CN111973485A - Wrinkle-removing composition gel for eyes and preparation method thereof - Google Patents
Wrinkle-removing composition gel for eyes and preparation method thereof Download PDFInfo
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- CN111973485A CN111973485A CN201910432604.6A CN201910432604A CN111973485A CN 111973485 A CN111973485 A CN 111973485A CN 201910432604 A CN201910432604 A CN 201910432604A CN 111973485 A CN111973485 A CN 111973485A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention relates to a wrinkle-removing composition gel for eyes and a preparation method thereof, which is characterized in that: the wrinkle-removing cream comprises wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked polymer, glycerol and deionized water in a mass ratio of 4-10:0.5-2:10-20:20-30:20-30, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose in a mass ratio of 1:1-3:0.6:2: 0.2-0.8. The wrinkle removing cream can simultaneously load five wrinkle removing components with different properties, namely acetyl hydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose, and has the beneficial effects of good wrinkle removing effect on eyes, good stability and good transdermal absorbability.
Description
Technical Field
The invention relates to the technical field of cosmetic preparation, in particular to a wrinkle-removing composition gel for eyes and a preparation method thereof.
Background
Wrinkles are the most obvious judgment basis for skin aging, and are generally used for judging the degree of skin aging at the positions of the eye periphery, the mouth angle, the neck and the like, because eye wrinkles appear relatively early due to the particularity of the eye structure. The eye wrinkles located at the outer canthus, also called as the crow's feet, are radially arranged and usually appear only when facial expressions such as smile are made, and belong to temporary wrinkles, however, with the increase of age, collagen in the skin is lost, elastic fibers lose vitality, the amount of grease secreted by sebaceous glands is reduced, the skin barrier function is reduced and gradually becomes loose, so that the eye wrinkles are increased and form permanent wrinkles. Generally, the wrinkle removing effect of the active substance is positively correlated with the irritation, and the existing wrinkle removing active substances have a plurality of problems of poor compatibility and poor wrinkle removing effect of a single active substance.
Eye skin is thin and sensitive, prickling and swelling can be caused by improper nursing, fat granules are generated, and even wrinkles can be accelerated. Compared with emulsion, cream and other dosage forms, the gel has low oil content, has the capability of partial residence, and is widely applied to eye products. The gel is usually made of macromolecular materials such as polymers and the like, can load active ingredients, and can realize the long-acting slow-release function by adding proper auxiliary ingredients, thereby meeting the requirements of eye wrinkle removal products on mildness and effectiveness. The existing eye gel usually uses hydroxypropyl methyl cellulose, carbomer and the like as carriers, but the hydrogel has weak sustained-release capability, cannot load a plurality of active ingredients with large property differences at the same time, and has limited contribution to reducing irritation.
Disclosure of Invention
The invention aims to solve the technical problem of providing wrinkle-removing composition gel for eyes, which can simultaneously load five wrinkle-removing active substances of acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose, and a preparation method thereof.
In order to solve the technical problems, the invention adopts the following technical scheme: a wrinkle-removing composition gel for the eye characterized by: the wrinkle-removing cream comprises wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked polymer, glycerol and deionized water in a mass ratio of 4-10:0.5-2:10-20:20-30:20-30, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose in a mass ratio of 1:1-3:0.6:2: 0.2-0.8.
The invention also provides a preparation method of the wrinkle-removing composition gel for eyes, which is characterized by comprising the following steps: the method comprises the following steps:
step 1: weighing wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked copolymer, glycerol and deionized water according to the mass ratio of 4-10:0.5-2:10-20:20-30:20-30, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose according to the mass ratio of 1:1-3:0.6:2: 0.2-0.8;
step 2: mixing 1/3 of the glycerol weighed in the step (1) with the acetylhydroxyproline, the tocopherol glucoside and the nicotinamide ribose weighed in the step (1), and uniformly stirring to obtain a mixed solution A;
And step 3: mixing the rest 2/3 mass of glycerol and 1/2 mass of deionized water weighed in the step 1 with the PEG-12 polymethylsiloxane/PPG-20 crosslinked copolymer, and uniformly stirring to obtain a mixed solution B;
and 4, step 4: mixing the carnosine, the thiotaurine and the hydroxypropyl gamma-cyclodextrin weighed in the step 1 with the rest deionized water, and uniformly stirring to obtain a mixed solution C;
and 5: and adding the mixed solution A into the mixed solution B, uniformly stirring at the rotating speed of 300-500rpm, then adding the mixed solution C, and continuously stirring for 10-30min to obtain the wrinkle-removing composition gel for eyes.
The gel strength of the gel obtained by the invention is 250-350 g/cm2Can be applied directly to the skin or added into eye lotion cream.
The ACETYL HYDROXYPROLINE (ACETYL HYDROXYPROLINE) has the serial number of 07795 in the catalogue of names of used cosmetic raw materials (2015 edition) in China, is an acetylated modified water-soluble amino acid derivative, has acidic aqueous solution, can help to supplement HYDROXYPROLINE in collagen, improves the activity of collagen, and has a barrier protection effect;
the CARNOSINE (CARNOSINE) has the serial number of 03150 in catalog of names of used cosmetic raw materials (2015 edition) in China, is a water-soluble dipeptide, is alkaline in water solution, can strengthen the Haverenke limit of fibroblasts, namely prolong the service life of the fibroblasts, increase the elasticity of skin, and can also remove active oxygen free Radicals (ROS) and alpha-beta unsaturated aldehyde formed in the oxidative stress process of cell membranes, thereby having strong oxidation resistance;
The tocopherol GLUCOSIDE (tocophenyl GLUCOSIDE) has the serial number of 06039 in the catalogue of names of used cosmetic raw materials (2015 edition) in China, can be dissolved in water, can effectively resist oxidation, activate and strengthen natural barriers of skin, and reduces the stimulation of environmental factors to the skin;
THIOTAURINE (THIOTAURINE), numbered 04376 in catalog of names of used cosmetic raw materials (2015 edition) in China, can prevent lipid peroxidation on skin surface.
The NICOTINAMIDE RIBOSIDE (NICOTINAMIDE RIBOSIDE) has the CAS number of 1341-23-7, is a water-soluble vitamin precursor, namely NICOTINAMIDE adenine dinucleotide (NAD +), can increase the content of NAD + in a human body, and the NAD + is an indispensable substance for activating acetylase and can be reduced along with the age, so the NICOTINAMIDE RIBOSIDE has the functions of preventing the aging of stem cells, maintaining the functions of the stem cells and regenerating muscles.
The PEG-12 polymethylsiloxane/PP G-20 crosslinked copolymer of the invention, numbered 00510 in catalog of names of used cosmetic raw materials (2015 edition) in China, is a polyether modified high molecular silicone elastomer, has high affinity with water and glycerol, and can form gel.
The HYDROXYPROPYL gamma-CYCLODEXTRIN (HYDROXYPROPYL gamma-CYCLODEXTRIN) disclosed by the invention has the CAS number of 128446-34-4, is one of gamma-CYCLODEXTRIN derivatives, has a special structure with internal hydrophobicity and external hydrophilicity, has a large internal cavity and high solubility compared with other configurations, and can improve the solubility and stability of active ingredients by forming an inclusion compound or emulsification stabilization.
The wrinkle-removing composition provided by the invention can effectively remove eye wrinkles from four aspects of improving collagen activity, prolonging the service life of elastic fibers, enhancing cell activity and strengthening skin barriers, and simultaneously fills up wrinkles in real time through the organic silicon elastomer, thereby realizing the effect of removing wrinkles in real time and for a long time.
The PEG-12 polymethylsiloxane/PP G-20 crosslinked copolymer adopted by the invention not only can fill up the skin texture, but also can form gel with a special net structure, can be used as a carrier to load active ingredients, and simultaneously plays a role in removing wrinkles instantly and for a long time. Although all the wrinkle-removing active substances provided by the invention are water-soluble, the physical and chemical properties such as the solubility, the pH value and the like in water are greatly different, and the wrinkle-removing active substances cannot stably coexist in an aqueous solution. The technical problem that various active ingredients with large property difference can not be loaded simultaneously by adopting hydroxypropyl methyl cellulose and carbomer in the prior art is solved.
To demonstrate the advantageous effects of the present invention, the following experiment was further performed.
1. Stability test:
the wrinkle-removing composition gel for eyes prepared in example 2 was selected as sample a (in which the content of active ingredients and mass% is acetohydroxyproline 1.5%, carnosine 1.8%, tocopherol glucoside 0.9%, thiotaurine 3%, nicotinamide ribose 0.3%); the gel prepared by the same method and using deionized water to replace hydroxypropyl gamma-cyclodextrin in the sample A is used as a sample B, the samples are respectively placed at 25 ℃ under the illumination condition for stability experiment, the properties of the samples are observed in 0, 1, 2 and 4 weeks, and acetyl hydroxyproline and carnosine are used as markers for measuring the content of active ingredients, and the results are shown in table 1.
Table 1: stability test results
As can be seen from table 1, the wrinkle-removing composition gel for eyes prepared by the invention has small changes in gel strength and active ingredient content through 4-week stability examination, while the gel strength of the sample B has a downward sliding trend, the change in active ingredient content is also obvious, and the sample B has a phenomenon of delamination when being placed at 40 ℃ for 4 weeks, which indicates that the addition of hydroxypropyl γ -cyclodextrin not only can further improve the stability of the active ingredient, but also can improve the stability of the gel system.
2. Permeability test:
the wrinkle-removing composition gel for eyes prepared in example 2 was selected as sample a (in which the content of active ingredients and mass% is acetohydroxyproline 1.5%, carnosine 1.8%, tocopherol glucoside 0.9%, thiotaurine 3%, nicotinamide ribose 0.3%); the gel prepared by the same method is used as a sample B, deionized water is used for replacing hydroxypropyl gamma-cyclodextrin in the sample A, the eye wrinkle removing composition with the same concentration as that in the sample A is directly dispersed in a glycerin/water (50: 50) solution to be used as a sample C, a suitable receiving medium is selected, a modified Franz pool method is adopted, simulated skin is used as a transdermal barrier, the samples are respectively and uniformly added into a supply pool in equal quantity, 6 parts are paralleled, sampling is carried out at a preset time point, carnosine is used as a marker, and the analysis content is determined, wherein the result is shown in Table 2.
Table 2: permeability test results
As can be seen from table 2, the release of sample a is relatively stable, the active ingredient of sample B has burst release phenomenon in the early stage, and reaches higher concentration in the initial stage, which may cause skin irritation, while the slow release of the active ingredient in the later stage cannot continuously play a role, and sample C has poor permeability and cannot be effectively absorbed through skin. In conclusion, the wrinkle-removing composition gel for eyes prepared by the present invention has the characteristics of improving the permeability of the active ingredient and slowly releasing the active ingredient, thereby reducing irritation and exerting the effect for a long time.
3. Human efficacy test for removing eye wrinkles:
in order to further prove the synergistic anti-aging effect of the anti-aging composition selected by the invention, a human body effect test is carried out, and the specific steps are as follows: 72 female volunteers aged 35-50 years were selected and divided into six groups of 12 individuals each. In the testing period, the volunteers used the eye creams added with the wrinkle-removing composition gel for eyes twice in the morning and at night, the addition amount of the wrinkle-removing composition gel for eyes in the eye creams used in each group is 5%, the compositions such as emulsifier, grease and the like and the preparation method are the same, wherein the wrinkle-removing composition gel for eyes added to the eye cream used in group 1 is the sample prepared in example 2, and the compositions and the proportions of the active ingredients of the wrinkle-removing composition gel for eyes in the eye creams used in each group are shown in table 3 (the percentages in table 3 are mass percent).
Table 3 content of active ingredients in eye cream for each group (mass percentage)
The eye tails of the volunteers are selected as test parts, and are followed up once before use, after use for 30min and after use for 2 and 4 weeks, the total number of the visits is 4, wherein the visit for 30min requires the volunteers to directly test, the visit for 2 and 4 weeks requires the volunteers to clean faces and then test, and the average depth of total wrinkles and the ratio of the area of the wrinkles are measured by the same person by adopting a PROMIS PICO wrinkle measuring instrument of Germany LMI Technologies company. The results are shown in Table 4.
Table 4: human body efficacy test results for removing eye wrinkles
As is clear from table 4, the wrinkle index change rates at 30min were not greatly different among the groups, and all of the groups had a good immediate effect of removing wrinkles in the eyes because the immediate effect of removing wrinkles in the eyes was derived from filling of wrinkles with the elastomer, and the types and proportions of the elastomers used in the groups were the same, and thus the differences were not large. In the follow-up visits of group 1 for 2 and 4 weeks, the change rates of the average depth of the total wrinkles are respectively 10.7% and 20.6%, the change rates of the wrinkle area ratio are respectively 18.4% and 25.0%, compared with other groups, the group 1 has a more obvious effect of removing the eye wrinkles, and the long-term effect of removing the eye wrinkles by the eye cream is mainly determined by active ingredients, so that the composition for removing the eye wrinkles provided by the invention has a better effect of removing the eye wrinkles by combining specific ingredients and a proportion.
In conclusion, the wrinkle removing cream can simultaneously load five wrinkle removing components with different properties, namely acetyl hydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose, and has the beneficial effects of good wrinkle removing effect on eyes, good stability and good transdermal absorbability.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below.
Example 1: a method for preparing wrinkle-removing composition gel for eyes comprises:
step 1: weighing wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked copolymer, glycerol and deionized water according to the mass ratio of 5:0.5:15:25:30, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose according to the mass ratio of 1:1:0.6:2: 0.5;
step 2: mixing 1/3 of the glycerol weighed in the step (1) with the acetylhydroxyproline, the tocopherol glucoside and the nicotinamide ribose weighed in the step (1), and uniformly stirring to obtain a mixed solution A;
and step 3: mixing the rest 2/3 mass of glycerol and 1/2 mass of deionized water weighed in the step 1 with the PEG-12 polymethylsiloxane/PPG-20 crosslinked copolymer, and uniformly stirring to obtain a mixed solution B;
and 4, step 4: mixing and stirring carnosine, thiotaurine and hydroxypropyl gamma-cyclodextrin with the rest deionized water to obtain a mixed solution C;
and 5: adding the mixed solution A into the mixed solution B, stirring at 300-500rpm, adding the mixed solution C, and stirring for 10-30min to obtain wrinkle removing composition gel with gel strength of 290 g/cm2。
The obtained wrinkle-removing composition gel for eye can be stored at 40 deg.C for 3 months without delamination.
Example 2: a method for preparing wrinkle-removing composition gel for eyes comprises:
step 1: weighing wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked copolymer, glycerol and deionized water according to the mass ratio of 6.0:1.0:18:30:25, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose according to the mass ratio of 1:1.2:0.6:2: 0.2;
step 2: mixing 1/3 of the glycerol weighed in the step (1) with the acetylhydroxyproline, the tocopherol glucoside and the nicotinamide ribose weighed in the step (1), and uniformly stirring to obtain a mixed solution A;
and step 3: mixing the rest 2/3 mass of glycerol and 1/2 mass of deionized water weighed in the step 1 with the PEG-12 polymethylsiloxane/PPG-20 crosslinked copolymer, and uniformly stirring to obtain a mixed solution B;
and 4, step 4: mixing and stirring carnosine, thiotaurine and hydroxypropyl gamma-cyclodextrin with the rest deionized water to obtain a mixed solution C;
and 5: adding the mixed solution A into the mixed solution B, stirring at 300-500rpm, adding the mixed solution C, and stirring for 10-30min to obtain wrinkle removing composition gel with gel strength of 320 g/cm2。
The obtained wrinkle-removing composition gel for eye can be stored at 40 deg.C for 3 months without delamination.
Example 3: a method for preparing wrinkle-removing composition gel for eyes comprises:
step 1: weighing wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked copolymer, glycerol and deionized water according to the mass ratio of 4.5:0.5:12:20:24, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose according to the mass ratio of 1:3:0.6:2: 0.6;
step 2: mixing 1/3 of the glycerol weighed in the step (1) with the acetylhydroxyproline, the tocopherol glucoside and the nicotinamide ribose weighed in the step (1), and uniformly stirring to obtain a mixed solution A;
and step 3: mixing the rest 2/3 mass of glycerol and 1/2 mass of deionized water weighed in the step 1 with the PEG-12 polymethylsiloxane/PPG-20 crosslinked copolymer, and uniformly stirring to obtain a mixed solution B;
and 4, step 4: mixing and stirring carnosine, thiotaurine and hydroxypropyl gamma-cyclodextrin with the rest deionized water to obtain a mixed solution C;
and 5: adding the mixed solution A into the mixed solution B, stirring at 300-500rpm, adding the mixed solution C, and stirring for 10-30min to obtain wrinkle removing composition gel with gel strength of 250 g/cm2。
The obtained wrinkle-removing composition gel for eye can be stored at 40 deg.C for 3 months without delamination.
Example 4: a method for preparing wrinkle-removing composition gel for eyes comprises:
step 1: weighing wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked copolymer, glycerol and deionized water according to the mass ratio of 10:2.0:20:25:25, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose according to the mass ratio of 1:2.5:0.6:2: 0.3;
step 2: mixing 1/3 of the glycerol weighed in the step (1) with the acetylhydroxyproline, the tocopherol glucoside and the nicotinamide ribose weighed in the step (1), and uniformly stirring to obtain a mixed solution A;
and step 3: mixing the rest 2/3 mass of glycerol and 1/2 mass of deionized water weighed in the step 1 with the PEG-12 polymethylsiloxane/PPG-20 crosslinked copolymer, and uniformly stirring to obtain a mixed solution B;
and 4, step 4: mixing and stirring carnosine, thiotaurine and hydroxypropyl gamma-cyclodextrin with the rest deionized water to obtain a mixed solution C;
and 5: adding the mixed solution A into the mixed solution B, stirring at 300-500rpm, adding the mixed solution C, and stirring for 10-30min to obtain wrinkle removing composition gel with gel strength of 340 g/cm2。
The obtained wrinkle-removing composition gel for eye can be stored at 40 deg.C for 3 months without delamination.
Example 5: a method for preparing wrinkle-removing composition gel for eyes comprises:
step 1: weighing wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked copolymer, glycerol and deionized water according to the mass ratio of 4:0.6:10:22.5:20, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose according to the mass ratio of 1:1.6:0.6:2: 0.8;
step 2: mixing 1/3 of the glycerol weighed in the step (1) with the acetylhydroxyproline, the tocopherol glucoside and the nicotinamide ribose weighed in the step (1), and uniformly stirring to obtain a mixed solution A;
and step 3: mixing the rest 2/3 mass of glycerol and 1/2 mass of deionized water weighed in the step 1 with the PEG-12 polymethylsiloxane/PPG-20 crosslinked copolymer, and uniformly stirring to obtain a mixed solution B;
and 4, step 4: mixing and stirring carnosine, thiotaurine and hydroxypropyl gamma-cyclodextrin with the rest deionized water to obtain a mixed solution C;
and 5: adding the mixed solution A into the mixed solution B, stirring at 300-500rpm, adding the mixed solution C, and stirring for 10-30min to obtain the wrinkle-removing composition with gel strength of 350 g/cm2。
The obtained wrinkle-removing composition gel for eye can be stored at 40 deg.C for 3 months without delamination.
Claims (2)
1. A wrinkle-removing composition gel for the eye characterized by: the wrinkle-removing cream comprises wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked polymer, glycerol and deionized water in a mass ratio of 4-10:0.5-2:10-20:20-30:20-30, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose in a mass ratio of 1:1-3:0.6:2: 0.2-0.8.
2. A method for preparing a wrinkle-removing composition gel for the eye according to claim 1, characterized in that: the method comprises the following steps:
step 1: weighing wrinkle-removing active substances, hydroxypropyl gamma-cyclodextrin, PEG-12 polymethylsiloxane/PPG-20 cross-linked copolymer, glycerol and deionized water according to the mass ratio of 4-10:0.5-2:10-20:20-30:20-30, wherein the wrinkle-removing active substances comprise acetylhydroxyproline, carnosine, tocopherol glucoside, thiotaurine and nicotinamide ribose according to the mass ratio of 1:1-3:0.6:2: 0.2-0.8;
step 2: mixing 1/3 of the glycerol weighed in the step (1) with the acetylhydroxyproline, the tocopherol glucoside and the nicotinamide ribose weighed in the step (1), and uniformly stirring to obtain a mixed solution A;
and step 3: mixing the rest 2/3 mass of glycerol and 1/2 mass of deionized water weighed in the step 1 with the PEG-12 polymethylsiloxane/PPG-20 crosslinked copolymer, and uniformly stirring to obtain a mixed solution B;
And 4, step 4: mixing the carnosine, the thiotaurine and the hydroxypropyl gamma-cyclodextrin weighed in the step 1 with the rest deionized water, and uniformly stirring to obtain a mixed solution C;
and 5: and adding the mixed solution A into the mixed solution B, uniformly stirring at the rotating speed of 300-500rpm, then adding the mixed solution C, and continuously stirring for 10-30min to obtain the wrinkle-removing composition gel for eyes.
Priority Applications (1)
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6056994A (en) * | 1983-09-08 | 1985-04-02 | Sunstar Inc | Tocopherol derivative |
| DE10032166A1 (en) * | 2000-07-01 | 2002-01-10 | Beiersdorf Ag | Cosmetic or dermatological formulation, e.g. hair colorant or formulation for treating skin damaged by aging, oxidation or light, contains physiologically-compatible thiosulfonic acid, e.g. thiotaurine |
| KR20160047914A (en) * | 2014-10-23 | 2016-05-03 | 주식회사 엘지생활건강 | Anti-aging cosmetic composition comprising precursor of Nicotinamide adenine dinucleotide |
| CN107260569A (en) * | 2017-05-25 | 2017-10-20 | 珀莱雅化妆品股份有限公司 | A kind of preparation method of eye-care compositions liposome |
-
2019
- 2019-05-23 CN CN201910432604.6A patent/CN111973485B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6056994A (en) * | 1983-09-08 | 1985-04-02 | Sunstar Inc | Tocopherol derivative |
| DE10032166A1 (en) * | 2000-07-01 | 2002-01-10 | Beiersdorf Ag | Cosmetic or dermatological formulation, e.g. hair colorant or formulation for treating skin damaged by aging, oxidation or light, contains physiologically-compatible thiosulfonic acid, e.g. thiotaurine |
| KR20160047914A (en) * | 2014-10-23 | 2016-05-03 | 주식회사 엘지생활건강 | Anti-aging cosmetic composition comprising precursor of Nicotinamide adenine dinucleotide |
| CN107260569A (en) * | 2017-05-25 | 2017-10-20 | 珀莱雅化妆品股份有限公司 | A kind of preparation method of eye-care compositions liposome |
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| CN111973485B (en) | 2021-10-22 |
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