CN111961654B - 耐热表型稳定遗传、携带负标记的重组口蹄疫病毒无毒株及o/a型口蹄疫二价灭活疫苗 - Google Patents

耐热表型稳定遗传、携带负标记的重组口蹄疫病毒无毒株及o/a型口蹄疫二价灭活疫苗 Download PDF

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CN111961654B
CN111961654B CN202010780070.9A CN202010780070A CN111961654B CN 111961654 B CN111961654 B CN 111961654B CN 202010780070 A CN202010780070 A CN 202010780070A CN 111961654 B CN111961654 B CN 111961654B
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fmdv
virus
type
mouth disease
recombinant
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CN111961654A (zh
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于力
杨德成
王海伟
周国辉
孙超
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Harbin Veterinary Research Institute of CAAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32161—Methods of inactivation or attenuation
    • C12N2770/32162—Methods of inactivation or attenuation by genetic engineering

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202010780070.9A 2020-08-05 2020-08-05 耐热表型稳定遗传、携带负标记的重组口蹄疫病毒无毒株及o/a型口蹄疫二价灭活疫苗 Active CN111961654B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202010780070.9A CN111961654B (zh) 2020-08-05 2020-08-05 耐热表型稳定遗传、携带负标记的重组口蹄疫病毒无毒株及o/a型口蹄疫二价灭活疫苗
PCT/CN2020/111715 WO2022027749A1 (fr) 2020-08-05 2020-08-27 Souche recombinante non toxique du virus de la fièvre aphteuse à héritage stable phénotypique résistant à la chaleur et à marqueur négatif et vaccin inactivé bivalent contre la fièvre aphteuse de type o/a

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CN202010780070.9A CN111961654B (zh) 2020-08-05 2020-08-05 耐热表型稳定遗传、携带负标记的重组口蹄疫病毒无毒株及o/a型口蹄疫二价灭活疫苗

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CN115896043B (zh) * 2022-07-07 2023-06-20 中国农业科学院兰州兽医研究所 一种o型口蹄疫疫苗候选株及其构建方法和应用
CN117210502A (zh) * 2023-09-13 2023-12-12 中国农业科学院兰州兽医研究所 口蹄疫病毒vp1蛋白免疫抑制位点突变的重组口蹄疫病毒株的构建

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105535957A (zh) * 2015-12-11 2016-05-04 中国农业科学院兰州兽医研究所 一种口蹄疫o、a型双价灭活标记疫苗及其制备方法
CN106397546A (zh) * 2016-10-31 2017-02-15 北京世纪元亨动物防疫技术有限公司 一种o型口蹄疫病毒人工重组抗原及其制备与应用
CN108085302A (zh) * 2016-11-21 2018-05-29 中国农业科学院哈尔滨兽医研究所 口蹄疫病毒温度敏感减毒株及其构建方法和用途

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CN101838658B (zh) * 2010-04-30 2012-02-08 中国农业科学院哈尔滨兽医研究所 O型口蹄疫病毒变异株及其编码基因和应用
CN102533798B (zh) * 2012-02-10 2013-07-17 中国农业科学院哈尔滨兽医研究所 表达a型口蹄疫病毒空衣壳重组腺病毒及其应用
CN103849637B (zh) * 2012-11-29 2015-12-23 于力 O型口蹄疫病毒耐酸突变株、其携带的衣壳蛋白及其编码基因和应用

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CN105535957A (zh) * 2015-12-11 2016-05-04 中国农业科学院兰州兽医研究所 一种口蹄疫o、a型双价灭活标记疫苗及其制备方法
CN106397546A (zh) * 2016-10-31 2017-02-15 北京世纪元亨动物防疫技术有限公司 一种o型口蹄疫病毒人工重组抗原及其制备与应用
CN108085302A (zh) * 2016-11-21 2018-05-29 中国农业科学院哈尔滨兽医研究所 口蹄疫病毒温度敏感减毒株及其构建方法和用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Identification of a conserved linear epitope using monoclonal antibody against non-structural protein 3A of foot-and-mouth disease virus with potential for differentiation between infected and vaccinated animals;Mingxia Wang等;《Research in Veterinary Science》;20190315;第124卷;第178-185页 *
口蹄疫反向疫苗研究进展;杨波等;《病毒学报》;20140324;第30卷(第2期);第213-220页 *

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