CN108514465A - Invasive lumbar fusion device filled with artificial bone - Google Patents
Invasive lumbar fusion device filled with artificial bone Download PDFInfo
- Publication number
- CN108514465A CN108514465A CN201810603183.4A CN201810603183A CN108514465A CN 108514465 A CN108514465 A CN 108514465A CN 201810603183 A CN201810603183 A CN 201810603183A CN 108514465 A CN108514465 A CN 108514465A
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- China
- Prior art keywords
- fusion device
- supporter
- invasive lumbar
- artificial bone
- lumbar fusion
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
- A61F2002/30891—Plurality of protrusions
- A61F2002/30892—Plurality of protrusions parallel
Abstract
This disclosure relates to which clinical orthopaedics repair field.Present disclose provides a kind of Invasive lumbar fusion devices filled with artificial bone comprising：Supporter, with substantially parallel upper and lower surface, and the multiple through-holes being formed between perforation upper surface and lower surface；And artificial bone, it is filled in the through-hole of supporter and forms protrusion from through-hole protrusion, artificial bone includes that degradable polymer and bone encourage material.In the disclosure, protrusion can be better contacted with intervertebral, between Invasive lumbar fusion device is preferably fixed on vertebra, fusion device and vertebra is inhibited generation relative shift or to fall off on horizontal direction (i.e. along with lumbar vertebrae generally perpendicular direction).In addition, artificial bone, which includes degradable polymer and bone, encourages material, therefore be conducive to fusion device degradation, and fusion structure is preferably formed with vertebra.
Description
Technical field
This disclosure relates to which clinical orthopaedics repair field, more particularly to a kind of Invasive lumbar fusion device filled with artificial bone.
Background technology
It is prominent with cervical spondylosis, cervical intervertebral disk with the change of the aggravation and modern metropolitan cities people's lives custom of aging of population
Go out the work that the backbone degenerative disease that disease, the protrasion of the lumbar intervertebral disci, lumbar spinal stenosis etc. are representative is just seriously affecting people
And life.Currently, the above-mentioned state of an illness in the early stage the stage when, mostly use conservative therapy greatly such as drug therapy, physical therapy.So
And with the exacerbation of conditions of patients, it needs to be considered as more effective therapy such as spinal fusion art to inhibit disease
The exacerbation of feelings.By taking the protrasion of the lumbar intervertebral disci as an example, when disc herniation compressing canalis spinalis is more than 1/3 or numbness of lower limbs, work occurs
When dynamic difficult, stool and urine inability, the at this moment therapeutic effect of conservative therapy unobvious need to consider pair at this time
Patient implements spinal fusion art.
In spinal fusion art, by the way that disc removal outstanding between vertebra, intervertebral fusion is then implanted between vertebra
Device is to induce spinal fusion together, to achieve the purpose that eliminate lesion.In the clinical application of spinal fusion art, due to vertebra
Between fusion device be placed in human body for a long time after surgery, therefore the factors such as the structure of Invasive lumbar fusion device, manufacturing technology, quality are all right
The postoperative effect of spinal fusion art plays an important role.
Patent document 1 discloses a kind of waist Invasive lumbar fusion device, by up and down fusion device ontology and be fused device sheet
Body encirclement is formed by bone graft area composition；In the annular wall of fusion device ontology in up and down and back and forth direction it is intensive be provided with it is logical
Hole.In addition, patent document 2 discloses a kind of spinal fusion device, which includes a supporter, which forms one
Accommodation space at least partly includes in the accommodation space：Hole shape structure.
However, in Invasive lumbar fusion device disclosed in above patent document 1 and 2, directly by fusion device be placed on vertebra it
Between, such as during patient motion, vertebra and fusion device are horizontal direction (i.e. along with lumbar vertebrae generally perpendicular direction)
On be possible to can have Relative sliding, cause fusion device to be subjected to displacement or fall off from vertebra.
Existing technical literature
Patent document 1：Chinese patent application publication number CN107625564A
Patent document 2：Chinese patent application Publication No. CN106913406A.
Invention content
The inventors of the present invention have found when studying problem of the prior art, how Invasive lumbar fusion device are preferably fixed on vertebra
Between be still needed in currently available technology improve aspect.The inventors of the present invention pass through optimization fusion device by clinical practice for many years
Structure, suitable artificial bone is filled in fusion device and is formed protrusion, fusion device can be preferably fixed on vertebra
Between bone.
The disclosure is made in view of above-mentioned situation, and its purpose is to provide one kind capable of being preferably fixed in vertebra
Between Invasive lumbar fusion device.
For this purpose, present disclose provides a kind of Invasive lumbar fusion devices filled with artificial bone comprising：Supporter has big
Parallel upper and lower surface is caused, and is formed with the multiple through-holes penetrated through between the upper surface and lower surface；And people
Work bone is filled in the through-hole of the supporter and forms protrusion from through-hole protrusion, and the artificial bone includes
Degradable polymer and bone encourage material.
In the disclosure, the multiple through-holes penetrated through between the upper surface and lower surface are formed in supporter, multiple
Artificial bone is also filled in through-hole, and artificial bone forms protrusion from through-hole protrusion, in this case, protrusion can
It is better contacted with intervertebral, between Invasive lumbar fusion device is preferably fixed on vertebra, fusion device is inhibited to exist with vertebra
Relative shift occurs on horizontal direction (i.e. along with lumbar vertebrae generally perpendicular direction) or falls off.In addition, artificial bone includes that can drop
The polymer and bone of solution encourage material, therefore are conducive to fusion device degradation, and preferably form fusion structure with vertebra.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the supporter, which also has, to be penetrated through on described
The main through-hole on surface and the lower surface, the internal diameter of the main through-hole are more than the internal diameter of the through-hole.In this case, can
The material for reducing supporter, increases the artificial bone used, to reduce internal rejection.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the protrusion includes from the upper surface
Upper process portion outstanding and from lower surface lower process portion outstanding.In this case, when Invasive lumbar fusion device is placed into vertebra
When between bone, between protrusion can be contacted with epipyramis, lower vertebra Invasive lumbar fusion device is preferably fixed on vertebra respectively, prevent
Invasive lumbar fusion device between vertebra from shifting or fall off.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the protrusion is point.This
In the case of, protrusion can be made to be generated with vertebra and preferably contacted, between Invasive lumbar fusion device is preferably fixed on vertebra, prevented
Invasive lumbar fusion device between vertebra from shifting or fall off.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the supporter is made of porous material.
In this case, Invasive lumbar fusion device can be made close to the structure of bone, qi and blood access is formed, be conducive to bone and continuously grow.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the aperture of the porous material be 50 μm extremely
500μm.In this case, the structure of Invasive lumbar fusion device can be made closer to the structure of skeleton, be more advantageous to bone company
Continuous growth.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the porosity of the supporter be 50% to
90%.In this case, used material when manufacture supporter can be reduced while ensureing that supporter has sufficient intensity
Material reduces human body rejection, meanwhile, it is capable to increase the volume for the artificial bone filled in spinal fusion device, promotes bone life
It is long.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the material of the supporter includes titanium, titanium
At least one of based alloy, cobalt-base alloys, nickel chromium stainless steel, tantalum, niobium, gold, silver, palladium, platinum.In this case, Neng Gougen
According to actual needs, suitable making material is selected.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, institute of the protrusion from the supporter
It states upper surface and/or the lower surface and protrudes 1mm to 3mm.In this case, Invasive lumbar fusion device can be made to be fixed on vertebra
While between bone, avoid influencing the therapeutic effect of Invasive lumbar fusion device because protrusion is excessively prominent.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the supporter is shape in substantially rectangular
The extrusion of body or square.In this case, Invasive lumbar fusion device can be made to be easier to fit between vertebra, is provided for vertebra
Stable support force.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the through-hole is in regular hexagonal prism shape.
In this case, honeycomb can be formed in supporter, since honeycomb can reduce stress concentration, made in supporter
Portion's structure stress distribution is more uniform, has higher strength and stiffness, therefore can have enough intensity ensureing supporter
In the case of, greatly reduce required material when manufacture supporter.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, in the supporter, the upper surface
It is respectively formed as and the matched surface of vertebra shape with the lower surface.In this case, Invasive lumbar fusion device can be preferably
It between embedded vertebra, and is bonded with vertebra, more stable support force is provided for vertebra, while it can be prevented in vertebra meta position
It moves or falls off.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the supporter is by being selected from 3D printing, machine
At least one of tool processing, digital control processing, mold processing are made.In this case, it can select to close according to actual conditions
Suitable processing method improves the machining accuracy of Invasive lumbar fusion device.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the artificial bone is with the supporter with mistake
The mode of cooperation of being full of coordinates.In this case, the surface contacted between artificial bone and supporter can generate elastic pressure, from
And artificial bone is made to couple with what supporter fastened.
In the Invasive lumbar fusion device filled with artificial bone involved by the disclosure, the material of the artificial bone is selected from biology and makes pottery
At least one of porcelain, medical macromolecular materials, medical composite material, nano-artificial bone.In this case, it can avoid
The autologous bone that patient is used in surgical procedure, causes more pains, and can induce bone growth to patient.
In accordance with the invention it is possible to which intervertebral Invasive lumbar fusion device can be preferably fixed in by providing one kind.
Description of the drawings
Embodiment of the disclosure will be explained in further detail solely by reference to the example of attached drawing now, wherein：
Fig. 1 is the status diagram of Invasive lumbar fusion device placement between the vertebrae shown involved by the disclosure.
Fig. 2 is the overall perspective view for showing the Invasive lumbar fusion device involved by the disclosure.
Fig. 3 is the decomposition diagram of the supporter and artificial bone that show the Invasive lumbar fusion device involved by the disclosure.
Fig. 4 is the stereogram for showing the supporter involved by the disclosure.
Fig. 5 is the vertical view for showing the supporter involved by the disclosure.
Fig. 6 is the sectional stereogram for showing the supporter involved by the disclosure and being intercepted along the directions hatching A-A'.
Fig. 7 is the schematic diagram for the variation for showing the supporter involved by the disclosure.
Fig. 8 is the schematic diagram for the example for showing the artificial bone involved by the disclosure.
Fig. 9 is the schematic diagram for the variation 1 for showing the artificial bone involved by the disclosure.
Figure 10 is the schematic diagram for the variation 2 for showing the artificial bone involved by the disclosure.
Specific implementation mode
All bibliography full texts of disclosure reference are incorporated herein by reference, as fully expounded.Unless otherwise
It defines, technical and scientific term used in the disclosure has is generally understood phase with disclosure those of ordinary skill in the art
Same meaning.The general guideline of many terms used in this application is provided for those skilled in the art.Art technology
Personnel will appreciate that in the practice for the disclosure with those similar or equivalent many methods described in the disclosure
And material.In fact, the disclosure is never limited to described method and material.Fig. 1 is the intervertebral shown involved by the disclosure
Fusion device places status diagram between the vertebrae.Fig. 2 is the integral vertical for showing the Invasive lumbar fusion device involved by the disclosure
Body figure.Fig. 3 is the decomposition diagram of the supporter and artificial bone that show the Invasive lumbar fusion device involved by the disclosure.
In general, in spinal fusion art, by by disc removal outstanding between vertebra, being then implanted between vertebra
Invasive lumbar fusion device is to induce spinal fusion growth together, to achieve the purpose that eliminate lesion (referring to Fig. 1).In spinal fusion
In the clinical application of art, since fusion device is placed in human body for a long time after surgery, fusion device can be well with vertebra
Form the success or not that fusion structure is the key that spinal fusion art.
This disclosure relates to it is a kind of can preferably be fixed in it is intervertebral filled with artificial bone Invasive lumbar fusion device 1 (with
Down sometimes referred to as " fusion device 1 ").In the present embodiment, fusion device 1 may include supporter 10 and artificial bone 20 (referring to Fig. 2
And Fig. 3).In supporter 10, it is filled with artificial bone 20, and artificial bone 20 protrudes from supporter 10 and forms protrusion 22 (slightly
It describes afterwards).
In the disclosure, as noted previously, as being formed between the perforation upper surface and lower surface in supporter 10
Multiple through-holes are filled with artificial bone 20 in through-holes, and artificial bone 20 protrudes from supporter 10 and forms protrusion 22, because
This, protrusion 22 can be better contacted with vertebra 2 (referring to Fig. 1), good interaction force be formed, so as to preferably
Between fusion device 1 is fixed on vertebra, inhibit fusion device 1 and vertebra 2 in horizontal direction (i.e. along the side substantially vertical with lumbar vertebrae
To) on occur relative shift or to fall off.
In addition, in fusion device 1, artificial bone 20 may include that degradable polymer and bone encourage material, therefore have
Conducive to the degradation of artificial bone 20 in fusion device 1, promote the growth of bone in fusion device 1, to promote fusion device 1 and vertebra 2 more
Form fusion structure well.
In addition, in some instances, artificial bone 20 can also be covered in the surface of supporter 10.In this case, people
The inside that work bone 20 is not only filled in supporter 10 is also covered in the surface of supporter 10, anti-thus, it is possible to reduce rejection in vivo
It answers.
Fig. 4 is the stereogram for showing the supporter involved by the disclosure.Fig. 5 is the support shown involved by the disclosure
The upward view of body.
In fusion device 1 involved by the disclosure, supporter 10 can have substantially parallel upper surface 11 and lower surface
12 (referring to Fig. 4 and Fig. 5).In addition, supporter 10 also has the side 13 of connection upper surface 11 and lower surface 12.
In some instances, supporter 10 can be shape in approximately cuboid or the structure of square.In supporter
In the case that 10 is cuboid or squares, side 13 may include the side 131 being oppositely arranged and side 133 and opposite
The side 132 of setting and side 134 (referring to Fig. 4).
In some instances, it could be formed with fillet between side 131 and side 132.In addition, side 131 and side 134
Between could be formed with fillet.In addition, could be formed with fillet between side 133 and side 132.In addition, side 133 and side
It could be formed with fillet between 134 (referring to Fig. 5).
In some instances, supporter 10 can be extrusion.Here, extrusion refers to by a section along a line
The said three-dimensional body that Duan Lashen is formed.
In addition, in supporter 10, multiple through-holes 14 between perforation upper surface 11 and lower surface 12 are could be formed with.It is propping up
In support body 10, the quantity of through-hole 14 is not particularly limited, such as the quantity of through-hole 14 can be 2,3,5,10 or more
It is multiple.In some instances, for internal rejection is reduced, multiple through-holes 14 can be equably arranged in supporter 10.
In some instances, the axial direction of through-hole 14 can vertical upper surface 11 and lower surface 12.In other examples
In, the axial direction of through-hole 14 can be formed with angle theta with upper surface 11 or lower surface 121.In some instances, through-hole 14
Axial direction is formed by angle theta with upper surface 11 or lower surface 121It can be 0 degree to 90 degree.For the axial direction for making through-hole 14
Direction and the Impact direction of supporter 10 keep consideration unanimous on the whole, angle theta1It can be 45 degree to 90 degree.
In addition, in supporter 10, multiple through holes of perforation upper surface 11 and side 13 can also be formed with.As a result, can
It is enough that artificial bone is for example filled in these through holes, promote bone in the growth of supporter 10, to promote intervertebral fusion.
In addition, in supporter 10, multiple through holes of perforation lower surface 12 and side 13 can also be formed with.In this case, together
Sample can promote bone in the growth of supporter 10, to promote intervertebral fusion.
Fig. 6 is the sectional stereogram for showing the supporter involved by the disclosure and being intercepted along the directions hatching A-A'.
In some instances, in supporter 10, through-hole 14 can be in regular hexagonal prism shape (referring to Fig. 6).In such case
Under, honeycomb can be formed in supporter 10, since honeycomb can reduce stress concentration, make 10 internal junction of supporter
Structure stress distribution is more uniform, has higher strength and stiffness, therefore can have enough intensity ensureing supporter 10
In the case of, greatly reduce required material when manufacture supporter 10.In some instances, the internal diameter of through-hole 14 for example can be
1mm-5mm.The example of the disclosure is without being limited thereto, and through-hole 14 can be with cylindrical form, truncated conical shape, terrace edge shape, positive trigone
Post shapes etc..
In some instances, supporter 10 can also have the main through-hole 15 of perforation upper surface 11 and lower surface 12.It is main logical
The internal diameter in hole 15 can be more than the internal diameter of through-hole 14.In this case, the material that can reduce supporter 10 increases and uses
Artificial bone, to reduce internal rejection.In some instances, the internal diameter of main through-hole 15 can be 2mm-10mm.
In some instances, main through-hole 15 can be 1,2,3,5,10 or more.For making supporter
The quantity of the compact consideration of 10 internal structures, main through-hole 15 can be 2, as shown in fig. 6, in supporter 10, be provided with master
Through-hole 15a and main through-hole 15b.In some instances, main through-hole 15a and main through-hole 15b can be symmetrically distributed in (the ginseng of supporter 10
See Fig. 5 and Fig. 6).In some instances, main through-hole 15a and main through-hole 15b can about supporter 10 longitudinal axis it is symmetrical.
In some instances, the axial direction of main through-hole 15 can vertical upper surface 11 and lower surface 12.Show at other
In example, the axial direction of main through-hole 15 can also be formed with angle theta with upper surface 11 or lower surface 122.In some instances, go out
In the axial direction and the consideration unanimous on the whole of 10 Impact direction of supporter that make main through-hole 15, angle theta2It can be 45 degree to 90
Degree.
In some instances, main through-hole 15 can also be in regular hexagonal prism shape.In this case, main through-hole 15 can be made
Also the part for becoming honeycomb in supporter 10 can be into one in the case where ensureing that supporter 10 has enough intensity
Step reduces used material when manufacture supporter 10.The example of the disclosure is without being limited thereto, main through-hole 15 can with cylindrical form,
Truncated conical shape, terrace edge shape, regular triangular prism shape etc..
In some instances, supporter 10 can be made of porous material.In this case, Invasive lumbar fusion device can be made
1 close to bone structure, formed qi and blood access, be conducive to bone and continuously grow.In some instances, the aperture of porous material can
Think 50 μm to 500 μm.In this case, the structure of Invasive lumbar fusion device 1 can be made closer to the structure of skeleton, more had
It is continuously grown conducive to bone.In addition, in some instances, the duct of porous material can be in the side roughly the same with qi and blood access
To.In this case, formation qi and blood access in the porous material can be more advantageous to.
In some instances, the material of supporter 10 can be biocompatible metal material.In this case, due to
Biocompatible metal material has more suitable intensity, toughness, wearability and resistance to relative to other biological compatibility material
Fatigue behaviour, it is thus possible to make the performance of supporter 10 more stablize, reliability higher.
In some instances, the biocompatible metal material in supporter 10 may include titanium, titanium-base alloy, cobalt-based conjunction
At least one of gold, nickel chromium stainless steel, tantalum, niobium, gold, silver, palladium, platinum.In this case, it can select according to actual needs
Select suitable making material.
In addition, in some instances, the biocompatible metal material in supporter 10 may include titanium, titanium-base alloy,
Cobalt-base alloys, medical stainless steel.In this case, due to titanium and other metal phase ratios, have very strong fatigue resistance,
Corrosion resistance and preferable biocompatibility, and the elasticity modulus of medical stainless steel and cobalt metal is higher, has higher intensity,
Therefore 10 material of supporter can be reduced while ensureing that supporter 10 has higher hardness and Resisting fractre toughness
Usage amount, to reduce internal rejection.
In some instances, the porosity of supporter 10 can be 50% to 90%.In this case, can ensure
While supporter 10 has sufficient intensity, used material when manufacture supporter 10 is reduced, reduces human body rejection, together
When, the volume for the artificial bone 20 filled in fusion device 1 can be increased, promote bone growth.
Fig. 7 is the schematic diagram for the variation for showing the supporter involved by the disclosure.
In some instances, in supporter 10, upper surface 11 and lower surface 12 can be respectively formed as and vertebra shape
Matched surface (referring to Fig. 7).In this case, fusion device 1 can be preferably embedded between vertebra, and is bonded with vertebra,
More stable support force is provided for vertebra, while can prevent it from displacement or falling off between vertebra.
The example of the disclosure is without being limited thereto, for example, in some instances, the upper surface 11 of supporter 10 can be and vertebra
The matched surface of shape, and lower surface 12 can be even curface.In other examples, the upper surface 11 of supporter 10 can
To be even curface, and lower surface 12 can be and the matched surface of vertebra shape.
In some instances, supporter 10 can be by 3D printing, mechanical processing, digital control processing, mold processing
At least one is made.In this case, suitable processing method can be selected according to actual conditions, improves Invasive lumbar fusion device 1
Machining accuracy.In some instances, supporter 10 may be used the mode of 3D printing and process.
Fig. 8 is the schematic diagram for the example for showing the artificial bone involved by the disclosure.Fig. 9 is shown involved by the disclosure
Artificial bone variation 1 schematic diagram.Figure 10 is the schematic diagram for the variation 2 for showing the artificial bone involved by the disclosure.
In some instances, artificial bone 20 may include filling part 21 and the protrusion being connect with filling part 21 22 and.Its
In, protrusion 22 is formed on filling part 21 (referring to Fig. 8).
In some instances, filling part 21 can be in and 14 matched shape of through-hole such as regular hexagonal prism shape.This
In the case of, protrusion 22 can be in positive hexagonal vertebra shape, at this point, the bottom surface of filling part 21 and the bottom surface of protrusion 22 are fitted and connected.
The example of the disclosure is without being limited thereto, for example, in some instances, filling part 21 can substantially cylindrical, five ribs
Column, triangular prism shape etc..In some instances, protrusion 22 can substantially be in coniform, positive pentagonal pyramid shape, positive four pyramids shape
Deng.For example, when filling part 21 is in substantially cylindric, protrusion 22 can be in substantially coniform.When filling part 21 is substantially in five
When prism, protrusion 22 can substantially be in pentagonal pyramid shape.
In addition, in some instances, protrusion 22 may include from 11 upper process portion 22a outstanding of upper surface and from following table
12 lower process portion 22b outstanding of face.Upper process portion 22a and lower process portion 22b are connect with the both ends of filling part 21 (referring to figure respectively
8).In this case, when fusion device 1 is placed between vertebra, protrusion 22 can couple with epipyramis, lower vertebra respectively with will
Fusion device 1 is preferably fixed between vertebra, prevents fusion device 1 from being slipped between vertebra.
In some instances, artificial bone 20 can only have from 11 protrusion 22 outstanding of upper surface.Protrusion 22 can be with
It is connect with the upper end of filling part 21 (referring to Fig. 9).In some instances, artificial bone 20 can only have outstanding from lower surface 12
Protrusion 22.Protrusion 22 can be connect with the lower end of filling part 21 (referring to Figure 10).
In addition, in some instances, protrusion 22 can be protruded from the upper surface of supporter 10 11 and/or lower surface 12
1mm to 3mm.In this case, fusion device 1 can be made to be fixed between vertebra well.For fusion device 1 is preferably solid
Due to intervertebral consideration, protrusion 22 can protrude 1mm to 3mm from the upper surface 11 of supporter 10 and lower surface 12.
In some instances, artificial bone 20 can coordinate in an interference fit with supporter 10.In this case,
The surface contacted between artificial bone 20 and supporter 10 can generate elastic pressure, to make artificial bone 20 be fastened with supporter 10
Connection.The example of the disclosure is without being limited thereto, and artificial bone 20 and the fit system of supporter 10 can also be clearance fit or mistake
Cross cooperation.
In some instances, as described above, artificial bone 20, which may include degradable polymer and bone, encourages material.Cause
This is conducive to the degradation of artificial bone 20 in fusion device 1, promotes the growth of bone in fusion device 1, to promote fusion device 1 and vertebra
2 preferably form fusion structure.
In some instances, degradable polymer may include natural macromolecular material, artificial synthesized high molecular material
Deng.Wherein, natural macromolecular material may include chitin and its derivative, collagen, Fibrin Glue etc..Artificial synthesized high score
Sub- material may include polylactic acid, polycaprolactone, polylactide polyglycolic acid copolymer etc..
In some instances, it may include inorganic material, nano material etc. that bone, which encourages material,.Wherein, inorganic material can
To include biodegradable class ceramics, hydroxyapatite, coral and cuttle bone etc..Nano material may include nano-hydroxy-apatite
Stone/collagen-based materials, hydroxyapatite/polylactic acid nanocomposite etc..
In some instances, the material of artificial bone 20 can be selected from bioceramic, medical macromolecular materials, medical composite wood
At least one of material, nano-artificial bone.In this case, it can avoid using the autologous bone of patient in the course of surgery,
More pains are caused to patient, and bone growth can be induced.Wherein, bioceramic may include hydroxyapatite, calcium phosphate,
Aluminium oxide etc..Medical macromolecular materials may include chitin, collagen, silicon rubber, polylactic acid, polyurethane etc..It is medical multiple
Condensation material can be combined by above-mentioned bioceramic material and above-mentioned medical macromolecular materials.Nano-artificial bone may include
Nanometer hydroxyapatite, zirconium oxide/alpha-alumina crystals Nano compound, nano-calcium phosphate/collagen etc..
The example of the disclosure is without being limited thereto, and the material for being filled in supporter 10 can also be autologous bone, allograph bone, Bones morphology
Answering for albumen, allograph bone and the composite material of artificial bone, the composite material of autologous bone and artificial bone, autologous bone and allograph bone occurs
The composite material etc. of condensation material, autologous bone and allograph bone and artificial bone.
In the implant surgery of Invasive lumbar fusion device 1 involved by the disclosure, first, by performing the operation vertebra outstanding between vertebra
Then Microdiscectomy is implanted into fusion device 1 between vertebra.Since fusion device 1 has protrusion 22, when fusion device 1 is implanted vertebra
Between when, protrusion 22 can be better contacted with vertebra, and interaction force is generated between vertebra.Protrusion 22 and vertebra are mutual
Between the active force that effect generates can make fusion device 1 be more firmly fixed to vertebra, inhibit fusion device 1 with vertebra in cross
Relative shift occurs on direction (i.e. along with lumbar vertebrae generally perpendicular direction) or falls off.
After surgery during rehabilitation, degradable polymer is degraded and absorbed in human body in artificial bone 20, and bone
It encourages the vertebra that material induction couples with fusion device 1 to grow together, and forms fusion structure.Supporter 10 can be and merge
The vertebra that device 1 couples provides stable support force, is conducive to the stabilization for keeping vertebra in rehabilitation course, one is grown in convenient for vertebra
It rises and forms fusion structure.
Although being illustrated to the present invention above in association with drawings and embodiments, it will be appreciated that on state
It is bright that the invention is not limited in any way.Those skilled in the art are without departing from the true spirit and scope of the present invention
Can the present invention be deformed and be changed as needed, these deformations and variation are within the scope of the present invention.
Claims (10)
1. a kind of Invasive lumbar fusion device filled with artificial bone, it is characterised in that：
Including：
Supporter, with substantially parallel upper and lower surface, and be formed with the perforation upper surface and lower surface it
Between multiple through-holes；And
Artificial bone is filled in the through-hole of the supporter and forms protrusion from through-hole protrusion, described artificial
Bone includes that degradable polymer and bone encourage material.
2. Invasive lumbar fusion device as described in claim 1, it is characterised in that：
Also there is the supporter the main through-hole for penetrating through the upper surface and the lower surface, the internal diameter of the main through-hole to be more than institute
State the internal diameter of through-hole.
3. Invasive lumbar fusion device as described in claim 1, it is characterised in that：
The protrusion includes from upper surface upper process portion outstanding and from lower surface lower process portion outstanding.
4. Invasive lumbar fusion device as described in claim 1, it is characterised in that：
The protrusion is point.
5. Invasive lumbar fusion device as claimed in claim 5, it is characterised in that：
The supporter is made of porous material, and the aperture of the porous material is 50 μm to 500 μm.
6. Invasive lumbar fusion device as described in claim 4 or 5, it is characterised in that：
The porosity of the supporter is 50% to 90%.
7. Invasive lumbar fusion device as described in claim 1, it is characterised in that：
The material of the supporter includes in titanium, titanium-base alloy, cobalt-base alloys, nickel chromium stainless steel, tantalum, niobium, gold, silver, palladium, platinum
It is at least one.
8. Invasive lumbar fusion device as described in claim 1, it is characterised in that：
The protrusion protrudes 1mm to 3mm from the upper surface of the supporter and/or the lower surface.
9. Invasive lumbar fusion device as described in claim 1, it is characterised in that：
In the supporter, the upper surface and the lower surface are respectively formed as and the matched surface of vertebra shape.
10. Invasive lumbar fusion device as described in claim 1, it is characterised in that：
The material of the artificial bone in bioceramic, medical macromolecular materials, medical composite material, nano-artificial bone extremely
Few one kind.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010768393.6A CN111920553B (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device with protrusions |
| CN201810603183.4A CN108514465B (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device filled with artificial bone |
| CN202010768376.2A CN111920552A (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device with a plurality of through holes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810603183.4A CN108514465B (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device filled with artificial bone |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010768376.2A Division CN111920552A (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device with a plurality of through holes |
| CN202010768393.6A Division CN111920553B (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device with protrusions |
Publications (2)
| Publication Number | Publication Date |
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| CN108514465A true CN108514465A (en) | 2018-09-11 |
| CN108514465B CN108514465B (en) | 2020-09-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010768376.2A Pending CN111920552A (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device with a plurality of through holes |
| CN201810603183.4A Active CN108514465B (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device filled with artificial bone |
| CN202010768393.6A Active CN111920553B (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device with protrusions |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010768376.2A Pending CN111920552A (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device with a plurality of through holes |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010768393.6A Active CN111920553B (en) | 2018-06-12 | 2018-06-12 | Intervertebral fusion device with protrusions |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN108514465B (en) | 2020-09-18 |
| CN111920553B (en) | 2021-09-24 |
| CN111920552A (en) | 2020-11-13 |
| CN111920553A (en) | 2020-11-13 |
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