CN111896422A - Online integrity detection method for sterilizing filter element - Google Patents
Online integrity detection method for sterilizing filter element Download PDFInfo
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- CN111896422A CN111896422A CN202010654675.3A CN202010654675A CN111896422A CN 111896422 A CN111896422 A CN 111896422A CN 202010654675 A CN202010654675 A CN 202010654675A CN 111896422 A CN111896422 A CN 111896422A
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- integrity
- upper chamber
- filter element
- sterilizing filter
- sterilizing
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- 230000001954 sterilising effect Effects 0.000 title claims abstract description 52
- 238000001514 detection method Methods 0.000 title claims abstract description 29
- 239000007788 liquid Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000007599 discharging Methods 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 12
- 239000008223 sterile water Substances 0.000 claims description 9
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 3
- 238000009736 wetting Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N7/00—Analysing materials by measuring the pressure or volume of a gas or vapour
- G01N7/10—Analysing materials by measuring the pressure or volume of a gas or vapour by allowing diffusion of components through a porous wall and measuring a pressure or volume difference
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The invention discloses an integrity online detection method of a sterilizing filter element, which comprises the following steps: (1) introducing liquid into the upper chamber of the filter with the sterilizing filter element until a water film is attached to the surface of the sterilizing filter element, stopping introducing the liquid, and discharging redundant liquid in the upper chamber; (2) introducing sterile gas into the upper chamber until the pressure in the upper chamber is stabilized at P1Then stopping introducing the sterile gas; (3) after waiting for a period of time, the pressure in the upper chamber is measured to be P2A 1 is to P1And P2Difference value DeltaP of (A) and set value P0And (3) comparison: when Δ P < P0The integrity of the sterilizing filter element reaches the standard; when DeltaP is more than or equal to P0And the integrity of the sterilizing filter element does not reach the standard. According to the online integrity detection method for the sterilizing filter element, disclosed by the invention, the online integrity detection of the sterilizing filter element can be realized without an integrity detector, the detection efficiency is improved, and the detection cost is reduced.
Description
Technical Field
The invention relates to the field of liquid sterilization and filtration, in particular to an online integrity detection method for a sterilization filter element.
Background
No matter in the beverage industry or in the medical industry, the terminal degerming filter core uses more and more extensively, and the direct relation product safety of integrality of terminal degerming filter core, in the use, the integrality of degerming filter core probably receives destruction, leads to degerming efficiency to descend, and the integrality detects to be the important method of judging degerming filter core integrality.
In the prior art, an off-line detection method is generally adopted, a degerming filter element is taken out from a production line filter, placed in a special filter or a clamp for laboratory test, and connected with an integrity detector for detection. Or online manual connection detection is adopted, the integrity detector is conveyed to the position near the filter of the production line, the integrity detector is connected with the filter, and then the integrity detector is started to check. The above methods all require manual connection of the integrity detector, and have low testing efficiency and relatively high testing cost.
Disclosure of Invention
The invention aims to provide an on-line detection method for the integrity of a sterilizing filter element, which can realize the on-line detection of the integrity of the sterilizing filter element without an integrity detector, improves the detection efficiency and reduces the detection cost.
In order to achieve the purpose, the invention adopts the technical scheme that:
an integrity online detection method of a sterilizing filter element comprises the following steps:
(1) introducing liquid into an upper chamber of a filter with an internally installed sterilization filter element until a water film is attached to the surface of the sterilization filter element, stopping introducing the liquid, and discharging redundant liquid in the upper chamber;
(2) introducing sterile gas into the upper chamber until the gas pressure in the upper chamber is stabilized at P1Then stopping introducing the sterile gas;
(3) after waiting for a period of time, measuring to obtain a value P of the air pressure in the upper chamber2A 1 is to P1And P2Difference value DeltaP of (A) and set value P0And (3) comparison:
when Δ P < P0Then the integrity of the degerming filter element reaches the standard；
When DeltaP is more than or equal to P0And the integrity of the sterilizing filter element does not reach the standard.
Preferably, in step (1), the upper chamber is put into communication with the outside atmosphere, and the time T elapses1Then, liquid is fully distributed in the upper chamber, and the upper chamber is disconnected from the external atmospheric pressure; then passes through time T2And then, a layer of water film is attached to the surface of the sterilizing filter element.
Preferably, in step (1), liquid flows into the lower chamber of the filter through the sterilizing filter element, and the liquid in the lower chamber is discharged.
Preferably, after step (3), the upper chamber is vented to ambient atmospheric pressure to remove the sterile gas therein.
Preferably, the filter is disconnected from the sterile water outlet before step (1), and is connected to the sterile water outlet when the integrity of the sterilizing cartridge is up to standard after step (3).
Preferably, in step (2), the low-pressure gas is passed into the upper chamber after aseptic filtration.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages: according to the online integrity detection method for the sterilizing filter element, disclosed by the invention, the liquid and the low-pressure gas are directly introduced into the upper cavity of the working filter to detect the integrity of the sterilizing filter element, and the online integrity detection of the sterilizing filter element can be realized without an integrity detector, so that the detection efficiency is improved, and the detection cost is reduced.
Drawings
FIG. 1 is a schematic view of the apparatus used in the method of the present invention.
Wherein: 1. a filter; 2. a sterilizing filter element; 3. caching a water tank; 4. a first pipeline; 5. a low pressure gas inlet; 6. a second pipeline; 7. a sterile water outlet; 8. a third pipeline; 9. a delivery pump; 10. a first pneumatic valve; 11. a first drain line; 12. a second pneumatic valve; 13. a gas sterilizing and filtering device; 14. a third pneumatic valve; 15. an electric proportional valve; 16. a fourth pneumatic valve; 17. a second drain line; 18. a fifth pneumatic valve; 19. an exhaust line; 20. a pressure sensor; 21. a sixth pneumatic valve; 22. an editable logic controller; 23. a data acquisition and computing system.
Detailed Description
The technical scheme of the invention is further explained by combining the attached drawings.
Referring to fig. 1, a sterilizing filter element 2 is arranged in a filter 1, a buffer water tank 3 is communicated with an upper chamber of the filter 1 through a first pipeline 4, a low-pressure air inlet 5 is communicated with the upper chamber of the filter 1 through a second pipeline 6, and a sterile water outlet 7 is communicated with a lower chamber of the filter 1 through a third pipeline 8.
The first pipeline 4 is connected with a delivery pump 9 positioned on the side of the buffer water tank 3, a first pneumatic valve 10 positioned on the side of the filter 1 and a first drainage pipeline 11 positioned between the delivery pump 9 and the first pneumatic valve 10, and the first drainage pipeline 11 is provided with a second pneumatic valve 12.
The second pipeline 6 is connected with a gas sterilizing and filtering device 13, a third pneumatic valve 14 and an electric proportional valve 15 which are arranged between the gas sterilizing and filtering device 13 and the low-pressure gas inlet 5, and a fourth pneumatic valve 16 which is arranged between the gas sterilizing and filtering device 13 and the filter 1.
The third line 8 is connected to a second drain line 17 between the sterile water outlet 7 and the filter 1, and a fifth pneumatic valve 18 is provided on the second line.
An exhaust pipeline 19 and a pressure sensor 20 are connected to an upper chamber of the filter 1, and a sixth pneumatic valve 21 is arranged on the exhaust pipeline 19. When sterile gas is introduced into the upper chamber through the second pipeline 6, the electric proportional valve 15 is adjusted according to the value of the pressure sensor 20, so that the pressure in the upper chamber is slowly increased.
The method for detecting the integrity of the sterilizing filter element on line is realized by the equipment and comprises the following steps:
(1) the fifth pneumatic valve 18 is opened, disconnecting the lower chamber of the filter 1 from the sterile water outlet 7.
(2) The delivery pump 9 and the first pneumatic valve 10 are opened, the second pneumatic valve 12 is closed, and the direction of the water is changed through the buffer water tank 3Liquid is introduced into the upper chamber of the filter 1; meanwhile, the sixth pneumatic valve 21 is opened to communicate the upper chamber with the external atmospheric pressure, so as to prevent incomplete wetting of the sterilizing filter element 2 and prevent the incomplete wetting of the sterilizing filter element after the time T1Then, the upper chamber is filled with the liquid, the sixth pneumatic valve 21 is closed, and the upper chamber is disconnected from the external atmospheric pressure; then passes through time T2Then, a layer of water film is attached to the surface of the sterilizing filter element 2; the delivery pump 9 is closed, the second pneumatic valve 12 is opened, and the redundant liquid in the upper chamber is discharged from the first liquid discharge pipeline 11;
during the wetting process, since the liquid flows through the sterilizing filter insert 2 into the lower chamber of the filter 1, the liquid in the lower chamber is discharged into the second drain line 17.
(3) Opening the third pneumatic valve 14 and the fourth pneumatic valve 16, introducing sterile gas into the upper chamber (the low-pressure gas passes through the gas sterilizing and filtering device 13 to obtain the sterile gas), adjusting the electric proportional valve 15 according to the value of the pressure sensor 20 to slowly increase the pressure in the upper chamber until the pressure in the upper chamber is stabilized at P1Thereafter, the third pneumatic valve 14 and the fourth pneumatic valve 16 are closed, and the supply of the sterile gas is stopped.
(4) At P1Under the pressure, the sterile gas freely diffuses on the water film on the surface of the sterilizing filter element 2, after a period of time (generally 10-20 minutes), the pressure value P in the upper chamber is measured2A 1 is to P1And P2Difference value DeltaP of (A) and set value P0And (3) comparison:
when Δ P < P0When the pressure in the upper chamber is reduced slowly, the integrity of the sterilizing filter element 2 reaches the standard;
when DeltaP is more than or equal to P0In time, the air pressure in the upper chamber is reduced quickly, and the integrity of the sterilizing filter element 2 does not reach the standard.
(5) After the test is completed, the sixth pneumatic valve 21 is opened to communicate the upper chamber with the outside atmosphere and to discharge the sterile gas therein.
(6) When the integrity of the sterilizing filter element 2 is calibrated, the fifth pneumatic valve 18 is closed, and the filter 1 is communicated with the sterile water outlet 7, so that the operation is continued.
Referring to FIG. 1, the above apparatus further comprisesAn edit logic controller 22 and a data acquisition and computation system 23, wherein the edit logic controller 22 is used to detect the control of the pump and valve during the process; the data acquisition and calculation system 23 is used for acquiring and calculating data in the detection process, judging the detection result, and inputting a set value P into the data acquisition and calculation system 23 when the detection is started0。
The above-mentioned embodiments are merely illustrative of the technical idea and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the scope of the present invention, and all equivalent changes or modifications made according to the spirit of the present invention should be covered in the scope of the present invention.
Claims (6)
1. An integrity online detection method of a sterilizing filter element is characterized by comprising the following steps: the method comprises the following steps:
(1) introducing liquid into an upper chamber of a filter with an internally installed sterilization filter element until a water film is attached to the surface of the sterilization filter element, stopping introducing the liquid, and discharging redundant liquid in the upper chamber;
(2) introducing sterile gas into the upper chamber until the gas pressure in the upper chamber is stabilized at P1Then stopping introducing the sterile gas;
(3) after waiting for a period of time, measuring to obtain a value P of the air pressure in the upper chamber2A 1 is to P1And P2Difference value DeltaP of (A) and set value P0And (3) comparison:
when Δ P < P0When the integrity of the sterilizing filter element reaches the standard;
when DeltaP is more than or equal to P0And the integrity of the sterilizing filter element does not reach the standard.
2. The method for the online detection of the integrity of a sterilizing filter cartridge according to claim 1, characterized in that: in the step (1), the upper chamber is communicated with the external atmospheric pressure for a time T1Then, liquid is fully distributed in the upper chamber, and the upper chamber is disconnected from the external atmospheric pressure; then passes through time T2And then, a layer of water film is attached to the surface of the sterilizing filter element.
3. The method for the online detection of the integrity of a sterilizing filter cartridge according to claim 1, characterized in that: in step (1), liquid flows into the lower chamber of the filter through the sterilizing filter element, and the liquid in the lower chamber is discharged.
4. The method for the online detection of the integrity of a sterilizing filter cartridge according to claim 1, characterized in that: after step (3), communicating the upper chamber with the outside atmosphere to vent the sterile gas therein.
5. The method for the online detection of the integrity of a sterilizing filter cartridge according to claim 1, characterized in that: disconnecting the filter from the sterile water outlet prior to step (1), and communicating the filter with the sterile water outlet after step (3) when the integrity of the sterilizing cartridge meets a standard.
6. The method for the online detection of the integrity of a sterilizing filter cartridge according to claim 1, characterized in that: in the step (2), the low-pressure gas is introduced into the upper chamber after being sterilized and filtered.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010654675.3A CN111896422A (en) | 2020-07-09 | 2020-07-09 | Online integrity detection method for sterilizing filter element |
| PCT/CN2021/105362 WO2022007916A1 (en) | 2020-07-09 | 2021-07-09 | Online testing method for integrity of sterilizing filter element |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010654675.3A CN111896422A (en) | 2020-07-09 | 2020-07-09 | Online integrity detection method for sterilizing filter element |
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| CN111896422A true CN111896422A (en) | 2020-11-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010654675.3A Pending CN111896422A (en) | 2020-07-09 | 2020-07-09 | Online integrity detection method for sterilizing filter element |
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| CN (1) | CN111896422A (en) |
| WO (1) | WO2022007916A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022007916A1 (en) * | 2020-07-09 | 2022-01-13 | 江苏新美星包装机械股份有限公司 | Online testing method for integrity of sterilizing filter element |
| CN115336665A (en) * | 2022-10-18 | 2022-11-15 | 黑龙江飞鹤乳业有限公司 | Lactoferrin treatment method and device and validity verification method |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114235666B (en) * | 2022-02-25 | 2022-05-06 | 徐州百艾电子科技有限公司 | System and method for detecting performance of filter element of purifier |
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| US5594161A (en) * | 1992-03-24 | 1997-01-14 | Pall Corporation | Method and apparatus for rapidly testing the integrity of filter elements |
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| JP2008246482A (en) * | 2008-06-04 | 2008-10-16 | L'air Liquide-Sa Pour L'etude & L'exploitation Des Procedes Georges Claude | Filter module for cryostatic temperature liquid and its integrity test method |
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| CN111896422A (en) * | 2020-07-09 | 2020-11-06 | 江苏新美星包装机械股份有限公司 | Online integrity detection method for sterilizing filter element |
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2020
- 2020-07-09 CN CN202010654675.3A patent/CN111896422A/en active Pending
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2021
- 2021-07-09 WO PCT/CN2021/105362 patent/WO2022007916A1/en active Application Filing
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| US5594161A (en) * | 1992-03-24 | 1997-01-14 | Pall Corporation | Method and apparatus for rapidly testing the integrity of filter elements |
| CN201732014U (en) * | 2010-08-20 | 2011-02-02 | 伊马莱富（北京）制药系统有限公司 | Online integrity test system of sterile filter |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022007916A1 (en) * | 2020-07-09 | 2022-01-13 | 江苏新美星包装机械股份有限公司 | Online testing method for integrity of sterilizing filter element |
| CN115336665A (en) * | 2022-10-18 | 2022-11-15 | 黑龙江飞鹤乳业有限公司 | Lactoferrin treatment method and device and validity verification method |
| CN115336665B (en) * | 2022-10-18 | 2023-02-03 | 黑龙江飞鹤乳业有限公司 | Lactoferrin treatment method and device and validity verification method |
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| Publication number | Publication date |
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| WO2022007916A1 (en) | 2022-01-13 |
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