CN111904876B - Isolation spray and preparation method thereof - Google Patents
Isolation spray and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
- A61K8/893—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by an alkoxy or aryloxy group, e.g. behenoxy dimethicone or stearoxy dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
Abstract
The invention relates to an isolated spray and a preparation method thereof. The barrier spray comprises: water a, potassium cetyl phosphate, acrylic acid/C10-30 alkanol acrylate crosspolymer, p-hydroxyacetophenone; ethylhexyl palmitate, ethylhexyl methoxycinnamate, silicone-15, octocrylene, titanium dioxide and triethoxyoctylsilane, wild soybean oil, polyglycerol-3 distearate, rice germ extract, rice extract; water b, arginine, 1, 2-hexanediol, essence and magnesium sulfate. The isolation spray is scientific and reasonable in compatibility of various effective components, and verified to be free of toxic substances, and has no irritation to skin, high safety performance and strong sun-screening and blue-light-screening effects through a skin irritation/corrosion test and a chick chorioallantoic membrane test; the preparation method has simple process and easy control, and can be used for mass production.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to an isolation spray and a preparation method thereof.
Background
The isolation spray is used for isolating ultraviolet rays, color cosmetics and environment from damaging skin, and can also play a role in homogenizing skin color and preventing sunburn.
Although the isolation spray is complete in function, the effects of whitening, sun protection, brightening and the like are achieved. However, as people's safety awareness continues to increase, the safety of the use of barrier sprays is receiving more and more attention.
Therefore, the technical scheme of the invention is provided.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides an isolation spray and a preparation method thereof. The isolation spray is scientific and reasonable in compatibility of various effective components, and verified to be free of toxic substances, and has no irritation to skin, high safety performance and strong sun-screening and blue-light-screening effects through a skin irritation/corrosion test and a chick chorioallantoic membrane test; the preparation method has simple process and easy control, and can be used for mass production.
The scheme provided by the invention is that the isolation spray comprises an A phase, a B phase and a C phase, wherein the A phase comprises the following raw materials in parts by weight: 82 to 86 parts of water, 1 to 2 parts of potassium cetyl phosphate, 0.08 to 0.12 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 0.4 to 0.6 part of p-hydroxyacetophenone; the phase B comprises the following raw materials in parts by weight: 3 to 5 parts of ethylhexyl palmitate, 1.5 to 2.5 parts of ethylhexyl methoxycinnamate, 1.5 to 2.5 parts of polysiloxane-15, 1.5 to 2.5 parts of octocrylene, 1.5 to 2.5 parts of titanium dioxide and triethoxyoctylsilane, and 0.8 to 1.2 parts of wild soybean oil, polyglycerol-3 distearate, a rice germ extract and a rice extract; the phase C comprises the following raw materials in parts by weight: 0.08 to 0.12 portion of water b, 0.04 to 0.08 portion of arginine, 0.4 to 0.6 portion of 1, 2-hexanediol, 0.04 to 0.06 portion of essence and 0.008 to 0.012 portion of magnesium sulfate.
Wherein "water a" and "water b" are both water, and "a" and "b" are also used only for distinction between different groups.
Preferably, the isolation spray comprises an A phase, a B phase and a C phase, wherein the A phase comprises the following raw materials in parts by weight: 84.18 parts of water a, 1.5 parts of potassium cetyl phosphate, 0.1 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 0.5 part of p-hydroxyacetophenone; the phase B comprises the following raw materials in parts by weight: 4 parts of ethylhexyl palmitate, 2 parts of ethylhexyl methoxycinnamate, 2 parts of polysiloxane-15 parts, 2 parts of octocrylene, 2 parts of titanium dioxide and triethoxyoctylsilane, and 1 part of wild soybean oil, polyglycerol-3 distearate, a rice germ extract and a rice extract; the phase C comprises the following raw materials in parts by weight: 0.1 part of water b, 0.06 part of arginine, 0.5 part of 1, 2-hexanediol, 0.05 part of essence and 0.01 part of magnesium sulfate.
Preferably, the weight ratio of titanium dioxide to triethoxyoctylsilane is 97; the weight ratio of the wild soybean oil, the polyglycerol-3 distearate, the rice germ extract and the rice extract was 64.
Preferably, the preparation method of the rice extract comprises the following steps:
(1) Cleaning and crushing rice seeds to obtain rice powder;
(2) Mixing the rice flour obtained in the step (1) with water, performing reflux extraction, and filtering to obtain a primary extracting solution and a primary filter residue after the reflux extraction is finished;
(3) Mixing the primary filter residue obtained in the step (2) with ethanol, performing reflux extraction, and filtering to obtain a secondary extracting solution and a secondary filter residue after the reflux extraction is finished;
(4) Mixing the primary extractive solution and the secondary extractive solution, concentrating, and drying to obtain rice extract.
Preferably, in the step (1), the grain size of the rice flour is 30-50 meshes.
Preferably, in the step (2), the temperature of the reflux extraction is 85-90 ℃, and the time of the reflux extraction is 2-4 h.
Preferably, in the step (3), the temperature of the reflux extraction is 68-72 ℃, and the time of the reflux extraction is 4-6 h.
Preferably, in the step (4), the drying temperature is 30-45 ℃.
In another aspect of the present invention, a method for preparing an isolation spray is provided, comprising the steps of:
(i) Heating the phase A raw material to a first set temperature, stirring and dissolving, adding the phase B raw material, and continuing homogenizing to obtain a mixed solution a;
(ii) And (3) cooling the mixed solution a to a second set temperature, then adding the C-phase raw material, and uniformly stirring to obtain the isolated spray.
Preferably, the first set temperature is 83-87 ℃; the second set temperature is 38-42 ℃.
The invention has the beneficial effects that:
1. the isolation spray disclosed by the invention is scientific and reasonable in compatibility of various effective components, and verified to be free of toxic substances, and has no irritation to skin, high safety performance and strong sun-screening and blue-light prevention effects through a skin irritation/corrosion test and a chick chorioallantoic membrane test.
2. The preparation method of the isolation spray has simple process and easy control, and can be used for mass production.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Example 1
The embodiment provides a preparation method of an isolated spray, which comprises the following steps:
(I) The rice extract is prepared by the following steps:
(1) Cleaning rice seeds for 3 times, naturally airing, crushing, and sieving with a 30-mesh sieve to obtain rice powder;
(2) Mixing 100g of the rice powder with 300g of water, performing reflux extraction at 85 ℃ for 2h, and filtering to obtain a primary extracting solution and a primary filter residue;
(3) Mixing the primary filter residue obtained in the step (2) with ethanol according to a weight ratio of 1;
(4) Mixing the primary and secondary extractive solutions, concentrating, and air drying at 30 deg.C to obtain rice extract.
(II) preparing an isolation spray by:
(i) 820g of water, 10g of potassium cetyl phosphate, 0.8g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 4g of p-hydroxyacetophenone are heated to 83 ℃, stirred and dissolved, then 30g of ethylhexyl palmitate, 15g of ethylhexyl methoxycinnamate, 15g of polysiloxane-15, 15g of octocrylene, 15g of a mixture of titanium dioxide and triethoxyoctylsilane, 8g of wild soybean oil, polyglycerol-3 distearate, a mixture of a rice germ extract and a rice extract are added, and stirring and homogenizing are continued to obtain a mixed solution a; wherein the weight ratio of the titanium dioxide to the triethoxyoctylsilane is 97; the weight ratio of the wild soybean oil, the polyglycerol-3 distearate, the rice germ extract and the rice extract is 64;
(ii) And cooling the mixed solution a to 38 ℃, then adding 0.8g of water, 0.4g of arginine, 4g of 1, 2-hexanediol, 0.4g of essence and 0.08g of magnesium sulfate, uniformly stirring, discharging after passing the inspection, sequentially standing, subpackaging, packaging, performing secondary inspection, and putting the finished product in storage.
Example 2
The embodiment provides a preparation method of an isolation spray, which comprises the following steps:
(I) The rice extract is prepared by the following steps:
(1) Cleaning rice seeds for 5 times, naturally airing, crushing, and sieving with a 50-mesh sieve to obtain rice powder;
(2) Mixing 100g of the rice flour and 400g of water, performing reflux extraction for 4 hours at 90 ℃, and filtering to obtain a primary extracting solution and a primary filter residue;
(3) Mixing the primary filter residue obtained in the step (2) with ethanol according to a weight ratio of 1;
(4) Mixing the primary and secondary extractive solutions, concentrating, and air drying at 45 deg.C to obtain rice extract.
(II) preparing an isolation spray by:
(i) 860g of water, 20g of potassium cetyl phosphate, 1.2g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 6g of p-hydroxyacetophenone are heated to 87 ℃, stirred and dissolved, then 50g of ethylhexyl palmitate, 25g of ethylhexyl methoxycinnamate, 25g of polysiloxane-15, 25g of octocrylene, 25g of a mixture of titanium dioxide and triethoxyoctylsilane, 12g of a mixture of wild soybean oil, polyglycerol-3 distearate, a rice germ extract and a rice extract are added, and stirring and homogenizing are continued to obtain a mixed solution a; wherein the weight ratio of the titanium dioxide to the triethoxyoctylsilane is 97; the weight ratio of the wild soybean oil, the polyglycerol-3 distearate, the rice germ extract and the rice extract is 64;
(ii) And cooling the mixed solution a to 42 ℃, then adding 1.2g of water, 0.8g of arginine, 6g of 1, 2-hexanediol, 0.6g of essence and 0.12g of magnesium sulfate, uniformly stirring, discharging after the inspection is qualified, sequentially standing, subpackaging, packaging, performing secondary inspection, and warehousing the finished product.
Example 3
The embodiment provides a preparation method of an isolated spray, which comprises the following steps:
(I) The rice extract is prepared by the following steps:
(1) Cleaning rice seeds for 5 times, naturally airing, crushing, and sieving with a 40-mesh sieve to obtain rice powder;
(2) Mixing 100g of the rice flour and 500g of water, performing reflux extraction for 3 hours at 88 ℃, and filtering to obtain a primary extracting solution and a primary filter residue;
(3) Mixing the primary filter residue obtained in the step (2) with ethanol according to a weight ratio of 1;
(4) Mixing the primary and secondary extractive solutions, concentrating, and air drying at 37 deg.C to obtain rice extract.
(II) preparing an isolation spray by:
(i) Heating 841.8g water, 15g potassium cetyl phosphate, 1g acrylic acid/C10-30 alkanol acrylate cross-linked polymer and 5g p-hydroxyacetophenone to 85 ℃, stirring to dissolve, adding 40g ethylhexyl palmitate, 20g ethylhexyl methoxycinnamate, 20g polysiloxane-15, 20g octocrylene, 20g mixture of titanium dioxide and triethoxyoctylsilane, 10g wild soybean oil, polyglycerol-3 distearate, rice germ extract and rice extract, and stirring to homogenize to obtain mixed solution a; wherein the weight ratio of the titanium dioxide to the triethoxyoctylsilane is 97; the weight ratio of the wild soybean oil, the polyglycerol-3 distearate, the rice germ extract and the rice extract is 64;
(ii) And cooling the mixed solution a to 40 ℃, then adding 1g of water, 0.6g of arginine, 5g of 1, 2-hexanediol, 0.5g of essence and 0.1g of magnesium sulfate, uniformly stirring, discharging after the inspection is qualified, sequentially standing, subpackaging, packaging, performing secondary inspection, and warehousing the finished product.
To verify the performance of the spray isolation, the following tests were performed.
The noxious substances in the barrier sprays obtained in examples 1 to 3 were tested according to GB 7916-1987 (hygienic Standard for cosmetics), the test standards are shown in Table 1, and the results are shown in Table 2.
TABLE 1 Limit of toxic substances in spray isolation
| Toxic substances | Limit amount of ppm |
| Mercury | 1 |
| Lead (in lead) | 40 |
| Arsenic (measured as arsenic) | 10 |
| Methanol | 0.2％ |
TABLE 2 test results
| Toxic substances | Example 1 | Example 2 | Example 3 |
| Mercury | Undetected | Not detected out | Not detected out |
| Lead (calculated as lead) | Not detected out | Not detected out | Not detected out |
| Arsenic (measured as arsenic) | Not detected out | Not detected out | Not detected out |
| Methanol | Not detected out | Not detected out | Not detected out |
(II) the barrier sprays obtained in examples 1-3 and similar products on the market (comparative examples) were tested for skin irritation/corrosion by:
(1) Shearing off hairs on two sides of the spine of the white rabbit about 24 hours before the test, wherein the epidermis cannot be damaged, and the hair removing range is about 3cm multiplied by 3cm respectively on the left side and the right side;
(2) About 0.5mL (g) of the test substance (bath oil) was applied directly to the skin, covered with two layers of gauze (2.5 cm. Times.2.5 cm) and a layer of cellophane or the like, and fixed with a non-irritating adhesive tape and bandage. The other side of the skin served as a control. Adopting a closed test, wherein the application time is 2h, and removing residual test substances by using warm water or a non-irritant solvent after the test is finished;
(3) Skin reactions at the smeared sites were observed for 1, 24, 48 and 72h after removal of the test substances, skin reaction scores were made according to table 3, comprehensive evaluation was made with the average value of the scores of the test animals, and skin irritation intensity was judged according to table 4 based on the highest average value of the scores at each observation time point of 24, 48 and 72 h.
TABLE 3 skin irritation response score
Table 4 skin irritation intensity grading
| Integral mean value | Strength of |
| 0～＜0.5 | Has no irritation |
| 0.5～＜2.0 | Light irritation |
| 2.0～＜6.0 | Middle irritation |
| 6.0～8.0 | Strong irritation |
The test results are shown in table 5.
TABLE 5 test results
| Group of | Example 1 | Example 2 | Example 3 | Comparative example |
| Results | Has no irritation | Has no irritation | Has no irritation | Light irritation |
(III) isolation sprays obtained in examples 1 to 3 and similar products commercially available (comparative example) were subjected to chick embryo chorioallantoic membrane testing by formulating the isolation sprays of the present invention as 0.1%, 0.5%, and 0.8% aqueous solutions, respectively, according to the technique disclosed in French official gazette, 12.12.26.1996, and the results are shown in Table 6.
TABLE 6 test results
| Concentration of | Example 1 | Example 2 | Example 3 | Comparative example |
| 0.1％ | 0 a | 0 | 0 | 2 |
| 0.5％ | 0 | 0 | 0 | 2 |
| 0.8％ | 0 | 0 | 0 | 4 |
Note a: a test result of 0 indicates no irritation at this concentration.
And (IV) carrying out sun protection performance tests on the release sprays obtained in examples 1 to 3 and the same commercial products (comparative example) and determining the sun protection factor (SPF value).
The test method comprises the following steps:
selecting a light source: a sunlight simulator xenon arc lamp is used as a light source, and the following conditions must be satisfied.
(1) Can continuously generate ultraviolet rays with the wavelength of 290-400 nm;
(2) After the light source output is filtered by the optical filter, the ultraviolet ray with the wavelength less than 290nm is less than 1 percent;
(3) After the light source output is filtered by the optical filter, the ultraviolet ray with the wavelength of more than 400nm is less than 5 percent;
(4) The light source should output stable and uniform light, and its fluctuation range on the irradiated plane should be less than 10%.
Selecting a subject satisfying the following conditions:
(i) Selecting healthy volunteer subjects 18-60 years old, and selecting male and female;
(ii) No history of photosensitive diseases exists in the past, and medicines influencing the photosensitivity are not used in the near term;
(iii) The skin types of the subjects are I, II and III, namely the subjects are sensitive to sunlight or ultraviolet irradiation, and sunburn is easy to occur after irradiation, and pigmentation is not easy to occur;
(iv) The skin of the tested part has no pigmentation, inflammation, scar, pigmented nevus, hairy and the like;
(v) Patients who have received anti-inflammatory drugs such as corticosteroid hormone for pregnancy, lactation, oral administration or external use, or similar tests within a month are excluded;
(vi) The number of people tested for each sunscreen cosmetic is more than 10 according to the method.
After testing, the SPF values are shown in table 7, where the SPF value is the average of all test results.
Table 7 SPF value test results
| Group of | Example 1 | Example 2 | Example 3 | Comparative example |
| SPF (specific pathogen free) | 10 | 12 | 12 | 6 |
And (V) carrying out blue light prevention performance tests on the isolated sprays obtained in examples 1 to 3 and similar products sold in the market (comparative example).
The test method comprises the following steps:
(a) Taking a transparent plate, enabling light rays to pass through the transparent plate, and spraying the isolation spray to one side of the transparent plate;
(b) And then, irradiating by using a blue light lamp, and placing a white observation bottom plate on the other side of the transparent plate for observing the blue light intensity, thereby judging the blue light prevention effect of the isolated spray.
The blue light prevention effect is shown in table 8.
TABLE 8 blue light prevention Effect
In conclusion, the isolation spray does not contain toxic substances, and results of skin irritation/corrosion tests and chick embryo chorioallantoic membrane tests show that the isolation spray has no irritation to skin, high safety performance and stronger sun-screening and blue light-preventing effects.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (1)
1. The isolating spray is characterized by comprising an A phase, a B phase and a C phase, wherein the A phase comprises the following raw materials in parts by weight: 84.18 parts of water a, 1.5 parts of potassium cetyl phosphate, 0.1 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and 0.5 part of p-hydroxyacetophenone; the phase B comprises the following raw materials in parts by weight: 4 parts of ethylhexyl palmitate, 2 parts of ethylhexyl methoxycinnamate, 152 parts of polysiloxane-152 parts, 2 parts of octocrylene, 2 parts of titanium dioxide and triethoxyoctylsilane, and 1 part of wild soybean oil, polyglycerol-3 distearate, a rice germ extract and a rice extract; the phase C comprises the following raw materials in parts by weight: 0.1 part of water b, 0.06 part of arginine, 0.5 part of 1, 2-hexanediol, 0.05 part of essence and 0.01 part of magnesium sulfate;
the weight ratio of the titanium dioxide to the triethoxyoctylsilane is 97; the weight ratio of the wild soybean oil, the polyglycerol-3 distearate, the rice germ extract and the rice extract is 64;
the preparation method of the rice extract comprises the following steps:
(1) Cleaning and crushing rice seeds to obtain rice powder; wherein the grain diameter of the rice powder is 30-50 meshes;
(2) Mixing the rice flour obtained in the step (1) with water, performing reflux extraction, and filtering to obtain a primary extracting solution and a primary filter residue after the reflux extraction is finished; wherein the temperature of the reflux extraction is 85-90 ℃, and the time of the reflux extraction is 2-4 h;
(3) Mixing the primary filter residue obtained in the step (2) with ethanol, performing reflux extraction, and filtering to obtain a secondary extracting solution and secondary filter residue after the reflux extraction is finished; wherein the temperature of the reflux extraction is 68-72 ℃, and the time of the reflux extraction is 4-6 h;
(4) Mixing the primary extractive solution and the secondary extractive solution, concentrating, and drying to obtain rice extract; wherein the drying temperature is 30-45 ℃;
the preparation method of the isolating spray comprises the following steps:
(i) Heating the phase A raw material to a first set temperature, stirring and dissolving, adding the phase B raw material, and continuing homogenizing to obtain a mixed solution a; wherein the first set temperature is 83-87 ℃;
(ii) Cooling the mixed solution a to a second set temperature, then adding the C-phase raw material, and uniformly stirring to obtain isolated spray; wherein the second set temperature is 38-42 ℃.
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