CN111936144B - Jak抑制剂 - Google Patents
Jak抑制剂 Download PDFInfo
- Publication number
- CN111936144B CN111936144B CN201980020463.5A CN201980020463A CN111936144B CN 111936144 B CN111936144 B CN 111936144B CN 201980020463 A CN201980020463 A CN 201980020463A CN 111936144 B CN111936144 B CN 111936144B
- Authority
- CN
- China
- Prior art keywords
- methyl
- pyrrolo
- pyrimidin
- amino
- azaspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862646167P | 2018-03-21 | 2018-03-21 | |
| US62/646,167 | 2018-03-21 | ||
| PCT/US2019/022657 WO2019182924A1 (en) | 2018-03-21 | 2019-03-18 | Jak inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111936144A CN111936144A (zh) | 2020-11-13 |
| CN111936144B true CN111936144B (zh) | 2023-12-22 |
Family
ID=67986579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980020463.5A Active CN111936144B (zh) | 2018-03-21 | 2019-03-18 | Jak抑制剂 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11365188B2 (https=) |
| EP (1) | EP3768272B1 (https=) |
| JP (1) | JP7462951B2 (https=) |
| CN (1) | CN111936144B (https=) |
| AU (1) | AU2019237991B2 (https=) |
| CA (1) | CA3093706A1 (https=) |
| WO (1) | WO2019182924A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA202092441A1 (ru) | 2016-06-07 | 2021-05-21 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| KR20240026521A (ko) | 2017-03-23 | 2024-02-28 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| CN112839935A (zh) | 2018-09-26 | 2021-05-25 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| JP2022506682A (ja) * | 2018-11-05 | 2022-01-17 | アビスタ ファーマ ソリューションズ，インコーポレーテッド | 化合物 |
| CA3125039A1 (en) | 2019-01-23 | 2020-07-30 | Theravance Biopharma R&D Ip, Llc | Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors |
| WO2020155931A1 (zh) | 2019-01-30 | 2020-08-06 | 格格巫（珠海）生物科技有限公司 | 一种jak抑制剂及其制备方法 |
| WO2022117075A1 (zh) * | 2020-12-04 | 2022-06-09 | 广州费米子科技有限责任公司 | 氮杂并环化合物、其制备方法及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102032934B1 (ko) * | 2011-12-21 | 2019-10-16 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 피롤 6원 헤테로아릴 고리 유도체, 그의 제조 방법, 및 그의 의약 용도 |
| MX368464B (es) | 2013-12-05 | 2019-10-02 | Pfizer | Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinil o y pirrolo[2,3-d]piridinilo. |
| WO2015131080A1 (en) | 2014-02-28 | 2015-09-03 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| EP3180344B1 (en) * | 2014-08-12 | 2019-09-18 | Pfizer Inc | Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase |
| EP3248980B1 (en) | 2015-01-20 | 2023-09-06 | Wuxi Fortune Pharmaceutical Co., Ltd | Jak inhibitor |
| WO2018169700A1 (en) | 2017-03-14 | 2018-09-20 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
-
2019
- 2019-03-18 JP JP2020550114A patent/JP7462951B2/ja active Active
- 2019-03-18 CA CA3093706A patent/CA3093706A1/en active Pending
- 2019-03-18 US US16/979,455 patent/US11365188B2/en active Active
- 2019-03-18 AU AU2019237991A patent/AU2019237991B2/en active Active
- 2019-03-18 WO PCT/US2019/022657 patent/WO2019182924A1/en not_active Ceased
- 2019-03-18 EP EP19770607.0A patent/EP3768272B1/en active Active
- 2019-03-18 CN CN201980020463.5A patent/CN111936144B/zh active Active
Non-Patent Citations (1)
| Title |
|---|
| Design, synthesis and evaluation of (R)-3-(7-(methylIJ7H-pyrroloij2,3-d]pyrimidin-4-yl)amino)-5-azaspiroij2.4]heptan-5-yl)-3-oxopropanenitrile as a JAK1-selective inhibitor;Chieyeon Chough等;《MedChemComm》(第undefined期);第477-489页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3093706A1 (en) | 2019-09-26 |
| CN111936144A (zh) | 2020-11-13 |
| WO2019182924A1 (en) | 2019-09-26 |
| EP3768272A4 (en) | 2021-08-11 |
| US20210053943A1 (en) | 2021-02-25 |
| EP3768272B1 (en) | 2025-07-30 |
| EP3768272A1 (en) | 2021-01-27 |
| JP7462951B2 (ja) | 2024-04-08 |
| AU2019237991B2 (en) | 2025-01-02 |
| JP2021518379A (ja) | 2021-08-02 |
| AU2019237991A1 (en) | 2020-10-15 |
| US11365188B2 (en) | 2022-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20251020 Address after: 314000 Zhejiang Province Jiaxing City Jiashan County Minhu Street Qiantang River Road 168 Building 17 Patentee after: Jiaxing Baimei Jihua Pharmaceutical Technology Co.,Ltd. Country or region after: China Address before: 101 Sherman Avenue, Edison, NJ, USA Patentee before: Liao Xibin Country or region before: U.S.A. |