CN111971032A - 包含有机硅丙烯酸杂化聚合物的透皮治疗系统 - Google Patents

包含有机硅丙烯酸杂化聚合物的透皮治疗系统 Download PDF

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Publication number
CN111971032A
CN111971032A CN201980025593.8A CN201980025593A CN111971032A CN 111971032 A CN111971032 A CN 111971032A CN 201980025593 A CN201980025593 A CN 201980025593A CN 111971032 A CN111971032 A CN 111971032A
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CN
China
Prior art keywords
active agent
transdermal therapeutic
therapeutic system
silicone
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980025593.8A
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English (en)
Chinese (zh)
Inventor
M.埃姆根布罗伊赫
G.沃尔
M.林
R.勃姆
C.施密茨
R.考夫曼
H-W.沃尔夫
N.鲁姆
A.施吕特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of CN111971032A publication Critical patent/CN111971032A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980025593.8A 2018-03-13 2019-03-11 包含有机硅丙烯酸杂化聚合物的透皮治疗系统 Pending CN111971032A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18161437.1 2018-03-13
EP18161437 2018-03-13
PCT/EP2019/056028 WO2019175109A1 (en) 2018-03-13 2019-03-11 Transdermal therapeutic system comprising a silicone acrylic hybrid polymer

Publications (1)

Publication Number Publication Date
CN111971032A true CN111971032A (zh) 2020-11-20

Family

ID=61628189

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980025593.8A Pending CN111971032A (zh) 2018-03-13 2019-03-11 包含有机硅丙烯酸杂化聚合物的透皮治疗系统

Country Status (7)

Country Link
US (1) US20210038532A1 (https=)
EP (1) EP3764998A1 (https=)
JP (1) JP2021517572A (https=)
CN (1) CN111971032A (https=)
BR (1) BR112020018300A2 (https=)
CA (1) CA3092757A1 (https=)
WO (1) WO2019175109A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118765196A (zh) * 2022-01-27 2024-10-11 Lts罗曼治疗系统股份公司 用于透皮施用赛乐西帕的透皮治疗系统
WO2025038382A1 (en) * 2023-08-11 2025-02-20 Momentive Performance Materials Inc. Pharmaceutical adhesive compositions

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060216340A1 (en) * 1997-02-24 2006-09-28 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US20100119585A1 (en) * 2006-11-21 2010-05-13 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for administering the active substance buprenorphine
CN102803420A (zh) * 2009-04-24 2012-11-28 汉高公司 基于硅氧烷丙烯酸杂化聚合物的粘合剂
EP2599847A1 (en) * 2011-11-29 2013-06-05 Dow Corning Corporation A Silicone Acrylate Hybrid Composition and Method of Making Same
CN103269698A (zh) * 2010-12-14 2013-08-28 阿西诺股份公司 用于施用活性物质的经皮治疗系统
CN105007906A (zh) * 2012-12-12 2015-10-28 Lts勒曼治疗系统股份公司 经皮递送系统
CN107406554A (zh) * 2015-02-09 2017-11-28 美国道康宁公司 多相有机硅丙烯酸类混杂粘弹性组合物及其制备方法
WO2018015424A1 (en) * 2016-07-22 2018-01-25 Lts Lohmann Therapie-Systeme Ag Control of adhesive domains

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362496A (en) * 1993-08-04 1994-11-08 Pharmetrix Corporation Method and therapeutic system for smoking cessation
US6974588B1 (en) * 1999-12-07 2005-12-13 Elan Pharma International Limited Transdermal patch for delivering volatile liquid drugs
TWI389709B (zh) * 2005-12-01 2013-03-21 Novartis Ag 經皮治療系統
EP2024406B1 (en) 2006-06-06 2012-08-01 Dow Corning Corporation A silicone acrylate hybrid composition
TW201338813A (zh) 2011-12-12 2013-10-01 洛曼治療系統股份有限公司 經皮遞送系統
US20170112781A1 (en) * 2015-10-27 2017-04-27 Noven Pharmaceuticals, Inc. Transdermal drug delivery systems with polyisobutylene face adhesive

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060216340A1 (en) * 1997-02-24 2006-09-28 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US20100119585A1 (en) * 2006-11-21 2010-05-13 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for administering the active substance buprenorphine
CN102803420A (zh) * 2009-04-24 2012-11-28 汉高公司 基于硅氧烷丙烯酸杂化聚合物的粘合剂
CN103269698A (zh) * 2010-12-14 2013-08-28 阿西诺股份公司 用于施用活性物质的经皮治疗系统
EP2599847A1 (en) * 2011-11-29 2013-06-05 Dow Corning Corporation A Silicone Acrylate Hybrid Composition and Method of Making Same
CN105007906A (zh) * 2012-12-12 2015-10-28 Lts勒曼治疗系统股份公司 经皮递送系统
CN107406554A (zh) * 2015-02-09 2017-11-28 美国道康宁公司 多相有机硅丙烯酸类混杂粘弹性组合物及其制备方法
WO2018015424A1 (en) * 2016-07-22 2018-01-25 Lts Lohmann Therapie-Systeme Ag Control of adhesive domains

Also Published As

Publication number Publication date
WO2019175109A1 (en) 2019-09-19
BR112020018300A2 (pt) 2020-12-22
CA3092757A1 (en) 2019-09-19
EP3764998A1 (en) 2021-01-20
US20210038532A1 (en) 2021-02-11
JP2021517572A (ja) 2021-07-26

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Application publication date: 20201120