthesis of extracellular matrix (ECM), type I collagen, type III collagen and glycosaminoglycan, repair skin barrier, improve red blood streak, resist aging, tender skin, brighten skin color, and inhibit the secretion of fibrotic growth factors;

oligopeptide-3 (Oligopeptide-3) is tridecapeptide composed of alanine, leucine, lysine and phenylalanine, has strong proliferation and mitosis promoting effects on 3T3 cells, and can be widely applied to cell repair;

the hydrolyzed placenta (sheep) extract is a biological raw material obtained by taking SPF sheep placenta, umbilical cord and amnion as basic culture substances and carrying out biological enzymolysis and high-degree purification, and comprises a precursor composition of growth differentiation factor 11(GDF-11) and high-concentration collagen, and extremely small molecules can be directly absorbed by surface skin to reach the dermis layer, so that the hydrolyzed placenta (sheep) extract has a very good cell growth effect, and promotes the elasticity and moisture retention of the skin;

the serum albumin has excellent anti-aging effect, can smooth fine wrinkles, improve the skin elasticity and improve the skin texture, has a unique linear chain molecular structure, has good transdermal absorption performance, promotes fibroblasts to synthesize collagen, promotes wound healing, repairs damaged skin, and gives the skin a silky moist and smooth touch feeling;

cordyceps MILITARIS (Cordyceps MILITARIS) extract has anti-inflammatory, antioxidant, anti-rash, water rash and other allergic reactions, and helps skin regeneration, and has the function of coordinating immune system, so that it can assist allergy treatment process, comprehensively improve immune system, and has the function of anti-allergy repairing problem skin;

the sodium hyaluronate is a high-molecular polymer high-grade polysaccharide consisting of D-glucuronic acid and N-acetylglucosamine, is one of main matrix components of the skin surface layer and the dermis of human, can prevent the generation of some enzymes in cells, reduces the formation of free radicals, plays an important role in preventing the free radicals from damaging cell structures, producing lipid peroxidation, causing the aging of the body and the like, has the physiological function of enabling water to enter intercellular spaces and combining with protein to form protein gel, protects cells from being invaded by pathogenic bacteria, accelerates the recovery of skin tissues, improves the healing and regeneration capacity of wounds, reduces scars, enhances the immunity and the like, and plays the roles of resisting wrinkles and wrinkles, delaying the aging of the whole skin of a human, beautifying and beautifying the face.

Compared with the prior art, the invention has the beneficial effects that:

1. in the implementation process, the ratio of the parts by weight of the serum albumin to the parts by weight of the snail mucus extract is controlled to be 1-8: 1, the freeze-dried powder prepared by the method obviously improves the factor bioactivity of the product on the basis of keeping moisture, can effectively healthily coat a sebaceous membrane, activates cell regeneration, enables skin tissues to be normally metabolized, and enables the appearance of the produced freeze-dried powder to be better;

2. according to the invention, the preparation process is optimized, the temperature and time in the preparation process and the content and proportion of each component are strictly controlled, especially the content of oligopeptide-1, oligopeptide-3, hydrolyzed placenta (sheep) extract and other components is controlled to reduce the wall hanging phenomenon of freeze-dried powder in the preparation process to be within 1.5%, so that the production loss of the product is greatly reduced, and the quality is improved;

3. the invention discloses a freeze-dried powder which focuses on repairing human skin problems, protecting healthy skin lipid membranes and activating cell regeneration, and is prepared by controlling the ratio of serum albumin to snail mucus extract in parts by weight to be 1-8: 1, the biological activity of the factor can be effectively improved, and the biological activity of the factor is improved by 10 percent;

4. in the implementation process, the invention unexpectedly discovers that the weight ratio of oligopeptide-1 to oligopeptide-3 to the hydrolyzed placenta (sheep) extract is controlled to be 1: 1: the freeze-dried powder prepared at 0.8-5 hours can effectively activate the activity of the biological protein when being compounded with an active agent.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The raw materials used in the following examples are all common commercial products, and therefore the sources thereof are not particularly limited, and sodium hyaluronate is food grade.

Example 1 lyophilized powder of ovine placenta extract

The freeze-dried powder comprises a phase A component and a phase B component;

the phase A component comprises the following components in parts by weight: 8 parts of oat beta-glucan, 5 parts of CORDYCEPS MILITARIS (CORDYCEPS MILITARIS) extract and 3 parts of sodium hyaluronate;

the phase B component comprises the following components in parts by weight: oligopeptide-13 parts, oligopeptide-33 parts, hydrolyzed placenta (sheep) extract 8 parts and serum albumin 3 parts.

The preparation method comprises the following steps: the method specifically comprises the following steps:

Embodiment 2A lyophilized powder of ovine placenta extract

The freeze-dried powder comprises a phase A component and a phase B component;

the phase A component comprises the following components in parts by weight: 12 parts of oat beta-glucan, 9 parts of CORDYCEPS MILITARIS (CORDYCEPS MILITARIS) extract and 7 parts of sodium hyaluronate;

the phase B component comprises the following components in parts by weight: oligopeptide-18 parts, oligopeptide-38 parts, hydrolyzed placenta (sheep) extract 12 parts and serum albumin 6 parts.

Embodiment 3A lyophilized powder of ovine placenta extract

The freeze-dried powder comprises a phase A component and a phase B component;

the phase A component comprises the following components in parts by weight: 10 parts of oat beta-glucan, 8 parts of CORDYCEPS MILITARIS (CORDYCEPS MILITARIS) extract and 5 parts of sodium hyaluronate;

Example 4A lyophilized powder of ovine placenta extract

The freeze-dried powder comprises a phase A component and a phase B component;

the phase A component comprises the following components in parts by weight: 15 parts of oat beta-glucan, 10 parts of CORDYCEPS MILITARIS (CORDYCEPS MILITARIS) extract and 8 parts of sodium hyaluronate;

the phase B component comprises the following components in parts by weight: oligopeptide-110 parts, oligopeptide-310 parts, hydrolyzed placenta (sheep) extract 15 parts, serum albumin 8 parts and snail mucus extract 3 parts.

(2) subjecting the mixture A obtained in step (1) to 0.22m²Filtering with filter membrane with pore diameter of g, adding B phase group with formula dosageUniformly mixing in the middle to obtain a mixture B;

Embodiment 5A lyophilized powder of ovine placenta extract

The freeze-dried powder comprises a phase A component and a phase B component;

the phase B component comprises the following components in parts by weight: oligopeptide-16 parts, oligopeptide-36 parts, hydrolyzed placenta (sheep) extract 10 parts, serum albumin 5 parts and snail mucus extract 2 parts.

Comparative example 1

The difference from example 3 is that: the weight ratio of oligopeptide-1, oligopeptide-3 and hydrolyzed placenta (sheep) extract is 1: 1: 0.5 parts of oligopeptide-18.8 parts, 38.8 parts of oligopeptide-38.4 parts of hydrolyzed placenta (sheep) extract, and the other operations are the same as in example 3.

Comparative example 2

The difference from example 3 is that: the weight ratio of oligopeptide-1, oligopeptide-3 and hydrolyzed placenta (sheep) extract is 1: 1: 8, namely oligopeptide-12.2 parts, oligopeptide-32.2 parts, hydrolyzed placenta (sheep) extract 17.6 parts, and the other operations are the same as the procedure in example 3.

Comparative example 3

The difference from example 5 is that: the ratio of the serum albumin to the snail mucus extract in parts by weight is 0.4: 1, 2 parts of serum albumin and 5 parts of snail mucus extract, and the other operations and steps are the same as those of example 5.

Comparative example 4

The difference from example 5 is that: the ratio of the serum albumin to the snail mucus extract in parts by weight is 9: 1, namely 6.3 parts of serum albumin and 0.7 part of snail mucus extract, and the other operations and steps are the same as those in example 5.

Comparative example 5

The difference from example 5 is that: the preparation method is the same as that disclosed in Chinese patent application 201810260596.7, namely the preparation method comprises the following steps:

1) dissolving oat beta-glucan, Cordyceps MILITARIS (Cordyceps MILITARIS) extract, sodium hyaluronate, oligopeptide-1, oligopeptide-3, hydrolyzed placenta (sheep) extract, serum albumin and snail mucus extract in water, placing in an autoclave, and sterilizing at constant temperature of 0.12MPa and 121 deg.C for 20min to obtain mixed solution A;

2) shaking the mixed solution A obtained in the step 1) uniformly, and filtering by using a filter membrane with the aperture of 0.1 mu m to obtain a mixed solution B;

3) standing the mixed solution B for 18h, filling, pre-freezing the filled liquid at-10 ℃, then sublimation-drying at 20 ℃ for 300 min, and packaging to obtain the product.

Effect test

1. Detection of wall hanging condition of obtained product

The detection method comprises the following steps: taking the freeze-dried powders in the examples 1-5 and the comparative examples 1-5 as samples, respectively taking 30mg of the freeze-dried powders and respectively filling the 30mg of the freeze-dried powders into 50mL beakers with scales; and simultaneously and respectively pouring the beakers filled with different samples into other beakers with the same scales, buckling and standing for 5min, and calculating the percentage of the product which is not poured out to the total amount of the product to be used as the wall hanging rate.

TABLE 1

Examples of the invention	Percentage of wall built-up%
		Example 1	1.2
Example 2	1.0
		Example 3	1.0
Example 4	1.1
		Example 5	0.6
Comparative example 1	1.8
		Comparative example 2	2.0
Comparative example 3	1.4
		Comparative example 4	1.3
Comparative example 5	2.4

As can be seen from table 1, the wall-hanging rate of the products prepared in examples 1 to 5 is low and can be as low as 2%, which indicates that the lyophilized powder of ovine placenta extract prepared in the present application has a low wall-hanging rate, greatly reduces the production loss of the products, and improves the quality, wherein the wall-hanging rate of example 5 is the lowest and is only 0.6%, and the wall-hanging rate of comparative examples 1 to 5 is higher than that of example 5, which indicates that the composition ratio and the preparation conditions of the lyophilized powder can affect the wall-hanging rate of the lyophilized powder.

2. Sensory evaluation test

Random search for men and women 20 persons sensory scores (color, shape and odor) were performed on the lyophilized powders of examples 1-5 and comparative examples 1-5, and 10 points were filled, to obtain table 2:

TABLE 2

Note: the data in the table are averaged.

As can be seen from the evaluation scores in Table 2, the lyophilized powders prepared in examples 1-5 of the present invention have high color, shape and odor scores, wherein the data of each group in example 5 is optimal, and the scores in comparative examples 1-5 are inferior to those in example 5. The method shows that the proportions of all components in the freeze-dried powder, the preparation conditions and the like have certain influence on the color, the shape and the smell of the freeze-dried powder.

3. Test of moisturizing effect of freeze-dried powder

Volunteer female volunteers were randomly selected 30 persons, of which 23-30 years old 15 persons and 30-40 years old 15 persons. The subject did not apply additional skin care to the test site within approximately 2 months. The test temperature is 35 ℃ and the humidity is 40-50%. The test zones are spaced 1cm apart, and each test zone is 3cmx3cm at 2mg/cm²Weighing the freeze-dried powder, pushing the freeze-dried powder into the lysozyme by using a latex glove, slightly shaking, uniformly smearing the freeze-dried powder in a test area, and waiting for 15 minutes for measurement. The water content of the stratum corneum of the skin was measured by capacitance method and the test results are shown in table 3 below.

TABLE 3

Note: the data in the table are averaged.

According to the detection data in the above table 3, it can be seen that the freeze-dried powders prepared in the embodiments 1 to 5 of the present invention have good moisturizing and water supplementing effects, the skin cuticle has a high water content after 30 days of using the freeze-dried powder, and the freeze-dried powder prepared in the embodiment 5 has the best water supplementing effect. Comparative examples 1-5 all scored less than example 5. The water replenishing and moisturizing effect of the freeze-dried powder is influenced to a certain extent by the proportion of each component in the freeze-dried powder, the preparation conditions and the like.

Finally, it is noted that the above-mentioned preferred embodiments illustrate rather than limit the invention, and that, although the invention has been described in detail with reference to the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the scope of the invention as defined by the appended claims.

Claims

1. The lyophilized powder of sheep placenta extract comprises a phase A component and a phase B component, and is characterized in that:

the phase A component comprises the following components in parts by weight: 8-15 parts of oat beta-glucan, 5-10 parts of cordyceps militaris extract and 3-8 parts of sodium hyaluronate;

the phase B component comprises the following components in parts by weight: 13-10 parts of oligopeptide-33-10 parts of oligopeptide, 8-15 parts of hydrolyzed sheep placenta extract and 3-8 parts of serum albumin.

2. The lyophilized powder of ovine placenta extract of claim 1, which is characterized in that: the phase A component comprises the following components in parts by weight: 9-12 parts of oat beta-glucan, 6-9 parts of cordyceps militaris extract and 4-7 parts of sodium hyaluronate;

the phase B component comprises the following components in parts by weight: 15-8 parts of oligopeptide-35-8 parts of oligopeptide, 9-12 parts of hydrolyzed sheep placenta extract and 4-6 parts of serum albumin.

3. The lyophilized powder of ovine placenta extract as claimed in claim 2, wherein: the phase A component comprises the following components in parts by weight: 10 parts of oat beta-glucan, 8 parts of cordyceps militaris extract and 5 parts of sodium hyaluronate;

the phase B component comprises the following components in parts by weight: oligopeptide-16 parts, oligopeptide-36 parts, hydrolyzed sheep placenta extract 10 parts and serum albumin 5 parts.

4. The lyophilized powder of ovine placenta extract of claim 1, which is characterized in that: the phase B component also contains 1-3 parts of snail mucus extract.

5. The lyophilized powder of ovine placenta extract as claimed in claim 4, wherein: the ratio of the serum albumin to the snail mucus extract in parts by weight is 1-8: 1.

6. lyophilized powder of ovine placenta extract according to claim 5, characterized in that: the ratio of the serum albumin to the snail mucus extract in parts by weight is 2.5: 1.

7. the lyophilized powder of ovine placenta extract of claim 1, which is characterized in that: the weight ratio of oligopeptide-1, oligopeptide-3 and hydrolyzed sheep placenta extract is 1: 1: 0.8-5.

8. The lyophilized powder of ovine placenta extract of claim 1, which is characterized in that: the weight ratio of oligopeptide-1, oligopeptide-3 and hydrolyzed sheep placenta extract is 3: 3: 5.

9. a preparation process of the lyophilized powder of ovine placenta extract as claimed in any one of claims 1 to 8, which is characterized in that: the method comprises the following steps:

10. The method of claim 9, wherein: the sterilization temperature of the high-pressure sterilization in the step (1) is 121 ℃, the sterilization time is 30 minutes, and the sterilization pressure is 0.12 MPa;

the aperture of the filtration in the step (2) is 0.22m²/g；

In the step (3), the pre-freezing temperature is-10 ℃ and the time is 120 minutes; the sublimation drying temperature is 20 ℃, and the time is 120 minutes; and drying again at 35 ℃ for 300 minutes.