CN111920553B

CN111920553B - Intervertebral fusion device with protrusions

Info

Publication number: CN111920553B
Application number: CN202010768393.6A
Authority: CN
Inventors: 孙杨; 王玉珏
Original assignee: Shenzhen Corliber Scientific
Current assignee: Shenzhen Corliber Scientific
Priority date: 2018-06-12
Filing date: 2018-06-12
Publication date: 2021-09-24
Anticipated expiration: 2038-06-12
Also published as: CN108514465A; CN111920553A; CN111920552A; CN108514465B

Abstract

The present disclosure relates to the field of clinical orthopedic repair. The present disclosure provides an intervertebral cage with a protrusion, comprising: a support body having an upper surface and a lower surface, and formed with a plurality of through holes penetrating between the upper surface and the lower surface, the support body being made of a porous material forming an air-blood passage; and an artificial bone having a filling portion for filling the through hole of the support body and a protrusion portion connected to the filling portion and protruding from the through hole, wherein the filling portion has a shape matching the through hole. In this case, the protrusions can be brought into better contact with the vertebrae, resulting in good interaction force, so that the cage can be better fixed between the vertebrae, suppressing relative displacement or falling-off of the cage and the vertebrae in the lateral direction (i.e., in a direction substantially perpendicular to the lumbar vertebrae).

Description

Intervertebral fusion device with protrusions

The application is a divisional application of patent application with application date of 2018, 12/06 and application number of 2018106031834, named as intervertebral cage filled with artificial bone.

Technical Field

The disclosure relates to the field of clinical orthopedic repair, in particular to an intervertebral fusion cage with a protruding part.

Background

With the aggravation of aging of population and the change of life habits of people in modern cities, spine degenerative diseases represented by cervical spondylosis, cervical intervertebral disc protrusion, lumbar spinal stenosis and the like seriously affect the work and life of people. At present, conservative treatment methods such as drug therapy and physical therapy are mostly adopted when the above-mentioned disease conditions are in the early stage. However, as the patient's condition becomes more severe, more effective treatments, such as vertebroplasty, are contemplated to inhibit the patient's condition from becoming worse. For example, in case of lumbar intervertebral disc protrusion, when the intervertebral disc protrusion presses the vertebral canal beyond 1/3 or numbness, difficulty in movement, weakness of urination and defecation, etc. of the lower limbs occur, the treatment effect of the conservative treatment method is not obvious, and the patient needs to be considered to perform vertebral fusion.

In the vertebral fusion, the intervertebral disc protruded between vertebrae is removed, and then an intervertebral fusion device is implanted between the vertebrae to induce the vertebrae to be fused together, so as to achieve the purpose of eliminating the focus. In the clinical application of the vertebral fusion, because the intervertebral fusion cage is placed in a human body for a long time after the operation, the factors such as the structure, the manufacturing technology, the quality and the like of the intervertebral fusion cage play an important role in the postoperative effect of the vertebral fusion.

Patent document 1 discloses a lumbar interbody fusion cage, which is composed of a fusion cage body that penetrates vertically and a bone grafting area that is surrounded by the fusion cage body; the annular wall of the fusion cage body is densely provided with through holes in the vertical and front-back directions. In addition, patent document 2 discloses a spinal fusion cage including a support body forming an accommodation space at least partially including: a pore-like structure.

However, in the intervertebral cage disclosed in the above patent documents 1 and 2, the cage is directly placed between the vertebrae, and for example, during movement of the patient, there is a possibility that relative slippage between the vertebrae and the cage in the lateral direction (i.e., in a direction substantially perpendicular to the lumbar), causing displacement or falling-off of the cage from the vertebrae.

Documents of the prior art

Patent document 1: chinese patent application publication No. CN107625564A

Patent document 2: chinese patent application publication No. CN 106913406A.

Disclosure of Invention

The present inventors have discovered, in studying the problems of the prior art, how to better secure an intervertebral cage between vertebrae is an area of improvement in the prior art. The present inventors have been able to fix the cage between vertebrae better through many years of clinical practice by optimizing the structure of the cage, filling the cage with a suitable artificial bone and forming the protrusions.

The present disclosure has been made in view of the above circumstances, and an object thereof is to provide an intervertebral cage that can be better fixed between vertebrae.

To this end, the present disclosure provides an intervertebral cage with a projection, characterized in that it comprises: a support body having an upper surface and a lower surface, and formed with a plurality of through holes penetrating between the upper surface and the lower surface, the support body being made of a porous material forming an air-blood passage; and an artificial bone having a filling portion for filling the through hole of the support body and a protrusion portion connected to the filling portion and protruding from the through hole, wherein the filling portion has a shape matching the through hole. In this case, the protrusions can be brought into better contact with the vertebrae, resulting in good interaction force, so that the cage can be better fixed between the vertebrae, suppressing relative displacement or falling-off of the cage and the vertebrae in the lateral direction (i.e., in a direction substantially perpendicular to the lumbar vertebrae).

In addition, in the intervertebral cage according to the present disclosure, the support body may optionally further include a side surface connecting the upper surface and the lower surface.

In addition, in the intervertebral cage according to the present disclosure, optionally, the porosity of the support body is 50% to 90%, and the pore size of the porous material is 50 μm to 500 μm. Under the condition, the structure of the interbody fusion cage can be closer to the structure of human bones, and the continuous growth of the bones is more facilitated.

In addition, in the intervertebral cage according to the present disclosure, optionally, the pore passage of the porous material may be substantially in the same direction as the direction of the qi-blood passage.

Additionally, in the intersomatic cage according to the present disclosure, optionally, the material of the support is a metallic biocompatible material including at least one of titanium, titanium-based alloy, cobalt-based alloy, nickel-chromium stainless steel, tantalum, niobium, gold, silver, palladium, and platinum. In this case, an appropriate material can be selected according to actual needs.

In addition, in the intervertebral cage according to the present disclosure, optionally, the artificial bone is fitted with the support body in an interference fit manner. In this case, it is possible to generate elastic pressure to the surface of the artificial bone in contact with the supporting body, thereby firmly coupling the artificial bone to the supporting body.

In addition, in the intervertebral cage according to the present disclosure, the protrusion may optionally include an upper protrusion protruding from the upper surface and a lower protrusion protruding from the lower surface. In this case, when the cage is placed between the vertebrae, the protrusions can be coupled with the upper and lower vertebrae, respectively, to better fix the cage between the vertebrae, preventing the cage from slipping out from between the vertebrae.

In addition, in the intervertebral cage according to the present disclosure, optionally, in the support body, the upper surface and the lower surface are respectively formed as surfaces that match the shape of vertebrae. In this case, the cage can be better inserted between and fitted to the vertebrae, providing more stable support to the vertebrae while preventing displacement or falling off between the vertebrae.

In addition, in the intervertebral cage according to the present disclosure, the protrusion may be a tip portion.

In addition, in the intervertebral cage according to the present disclosure, optionally, the surface of the support body is covered with an artificial bone material. In this case, the in vivo rejection reaction can be reduced.

According to the present invention, it is possible to provide an intervertebral cage which can be better fixed between vertebrae.

Drawings

Embodiments of the present disclosure will now be explained in further detail, by way of example only, with reference to the accompanying drawings, in which:

fig. 1 is a schematic view illustrating a state in which an intervertebral cage according to the present disclosure is placed between vertebrae.

Fig. 2 is an overall perspective view illustrating an intervertebral cage according to the present disclosure.

Fig. 3 is an exploded view illustrating a support body and an artificial bone of an intervertebral cage according to the present disclosure.

Fig. 4 is a perspective view showing the support body according to the present disclosure.

Fig. 5 is a plan view showing the support body according to the present disclosure.

Fig. 6 is a sectional perspective view showing a support body according to the present disclosure taken along a section line a-a'.

Fig. 7 is a schematic diagram illustrating a modification of the support body according to the present disclosure.

Fig. 8 is a schematic diagram illustrating an example of an artificial bone according to the present disclosure.

Fig. 9 is a schematic diagram showing a modified example 1 of the artificial bone according to the present disclosure.

Fig. 10 is a schematic diagram showing a modification 2 of the artificial bone according to the present disclosure.

Detailed Description

All references cited in this disclosure are incorporated by reference in their entirety as if fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. General guidance for many of the terms used in this application is provided to those skilled in the art. Those of skill in the art will recognize many methods and materials similar or equivalent to those described herein that can be used in the practice of the present disclosure. Indeed, the disclosure is in no way limited to the methods and materials described. Fig. 1 is a schematic view illustrating a state in which an intervertebral cage according to the present disclosure is placed between vertebrae. Fig. 2 is an overall perspective view illustrating an intervertebral cage according to the present disclosure. Fig. 3 is an exploded view illustrating a support body and an artificial bone of an intervertebral cage according to the present disclosure.

Generally, in a vertebral fusion, a lesion is removed by removing a protruded intervertebral disc between vertebrae and then implanting an intervertebral cage between the vertebrae to induce vertebral fusion growth together (see fig. 1). In the clinical application of the vertebral fusion, the fusion cage is placed in a human body for a long time after the operation, so that the fusion cage and the vertebrae can well form a fusion structure, which is the key of the success of the vertebral fusion.

The present disclosure relates to an artificial bone-filled intervertebral cage 1 (hereinafter sometimes referred to as "cage 1") that can be better secured between vertebrae. In the present embodiment, the fusion cage 1 may include a support body 10 and an artificial bone 20 (see fig. 2 and 3). In the support body 10, the artificial bone 20 is filled, and the artificial bone 20 protrudes from the support body 10 to form a protrusion 22 (described later).

In the present disclosure, as described above, since the support body 10 is formed with the plurality of through holes penetrating between the upper surface and the lower surface, the artificial bone 20 is filled in the through holes, and the artificial bone 20 protrudes from the support body 10 to form the protrusions 22, the protrusions 22 can be brought into better contact with the vertebrae 2 (see fig. 1), a good interaction force is formed, so that the fusion cage 1 can be better fixed between the vertebrae, and the relative displacement or falling off of the fusion cage 1 and the vertebrae 2 in the lateral direction (i.e., in the direction substantially perpendicular to the lumbar vertebrae) is suppressed.

In addition, in the cage 1, the artificial bone 20 may include a degradable polymer and a bone growth promoting material, thereby facilitating the degradation of the artificial bone 20 in the cage 1, promoting the growth of bone in the cage 1, and thus promoting better formation of the fusion construct between the cage 1 and the vertebra 2.

In addition, in some examples, the artificial bone 20 may also cover the surface of the support body 10. In this case, the artificial bone 20 is not only filled in the support body 10 but also covers the surface of the support body 10, thereby reducing the in vivo rejection reaction.

Fig. 4 is a perspective view showing the support body according to the present disclosure. Fig. 5 is a bottom view illustrating the support body according to the present disclosure.

In the fusion cage 1 according to the present disclosure, the support body 10 may have an upper surface 11 and a lower surface 12 which are substantially parallel (see fig. 4 and 5). In addition, the support body 10 has a side surface 13 connecting the upper surface 11 and the lower surface 12.

In some examples, the support body 10 may be a structural body having a substantially rectangular parallelepiped or square outer shape. In the case where the support body 10 is a rectangular parallelepiped or a square, the side 13 may include a side 131 and a side 133 oppositely disposed, and a side 132 and a side 134 oppositely disposed (see fig. 4).

In some examples, side 131 and side 132 may be rounded. In addition, rounded corners may be formed between the side surfaces 131 and 134. In addition, rounded corners may be formed between the side surfaces 133 and 132. In addition, rounded corners may be formed between the side surfaces 133 and 134 (see fig. 5).

In some examples, the support body 10 may be a stretched body. Here, the stretched body refers to a three-dimensional body formed by stretching one section along one line segment.

In addition, the support body 10 may be formed with a plurality of through holes 14 penetrating between the upper surface 11 and the lower surface 12. In the support body 10, the number of the through holes 14 is not particularly limited, and for example, the number of the through holes 14 may be 2, 3, 5, 10 or more. In some examples, a plurality of through holes 14 may be uniformly arranged in the support body 10 for the purpose of reducing in vivo rejection reactions.

In some examples, the axial direction of the through-hole 14 may be perpendicular to the upper surface 11 and the lower surface 12. In other examples, the axial direction of the through-hole 14 may form an angle θ with the upper surface 11 or the lower surface 12₁. In some examples, the axial direction of the through hole 14 forms an angle θ with the upper surface 11 or the lower surface 12₁And may be 0 to 90 degrees. The included angle θ is set in consideration of keeping the axial direction of the through hole 14 substantially consistent with the force-receiving direction of the support body 10₁And may be 45 to 90 degrees.

The support body 10 may be formed with a plurality of through holes penetrating the upper surface 11 and the side surfaces 13. This allows, for example, artificial bone to be filled in these through holes, thereby promoting the growth of bone in the support 10 and promoting fusion between vertebrae. The support body 10 may be formed with a plurality of through holes penetrating the lower surface 12 and the side surfaces 13. In this case, too, the growth of bone in the support body 10 can be promoted, thus promoting the fusion between the vertebrae.

In some examples, the through-holes 14 may have a regular hexagonal prism shape in the support body 10 (see fig. 6). In this case, a honeycomb structure can be formed in the support body 10, and since the honeycomb structure can reduce stress concentration, the stress distribution of the internal structure of the support body 10 is more uniform, and the strength and rigidity are higher, the material required for manufacturing the support body 10 can be greatly reduced while ensuring sufficient strength of the support body 10. In some examples, the inner diameter of the through-hole 14 may be, for example, 1mm to 5 mm. Examples of the present disclosure are not limited thereto, and the through-hole 14 may also have a cylindrical shape, a circular truncated cone shape, a truncated pyramid shape, a regular triangular prism shape, or the like.

In some examples, the support body 10 may also have a main through hole 15 passing through the upper surface 11 and the lower surface 12. The inner diameter of the main through hole 15 may be larger than the inner diameter of the through hole 14. In this case, the material of the support body 10 can be reduced, and the artificial bone material used can be increased, thereby reducing the in vivo rejection reaction. In some examples, the inner diameter of the main through hole 15 may be 2mm to 10 mm.

In some examples, the primary vias 15 may be 1, 2, 3, 5, 10, or more. The number of the main through holes 15 may be 2 in view of making the internal structure of the support body 10 compact, and as shown in fig. 6, in the support body 10, main through holes 15a and main through holes 15b are provided. In some examples, the main through holes 15a and the main through holes 15b may be symmetrically distributed in the support body 10 (see fig. 5 and 6). In some examples, the main through

holes

15a and 15b may be symmetrical about a longitudinal axis of the support body 10.

In some examples, the axial direction of the main through hole 15 may be perpendicular to the upper surface 11 and the lower surface 12. In other examples, the axial direction of the main through hole 15 may form an included angle θ with the upper surface 11 or the lower surface 12₂. In some examples, the included angle θ is considered to be substantially consistent with the axial direction of the main through hole 15 and the force direction of the support body 10₂And may be 45 to 90 degrees.

In some examples, the main through hole 15 may also have a regular hexagonal prism shape. In this case, the main through holes 15 can be also a part of the honeycomb structure in the support body 10, and the material used in manufacturing the support body 10 can be further reduced while ensuring sufficient strength of the support body 10. Examples of the present disclosure are not limited thereto, and the main through hole 15 may have a cylindrical shape, a circular truncated cone shape, a truncated pyramid shape, a regular triangular prism shape, or the like.

In some examples, the support body 10 may be composed of a porous material. In this case, the intervertebral cage 1 can be brought close to the bone structure to form a qi/blood passage, which is advantageous for the continuous growth of the bone. In some examples, the pore size of the porous material may be 50 μm to 500 μm. In this case, the structure of the intervertebral cage 1 can be made closer to the structure of the human skeleton, which is more beneficial to the continuous growth of the skeleton. In addition, in some examples, the pores of the porous material may be in substantially the same direction as the qi and blood pathway. In this case, it is possible to more favorably form the qi-blood passage in the porous material.

In some examples, the material of the support body 10 may be a metal biocompatible material. In this case, since the metal biocompatible material has more suitable strength, toughness, wear resistance, and fatigue resistance than other biocompatible materials, the performance of the support body 10 can be more stable and more reliable.

In some examples, the metallic biocompatible material in the support body 10 may include at least one of titanium, titanium-based alloys, cobalt-based alloys, nickel-chromium stainless steel, tantalum, niobium, gold, silver, palladium, platinum. In this case, an appropriate material can be selected according to actual needs.

Additionally, in some examples, the metallic biocompatible material in the support body 10 may include titanium, titanium-based alloys, cobalt-based alloys, medical stainless steel. In this case, since titanium metal has high fatigue resistance, corrosion resistance and biocompatibility compared with other metals, and medical stainless steel and cobalt metal have high elastic modulus and high strength, the amount of the material used for the support body 10 can be reduced while ensuring high hardness and fracture toughness of the support body 10, thereby reducing in vivo rejection reaction.

In some examples, the porosity of the support 10 may be 50% to 90%. In this case, while sufficient strength of the support body 10 is ensured, the material used in manufacturing the support body 10 can be reduced, the rejection reaction of the human body can be reduced, and the volume of the artificial bone 20 filled in the fusion cage 1 can be increased, and the bone growth can be promoted.

In some examples, in the support body 10, the upper surface 11 and the lower surface 12 may be respectively formed as surfaces that match the shape of the vertebrae (see fig. 7). In this case, the cage 1 can be better inserted between the vertebrae and fitted to the vertebrae, providing more stable supporting force to the vertebrae while preventing it from being displaced or falling off between the vertebrae.

Examples of the present disclosure are not limited thereto, for example, in some examples, the upper surface 11 of the support body 10 may be a surface that matches the shape of a vertebra, while the lower surface 12 may be a flat surface. In other examples, the upper surface 11 of the support body 10 may be a flat surface and the lower surface 12 may be a surface that matches the shape of the vertebrae.

In some examples, the support body 10 may be made of at least one selected from 3D printing, machining, numerical control machining, and mold machining. In this case, an appropriate processing method can be selected according to actual conditions, and the processing accuracy of the intervertebral fusion device 1 can be improved. In some examples, the support body 10 may be processed by means of 3D printing.

Fig. 8 is a schematic diagram illustrating an example of an artificial bone according to the present disclosure. Fig. 9 is a schematic diagram showing a modified example 1 of the artificial bone according to the present disclosure. Fig. 10 is a schematic diagram showing a modification 2 of the artificial bone according to the present disclosure.

In some examples, the artificial bone 20 may include a filling part 21 and a protrusion part 22 connected to the filling part 21. Wherein the protrusion 22 is formed on the filling part 21 (see fig. 8).

In some examples, the filling part 21 may have a shape matching the through-hole 14, such as a regular hexagonal prism shape. In this case, the protrusion 22 may have a regular hexagonal pyramid shape, and in this case, the bottom surface of the filling portion 21 is in close contact with the bottom surface of the protrusion 22.

Examples of the present disclosure are not limited thereto, and for example, in some examples, the filling part 21 may be substantially cylindrical, pentagonal, triangular, or the like. In some examples, the protrusions 22 may be substantially conical, pentagonal, pyramidal, etc. For example, when the filling portion 21 has a substantially cylindrical shape, the protrusion portion 22 may have a substantially conical shape. When the filling portion 21 has a substantially pentagonal prism shape, the protrusion portion 22 may have a substantially pentagonal pyramid shape.

Additionally, in some examples, protrusions 22 may include an upper protrusion 22a protruding from upper surface 11 and a lower protrusion 22b protruding from lower surface 12. The upper and

lower protrusions

22a and 22b are connected to both ends of the filling part 21, respectively (see fig. 8). In this case, when the cage 1 is placed between the vertebrae, the protrusions 22 can be coupled with the upper and lower vertebrae, respectively, to better fix the cage 1 between the vertebrae, preventing the cage 1 from slipping out from between the vertebrae.

In some examples, the artificial bone 20 may have only the projections 22 protruding from the upper surface 11. The protrusion 22 may be connected with the upper end of the filling part 21 (see fig. 9). In some examples, the artificial bone 20 may have only the projections 22 protruding from the lower surface 12. The protrusion 22 may be connected with the lower end of the filling part 21 (see fig. 10).

Furthermore, in some examples, the protrusions 22 may protrude 1mm to 3mm from the upper surface 11 and/or the lower surface 12 of the support body 10. In this case, the cage 1 can be well fixed between the vertebrae. The protrusion 22 may protrude from the upper and

lower surfaces

11 and 12 of the supporting body 10 by 1mm to 3mm in view of better fixing of the cage 1 between vertebrae.

In some examples, the artificial bone 20 and the support body 10 may be fitted in an interference fit. In this case, the surface in contact between the artificial bone 20 and the support body 10 can generate elastic pressure, thereby securely coupling the artificial bone 20 with the support body 10. Examples of the present disclosure are not limited thereto, and the fitting manner of the artificial bone 20 to the support body 10 may also be a clearance fit or a transition fit.

In some examples, as described above, the artificial bone 20 may include a degradable polymer and a bone growth promoting material. Thereby facilitating the degradation of the artificial bone 20 in the cage 1 and promoting the growth of bone in the cage 1, thereby promoting the cage 1 and the vertebra 2 to better form a fusion structure.

In some examples, the degradable polymer may include a natural polymer material, a synthetic polymer material, and the like. Wherein, the natural polymer material can comprise chitin and derivatives thereof, collagen, fibrin glue, and the like. The synthetic polymer material may include polylactic acid, polycaprolactone, polylactic-polyglycolic acid copolymer, etc.

In some examples, the bone growth promoting material may include inorganic materials, nanomaterials, and the like. Wherein the inorganic material may comprise biodegradable ceramics, hydroxyapatite, coral, cuttlefish bone, etc. The nano material may include nano hydroxyapatite/collagen material, hydroxyapatite/polylactic acid nano composite material, etc.

In some examples, the material of the artificial bone 20 may be selected from at least one of bioceramics, medical polymers, medical composites, and nano-artificial bones. In this case, it is possible to prevent the patient from using autologous bone during surgery, causing more pain to the patient, and to induce bone growth. The bioceramic may include hydroxyapatite, calcium phosphate, alumina, etc., among others. The medical polymer material may include chitin, collagen, silicone rubber, polylactic acid, polyurethane, etc. The medical composite material can be formed by compounding the biological ceramic material and the medical polymer material. The nano artificial bone may include nano hydroxyapatite, zirconia/alumina crystal nano compound, nano calcium phosphate/collagen, etc.

Examples of the present disclosure are not limited thereto, and the material filled in the support body 10 may also be autologous bone, allogeneic bone, bone morphogenetic protein, a composite material of allogeneic bone and artificial bone, a composite material of autologous bone and allogeneic bone and artificial bone, and the like.

In the operation of implanting the intervertebral cage 1 according to the present disclosure, first, the intervertebral disc protruding between the vertebrae is surgically removed, and then the cage 1 is implanted between the vertebrae. Since the cage 1 has the projection 22, the projection 22 can be brought into better contact with the vertebrae when the cage 1 is implanted between the vertebrae, creating an interaction force with the vertebrae. The forces generated by the interaction of the protrusions 22 with the vertebrae enable the cage 1 to be more firmly fixed between the vertebrae, inhibiting relative displacement or expulsion of the cage 1 and the vertebrae in the transverse direction (i.e. in a direction substantially perpendicular to the lumbar spine).

During the post-operative rehabilitation, the degradable polymer in the artificial bone 20 is degraded and absorbed in the human body, and the bone encourages the material to induce the vertebrae coupled to the cage 1 to grow together and form a fusion structure. The support body 10 can provide stable supporting force for the vertebrae coupled with the fusion cage 1, which is beneficial to keep the vertebrae stable during the rehabilitation process and facilitates the vertebrae to grow together to form a fusion structure.

While the invention has been described in detail in connection with the drawings and the embodiments, it is to be understood that the above description is not intended to limit the invention in any way. Those skilled in the art can make modifications and variations to the present invention as needed without departing from the true spirit and scope of the invention, and such modifications and variations are within the scope of the invention.

Claims

1. An intervertebral cage having a protrusion, comprising: a support body having an upper surface and a lower surface, and formed with a plurality of through holes penetrating between the upper surface and the lower surface, an axial direction of the through holes being perpendicular to the upper surface and the lower surface, the support body being composed of a porous material forming an air-blood passage; and an artificial bone having a filling portion for filling the through hole of the support body and a protrusion portion connected to the filling portion and protruding from the through hole to be in contact with a vertebra, wherein the filling portion has a shape matching the through hole, the artificial bone is fitted to the support body by interference fit, and the protrusion portion is tapered.

2. The intervertebral cage of claim 1, wherein:

the support body further comprises a side surface connecting the upper surface and the lower surface.

3. The intervertebral cage of claim 1, wherein:

the porosity of the support is 50% to 90%, and the pore diameter of the porous material is 50 μm to 500 μm.

4. The intervertebral cage of claim 1 or 3, wherein:

the direction of the pore channels of the porous material is substantially the same as the direction of the qi-blood passage.

5. The intervertebral cage of claim 1, wherein:

the material of the support body is a metal biocompatible material, and the metal biocompatible material comprises at least one of titanium, titanium-based alloy, cobalt-based alloy, nickel-chromium stainless steel, tantalum, niobium, gold, silver, palladium and platinum.

6. The intervertebral cage of claim 1, wherein:

the protrusion includes an upper protrusion protruding from the upper surface and a lower protrusion protruding from the lower surface.

7. The intervertebral cage of claim 1, wherein:

in the support body, the upper surface and the lower surface are respectively formed as surfaces that match the shape of vertebrae.

8. The intervertebral cage of claim 1, wherein:

the surface of the support body is covered with artificial bone material.