CN111936144B - Jak抑制剂 - Google Patents

Jak抑制剂 Download PDF

Info

Publication number
CN111936144B
CN111936144B CN201980020463.5A CN201980020463A CN111936144B CN 111936144 B CN111936144 B CN 111936144B CN 201980020463 A CN201980020463 A CN 201980020463A CN 111936144 B CN111936144 B CN 111936144B
Authority
CN
China
Prior art keywords
methyl
pyrrolo
pyrimidin
amino
azaspiro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980020463.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN111936144A (zh
Inventor
廖细斌
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiaxing Baimei Jihua Pharmaceutical Technology Co ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CN111936144A publication Critical patent/CN111936144A/zh
Application granted granted Critical
Publication of CN111936144B publication Critical patent/CN111936144B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980020463.5A 2018-03-21 2019-03-18 Jak抑制剂 Active CN111936144B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862646167P 2018-03-21 2018-03-21
US62/646,167 2018-03-21
PCT/US2019/022657 WO2019182924A1 (en) 2018-03-21 2019-03-18 Jak inhibitors

Publications (2)

Publication Number Publication Date
CN111936144A CN111936144A (zh) 2020-11-13
CN111936144B true CN111936144B (zh) 2023-12-22

Family

ID=67986579

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980020463.5A Active CN111936144B (zh) 2018-03-21 2019-03-18 Jak抑制剂

Country Status (7)

Country Link
US (1) US11365188B2 (https=)
EP (1) EP3768272B1 (https=)
JP (1) JP7462951B2 (https=)
CN (1) CN111936144B (https=)
AU (1) AU2019237991B2 (https=)
CA (1) CA3093706A1 (https=)
WO (1) WO2019182924A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX388576B (es) 2016-06-07 2025-03-20 Jacobio Pharmaceuticals Co Ltd Derivados heterociclicos novedosos utiles como inhibidores de shp2.
EA202190196A1 (ru) 2017-03-23 2021-08-31 Джакобио Фармасьютикалс Ко., Лтд. Новые гетероциклические производные, применимые в качестве ингибиторов shp2
US20210393623A1 (en) 2018-09-26 2021-12-23 Jacobio Pharmaceuticals Co., Ltd. Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
BR112021008742A2 (pt) * 2018-11-05 2021-08-10 Avista Pharma Solutions, Inc. compostos químicos
CN113498352A (zh) 2019-01-23 2021-10-12 施万生物制药研发Ip有限责任公司 作为jak抑制剂的咪唑并[1,5-a]吡啶、1,2,4-三唑并[4,3-a]吡啶和咪唑并[1,5-a]吡嗪
MX2021008984A (es) 2019-01-30 2021-09-08 Felicamed Biotechnology Co Ltd Inhibidor jak y metodo de preparacion del mismo.
WO2022117075A1 (zh) * 2020-12-04 2022-06-09 广州费米子科技有限责任公司 氮杂并环化合物、其制备方法及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2796460T (pt) 2011-12-21 2018-11-05 Shanghai hengrui pharmaceutical co ltd Derivado pirrole de anel heteroarilo de seis membros, método de preparação do mesmo e suas utilizações médicas
SI3077395T1 (en) * 2013-12-05 2018-03-30 Pfizer Inc. Pyrrolo(2,3-d)pyrimidinyl, pyrrolo(2,3-b)pyrazinyl and pyrrolo(2,3-d)pyridinyl acrylamides
WO2015131080A1 (en) * 2014-02-28 2015-09-03 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
WO2016024185A1 (en) * 2014-08-12 2016-02-18 Pfizer Inc. Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase
EA036122B1 (ru) * 2015-01-20 2020-09-30 Уси Форчун Фармасьютикал Ко., Лтд Ингибитор jak
WO2018169700A1 (en) * 2017-03-14 2018-09-20 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compounds and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Design, synthesis and evaluation of (R)-3-(7-(methylIJ7H-pyrroloij2,3-d]pyrimidin-4-yl)amino)-5-azaspiroij2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor;Chieyeon Chough等;《MedChemComm》(第undefined期);第477-489页 *

Also Published As

Publication number Publication date
AU2019237991B2 (en) 2025-01-02
EP3768272A1 (en) 2021-01-27
EP3768272A4 (en) 2021-08-11
US11365188B2 (en) 2022-06-21
EP3768272B1 (en) 2025-07-30
JP7462951B2 (ja) 2024-04-08
AU2019237991A1 (en) 2020-10-15
JP2021518379A (ja) 2021-08-02
CA3093706A1 (en) 2019-09-26
CN111936144A (zh) 2020-11-13
US20210053943A1 (en) 2021-02-25
WO2019182924A1 (en) 2019-09-26

Similar Documents

Publication Publication Date Title
CN111936144B (zh) Jak抑制剂
KR102429419B1 (ko) Rho-키나아제 억제제로서 티로신 아마이드 유도체
CN110062758B (zh) 作为rho-激酶抑制剂的二环二氢嘧啶-甲酰胺衍生物
KR101792837B1 (ko) 키나아제 억제제로서 사용을 위한 이미다조피라진
CN104918945B (zh) 作为jak抑制剂的三环稠合噻吩衍生物
CN101983199B (zh) 1-杂环基-1，5-二氢-吡唑并[3，4-d]嘧啶-4-酮衍生物及其作为pde9a调节剂的用途
CN104884458B (zh) 作为蛋白质激酶抑制剂的稠合杂环化合物
RS53167B (sr) Derivati 1-heterociklil-1,5-dihidro-pirazolo[3,4-d]pirimidin-4-ona i njihova primena u vidu pde9a modulatora
CN101647802A (zh) 具有PDE-5抑制活性的5,7-二氨基吡唑并[4,3-d]嘧啶及其组合物
JP2020506899A (ja) Ｍａｇｌ阻害薬としての１，１，１−トリフルオロ−３−ヒドロキシプロパン−２−イルカルバマート誘導体
CN104837844B (zh) 作为酪蛋白激酶1 d/e抑制剂的吡唑取代的咪唑并哌嗪
CN114805361B (zh) 一类氨基取代的芳香杂环并吡唑类化合物、制备方法和用途
TWI222449B (en) Triazolo-pyridazine derivatives as ligands for GABA receptors
WO2016192630A1 (zh) 一类具有激酶抑制活性的化合物、制备方法和用途
CN116888126B (zh) 一种酪蛋白激酶抑制剂的化合物
CN113429427A (zh) 杂环化合物及其制备方法和药物用途
CN111808077B (zh) 哌嗪酰胺衍生物，其制备方法及其在医药上的用途
CN116693538A (zh) 一种吡唑并嘧啶类衍生物、其制备方法及用途
CN115703783A (zh) 吡咯并嘧啶类衍生物及其制备方法和用途
HK40077297B (zh) 氮杂-喹啉化合物及其用途
HK40010452A (en) Bicyclic dihydropyrimidine-carboxamide derivatives as rho-kinase inhibitors
HK1156606A (en) Pyrazolopyrimidines and their use for the treatment of cns disorders

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20251020

Address after: 314000 Zhejiang Province Jiaxing City Jiashan County Minhu Street Qiantang River Road 168 Building 17

Patentee after: Jiaxing Baimei Jihua Pharmaceutical Technology Co.,Ltd.

Country or region after: China

Address before: 101 Sherman Avenue, Edison, NJ, USA

Patentee before: Liao Xibin

Country or region before: U.S.A.