CN111888426A - Medicine for treating diabetes - Google Patents

Abstract

The invention discloses a medicine for treating diabetes, which is an over-the-counter medicine for endocrine system diseases and mainly comprises the following components in part by weight: type 2 diabetes, and pre-diabetes, which are less symptomatic, can reduce blood glucose to or near the normal range. The invention is composed of 12 traditional Chinese medicines such as frosted mulberry leaf, rhizoma anemarrhenae, radix ophiopogonis and the like. Processing into film coated tablet, capsule or sugar-free granule for oral administration. It has mild medicinal properties and no toxic or side effects. The product has effects of clearing heat, moistening dryness, invigorating qi, nourishing yin, promoting fluid production, and quenching thirst. Can promote the cell to secrete insulin, and achieve the effects of reducing blood sugar and urine sugar. Can enhance immunity, prevent complications, prevent or relieve diseases of large blood vessel, capillary vessel and nervous system, and reduce risk factors such as hypertension and hyperlipemia. The composition can be used together with western medicines to reduce the dosage and side effects of western medicines. Improving symptoms, prolonging the life, improving the life quality of patients and solving the problem that no specific medicine is available for treating type 2 diabetes and diabetes at the early stage at present.

Description

Medicine for treating diabetes

The invention relates to an oral medicine for treating endocrine system diseases, in particular to a medicine for treating diabetes, which is prepared by taking pure traditional Chinese medicines as raw materials.

Background art diabetes mellitus is an endocrine disease in which insulin secretion is relatively or absolutely reduced by various causes, and the most typical symptoms are polydipsia, polyphagia, polyuria and emaciation. Normally, the human pancreas secretes a hormone that lowers blood glucose, which we call insulin. In diabetic patients, the pancreatic function is reduced, and insulin secretion is insufficient; or the human body can not fully utilize the insulin in the body, so that the glucose can not enter cells, thereby causing the metabolic disorder of sugar, fat, protein and the like, and the diabetes is characterized by high blood sugar and diabetes, the fasting blood sugar is more than 7.0mmol/L, the blood sugar is more than 11.1mmol/L after 2 hours of meal, and the diabetes is accompanied by the symptoms of diabetes, thus the diabetes can be diagnosed. 6.1-7.0 mmol/L of fasting blood sugar or 7.8-11.0 mmol/L of blood sugar 2 hours after meal, which belongs to impaired fasting blood sugar or impaired glucose tolerance and can also be called as pre-diabetes. Diabetes is a lifelong disease, can cause human body microvascular and macrovascular diseases if the diabetes cannot be effectively treated in time, can cause binocular blindness, renal failure, cardiovascular and cerebrovascular diseases and other complications which seriously affect the quality of life and even endanger life, can become cardiovascular and cerebrovascular diseases, can threaten the 3 rd non-infectious epidemic disease of human health, disability and death after malignant tumor, and is the first diabetes kingdom in China.

Diabetes can be classified into type 1 diabetes, type 2 diabetes, gestational diabetes and other specific types of diabetes.

Type 1 diabetes mellitus is characterized in that insulin secreted in the body is absolutely insufficient and not enough for the body to use, diabetic ketosis is easy to occur in moderate degree, insulin is required to be used for treatment, the diabetes mellitus is frequently developed in childhood, and the onset of the diabetes mellitus is acute, so the diabetes mellitus is also called insulin-dependent diabetes mellitus.

Type 2 diabetes, which is the most common type of diabetes among the elderly, is not necessarily dependent on insulin therapy, and is also called non-insulin-dependent diabetes mellitus, because type 2 diabetes patients in China account for more than 90% of the total diabetes.

Gestational diabetes occurs during pregnancy in women, most often 24-48 weeks after pregnancy, and post-partum blood glucose levels return to normal, but a few patients remain in the hyperglycemic phase.

Diabetes belongs to the category of 'diabetes' in traditional Chinese medicine, and the traditional Chinese medicine considers that: the congenital deficiency of the patients, the five internal organs failing to be nourished and weak, deficiency of both qi and blood, deficiency of healthy qi being the basis of the disease, invasion of six exogenous pathogenic factors due to unconsolidation of healthy qi, pathogenic stagnation of pathogenic factors transforming into heat, endogenous dryness-heat consuming qi impairing yin. The deficiency of yin can lead to the accumulation of dryness-heat, which can damage yin-fluid and cause severe circulation and eventually diabetes. The pathogenesis generally belongs to: yin deficiency is the root cause and dryness-heat is the secondary cause. For treatment, yin is nourished to promote the production of body fluid to strengthen body resistance, and heat is cleared away to moisten dryness to treat the symptoms.

In the process of treating diabetes, the curative effect of the traditional Chinese medicine is not exact for treating the patients with type 1 diabetes. But for the patients with type 2 diabetes with mild symptoms, the traditional Chinese medicine can obtain better curative effect by combining diet and exercise treatment. Other most diabetes patients combine the Chinese and western medicines, and have positive effects on improving symptoms, preventing complications and reducing the dosage and side effects of western medicines.

The invention aims to provide an oral medicine for treating diabetes, which has the effects of clearing heat, moistening dryness, tonifying qi, nourishing yin, promoting the production of body fluid and quenching thirst. Can promote the cells to secrete insulin, achieve the effects of reducing blood sugar and urine sugar, enhance the immune function of the organism, prevent the occurrence and the growth of complications, avoid or lighten the pathological changes of large blood vessels, micro blood vessels and a nervous system, reduce the risk factors such as hypertension, hyperlipidemia and the like, and reduce the dosage and the side effect of western medicines. Improving symptoms, prolonging life and improving life quality of patients.

The technical scheme of the invention is realized in the following mode:

a medicine for treating diabetes is an oral medicine prepared by processing or refining a traditional Chinese medicine prescription, and the prescription is as follows: 16 g of frosted mulberry leaf, 9 g of rhizoma anemarrhenae, 12 g of dwarf lilyturf tuber, 12 g of dried rehmannia root, 9 g of fragrant solomonseal rhizome, 3 g of golden thread, 12 g of astragalus root, 12 g of Chinese yam, 10 g of flatstem milkvetch seed, 10 g of medlar, 12 g of salvia miltiorrhiza and 6 g of lychee seed.

The prescription consists of 12 traditional Chinese medicines according to a proportion, the weight of the traditional Chinese medicine is 123 g, and the traditional Chinese medicine has no toxic or side effect when being taken orally.

According to the proportion of the medicines of the formula and the proportion of the medicines, namely the relative dosage, the medicines are processed or refined to prepare capsules, tablets or sugar-free granules for oral administration.

The prescription is an agent for treating both the incidental and fundamental aspects. Diabetes mellitus with polydipsia, polyphagia, polyuria and the like can be seen simultaneously, and thirst with polydipsia is mainly called as the upper jiao and belongs to the lung. The polyphagia with limosis is called as Xiaozhong, which belongs to stomach. Diuresis or urine like fat paste, mainly sweet in flavor, is called Xixiao, and belongs to kidney. Clinically, the upper jiao is mild, the middle jiao is inferior and the lower jiao is severe. The treatment is mainly to nourish yin and is assisted by clearing heat. In the later stage of lower energizer, yin impairment affecting yang, manifested as deficiency of both yin and yang, it is advisable to supplement both yin and yang. In the recipe, frosted mulberry leaves are bitter and sweet, cold in nature, bitter and cold in nature to discharge heat, sweet and cold in nature to benefit yin. Sang Ye can clear and descend along with clearing and descending, improving vision and quenching thirst. Frosted mulberry leaf has the effects of nourishing yin and cooling blood, clearing intestine and expelling toxin, calming liver and improving eyesight, inducing diuresis and treating stranguria, reducing blood sugar, blood pressure and blood fat, resisting tumor and descending foul breath. The mulberry leaf polysaccharide and the mulberry leaf alkaloid can promote cells to secrete insulin, so that the effect of reducing blood sugar is achieved. The mulberry leaves can remove free radicals in vivo, resist oxidation and resist aging. Myocardial infarction and cerebral hemorrhage are the result of capillary vessel blockage, and mulberry leaves contain flavonoid components for strengthening capillary vessels and reducing blood viscosity, and can effectively reduce the attack of heart and cerebral vessels. The mulberry leaves are a preferred medicine for treating diabetes in the prescription, are clean and tonic, have no damage to internal organs, are suitable for the old and the young and can be used in four seasons. Rhizoma anemarrhenae, radix Ophiopogonis, rehmanniae radix, rhizoma Polygonati Odorati, and Coptidis rhizoma have effects of nourishing yin, clearing heat, moistening dryness, promoting fluid production, relieving restlessness, quenching thirst, and adjuvant treating diabetes with principal drug for treating polydipsia, polyphagia, diuresis, marasmus, thirst, pharyngoxerosis, and constipation. The astragalus, the Chinese yam, the wolfberry fruit and the flatstem milkvetch seed have the effects of tonifying qi and the kidney, coordinating yin and yang and promoting each other, can be used together with the main medicines for reducing blood sugar, and can treat the diabetes diseases such as dizziness, palpitation, polyphagia, hunger, insomnia, frequent micturition and the like. The salvia miltiorrhiza and the lychee seed are used for regulating qi and blood, strengthening the force of promoting blood circulation and removing blood stasis, the diabetes mellitus enters collaterals for a long time to cause blood stasis, the effects of nourishing yin and purging fire are poor only by using products, and the effects of dredging collaterals, promoting blood circulation and regulating qi can be improved, the blood sugar is reduced, and the complications are prevented and treated.

The invention has the positive effects that:

pure Chinese medicine, low cost, wide source of medicinal materials, mild property and no toxic or side effect. The product has effects of clearing heat, moistening dryness, invigorating qi, nourishing yin, promoting fluid production, quenching thirst, promoting cell secretion of insulin, and lowering blood sugar and urine sugar; enhancing immunity, preventing and treating complications, preventing or relieving diseases of large blood vessel, capillary vessel and nervous system, and reducing risk factors such as hypertension and hyperlipemia. For patients with mild type 2 diabetes or pre-diabetes, the blood sugar can be recovered to normal, and the general symptoms can be eliminated. For most other diabetes patients, the product is combined with western medicines, and has positive effects on improving symptoms, preventing and treating complications, and reducing the dosage and side effects of the western medicines. Solves the problem that no specific traditional Chinese medicine is available for treating diabetes and complications thereof at present.

The properties and functions of the 12 Chinese medicinal herbs in this prescription will be further explained below.

Mulberry leaf is bitter, sweet and cold. It enters lung and liver meridians. Disperse wind-heat, clear lung-heat and moisten dryness, pacify liver and improve vision. It can be used for treating fever, headache, dry lung, cough, dry throat, thirst, liver yang, conjunctival congestion, and swelling and pain. For cough with sticky phlegm, dry throat and thirst due to lung and stomach yin deficiency with warm dryness coming, it is combined with sang Ye, Zhi mu, Mai Dong and Yu Zhu to clear lung and nourish yin, promote fluid production and moisten dryness.

Zhi mu is bitter, sweet and cold. It enters lung, stomach and kidney meridians. Clear heat and purge fire, nourish yin to moisten dryness, induce diuresis and remove dampness. Can be used for treating dysphoria with smothery sensation, diabetes, cough due to lung heat, hectic fever due to yin deficiency, constipation due to intestinal dryness. Anemarrhena asphodeloides is the essential herb for diabetes, and has the effects of relieving fever, lowering blood sugar, and alleviating diarrhea.

Mai Dong is sweet, slightly bitter and slightly cold. Nourish yin to moisten dryness, nourish stomach to promote fluid production, clear heart fire and relieve restlessness. It can be used for treating dry cough due to lung dryness, asthenia, dysphoria, diabetes, fever, body fluid injury, dry throat, dry mouth, and constipation. The ophiopogon root has the functions of obviously reducing blood sugar, protecting heart and the like.

Gan Di Huang is sweet and cold. It enters heart, liver and kidney meridians. Clear heat and cool blood, nourish yin and promote the production of body fluid. It can be used for treating fever polydipsia, yin deficiency with internal heat, bone steaming with internal heat, diabetes, macula, and erythra. The rehmanniae radix has antiinflammatory, heart tonifying, blood pressure lowering, blood sugar lowering, and purgative effects.

Yu Zhu is sweet and neutral. It enters lung and stomach meridians. Nourish yin and moisten lung, promote the production of body fluid and nourish stomach. It can be used for treating yin impairment due to febrile disease, cough, polydipsia, diabetes, and hyperphagia, and rhizoma Polygonati Odorati has effects of reducing blood lipid, lowering blood sugar, and relieving formation of atherosclerotic plaque.

Huang Lian is bitter and cold. It enters heart, spleen, stomach, liver, gallbladder and large intestine meridians. Clear heat and dry dampness, purge fire and remove toxicity. It is indicated for fullness due to damp-heat, hyperactivity of heart-fire, restlessness and insomnia. The yellow wine has the functions of reducing blood sugar, blood pressure and the like.

Yam is sweet and neutral. It enters spleen, lung and kidney meridians. Tonify qi, nourish yin, tonify spleen, lung and kidney, secure essence and stop leukorrhagia. It can be used for treating spleen qi deficiency, kidney deficiency, spermatorrhea, frequent micturition, and diabetes.

Flatstem milkvetch seed, semen astragali Complanati, sweet and warm. It enters liver and kidney meridians. To tonify kidney, secure essence, nourish liver and improve vision. It can be used for treating deficiency of liver and kidney, spermatorrhea, premature ejaculation, frequent micturition, and enuresis. The semen astragali Complanati can regulate physiological function of organism, is a tonic medicine with original shape adapting effect, and has effects of lowering blood pressure, reducing blood lipid, reducing enzyme, and increasing cerebral blood flow.

Wolfberry fruit, fructus Lycii, sweet in taste and neutral in nature. It enters liver, kidney and lung meridians. Nourishing liver, replenishing kidney essence and moistening lung. It is used for treating liver and kidney deficiency, dizziness, blurred vision, diabetes, and polydipsia. Fructus Lycii has effects of delaying aging, lowering blood sugar, lowering blood pressure, and reducing blood lipid. Wolfberry fruit, dried rehmannia root, astragalus root, ophiopogon root, Chinese yam and the like have the functions of increasing yin nourishing and promoting the production of body fluid, and are used for treating diabetes.

Dan Shen is bitter and cold. It enters heart and liver meridians. Promoting blood circulation, removing blood stasis, cooling blood, relieving pain, nourishing blood, and tranquilizing mind. It can be used for treating menoxenia, amenorrhea due to blood stagnation, sore, pain, swelling and pain, palpitation, severe palpitation, and insomnia. Has certain curative effect on cerebral arteriosclerosis, cerebral apoplexy, cerebral thrombosis, hypertension, coronary heart disease, etc. The red sage root has obvious curative effect on diabetes complicated with chronic multiple peripheral neuritis.

The lychee seeds are sweet, astringent and warm. It enters liver and stomach meridians. Regulate qi to alleviate pain, dispel cold and dissipate stagnation. It can be used for treating hernia pain, gastralgia, and diabetes. The lychee seed can be used for treating non-insulin-dependent diabetes mellitus without complications for the middle-aged and the elderly, and has a remarkable effect.

The function, indication and the like of the medicament for treating diabetes of the invention are explained below.

[ function ] clearing heat and moistening dryness, supplementing qi and nourishing yin, promoting the production of body fluid and quenching thirst, tonifying kidney and reducing urination.

[ the main treatment ] is type 2 diabetes, pre-diabetes and complications thereof.

The medicine composition includes 12 kinds of Chinese medicinal materials, including mulberry leaf, litchi seed, etc.

[ formulation type ] film-coated tablet, capsule or sugar-free granule.

[ Properties ] this product is tan, fragrant, bitter and sweet.

[ action class ] this product is an over-the-counter drug for endocrine system diseases.

The dosage is 3-5 g for oral administration (crude drug), 2-3 times daily, or following the advice of doctor. Two months is a treatment course, and the traditional Chinese medicine can be used as appropriate after being taken for one treatment course.

The product is suitable for patients with type 2 diabetes and diabetes at the early stage, and is contraindicated for pregnant women. Can be used together with western medicines for reducing blood sugar, but should avoid taking the western medicines and the western medicines simultaneously as much as possible to avoid drug reaction and toxic and side effects. It should be used with cautions for patients with deficiency-cold of spleen and stomach and hypotension.

Embodiments of the present invention are clinical applications, and are described as follows:

[ case one ] some Liu, male, 78 years old, Shangcai county Qihai village, moderate type 2 diabetes patients, 2010 village hospital test results, fasting blood sugar 9.2mmol/L, urine sugar (++), with cholesterol, triacylglycerol rise, emaciation, polyphagia, polydipsia, polyuria, cough, pharyngalgia, thirst, dry stool and other symptoms. The patient has a red tongue with thin and yellow coating and a rapid pulse. The medicine is taken 3 times a day, 5 g each time, at 4 months in 2010, and after one month, the blood sugar returns to normal. After another two months of administration, the blood sugar stabilized at 5.1mmol/L and the symptoms disappeared. The medicine is taken at a later time to prevent relapse.

"case two" Yan A male, 69 years old, Shancai county tower bridgetown, is healthy and mainly at home. In 2018, in the next half year, because sweet potatoes and other sweet foods are eaten for a long time for more than 6 months, symptoms such as thirst, frequent micturition, dizziness and the like appear, and the detection result of a Taqiaozhen hospital is as follows: 6.2mmol/L of fasting blood sugar, 145-76 mm Hg of blood pressure, which belongs to the pre-stage of diabetes, the blood pressure is high, the medicine is taken in 1 month in 2019, and the blood sugar is stable after two weeks: 5.1mmol/L, blood pressure 130-75 mmHg, and the medicine is still taken discontinuously at present to prevent relapse.

Claims (2)

1. The medicine for treating diabetes is characterized by comprising 16 g of frosted mulberry leaf, 9 g of rhizoma anemarrhenae, 12 g of radix ophiopogonis, 12 g of dried rehmannia root, 9 g of polygonatum odoratum, 3 g of coptis root, 12 g of astragalus root, 12 g of Chinese yam, 10 g of flatstem milkvetch seed, 10 g of medlar, 12 g of salvia miltiorrhiza and 6 g of lychee seed.

2. Pharmaceutical according to claim 1, characterized in that it is a film-coated tablet, a capsule or a sugar-free granulate.