CN111921405A - Preparation equipment and preparation process of western medicine composition for treating diabetes - Google Patents

Preparation equipment and preparation process of western medicine composition for treating diabetes Download PDF

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Publication number
CN111921405A
CN111921405A CN202010410517.3A CN202010410517A CN111921405A CN 111921405 A CN111921405 A CN 111921405A CN 202010410517 A CN202010410517 A CN 202010410517A CN 111921405 A CN111921405 A CN 111921405A
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fixedly connected
rod
driving
strip
medicine composition
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Chinese (zh)
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侯西成
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/70—Pre-treatment of the materials to be mixed
    • B01F23/713—Sieving materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/75455—Discharge mechanisms characterised by the means for discharging the components from the mixer using a rotary discharge means, e.g. a screw beneath the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F35/93—Heating or cooling systems arranged inside the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F2035/99—Heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions

Abstract

The invention discloses a preparation device and a preparation process of a western medicine composition for treating diabetes, and the preparation device comprises a screen machine base and a reaction kettle, wherein the upper end of the screen machine base is provided with a plurality of strip-shaped openings, the insides of the strip-shaped openings are elastically connected with a driving mechanism for providing power through first springs, the driving mechanism comprises a driving rod which is in sliding connection with the inner walls of the strip-shaped openings through the first springs, the inner bottom of the driving rod is fixedly connected with a driving motor, the tail end of an output shaft of the driving motor is fixedly connected with a rotary table, the inside of the rotary table is fixedly connected with a fixed shaft, and the outer edge of the fixed shaft is rotatably connected. The invention has reasonable structure, and the raw materials are mixed by using the screen at the initial stage of material taking, and the elastic mechanism is added at the stirring blade during mixing and stirring, so that the mixing degree is higher, the material consumption is more accurate, and the effect is better.

Description

Preparation equipment and preparation process of western medicine composition for treating diabetes
Technical Field
The invention relates to the technical field of diabetes treatment, in particular to equipment and a process for preparing a western medicine composition for treating diabetes.
Background
Diabetes is a syndrome of disturbances of carbohydrate, protein, and fat metabolism due to insulin deficiency in the body or failure of insulin to exert normal physiological effects on target cells. Diabetes is primarily characterized by long-term hyperglycemia. Diabetes can damage multiple systems throughout the body, with the major damage being to the cardiovascular system. Chronic disease can cause chronic progressive lesions of tissues such as eyes, kidneys, nerves, heart, blood vessels and the like, and cause functional defects and failure. Diabetes is mainly caused by environmental factors and genetic factors, is a lifelong disease, and can be controlled by selecting correct medicines although the diabetes cannot be completely cured, so that the patients live over the lives of normal people. However, the existing equipment and process for preparing the western medicine composition for treating diabetes have some problems, such as;
1. the existing western medicine composition preparation equipment for treating diabetes and the preparation process thereof cannot well mix the raw materials at the initial stage of material taking, thereby influencing the curative effect of the pharmaceutical finished product;
2. the existing equipment and process for preparing the western medicine composition for treating diabetes cannot collect raw materials well in the later stage of pharmacy, and further influence the cleanliness of finished pharmacy products.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides equipment and a process for preparing a western medicine composition for treating diabetes.
The invention provides a preparation device of a western medicine composition for treating diabetes, which comprises a screen machine base and a reaction kettle, wherein the upper end of the screen machine base is provided with a plurality of strip-shaped openings, the insides of the strip-shaped openings are elastically connected with a driving mechanism for providing power through a first spring, the driving mechanism comprises a driving rod which is slidably connected with the inner walls of the strip-shaped openings through the first spring, the inner bottom of the driving rod is fixedly connected with a driving motor, the tail end of an output shaft of the driving motor is fixedly connected with a rotary disc, the inside of the rotary disc is fixedly connected with a fixed shaft, the outer edge of the fixed shaft is rotatably connected with a rotary rod, the other end of the rotary rod is rotatably connected with another fixed shaft, the rear end of the other fixed shaft is fixedly connected with a driven rod, the upper end of the driven rod is fixedly, the lower extreme of motor rotates and is connected with the rabbling mechanism that is used for stirring the mixture, reation kettle's middle part fixedly connected with heating plate, the inside of heating plate is equipped with the slide mechanism who is used for separating the material.
Preferably, a fixed shaft is fixedly connected to the middle of the strip-shaped opening, a first spring is elastically connected between the side wall of the strip-shaped opening and the driving rod, between the driving rod and the fixed shaft, between the fixed shaft and the driven rod, and a second spring is elastically connected between the driven rod and the other side wall of the strip-shaped opening.
Preferably, the stirring mechanism comprises a rotating shaft fixedly connected with the tail end of an output shaft of the motor, a fixed block is fixedly connected to the outer edge of the middle of the rotating shaft, two symmetrically arranged second fixed rods are fixedly connected to the outer edge of the fixed block, the second fixed rods are elastically connected with the sliding rods through springs in inner circular cavities of the second fixed rods, a stirring rod is fixedly connected to the front end of each sliding rod, a first permanent magnet is fixedly connected to the front end of each stirring rod, and two second permanent magnets which are mutually exclusive with the first permanent magnet are fixedly connected to the inner wall of the reaction kettle.
Preferably, slide mechanism is including setting up in the inside bar chamber of heating plate, the inside rotation in bar chamber is connected with the threaded rod, the inner wall sliding connection in bar chamber has the slide, slide and threaded rod threaded connection, the front end of slide passes through the guide arm and links to each other with the card strip, the inside of heating plate is equipped with the opening unanimous with card strip shape.
The invention also provides a preparation process of the western medicine composition for treating diabetes, which comprises the following steps:
s1, taking materials: weighing 200-300g of microcrystalline cellulose, 200-300g of low-substituted hydroxypropyl cellulose, 200-300g of starch, sieving the starch with a 60-80 mesh sieve, collecting the starch with the sieve at a tray, and uniformly mixing, and collecting 50-60g of each of the main medicaments of mepyrad, dimethoate and pyridine with the sieve at the tray, sieving the mixture with the 60-80 mesh sieve, and uniformly mixing the mixture with the materials;
s2, mixing: adding 1.5-2L/5% PVP 95% ethanol solution into the reaction kettle, adding the mixed material in S1 into the reaction kettle, and starting a motor to stir the mixed solution for 10-15min to uniformly mix the mixed solution;
s3, drying: opening a flow guide port, introducing the mixed liquid prepared in the step S2 into the lower-layer cavity, and then opening a heating lamp to dry the inflowing mixed liquid;
s4, collecting: rotating the threaded rod to enable the clamping strip to move backwards under the driving of the sliding plate, and then moving the roller downwards to enable the dried material to be conveyed to the spiral feeder through the opening in the heating plate and to be conveyed out of the reaction kettle;
s5, tabletting: and (3) repeatedly and uniformly mixing the material collected in the step (S4) with 500-800g of sodium carboxymethyl starch and magnesium stearate which pass through a 60-mesh screen, and then sending the mixture to a tablet machine to be pressed into tablets.
Preferably, a temperature control switch is arranged inside the heating lamp, the drying temperature is maintained at 45 ℃, and the drying time is 3-4 h.
According to the invention, the raw materials are mixed by using the screen at the material taking initial stage, and the elastic mechanism is added at the stirring blade during mixing and stirring, so that the mixing degree is higher, the material consumption is more accurate, and the effect is better; through set up the cylinder in reation kettle bottom to can be automatic send the material after the drying to screw feeder and see off reation kettle through heating plate department opening, reduced artificial operation, increased the cleanliness factor of medicine.
Drawings
FIG. 1 is a schematic structural diagram of a screen machine of an apparatus for preparing a western medicine composition for treating diabetes according to the present invention;
FIG. 2 is a sectional view of a screen machine of an apparatus for preparing a western medicinal composition for treating diabetes according to the present invention;
FIG. 3 is a schematic view of a reaction kettle of the apparatus for preparing a western medicine composition for treating diabetes according to the present invention;
FIG. 4 is a schematic structural diagram of a stirring mechanism of the apparatus for preparing a western medicine composition for treating diabetes according to the present invention;
FIG. 5 is a sectional view of a heating plate of the apparatus for preparing a pharmaceutical composition for treating diabetes according to the present invention.
In the figure: 1 screen cloth machine base, 2 driving levers, 3 turntables, 4 bull sticks, 5 driven levers, 6 trays, 7 screen cloths, 8 first fixed levers, 9 bar mouths, 10 first springs, 11 reation kettle, 12 motors, 13 fixed blocks, 14 second fixed levers, 15 slide bars, 16 first permanent magnets, 17 second permanent magnets, 18 fixed discs, 19 diversion mouths, 20 heating lamps, 21 rotating shafts, 22 rollers, 23 screw feeders, 24 heating discs, 25 bar-shaped cavities, 26 threaded rods, 27 sliding plates, 28 clamping bars.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Example 1:
the invention provides a preparation device of a western medicine composition for treating diabetes, which comprises a screen machine base 1 and a reaction kettle 11, wherein the upper end of the screen machine base 1 is provided with a plurality of strip-shaped ports 9, the insides of the strip-shaped ports 9 are elastically connected with a driving mechanism for providing power through first springs 10, the driving mechanism comprises a driving rod 2 which is connected with the inner walls of the strip-shaped ports 9 in a sliding manner through the first springs 10, the inner bottom of the driving rod 2 is fixedly connected with a driving motor, the tail end of an output shaft of the driving motor is fixedly connected with a rotary disc 3, the inside of the rotary disc 3 is fixedly connected with a fixed shaft, the outer edge of the fixed shaft is rotatably connected with a rotary rod 4, the other end of the rotary rod 4 is rotatably connected with another fixed shaft, the rear end of the another fixed shaft is fixedly connected with a driven rod 5, the upper end of the driven rod 5 is fixedly connected with a, the middle part of reaction kettle 11 is fixedly connected with heating plate 24, and the inside of heating plate 24 is equipped with the slide mechanism who is used for separating the material.
Specifically, a fixed shaft is fixedly connected to the middle of the strip-shaped opening 9, and first springs 10 are elastically connected between the side wall of the strip-shaped opening 9 and the driving rod 2, between the driving rod 2 and the fixed shaft, between the fixed shaft and the driven rod 5, and between the driven rod 5 and the other side wall of the strip-shaped opening 9.
Specifically, the stirring mechanism includes a rotating shaft 21 fixedly connected with the end of the output shaft of the motor 12, a fixed block 13 is fixedly connected with the middle outer edge of the rotating shaft 21, two second fixed rods 14 symmetrically arranged are fixedly connected with the outer edge of the fixed block 13, the second fixed rods 14 are elastically connected with the sliding rods 15 through springs in inner circular cavities thereof, the stirring rod is fixedly connected with the front end of the sliding rods 15, a first permanent magnet 16 is fixedly connected with the front end of the stirring rod, and two second permanent magnets 17 repelling with the first permanent magnet 16 are fixedly connected with the inner wall of the reaction kettle 11.
Specifically, slide mechanism is including setting up in the inside bar chamber 25 of heating plate 24, and the inside rotation in bar chamber 25 is connected with threaded rod 26, and the inner wall sliding connection of bar chamber 25 has slide 27, slide 27 and threaded rod 26 threaded connection, and slide 27's front end passes through bar mouth 9 guide arm and links to each other with card strip 28, and the inside of heating plate 24 is equipped with the opening unanimous with card strip 28 shape.
The invention also provides a preparation process of the western medicine composition for treating diabetes, which comprises the following steps:
s1, taking materials: weighing 200g of microcrystalline cellulose and 200g of low-substituted hydroxypropyl cellulose, weighing 200g of starch, sieving with a 60-mesh sieve 7, collecting on a tray 6, uniformly mixing, weighing 50g of main drugs of mepyrad, dimethoate and pyribendazole, sieving with the 60-mesh sieve 7, collecting on the tray 6, and uniformly mixing with the upper materials;
s2, mixing: adding 1.5L/5% PVP 95% ethanol solution into reaction kettle 11, adding the mixed material in S1 into reaction kettle 11, and starting motor 12 to stir the mixed solution for 10min to mix the mixed solution uniformly;
s3, drying: opening the diversion port 19, introducing the mixed liquid prepared in the step S2 into the lower-layer cavity, and then opening the heating lamp 20 to dry the inflowing mixed liquid;
s4, collecting: rotating the threaded rod 26 to enable the clamping strip 28 to move backwards under the driving of the sliding plate 27, and then moving the roller 22 downwards, so that the dried material is conveyed to the spiral feeder through the opening in the heating plate 24 and is conveyed out of the reaction kettle 11;
s5, tabletting: and (3) repeatedly and uniformly mixing the material collected in the step (S4) with 500g of sodium carboxymethyl starch and magnesium stearate which pass through a 60-mesh screen 7, and then feeding the mixture to a tablet machine to be pressed into tablets.
Specifically, a temperature control switch is provided inside the heating lamp 20, and the drying temperature is maintained at 45 ℃ and is often 3 hours.
Example 2:
the invention provides a preparation device of a western medicine composition for treating diabetes, which comprises a screen machine base 1 and a reaction kettle 11, wherein the upper end of the screen machine base 1 is provided with a plurality of strip-shaped ports 9, the insides of the strip-shaped ports 9 are elastically connected with a driving mechanism for providing power through first springs 10, the driving mechanism comprises a driving rod 2 which is connected with the inner walls of the strip-shaped ports 9 in a sliding manner through the first springs 10, the inner bottom of the driving rod 2 is fixedly connected with a driving motor, the tail end of an output shaft of the driving motor is fixedly connected with a rotary disc 3, the inside of the rotary disc 3 is fixedly connected with a fixed shaft, the outer edge of the fixed shaft is rotatably connected with a rotary rod 4, the other end of the rotary rod 4 is rotatably connected with another fixed shaft, the rear end of the another fixed shaft is fixedly connected with a driven rod 5, the upper end of the driven rod 5 is fixedly connected with a, the middle part of reaction kettle 11 is fixedly connected with heating plate 24, and the inside of heating plate 24 is equipped with the slide mechanism who is used for separating the material.
Specifically, a fixed shaft is fixedly connected to the middle of the strip-shaped opening 9, and first springs 10 are elastically connected between the side wall of the strip-shaped opening 9 and the driving rod 2, between the driving rod 2 and the fixed shaft, between the fixed shaft and the driven rod 5, and between the driven rod 5 and the other side wall of the strip-shaped opening 9.
Specifically, the stirring mechanism includes a rotating shaft 21 fixedly connected with the end of the output shaft of the motor 12, a fixed block 13 is fixedly connected with the middle outer edge of the rotating shaft 21, two second fixed rods 14 symmetrically arranged are fixedly connected with the outer edge of the fixed block 13, the second fixed rods 14 are elastically connected with the sliding rods 15 through springs in inner circular cavities thereof, the stirring rod is fixedly connected with the front end of the sliding rods 15, a first permanent magnet 16 is fixedly connected with the front end of the stirring rod, and two second permanent magnets 17 repelling with the first permanent magnet 16 are fixedly connected with the inner wall of the reaction kettle 11.
Specifically, slide mechanism is including setting up in the inside bar chamber 25 of heating plate 24, and the inside rotation in bar chamber 25 is connected with threaded rod 26, and the inner wall sliding connection of bar chamber 25 has slide 27, slide 27 and threaded rod 26 threaded connection, and slide 27's front end passes through bar mouth 9 guide arm and links to each other with card strip 28, and the inside of heating plate 24 is equipped with the opening unanimous with card strip 28 shape.
The invention also provides a preparation process of the western medicine composition for treating diabetes, which comprises the following steps:
s1, taking materials: weighing 250g of microcrystalline cellulose and 250g of low-substituted hydroxypropyl cellulose, taking 250g of starch, sieving the starch with a 70-mesh sieve 7, collecting the starch on a tray 6, uniformly mixing, taking 55g of main drugs of mepyrad, dimethoate and pyribendazole, sieving the starch with the 70-mesh sieve 7, collecting the starch on the tray 6, and uniformly mixing with the upper materials;
s2, mixing: adding 1.75L/5% PVP 95% ethanol solution into reaction kettle 11, adding the mixed material in S1 into reaction kettle 11, and starting motor 12 to stir the mixed solution for 12.5min to mix the mixed solution uniformly;
s3, drying: opening the diversion port 19, introducing the mixed liquid prepared in the step S2 into the lower-layer cavity, and then opening the heating lamp 20 to dry the inflowing mixed liquid;
s4, collecting: rotating the threaded rod 26 to enable the clamping strip 28 to move backwards under the driving of the sliding plate 27, and then moving the roller 22 downwards, so that the dried material is conveyed to the spiral feeder through the opening in the heating plate 24 and is conveyed out of the reaction kettle 11;
s5, tabletting: and (3) repeatedly and uniformly mixing the material collected in the step (S4) with 650g of sodium carboxymethyl starch and magnesium stearate which pass through a 60-mesh screen 7, and then feeding the mixture to a tablet machine to be pressed into tablets.
Specifically, a temperature control switch is arranged inside the heating lamp 20, the drying temperature is maintained at 45 ℃, and the drying time is 3.5 hours.
Example 3:
the invention provides a preparation device of a western medicine composition for treating diabetes, which comprises a screen machine base 1 and a reaction kettle 11, wherein the upper end of the screen machine base 1 is provided with a plurality of strip-shaped ports 9, the insides of the strip-shaped ports 9 are elastically connected with a driving mechanism for providing power through first springs 10, the driving mechanism comprises a driving rod 2 which is connected with the inner walls of the strip-shaped ports 9 in a sliding manner through the first springs 10, the inner bottom of the driving rod 2 is fixedly connected with a driving motor, the tail end of an output shaft of the driving motor is fixedly connected with a rotary disc 3, the inside of the rotary disc 3 is fixedly connected with a fixed shaft, the outer edge of the fixed shaft is rotatably connected with a rotary rod 4, the other end of the rotary rod 4 is rotatably connected with another fixed shaft, the rear end of the another fixed shaft is fixedly connected with a driven rod 5, the upper end of the driven rod 5 is fixedly connected with a, the middle part of reaction kettle 11 is fixedly connected with heating plate 24, and the inside of heating plate 24 is equipped with the slide mechanism who is used for separating the material.
Specifically, a fixed shaft is fixedly connected to the middle of the strip-shaped opening 9, and first springs 10 are elastically connected between the side wall of the strip-shaped opening 9 and the driving rod 2, between the driving rod 2 and the fixed shaft, between the fixed shaft and the driven rod 5, and between the driven rod 5 and the other side wall of the strip-shaped opening 9.
Specifically, the stirring mechanism includes a rotating shaft 21 fixedly connected with the end of the output shaft of the motor 12, a fixed block 13 is fixedly connected with the middle outer edge of the rotating shaft 21, two second fixed rods 14 symmetrically arranged are fixedly connected with the outer edge of the fixed block 13, the second fixed rods 14 are elastically connected with the sliding rods 15 through springs in inner circular cavities thereof, the stirring rod is fixedly connected with the front end of the sliding rods 15, a first permanent magnet 16 is fixedly connected with the front end of the stirring rod, and two second permanent magnets 17 repelling with the first permanent magnet 16 are fixedly connected with the inner wall of the reaction kettle 11.
Specifically, slide mechanism is including setting up in the inside bar chamber 25 of heating plate 24, and the inside rotation in bar chamber 25 is connected with threaded rod 26, and the inner wall sliding connection of bar chamber 25 has slide 27, slide 27 and threaded rod 26 threaded connection, and slide 27's front end passes through bar mouth 9 guide arm and links to each other with card strip 28, and the inside of heating plate 24 is equipped with the opening unanimous with card strip 28 shape.
The invention also provides a preparation process of the western medicine composition for treating diabetes, which comprises the following steps:
s1, taking materials: weighing 300g of microcrystalline cellulose and 300g of low-substituted hydroxypropyl cellulose, weighing 300g of starch, sieving the starch with an 80-mesh sieve 7, collecting the starch on a tray 6, uniformly mixing, weighing 60g of main drugs of mepyrad, dimethoate and pyribendazole, sieving the starch with the 80-mesh sieve 7, collecting the starch on the tray 6, and uniformly mixing with the upper materials;
s2, mixing: adding 2L/5% PVP 95% ethanol solution into the reaction kettle 11, adding the mixed material in S1 into the reaction kettle 11, and then starting the motor 12 to stir the mixed solution for 15min to uniformly mix the mixed solution;
s3, drying: opening the diversion port 19, introducing the mixed liquid prepared in the step S2 into the lower-layer cavity, and then opening the heating lamp 20 to dry the inflowing mixed liquid;
s4, collecting: rotating the threaded rod 26 to enable the clamping strip 28 to move backwards under the driving of the sliding plate 27, and then moving the roller 22 downwards, so that the dried material is conveyed to the spiral feeder through the opening in the heating plate 24 and is conveyed out of the reaction kettle 11;
s5, tabletting: and (3) repeatedly and uniformly mixing the material collected in the step (S4) with 800g of sodium carboxymethyl starch and magnesium stearate which pass through a 60-mesh screen 7, and then feeding the mixture to a tablet machine to be pressed into tablets.
Specifically, a temperature control switch is provided inside the heating lamp 20, and the drying temperature is maintained at 45 ℃ for 4 hours.
In the invention, only a screen machine base 1 is horizontally placed at a proper position, then 300g of microcrystalline cellulose 200-, the medicine and the solution are mixed more uniformly, the diversion port 19 is opened after the mixture is stirred for 10-15min, the stirred mixture is introduced into the lower cavity, then the heating lamp 20 is turned on, the flowing mixture is dried for 3-4h, the threaded rod 26 is rotated to drive the clamping strip 28 at the front end of the sliding plate 27 to move backwards, the roller 22 moves downwards, the dried medicine mixture is sent into the spiral feeder 23 below the heating plate 24 along the opening inside the heating plate 24 and is sent out of the reaction kettle 11, the collected material and 500 plus 800g of sodium carboxymethyl starch and magnesium stearate which pass through the 60-mesh screen 7 are repeatedly mixed uniformly and then are sent to the tablet press to be in a tablet shape.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (6)

1. Western medicine composition preparation equipment for treating diabetes is characterized by comprising a screen machine base (1) and a reaction kettle (11), wherein a plurality of strip-shaped openings (9) are formed in the upper end of the screen machine base (1), a driving mechanism used for providing power is elastically connected to the insides of the strip-shaped openings (9) through first springs (10), the driving mechanism comprises a driving rod (2) which is slidably connected with the inner wall of each strip-shaped opening (9) through the first springs (10), a driving motor is fixedly connected to the inner bottom of the driving rod (2), a rotary disc (3) is fixedly connected to the tail end of an output shaft of the driving motor, a fixed shaft is fixedly connected to the inside of the rotary disc (3), a rotary rod (4) is rotatably connected to the outer edge of the fixed shaft, another fixed shaft is rotatably connected to the other end of the rotary rod (4), and a driven rod (5) is fixedly connected to the rear end, the utility model discloses a material separation device, including reation kettle (11), the first dead lever of upper end fixedly connected with (8) of driven lever (5), the top fixedly connected with motor (12) of reation kettle (11), the lower extreme of motor (12) rotates and is connected with the rabbling mechanism that is used for stirring the mixture, the middle part fixedly connected with heating plate (24) of reation kettle (11), the inside of heating plate (24) is equipped with the slide mechanism who is used for separating the material.
2. The apparatus for preparing a western medicine composition for the treatment of diabetes according to claim 1, wherein a fixed shaft is fixedly connected to the middle of the bar-shaped opening (9), a first spring (10) is elastically connected between the side wall of the bar-shaped opening (9) and the driving lever (2), between the driving lever (2) and the fixed shaft, between the fixed shaft and the driven lever (5), and another side wall of the driven lever (5) and the bar-shaped opening (9).
3. The equipment for preparing the western medicine composition for treating diabetes mellitus according to claim 1, wherein the stirring mechanism comprises a rotating shaft (21) fixedly connected with the tail end of an output shaft of the motor (12), a fixed block (13) is fixedly connected to the outer edge of the middle of the rotating shaft (21), two symmetrically arranged second fixed rods (14) are fixedly connected to the outer edge of the fixed block (13), the second fixed rods (14) are elastically connected with the sliding rods (15) through springs in inner circular cavities of the second fixed rods, a stirring rod is fixedly connected to the front ends of the sliding rods (15), a first permanent magnet (16) is fixedly connected to the front ends of the stirring rods, and two second permanent magnets (17) repelling from the first permanent magnet (16) are fixedly connected to the inner wall of the reaction kettle (11).
4. The western medicine composition preparation device for treating diabetes according to claim 1, wherein the sliding mechanism comprises a bar-shaped cavity (25) arranged inside the heating plate (24), a threaded rod (26) is rotatably connected inside the bar-shaped cavity (25), a sliding plate (27) is slidably connected to the inner wall of the bar-shaped cavity (25), the sliding plate (27) is in threaded connection with the threaded rod (26), the front end of the sliding plate (27) is connected with the clamping strip (28) through a bar-shaped opening (9) guide rod, and an opening with the same shape as the clamping strip (28) is arranged inside the heating plate (24).
5. The preparation process of the western medicine composition for treating diabetes is characterized by comprising the following steps:
s1, taking materials: weighing 200-300g of microcrystalline cellulose, 200-300g of low-substituted hydroxypropyl cellulose, 200-300g of starch, passing through a 60-80 mesh screen (7), collecting the starch, uniformly mixing the starch, the 60-80 mesh screen (7), collecting 50-60g of each of mepyram, dimethoate and pyridine, passing through the 60-80 mesh screen (7), collecting the starch, the dipyridamole and the pyridine, and uniformly mixing the starch, the dipyridamole and the pyridine with the materials;
s2, mixing: adding 1.5-2L/5% PVP 95% ethanol solution into the reaction kettle (11), adding the mixed material in S1 into the reaction kettle (11), and starting the motor (12) to stir the mixed solution for 10-15min to uniformly mix the mixed solution;
s3, drying: opening the diversion port (19), introducing the mixed liquid prepared in the step S2 into the lower-layer cavity, and then opening the heating lamp (20) to dry the inflowing mixed liquid;
s4, collecting: the threaded rod (26) is rotated, so that the clamping strip (28) moves backwards under the driving of the sliding plate (27), and then the roller (22) moves downwards, so that the dried material is conveyed to the spiral feeder through an opening in the heating plate (24) and is conveyed out of the reaction kettle (11);
s5, tabletting: and (3) repeatedly and uniformly mixing the material collected in the step (S4) with 500-800g of sodium carboxymethyl starch and magnesium stearate which pass through a 60-mesh screen (7), and then sending the mixture to a tablet press to be pressed into tablets.
6. The preparation process of the western medicine composition for treating diabetes mellitus according to claim 5, wherein a temperature control switch is arranged inside the heating lamp (20), the drying temperature is maintained at 45 ℃, and the drying time is 3-4 h.
CN202010410517.3A 2020-05-15 2020-05-15 Preparation equipment and preparation process of western medicine composition for treating diabetes Withdrawn CN111921405A (en)

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Publication number Priority date Publication date Assignee Title
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CN208643246U (en) * 2018-05-28 2019-03-26 射阳县和丰食品有限公司 A kind of wheat blueness vibration screening device
CN208964782U (en) * 2018-08-24 2019-06-11 北京水木益华环保科技有限公司 A kind of low temperature eddy flow turntable material desiccation machine
CN209584199U (en) * 2019-02-19 2019-11-05 包头轻工职业技术学院 High efficiency biological fermentation apparatus

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090045535A1 (en) * 2005-05-09 2009-02-19 Yousuke Miyashita Method of producing organic particles and production apparatus usable for the same
CN204583003U (en) * 2015-05-05 2015-08-26 盐城卫生职业技术学院 Servicing unit prepared by medicine
CN108543606A (en) * 2018-03-13 2018-09-18 汤琴 A kind of biological medicament grinding device
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