CN111942632B - Automatic nuclide split charging device and method - Google Patents

Automatic nuclide split charging device and method Download PDF

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Publication number
CN111942632B
CN111942632B CN202010578726.9A CN202010578726A CN111942632B CN 111942632 B CN111942632 B CN 111942632B CN 202010578726 A CN202010578726 A CN 202010578726A CN 111942632 B CN111942632 B CN 111942632B
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module
stock solution
subpackaging
nuclide
split charging
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CN111942632A (en
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蒋皆恢
代双杰
左传涛
马进
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University of Shanghai for Science and Technology
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University of Shanghai for Science and Technology
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B57/00—Automatic control, checking, warning, or safety devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
    • B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
    • B67C3/22—Details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
    • B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
    • B67C3/22—Details
    • B67C3/26—Filling-heads; Means for engaging filling-heads with bottle necks
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
    • G06F3/01—Input arrangements or combined input and output arrangements for interaction between user and computer
    • G06F3/048—Interaction techniques based on graphical user interfaces [GUI]
    • G06F3/0484—Interaction techniques based on graphical user interfaces [GUI] for the control of specific functions or operations, e.g. selecting or manipulating an object, an image or a displayed text element, setting a parameter value or selecting a range
    • G—PHYSICS
    • G08—SIGNALLING
    • G08C—TRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C17/00—Arrangements for transmitting signals characterised by the use of a wireless electrical link
    • G08C17/02—Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
    • G—PHYSICS
    • G08—SIGNALLING
    • G08C—TRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C19/00—Electric signal transmission systems

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  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Human Computer Interaction (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The invention discloses an automatic nuclide subpackaging device which comprises a user interaction module, an information switching module, an activity meter, a label printer and a stock solution subpackaging module, wherein the user interaction module is connected with the information switching module through a communication interface; the system comprises a user interaction module, a stock solution subpackaging module and a data storage module, wherein the user interaction module is used for guiding a user and controlling the stock solution subpackaging module to complete nuclide subpackaging and data storage; the information switching module is connected with other modules and used for switching information; the activity meter is used for measuring the activity of various nuclides in real time; the label printer is used for printing basic subpackage information; and the stock solution subpackaging module is used for completing automatic subpackaging of nuclides. The automatic nuclide subpackaging device and method provided by the invention have the advantages of rich functions, high subpackaging precision, convenience and quickness in user operation, flexible communication mode, capability of correcting nuclide decay and convenience in maintenance. And the user only needs to install software corresponding to the automatic nuclide subpackaging device and log in the software, and then the nuclide subpackaging operation can be completed according to the subpackaging prompt operation.

Description

Automatic nuclide split charging device and method
Technical Field
The invention relates to the technical field of automatic nuclide split charging, in particular to an automatic nuclide split charging device and method.
Background
Nuclides are widely used in medical clinical diagnosis and treatment at present, but because nuclides have strong radioactivity, radioactive damage is inevitably caused to nuclear medicine workers. From production to clinical diagnostic treatment, nuclides of high concentration are diluted and separated into nuclides of low concentration for treatment and diagnosis of patients. However, the current main nuclide dispensing method is manual dispensing, and nuclear medicine workers must be in close contact with nuclides when performing manual dispensing, and although certain protection is provided, the nuclide dispensing still causes damage to the bodies of the nuclear medicine workers, and even the nuclide dispensing can be life-threatening due to long-term contact. Therefore, an automatic nuclide dispensing device with an automatic dispensing function and capable of being remotely controlled by nuclear medicine workers is a development trend of future nuclide dispensing.
However, the existing automated nuclide dispensing device in the market at present mainly has the following defects:
1. the communication mode can not meet the actual requirements of China. At present, the communication mode of most of automatic nuclide subpackaging devices is mainly wired communication, although a few of automatic nuclide subpackaging devices can realize wireless WiFi communication, when a nuclide subpackaging instrument is placed in a closed hot chamber for subpackaging, due to the fact that the hot chamber shields WiFi signals, the WiFi signals cannot penetrate through the hot chamber, and therefore the communication mode of an internal wireless WiFi module cannot meet the actual requirements of nuclear medicine subjects in China;
2. the decay of a nuclide cannot be compensated for. The conventional automatic nuclide split charging device can only ensure that the activity of the nuclide split charged into a medicine bottle or an injection needle cylinder meets the requirements of a user after split charging is finished, but a certain time is still needed from the moment when the nuclide split charging is finished to the moment when the nuclide is injected into a patient, and the nuclide precision can be greatly influenced by the decay of the nuclide within the time for the nuclide with short half-life time;
3. the maintenance of the device is difficult. At present, most of operating software of the automatic nuclide subpackaging devices does not provide a device debugging window, and later-period maintenance is inconvenient.
Disclosure of Invention
In view of the above defects in the prior art, the technical problems to be solved by the invention are that the communication mode of the automatic nuclide dispensing device in the prior art cannot meet the actual requirements of China, cannot compensate decay of nuclides, is difficult to maintain, and the like. Therefore, the automatic nuclide split charging device and method provided by the invention have the advantages of high split charging precision and convenience in operation, and can be used for operating the nuclide split charging instrument in a hot room in a wireless WiFi communication mode, compensating for decay of nuclides and facilitating maintenance. And the user only needs to install software corresponding to the automatic nuclide subpackaging device and log in the software, and then subpackaging operation can be completed according to the subpackaging prompt operation.
In order to achieve the aim, the invention provides an automatic nuclide subpackaging device which comprises a user interaction module, an information switching module, an activity meter, a label printer, a stock solution subpackaging module and an information switching module; wherein,
the user interaction module is used for guiding a user and controlling the stock solution subpackaging module to complete nuclide subpackaging, nuclide compensation and data storage;
the information switching module is connected with the user interaction module, the activity meter, the label printer and the stock solution subpackaging module and used for switching information of the user interaction module, the activity meter, the label printer and the stock solution subpackaging module, wherein the information switching module and the user interaction module can be communicated in a wired communication mode or a wireless WiFi communication mode, and the information switching module, the activity meter, the label printer and the stock solution subpackaging module are all in a wired communication mode;
the activity meter is used for measuring the activity of various nuclides in real time;
the label printer is used for printing basic subpackage information;
and the stock solution subpackaging module is used for completing automatic subpackaging of nuclides.
Furthermore, the hardware of the user interaction module is set as a tablet or a computer, and the software system comprises a main window module, a login module, a nuclide subpackaging module, an equipment maintenance module, a system parameter setting module, a recording query module, a user management module, a software-related module, a database module and a first communication module; the main window module provides switching and module display function interfaces of all modules for a user, the login module provides a login function interface for the user, the user management module provides an account registration and password modification function interface for the user, the system parameter setting module and the equipment maintenance module provide a device debugging function interface for the user, the record query module provides a subpackaging record query and function query function interface for the user, the software module mainly provides a device introduction function interface for the user, the database module mainly provides a table data storage function, and the first communication module mainly realizes communication between the user interaction module and the information transfer module.
Further, the nuclide dispensing module comprises a user operation guiding unit, a pipeline state unit and a device state unit; the guide user operation unit is used for guiding a user to realize sub-packaging, calculating the attenuation of the nuclide in the period of time of the injection time and the sub-packaging starting time of the patient, and compensating the sub-packaged nuclide during sub-packaging; the pipeline state unit is used for displaying the operation process of the stock solution split charging module of the nuclide in real time; the device state unit is used for displaying the original liquid radioactive quantity, the original liquid volume, the original liquid radioactive concentration, the activity meter measured value, the activity meter connection state and the original liquid subpackaging module connection state.
Furthermore, the system parameter setting module is used for completing the setting of the volume of the stock solution bottle, the stock solution filling amount of the stock solution bottle connecting hose, the stock solution filling amount of the pipeline between the three-way valve IV and the three-way valve V, the physiological saline filling amount of the physiological saline bottle connecting hose, the correction error of the stock solution needle cylinder and the correction error of the split charging needle cylinder.
Furthermore, the user interaction module comprises an equipment maintenance module, the equipment maintenance module is used for debugging and displaying the operation conditions of two electric cylinders and five steering engines in the stock solution subpackaging module, and a user can conveniently maintain the steering engines and the electric cylinders in the stock solution subpackaging module through an interface.
Further, the information switching module comprises a first power module, a first processor module and a second communication module, the first power module is used for supplying power to the information switching module, the first processor module is used for completing information switching between the user interaction module and the stock solution subpackaging module, between the activity meter and the label printer, and the second communication module is mainly used for completing communication between the processor and the activity meter, between the activity meter and the label printer, between the stock solution subpackaging module and between the activity meter and the label printer.
Further, the label printer mainly functions to print labels of basic dispensing information (nuclide type, patient name, injection time, nuclide activity, nuclide volume, and operator); the activity meter can measure the activity of various nuclides in real time; the stock solution subpackaging module mainly completes automatic subpackaging of nuclides.
Further, stoste partial shipment module includes second processor module, steering wheel module, electric jar module, the bubble sensor, the second power module, third communication module and partial shipment pipeline module, second processor module is connected with steering wheel module, electric jar module, the bubble sensor module respectively, third communication module is responsible for second processor module and steering wheel module, the communication between electric jar module and the information switching module, second power module is the power supply of whole stoste partial shipment module, partial shipment pipeline module and electric jar module, steering wheel module and bubble sensor are connected.
Further, the electric cylinder module selects two high-precision, integrated and intelligent miniature electric cylinders. The electric cylinder supports a Modbus protocol and is provided with a state monitoring system, so that the processor module can control the electric cylinder which is connected in parallel on the serial bus on one serial bus respectively, feed back the state information of the electric cylinder and avoid maintaining the electric cylinder when necessary.
Furthermore, five integrated and intelligent steering engines are selected for the steering engine module. The steering engine supports a Modbus protocol and is provided with a state monitoring system, so that the processor module can control the steering engine connected in parallel on a serial bus and acquire state information of the steering engine on the serial bus respectively.
Further, the split charging pipeline module comprises a threaded injection needle cylinder, an injection needle cylinder connecting hose, a hard tube, a sterilization filter, a 10ml threaded split charging needle cylinder, a physiological saline bottle connecting hose, a split charging bottle connecting hose, a stock solution bottle connecting hose, a 5ml threaded stock solution needle cylinder and 5 three-way valves; the three-way valve is connected with a threaded port injection needle cylinder through an injection needle cylinder connecting hose according to the sequence from left to right, the upper port of the three-way valve I is connected with a threaded port split charging needle cylinder, and the right port of the three-way valve I is connected with the left port of the three-way valve II through a hard tube; the upper port of the three-way valve II is connected with the sterilization filter, and the right port of the three-way valve II is connected with the left port of the three-way valve III through a hard pipe; the upper port of the three-way valve III is connected with the physiological saline bottle through a physiological saline bottle connecting hose, and the right port of the three-way valve III is connected with the left port of the three-way valve IV through a hard pipe; the upper port of the three-way valve IV is connected with the split charging bottle through a split charging bottle connecting hose, wherein one end of the split charging bottle connecting hose is a needle head, and the lower port of the three-way valve IV is connected with the upper port of the three-way valve V through a hard pipe; the right port of the three-way valve V is connected with the stock solution bottle through a stock solution bottle connecting hose, one end of the stock solution bottle connecting hose is a needle head, and the lower port of the three-way valve V is connected with a threaded port stock solution needle cylinder.
The split charging pipeline module is connected with the electric cylinder module, the steering engine module and the bubble sensor, and specifically comprises that the electric cylinder of the split charging needle cylinder is fixed on the left side inside the stock solution split charging module, a push rod I is connected above the electric cylinder of the split charging needle cylinder, the push rod I can extend out of the stock solution split charging module upwards, the upper side of the push rod I is connected with a transverse outwards-facing push rod II, the other side of the push rod II is provided with a groove, the top of a push handle of the needle cylinder can be placed below the groove, and a rotating nut is arranged above the groove and can fix the push handle of the needle cylinder; the electric cylinder of the stock solution syringe is fixed on the right side edge inside the stock solution subpackaging module, a push rod III is connected below the electric cylinder of the stock solution syringe, the push rod III is connected with a transversely outward push rod IV which can extend out of the stock solution subpackaging module, and the other side of the push rod IV is the same as the other side of the push rod II; the five steering engines are respectively connected with grooves of the three-way valve, and the grooves are used for placing the three-way valve of the split charging pipeline; the outer left side and the outer right side of the stock solution subpackaging module are respectively provided with a square handle with a hollow middle part, and the edge of the handle is oval, so that the stock solution subpackaging module is convenient to carry; a bubble sensor is fixed below the outer front side of the stock solution subpackaging module, a groove of the bubble sensor can be embedded into an injection syringe connecting hose, two hooks with short distance facing outwards are arranged below the bubble sensor, and the injection syringe is erected between the two hooks; the fixing device for the split charging pipeline is a fixing rod capable of rotating, the fixing rod is elastic, and the fixing device is mainly used for rotating to the split charging pipeline to fix the split charging pipeline.
Yet another embodiment of the present invention provides a method of using an automated nuclide dispensing apparatus, comprising the steps of:
1) preparing for subpackaging: checking whether the stock solution split charging module and the activity meter are connected or not;
2) inputting the type of the split nuclide;
3) and (3) measuring the activity of the stock solution: the method comprises two modes of directly inputting and measuring the activity of stock solution;
4) positioning an original point: moving an electric cylinder and a steering engine of the stock solution subpackaging module to default positions;
5) installing a split charging pipeline;
6) and (3) measuring the concentration of the stock solution: the method comprises two modes of directly inputting and measuring the radioactive concentration of the stock solution;
7) installing an injection syringe or a medicine bottle;
8) set up the partial shipment parameter, the partial shipment parameter mainly includes the partial shipment foundation, fills salt solution partial shipment classification, serial number, patient age and weight, stoste activity ratio, stoste volume, total sum and injection time's input, and the user can calculate the nuclide activity ratio of actual partial shipment according to the injection time of input, and the nuclide activity ratio that the patient need inject after the effectual partial shipment parameter of input, calculates according to being: any nuclide substantially satisfies N ═ N0e-λtThe law of radioactive decay of (1), wherein N0Is the original radioactivity, N is the radioactivity after t time, and lambda is the decay constant; firstly, calculating the decay constant lambda of each nuclide according to the half-life period of each nuclide, and finally calculating
Figure GDA0003363935710000041
9) Starting to split charging;
10) and (3) subpackaging is completed: it is determined whether to continue dispensing and printing labels.
The pipeline state unit can display the operation process of the nuclide split charging device in real time. The device state module mainly displays the original liquid radiation amount, the original liquid volume, the original liquid concentration, the activity meter measured value, the activity meter connection state and the original liquid subpackaging module connection state.
Technical effects
1) The device adopts a high-precision electric cylinder, and air is used for purging the pipeline of the split charging pipeline module, so that the split charging precision is high, and the split charging error can be guaranteed within +/-2%;
2) the device can calculate the decay variable of the nuclide in the period from the completion of the nuclide split charging to the injection of the patient, and compensate during the split charging, thereby reducing the error caused by the decay of the nuclide along with the time;
3) the device has rich functions and can automatically measure the activity and concentration of the stock solution; subpackaging according to volume or activity; can be subpackaged into medicine bottles or syringes; when the syringe is subpackaged to the syringe, the air in the syringe can be effectively eliminated during subpackaging;
4) the device provides a perfect system debugging interface, and is convenient for later maintenance; a user can adjust the packaging device through a system parameter setting interface, so that the packaging precision is improved; the electric cylinder and the steering engine of the assembly device can be debugged through an equipment maintenance interface;
5) the control information of the nuclide split charging module can be transmitted to the information transfer module outside the hot chamber by the user interaction module of the device through a WiFi communication mode, and the control information of the nuclide split charging module is transmitted to the nuclide split charging module inside the hot chamber through a wired communication mode by the information transfer module, so that the nuclide split charging module is controlled by the user interaction module through a wireless WiFi communication mode;
6) the device has small volume, small occupied space and convenient software operation; the split charging pipeline is positioned outside the split charging device, and the split charging pipeline is convenient to replace;
the conception, the specific structure and the technical effects of the present invention will be further described with reference to the accompanying drawings to fully understand the objects, the features and the effects of the present invention.
Drawings
FIG. 1 is a system block diagram of an automated nuclide dispensing device in accordance with a preferred embodiment of the present invention;
FIG. 2 is a block diagram of a hardware system of a raw liquid dispensing module of an automated nuclide dispensing apparatus in accordance with a preferred embodiment of the present invention;
FIG. 3 is a schematic diagram of a dispensing line structure of a raw liquid dispensing module of an automated nuclide dispensing apparatus according to a preferred embodiment of the present invention;
FIG. 4 is a plan view of a mechanical structure of a raw liquid dispensing module of an automated nuclide dispensing apparatus according to a preferred embodiment of the present invention;
FIG. 5 is a software system framework diagram of a user interaction module of an automated nuclide dispensing apparatus in accordance with a preferred embodiment of the present invention.
Detailed Description
The embodiment of the invention provides an automatic nuclide subpackaging device which comprises a user interaction module, an information switching module, an activity meter, a label printer, a stock solution subpackaging module and an information switching module, wherein the user interaction module is used for carrying out the operation of the activity meter; wherein,
the user interaction module is used for guiding a user and controlling the stock solution subpackaging module to complete nuclide subpackaging and data storage;
the information switching module is connected with the user interaction module, the activity meter, the label printer and the stock solution subpackaging module and is used for switching information of the user interaction module, the activity meter, the label printer and the stock solution subpackaging module; the information switching module and the user interaction module can communicate in a wired communication mode or a wireless WiFi communication mode, and the information switching module, the activity meter, the label printer and the stock solution subpackaging module all adopt wired communication modes;
the activity meter is used for measuring the activity of various nuclides in real time;
the label printer is used for printing basic subpackage information;
and the stock solution subpackaging module is used for completing automatic subpackaging of nuclides.
The hardware of the user interaction module is set as a tablet or a computer, and the software system comprises a main window module, a login module, a nuclide subpackage module, an equipment maintenance module, a system parameter setting module, a record query module, a user management module, a software-related module, a database module and a first communication module;
the main window module provides a switching and module display function interface of each module for a user, and specifically comprises a login module, a nuclide subpackaging module, a system parameter setting module, a record query module, a user management module, an equipment maintenance module and a function related to software module switching and interface display.
The login module provides a login function interface for a user, and the user can enter the subpackage interface only by inputting a correct account and a correct password.
The user management module provides an account registration and password modification function interface for the user, wherein the user registration comprises the completion of account, password, name, gender, birth date, hospital and job information.
The system parameter setting module and the equipment maintenance module provide a device debugging function interface for a user,
the record query module provides a subpackage record query and function query function interface for a user, and the record query module provides a subpackage record query mode according to date and user name for the user; the inquired records can be displayed on a record inquiry interface, and can also be saved in an Excel format document.
The software module mainly provides a device introduction function interface for a user.
The database module mainly provides a storage function of the table data, and the first communication module mainly realizes communication between the user interaction module and the information transfer module. The database module is mainly used for storing subpackage information (subpackage basis, filling of saline water, subpackage category, serial number, patient age and weight, stock solution activity, stock solution volume, total volume and injection time), user information, system parameter information and subpackage record information (subpackage basis, filling of saline water, subpackage category, serial number, patient age and weight, stock solution activity, stock solution volume, total volume, injection time, subpackage time and operator name).
The first communication module is mainly used for finishing the communication between the user interaction module and the information transfer module.
The nuclide split charging module comprises a user operation guiding unit, a pipeline state unit and a device state unit; the guide user operation unit is used for guiding a user to realize sub-packaging, calculating the attenuation of the nuclide in the period of time of the injection time and the sub-packaging starting time of the patient, and compensating the sub-packaged nuclide during sub-packaging; the pipeline state unit is used for displaying the operation process of the stock solution split charging module of the nuclide in real time; the device state unit is used for displaying the original liquid radiation amount, the original liquid volume, the original liquid concentration, the activity meter measuring value, the activity meter connecting state and the original liquid subpackaging module connecting state.
The system parameter setting module is used for completing the setting of the volume of the stock solution bottle, the stock solution filling amount of the stock solution bottle connecting hose, the stock solution filling amount of the pipeline between the three-way valve IV and the three-way valve V, the physiological saline filling amount of the physiological saline bottle connecting hose, the correction error of the stock solution needle cylinder and the correction error of the split charging needle cylinder. Because stock solution is easy to remain in the pipeline between the three-way valve IV and the three-way valve V in the split charging process, and the remaining stock solution is uncertain in each split charging process, the stock solution is always filled between the two pipelines in the split charging process so as to ensure the constant stock solution amount of the two pipelines and facilitate the control of split charging errors; the normal saline pipeline is filled with normal saline so as to ensure that the normal saline in the normal saline pipeline is constant; the interface is arranged on the system parameter interface, and the filling quantity of the stock solution bottle connecting hose, the pipeline between the three-way valve IV and the three-way valve V and the normal saline connecting hose can be adjusted so as to fill the appropriate stock solution or normal saline into the subpackaging pipeline through the system parameter interface after the length and the size of the subpackaging pipeline are changed. Because the precision of every electric jar exists the difference among the partial shipment device, and can change with the electric jar is connected stoste cylinder and partial shipment cylinder size, consequently provides stoste cylinder and partial shipment cylinder at the system setting interface and corrects the error interface, guarantees that the stoste cylinder can accurately extract the stoste volume that needs, and the partial shipment cylinder can accurately extract the physiological saline volume that needs. The user can maintain the device through the system parameter interface when the partial shipment pipeline changes for the device partial shipment precision reaches the user's requirement.
The user interaction module comprises an equipment maintenance module, the equipment maintenance module is used for debugging two electric cylinders and five steering engines in the stock solution subpackaging module and displaying the running conditions, and a user can conveniently maintain the steering engines and the electric cylinders in the stock solution subpackaging module through an interface. Specifically, the cylinder information includes status (enable, fault, in-place, in-motion, stop, wait for input signal, warning, initialization), warning (CCW limit, CW limit, undervoltage, motion @ not enable, heavy load status, save failure, NV storage, communication alarm), fault (position error over-limit, driver over-temperature, overvoltage, internal voltage alarm, motor short circuit, winding open circuit, encoder connection), steering engine information includes (input voltage error, angle limit error, overheat error, range error, check code error, overload error), the cylinder can perform operation speed and syringe capacity setting, and the operation of original point search, motor operation and stop operation, the steering wheel can carry out the operation of 0 degree, 90 degrees, 180 degrees rotations, and the user can be very convenient maintains steering wheel and the electric jar in the stoste partial shipment module through this interface.
The information switching module comprises a first power supply module, a first processor module and a second communication module, wherein the first power supply module is used for supplying power to the information switching module, the model of the first processor module is an STM32H743 XIH6 processor, the first processor module is used for completing information switching between the user interaction module and the stock solution subpackaging module, the activity meter and the label printer, the information switching module mainly comprises the step of switching the information of the user interaction module to the label printer and the stock solution subpackaging module, the activity meter information is switched to the user interaction module, and the stock solution subpackaging module is switched to the user interaction module. The first power supply module supplies power for 220V commercial power, and outputs 12V and 3.3V direct-current voltage after passing through the first power supply module.
The second communication module comprises five COM ports supporting RS232 protocol and a WiFi-to-RS 232 module. The second communication module mainly completes communication between the processor and the activity meter, the label printer, the stock solution subpackaging module and the tablet/computer, wherein the processor and the activity meter, the label printer, the stock solution subpackaging module and the tablet/computer are communicated by adopting an RS232 protocol, and in addition, the user interaction module and the information switching module can also be communicated by WiFi, so that the effect of controlling the nuclide subpackaging module in a wireless WiFi communication mode is realized.
The switching process of the information switching module comprises the following steps:
1) and after the power supply is switched on, monitoring commands of the user interaction module and the stock solution subpackaging module all the time.
2) If the data of the user interaction module is monitored, judging whether the control command data of the stock solution subpackaging module is received or not, and transferring the data to the stock solution subpackaging module; if the received command is a printing command, the data is transferred to the label printer.
3) And if the state data of the raw liquid subpackaging module is monitored, the state data is transferred to the user interaction module.
4) The information switching module reads the activity data of the activity meter at regular time and switches the activity data to the user interaction module.
Further, the label printer mainly functions to print labels of basic dispensing information (nuclide type, patient name, injection time, nuclide activity, nuclide volume, and operator); the activity meter can measure the activity of various nuclides in real time; the stock solution subpackaging module mainly completes automatic subpackaging of nuclides.
Further, stoste partial shipment module includes second processor module, steering wheel module, electric jar module, bubble sensor, second power module, third communication module and partial shipment pipeline module, and second processor module is connected with steering wheel module, electric jar module, bubble sensor and information switching module respectively, and second power module is responsible for providing stable DC power for each module, and partial shipment pipeline module is connected with electric jar module, steering wheel module and bubble sensor.
The second power supply module supplies power for 220V commercial power, and outputs 19V, 5V and 3.3V direct current voltage after passing through the second power supply module.
The second processor module is STM32H743 XIH6 treater, mainly used control steering wheel module, bubble sensor module and electric jar module to and realize communicating with information switching module.
The steering engine module is provided with five steering engines in total, and after the steering engines are combined and fixed with a three-way valve of the split charging pipeline module, the valve can be controlled to rotate, so that the connection state of three ports of the valve is controlled; wherein the steering wheel supports Modbus communication protocol, and the treater only needs a serial ports communication interface just can control five steering wheels.
The electric cylinder module is provided with two electric cylinders which are combined and fixed with a stock solution needle cylinder and a split charging needle cylinder piston bolt of the split charging pipeline module, and can control the needle cylinder piston bolt to move up and down; wherein the electric jar supports the Modbus communication protocol, and the processor only needs a serial ports communication interface just can control two electric jars.
The bubble sensor is mainly used for detecting whether bubbles exist in the pipeline.
The third communication module mainly completes communication between the processor and the information switching module, the electric cylinder module, the steering engine module and the bubble sensor module, wherein the processor and the information switching module meet an RS232 protocol, and the processor, the electric cylinder module and the steering engine module meet an RS485 protocol.
The split charging pipeline module comprises a threaded injection needle cylinder (medicine bottle), an injection needle cylinder connecting hose, a hard tube, a sterilization filter, a 10ml threaded split charging needle cylinder, a physiological saline bottle connecting hose, a split charging bottle connecting hose, a stock solution bottle connecting hose, a 5ml threaded stock solution needle cylinder and 5 three-way valves; the three-way valve is sequentially arranged from left to right, the left port of the three-way valve I is connected with a threaded port injection needle cylinder (medicine bottle) through an injection needle cylinder connecting hose, the upper port of the three-way valve I is connected with a threaded port split charging needle cylinder, and the right port of the three-way valve I is connected with the left port of the three-way valve II through a hard pipe; the upper port of the three-way valve II is connected with the sterilization filter, and the right port of the three-way valve II is connected with the left port of the three-way valve III through a hard pipe; the upper port of the three-way valve III is connected with the physiological saline bottle through a physiological saline bottle connecting hose, and the right port of the three-way valve III is connected with the left port of the three-way valve IV through a hard pipe; the upper port of the three-way valve IV is connected with the split charging bottle through a split charging bottle connecting hose, wherein one end of the split charging bottle connecting hose is a needle head, and the lower port of the three-way valve IV is connected with the upper port of the three-way valve V through a hard pipe; the right port of the three-way valve V is connected with a stock solution bottle through a stock solution bottle connecting hose, wherein the stock solution bottle is connected with a syringe needle at one end of the hose, and the lower port of the three-way valve V is connected with a threaded port stock solution syringe; the distance between each three-way valve was 36 mm.
The split charging pipeline module is connected with the electric cylinder module, the steering engine module and the bubble sensor, and specifically comprises that the electric cylinder of the split charging needle cylinder is fixed on the left side inside the stock solution split charging module, a push rod I is connected above the electric cylinder of the split charging needle cylinder, the push rod I can extend out of the stock solution split charging module upwards, the upper side of the push rod I is connected with a push rod II which transversely faces outwards, the other side of the push rod II is provided with a groove, the top of a push handle of the needle cylinder can be placed below the groove, and a rotating nut is arranged above the groove and can fix the push handle of the needle cylinder; the electric cylinder of the stock solution syringe is fixed on the right side edge inside the stock solution subpackaging module, a push rod III is connected below the electric cylinder of the stock solution syringe, the push rod III is connected with a transversely outward push rod IV which can extend out of the stock solution subpackaging module, and the other side of the push rod IV is the same as the other side of the push rod II; the five steering engines are respectively connected with grooves of the three-way valve, and the grooves are used for placing the three-way valve of the split charging pipeline; the outer left side and the outer right side of the stock solution subpackaging module are respectively provided with a square handle with a hollow middle part, and the edge of the handle is oval, so that the stock solution subpackaging module is convenient to carry; a bubble sensor is fixed below the outer front side of the stock solution subpackaging module, a groove of the bubble sensor can be embedded into a connecting hose of an injection syringe of the subpackaging pipeline, two hooks with short distance facing outwards are arranged below the groove of the bubble sensor, and the injection syringe is erected between the two hooks; the fixing device for the split charging pipeline is a fixing rod capable of rotating, the fixing rod is elastic, and the fixing device is mainly used for rotating to the split charging pipeline to fix the split charging pipeline.
Yet another embodiment of the present invention provides a method of using an automated nuclide dispensing apparatus, comprising the steps of:
1) preparing for subpackaging: checking whether the stock solution split charging module and the activity meter are connected or not;
2) inputting the type of the split nuclide;
3) and (3) measuring the activity of the stock solution: the method comprises two modes of directly inputting and measuring the activity of stock solution;
4) positioning an original point: moving an electric cylinder and a steering engine of the stock solution subpackaging module to default positions;
5) installing a split charging pipeline;
6) determination of the mean radioactive concentration of the stock solution: the method comprises two modes of directly inputting and measuring the average radioactive concentration of stock solution;
7) set up the partial shipment parameter, the partial shipment parameter mainly includes the partial shipment foundation (activity degree and volume), fill salt solution (do not need and need), partial shipment classification (cylinder and medicine bottle), serial number, patient age and weight, stoste activity degree, stoste volume, total volume (salt solution + stoste) and the input of injection time, the user can be according to the injection time of input, and the nuclide activity degree that the patient need inject after the effectual partial shipment parameter of input, calculate the nuclide activity degree of actual partial shipment, calculate the foundation and be: any nuclide basically meets the radioactive decay constant law that N is N0 e-lambdat, wherein N0 is original radioactivity, N is radioactivity after t time, and lambada is a decay constant; firstly, calculating a decay constant lambda of each nuclide through the half-life period of each nuclide, and finally calculating;
8) starting to split charging;
9) and (3) subpackaging is completed: it is determined whether to continue dispensing and printing labels.
The pipeline state unit can display the operation process of the nuclide split charging module in real time. The device state module mainly displays the original liquid radiation amount, the original liquid volume, the original liquid radioactive concentration, the activity meter measured value, the activity meter connection state and the original liquid subpackaging module connection state.
Wherein, the main steps that stoste partial shipment module carries out the partial shipment include:
1) judging whether the split charging is based on activity split charging or volume split charging;
2) if the split charging is based on split charging according to the activity, the split charging steps are as follows: a. the stock solution activity a is split charged according to the requirement0And the mean radioactive concentration c of the stock solution0Calculating the volume v of the extracted stock solution0(ii) a b. The three-way valve is controlled by the steering engine to rotate so as to form a passage between the stock solution bottle and the stock solution syringe, and the stock solution syringe is controlled by the electric cylinder to enable 95 percent v0The stock solution is extracted to a stock solution syringe; c. the three-way valve is controlled by the steering engine to rotate so that a passage is formed between the stock solution syringe and the split charging bottle, and the electric cylinder controls the stock solution in the stock solution syringe to be pushed to the split charging bottle; d. the three-way valve is controlled by the steering engine to rotate so as to form a passage between the split charging syringe and the sterilization filter, and the electric cylinder controls the split charging syringe to pump a certain amount of air into the split charging syringe; e. the three-way valve is controlled by the steering engine to rotate so as to form a passage between the split charging needle cylinder and the split charging bottle, and the electric cylinder controls the split charging needle cylinder to inject air into the split charging bottle, so that residual stock solution in a pipeline can enter the split charging bottle, and the split charging accuracy is ensured; f. according to activity change a in the divided bottle1And the volume of liquid in the divided bottle is 95% v0Average radioactive concentration c of the new stock solution1＝a1/(95％*v0) (ii) a g. By passing through the stock solutionThe stock solution is extracted by the syringe and is compensated and bottled, and the volume of the compensated stock solution is v1＝(a0-a1)/c1；
3) If the split charging is based on the split charging according to the volume, a, the three-way valve is controlled by the steering engine to rotate so as to form a passage between the stock solution bottle and the stock solution syringe, and the electric cylinder is used for controlling the stock solution syringe to extract v0The stock solution is volumed to the stock solution syringe; b. the three-way valve is controlled by the steering engine to rotate so that a passage is formed between the stock solution syringe and the split charging bottle, and the electric cylinder controls the stock solution in the stock solution syringe to be pushed to the split charging bottle; c. the three-way valve is controlled by the steering engine to rotate so as to form a passage between the split charging syringe and the sterilization filter, and the electric cylinder controls the split charging syringe to pump a certain amount of air into the split charging syringe; d. the three-way valve is controlled by the steering engine to rotate so as to form a passage between the split charging needle cylinder and the split charging bottle, and the electric cylinder controls the split charging needle cylinder to inject air into the split charging bottle, so that residual stock solution in a pipeline can enter the split charging bottle, and the split charging accuracy is ensured;
4) if the nuclide in the split charging bottle needs to be diluted by adding the physiological saline, the steering engine controls the three-way valve to rotate so as to form a passage between the split charging syringe and the physiological saline bottle, and as shown in fig. 4, the electric cylinder controls the split charging syringe to extract a certain amount of physiological saline from the physiological saline bag;
5) if the physiological saline is extracted, the steering engine controls the three-way valve to rotate so as to form a passage between the split charging needle cylinder and the split charging bottle, and the electric cylinder controls the split charging needle cylinder to inject the physiological saline in the split charging needle cylinder into the split charging bottle;
6) the steering engine controls the three-way valve to rotate so as to form a passage between the split charging needle cylinder and the split charging bottles, and the electric cylinder controls the split charging needle cylinder to extract split charging medicines in the split charging bottles to the split charging needle cylinder;
7) if the subpackage category is medicine bottle subpackage, the steering engine controls the three-way valve to rotate so that a passage is formed between the subpackage needle cylinder and the injection needle cylinder, and the electric cylinder controls the subpackage needle cylinder so that air in the subpackage needle cylinder is pushed to the injection needle cylinder;
8) if the partial shipment classification is the cylinder partial shipment, carry out the rotation by steering wheel control three-way valve and make to form the route between partial shipment cylinder and the injection cylinder, by electric jar control partial shipment cylinder with the partial shipment medicine propelling movement in the partial shipment cylinder to the injection cylinder, detect the pipeline gas by having the propelling movement of stopping the electric jar when gaseous to having no gas again when having gas when bubble sensor.
Referring to a specific example, the apparatus of the present invention is described below, and as shown in fig. 1, a system framework of an automated nuclide dispensing apparatus includes a user interaction module (100), a liveness meter (200), a stock solution injection module (300), an information transfer module (400), and a label printer (500). The information switching module is provided with a first processor module (401), a first power supply module (403) and a second communication module (404, 405, 406, 407, 408, 409, 410); the first power supply (403) supplies power to 220V mains supply, and converts the mains supply into 12V and 3.3V direct current voltages to supply power to the information switching module; the information transfer module (400) communicates with the user interaction module (100) through the COM1 (405); the user interaction module can also communicate with a Wifi _ RS232 module (404) through the COM6(410), and the Wifi _ RS232 module (404) converts a Wifi signal into an RS232 signal and then communicates with the MCU (401) through the COM6 (410); the information transfer module (400) is communicated with the activity meter (200) through the COM2(406), the activity meter (200) can be used for measuring the activity of various nuclides, the measurement precision is high, and the measurement time is short; the information switching module (400) is communicated with the stock solution subpackaging module (300) through the COM3(407), and the first processor module (401) can receive a control signal of the user interaction module (100) and forward the control signal to the stock solution injection module (300) and also can forward state data of the stock solution injection module (300) to the user interaction module (100); the information switching module (400) is communicated with the label printer (500) through the COM5(409), and the label printer (500) is used for printing the subpackaging data; the information transfer module (400) reserves COM4(408) for extended use; the COM1(405), COM2(406), COM3(407), COM4(408), COM5(409) and COM6(410) of the second communication module support the RS232 protocol.
As shown in fig. 2, the raw liquid dispensing module (300) includes a second processor module (310), a bubble sensor (320), a steering engine module (330), an electric cylinder module (340), a second power module (350), a third communication module (360, 370, 380) and a dispensing pipeline module (600). The second processor module (310) is connected with the bubble sensor (320) and judges whether gas exists in the pipeline or not by reading the level state of an output port of the bubble sensor; the second processor module (310) is connected with the steering engine module (330) through COM1(370), an RS485 communication protocol is supported, and five steering engines in the steering engine module support a ModBus protocol, namely one COM port can control five steering engines; the second processor module (310) is connected with the electric cylinder module (340) through COM2(360), an RS485 communication protocol is supported, and two electric cylinders in the rudder electric cylinder module support a ModBus protocol, namely one COM port can control the two electric cylinders; the second processor module (310) is connected with the information transfer module (401) through COM3(380), and supports RS232 communication protocol; the second power supply module (350) converts the 220V commercial power into direct-current voltages of 19V, 5V and 3.3V to supply power for the nuclide dispensing module.
As shown in fig. 3, the dispensing line of the stock solution dispensing module (300) has the following structure: a 5ml/10ml threaded injection syringe or a medicine bottle (601), an injection syringe connecting hose (602), a hard tube (603), a sterilizing filter (604), a 10ml threaded split charging syringe (605), a physiological saline bottle connecting hose (606), a split charging bottle connecting hose (607), a stock solution bottle connecting hose (608), a 5ml threaded-port stock solution syringe (609), a thickened hose part (610) of the injection syringe connecting hose and a three-way valve (611).
As shown in fig. 4, the mechanical structure of the stock solution dispensing module (300) is: an electric cylinder (612) of the split charging needle cylinder is fixed on the left side inside the stock solution split charging module, a push rod I is connected above the electric cylinder (612) of the split charging needle cylinder, the push rod I can extend out of the stock solution split charging module upwards, the upper side of the push rod I is connected with a transverse outward push rod II, the other side of the push rod II is provided with a groove, the top of a push handle of the needle cylinder can be placed below the groove, and a rotating nut is arranged above the groove and can fix the push handle of the needle cylinder; an electric cylinder (616) of the stock solution syringe fixes the right side edge inside the stock solution split charging module, a push rod III is connected below the electric cylinder (616) of the stock solution syringe, the push rod III is connected with a transversely outward push rod IV which can extend out of the stock solution split charging module, and the other side of the push rod IV is the same as the other side of the push rod II; the five steering engines are respectively connected with grooves of the three-way valve, and the grooves are used for placing a three-way valve (611) part of the split charging pipeline; the outer left side and the outer right side of the stock solution subpackaging module are respectively provided with a square handle (613) with a hollow middle part, and the edge of the handle is oval, so that the stock solution subpackaging module is convenient to carry; a bubble sensor (614) is fixed below the outer front side of the stock solution subpackaging module, a groove of the bubble sensor is used for placing a thickened hose part (610) of a connecting hose of the injection syringe, two hooks (615) with short distance facing outwards are arranged below the groove of the bubble sensor, and the injection syringe is erected between the two hooks; the sub-packaging pipeline fixing device (617) is a fixing rod capable of rotating, and the fixing rod is elastic and mainly used for rotating to a sub-packaging pipeline to fix the sub-packaging pipeline.
As shown in fig. 5, the user interaction module (700) is a human-computer interaction module, and mainly includes a login module (701), a user management module (702), a system parameter setting module (703), a subpackaging module (704), a record query module (705), an equipment maintenance module (706), a software-related module (707), a main window module (708), a first communication module (710), and a database module (709). The main window module mainly comprises an interface navigation bar (800) and a specific interface (801), wherein the interface navigation bar comprises a subpackage interface skip button (802), a system parameter setting interface skip button (803), a recording query interface skip button (804), an equipment maintenance interface skip button (805), a user management interface skip button (806), a software interface skip button (807), an exit button (808), system time (809) and a software name (810), and mainly realizes the functions of skipping among software interfaces and exiting programs.
The login module (701) mainly comprises a login information frame, and a user name and a password of a user need to be filled in, so that the login function of the registered user is mainly realized.
The nuclide dispensing module (704) is mainly composed of a guide user operation interface, a pipeline state interface and a device state information interface, wherein the device state information comprises: the COM port state of the stock solution subpackaging module, the COM state of the activity meter, the radioactive amount of the stock solution, the residual volume of the stock solution, the radioactive concentration of the stock solution and the activity of the stock solution are green, the COM port state of the stock solution subpackaging module and the COM state of the activity meter are normal in connection and red, and the COM port state of the stock solution subpackaging module and the COM state of the activity meter are not connected; the user operation interface is guided to mainly realize the function of guiding a user to carry out subpackage operation; the pipeline state interface mainly realizes the display of the split charging process.
The system parameter setting interface (703) mainly realizes the setting and modifying functions of system parameters (the volume of a stock solution bottle, the filling amount of a pipeline (a stock solution connecting hose, a pipeline between a physiological saline bottle connecting hose, a three-way valve IV and a three-way valve V) and correction errors (a stock solution syringe and a split charging syringe), saves the filled system parameters, and cancels the system parameters saved before recovery.
The record query interface (705) inputs the start date and the end date to be queried, the function of querying the history record of the subpackage operation can be realized by clicking for query, and the function of storing the information into the Excel table can be realized by clicking for storage.
The equipment maintenance interface (706) is composed of the electric cylinder of the stock solution needle cylinder, the electric cylinder of the split charging needle cylinder, five steering engines, the states of the steering engines and the operation information of the two electric cylinders, and mainly realizes the functions of controlling and operating the electric cylinder of the stock solution needle cylinder, the electric cylinder of the split charging needle cylinder and the five steering engines and displaying the state information of the electric cylinder and the steering engines, so that maintenance personnel can maintain the equipment conveniently.
The user management interface (702) is composed of user management and password modification, relevant information is filled in the user management interface, a new user can be registered by clicking a registered user, and the password modification is carried out on the password modification interface, so that the functions of user registration and information modification are mainly realized.
The function introduction and the version information of the software are displayed on an information frame about the software interface (702), and the return is to jump to the split interface.
The automatic nuclide subpackaging device adopts the high-precision electric cylinder, the nuclide residue of a subpackaging pipeline is low, the subpackaging precision is high, and the subpackaging error can be guaranteed to be within +/-2%; the device can calculate the decay variable of the nuclide in the period from the completion of the nuclide split charging to the injection of the patient, and compensate during the split charging, thereby reducing the error caused by the decay of the nuclide along with the time; the device has rich functions and can automatically measure the activity and concentration of the stock solution; subpackaging according to volume or activity; can be subpackaged into medicine bottles or syringes; when the needle cylinder is subpackaged, the air in the needle cylinder can be well eliminated during subpackaging; the device provides a perfect system debugging interface, and is convenient for later maintenance; a user can adjust the packaging device through a system parameter setting interface, so that the packaging precision is improved; the electric cylinder and the steering engine of the assembly device can be debugged through an equipment maintenance interface; the device can control the nuclide split charging module placed in the hot chamber in a WiFi mode, and a software interface of the tablet/computer can display the running state of the device in real time in a graphical mode; the device has small volume, small occupied space and convenient software operation; the split charging pipeline is positioned outside the split charging device, and the split charging pipeline is convenient to replace; the device can complete the sub-packaging of various nuclides and can sub-package various medical nuclides according to the requirements of users.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims (7)

1. An automatic nuclide split charging device is characterized by comprising a user interaction module, an activity meter, a label printer, a stock solution split charging module and an information switching module; wherein,
the user interaction module is used for guiding a user and controlling the stock solution subpackaging module to complete nuclide subpackaging, nuclide compensation and data storage;
the information switching module is connected with the user interaction module, the activity meter, the label printer and the stock solution subpackaging module and is used for switching information of the user interaction module, the activity meter, the label printer and the stock solution subpackaging module;
the activity meter is used for measuring the activity of a plurality of nuclides in real time;
the label printer is used for printing basic subpackage information;
the stock solution subpackaging module is used for completing automatic subpackaging of nuclides;
the hardware of the user interaction module is set as a tablet or a computer, and the software system comprises a main window module, a login module, a nuclide subpackaging module, an equipment maintenance module, a system parameter setting module, a record query module, a user management module, a software-related module, a database module and a first communication module; the system comprises a main window module, a login module, a user management module, a system parameter setting module, a device debugging function interface, a record query module, a software module, a database module and a first communication module, wherein the main window module provides switching and module display function interfaces of each module for a user, the login module provides a login function interface for the user, the user management module provides an account registration and password modification function interface for the user, the system parameter setting module and the equipment maintenance module provide a device debugging function interface for the user, the record query module provides a subpackaging record query function interface for the user, the software module mainly provides a device introduction function interface for the user, the database module mainly provides a table data storage function, and the first communication module mainly realizes communication between a user interaction module and an information transfer module;
the nuclide split charging module comprises a user operation guiding unit, a pipeline state unit and a device state unit; the guide user operation unit is used for guiding a user to realize sub-packaging, calculating the attenuation of the nuclide in the period of time between the injection time of the patient and the sub-packaging starting time of the nuclide, and compensating the sub-packaged nuclide during sub-packaging; the pipeline state unit is used for displaying the operation process of the stock solution split charging module of the nuclide in real time; the device state unit is used for displaying the original liquid radioactive quantity, the original liquid volume, the original liquid radioactive concentration, the activity meter measured value, the activity meter connection state and the original liquid subpackaging module connection state;
the system parameter setting module is used for completing the setting of the volume of the stock solution bottle, the stock solution filling amount of the stock solution bottle connecting hose, the stock solution filling amount of the pipeline between the three-way valve IV and the three-way valve V, the physiological saline filling amount of the physiological saline bottle connecting hose, the correction error of the stock solution needle cylinder and the correction error of the split charging needle cylinder.
2. An automatic nuclide racking device as in claim 1 wherein the user interaction module comprises an equipment maintenance module for providing debugging and operational status display of two electric cylinders and five steering engines in the stock solution racking module, and the user can conveniently maintain the steering engines and electric cylinders in the stock solution racking module through the interface.
3. An automated nuclide dispensing apparatus as defined in claim 1 wherein the information transfer module comprises a first power module for supplying power to the information transfer module, a first processor module for performing information transfer between the user interaction module and the stock solution dispensing module, the activity meter, and the label printer, and a second communication module comprising five COM ports supporting RS232 protocol and a Wifi to RS232 module.
4. An automatic nuclide subpackaging device as defined in claim 1 wherein the stock solution subpackaging module comprises a second processor module, a steering engine module, an electric cylinder module, a bubble sensor, a second power module, a third communication module and a subpackaging pipeline module; the second processor module is respectively connected with the steering engine module, the electric cylinder module and the bubble sensor, the third communication module is used for communication between the second processor module and the steering engine module, the electric cylinder module and the information switching module, the second power module supplies power for the whole stock solution subpackaging module, and the subpackaging pipeline module is connected with the electric cylinder module, the steering engine module and the bubble sensor.
5. The automated nuclide dispensing device of claim 4, wherein the dispensing line module comprises a threaded injection syringe, an injection syringe connection hose, a hard tube, a sterilization filter, a 10ml threaded dispensing syringe, a normal saline bottle connection hose, a dispensing bottle connection hose, a stock solution bottle connection hose, a 5ml threaded stock solution syringe, 5 three-way valves; the three-way valve is characterized in that according to the sequence from left to right, a left port of a three-way valve I is connected with a threaded port injection needle cylinder through an injection needle cylinder connecting hose, an upper port of the three-way valve I is connected with a threaded port split charging needle cylinder, and a right port of the three-way valve I is connected with a left port of a three-way valve II through a hard pipe; the upper port of the three-way valve II is connected with the sterilization filter, and the right port of the three-way valve II is connected with the left port of the three-way valve III through a hard pipe; the upper port of the three-way valve III is connected with the physiological saline bottle through a physiological saline bottle connecting hose, and the right port of the three-way valve III is connected with the left port of the three-way valve IV through a hard pipe; the upper port of the three-way valve IV is connected with the split charging bottle through a split charging bottle connecting hose, wherein one end of the connecting hose is a needle head, and the lower port of the three-way valve IV is connected with the upper port of the three-way valve V through a hard pipe; the right port of the three-way valve V is connected with the stock solution bottle through a stock solution bottle connecting hose, one end of the connecting hose is a needle head, and the lower port of the three-way valve V is connected with a threaded port stock solution needle cylinder; the distance between each three-way valve was 36 mm.
6. The automated nuclide racking device of claim 4, wherein the racking line module is connected to the electric cylinder module, the steering engine module, and the bubble sensor and specifically comprises: the electric cylinder of the split charging needle cylinder is fixed on the left side inside the stock solution split charging module, a push rod I is connected above the electric cylinder of the split charging needle cylinder, the push rod I can extend out of the stock solution split charging module upwards, the upper side of the push rod I is connected with a transversely outward push rod II, the other side of the push rod II is provided with a groove, the top of a push handle of the needle cylinder can be placed below the groove, and a rotating nut is arranged above the groove and can fix the push handle of the needle cylinder; the electric cylinder of the stock solution syringe fixes the right side edge inside the stock solution subpackaging module, a push rod III is connected below the electric cylinder of the stock solution syringe, the push rod III is connected with a transversely outward push rod IV which can extend out of the stock solution subpackaging module, and the other side of the push rod IV is the same as the other side of the push rod II; the five steering engines are respectively connected with grooves of the three-way valve, and the grooves are used for placing the three-way valve of the split charging pipeline; the outer left side and the outer right side of the stock solution subpackaging module are respectively provided with a square handle with a hollow middle part, and the edge of the handle is oval, so that the stock solution subpackaging module is convenient to carry; a bubble sensor is fixed below the outer front side of the stock solution subpackaging module, a groove of the bubble sensor can be embedded into an injection syringe connecting hose of a subpackaging pipeline, two hooks with short distance facing outwards are arranged below the bubble sensor, and a subpackaging syringe is erected between the two hooks; the fixing device for the split charging pipeline is a fixing rod capable of rotating, the fixing rod is elastic, and the fixing device is mainly used for rotating to the split charging pipeline to fix the split charging pipeline.
7. A method of using an automated nuclide dispensing apparatus as claimed in any one of claims 1 to 6 comprising the steps of:
1) preparing for subpackaging: checking whether the stock solution split charging module and the activity meter are connected or not;
2) inputting the type of the split nuclide;
3) and (3) measuring the activity of the stock solution: the method comprises two modes of directly inputting and measuring the activity of stock solution;
4) positioning an original point: moving an electric cylinder and a steering engine of the stock solution subpackaging module to default positions;
5) installing a split charging pipeline;
6) and (3) measuring the concentration of the stock solution: the method comprises two modes of directly inputting and measuring the radioactive concentration of the stock solution;
7) installing an injection syringe or a medicine bottle;
8) set up the partial shipment parameter, the partial shipment parameter mainly includes the partial shipment foundation, fills salt solution, partial shipment classification, serial number, patient age and weight, stoste activity degree, stoste volume, total sum and injection time's input, and the user can calculate the nuclide activity degree of actual partial shipment according to the injection time of input, and the nuclide activity degree that the patient needs the injection after the effectual partial shipment parameter of input, calculates according to being: any nuclide substantially satisfies N ═ N0e-λtThe law of radioactive decay of (1), wherein N0Is the original radioactivity, N is the radioactivity after t time, and lambda is the decay constant; firstly, calculating the decay constant lambda of each nuclide according to the half-life period of each nuclide, and finally calculating
Figure FDA0003363935700000031
9) Starting to split charging;
10) and (3) subpackaging is completed: it is determined whether to continue dispensing and printing labels.
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CN113104265B (en) * 2021-04-16 2022-09-16 何蔚梁 Intelligent food material subpackaging device, method and system
CN113926023A (en) * 2021-08-30 2022-01-14 上海盛榕医疗器械科技有限公司 Integrated full-automatic nuclide split charging injection device and method
CN115108063A (en) * 2022-04-15 2022-09-27 广西盈赛数字科技有限公司 Device for automatically subpackaging nuclide by using mechanical arm and subpackaging method thereof
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CN2905751Y (en) * 2006-01-09 2007-05-30 罗珂 Automatic split-packing instrument for radioactive nuclide liquor
CN100579890C (en) * 2007-08-16 2010-01-13 山东省立医院 Automatic dilution split charging instrument of radionuclide liquid medicine and dilution split charging method thereof
FR2937618B1 (en) * 2008-10-23 2010-12-24 Commissariat Energie Atomique STERILE DEVICE FOR SINGLE USE IN THE PREPARATION OF A RADIOPHARMACEUTICAL DRUG, SYSTEM AND METHOD USING THE SAME
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