CN108186905A - A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of Chinese medicine compositions for treating extreme heat due to deficiency of yin patients with type Ⅰ DM and preparation method thereof, are related to diabetes medicament preparing technical field, include the raw material of following parts by weight：20 30 parts of Radix Notoginseng, 20 30 parts of the stem of noble dendrobium, 20 30 parts of balsam pear, 15 25 parts of American Ginseng, 10 20 parts of the coptis, 20 30 parts of radix scutellariae, 15 25 parts of lily, 15 25 parts of rhizoma anemarrhenae, 15 25 parts of prepared rehmannia root, 10 20 parts of brush-cherry seed, 7 15 parts of dark plum, 15 25 parts of Radix Glycyrrhizae.The present invention is for the symptom of the extreme heat due to deficiency of yin of diabetes early stage, carry out dialectical compatibility using a variety of Chinese herbal medicines, play nourishing Yin and clearing heat, purging intense heat go it is dry, promote the production of body fluid and be tired of, can effectively reduce blood glucose, the blood lipids index of extreme heat due to deficiency of yin diabetes mellitus type, improve clinical symptoms, and be made of pure Chinese medicine, safe Small side effects are significant in efficacy, it is rapid-action, preparation method is simple, is establishing good the effect of working and resting with that on the basis of eating habit, can reach treating both manifestation and root cause of disease to diabetes.
Description
Technical field
The present invention relates to diabetes medicament preparing technical fields, and in particular to a kind of to treat in extreme heat due to deficiency of yin patients with type Ⅰ DM
Drug composition and preparation method thereof.
Background technology
Diabetes are the chronic incretion metabolism diseases characterized by hyperglycemia, pathologic basis for insulin definitely sum/
Or opposite shortage, and then cause sugar, fat, protein, water and a series of metabolic disorders of electrolyte.Global diabetes number is up to
4.22 hundred million, every 11 people just have 1 people to suffer from diabetes.China has become global first diabetes big country, and patient numbers account for the whole world
1/3, and newly-increased patient about 1,500,000 every year, wherein about 97% patient belongs to type II diabetes.Diabetes become after tumour and
Third position after cardiovascular and cerebrovascular disease seriously endangers the chronic disease of human health, is known as " 21 century by the World Health Organization
Disaster ".
Traditional Chinese medicine thinks that diabetes can be divided into 3 types, i.e. extreme heat due to deficiency of yin type, gas the moon two according to the different phase of disease
Deficiency and yin-yang deficiency type, wherein extreme heat due to deficiency of yin patients with type Ⅰ DM belong to diabetes early stage, and clinical manifestation is thirst and drinking, small
Just frequency, mouth parched and tongue scorched, rapid digestion of food and polyorexia etc..Though traditional Western medicine hypoglycemic Regimen Chemotherapy diabetes have certain curative effect, effect is not
Ideal, the organs such as liver, kidney to human body have certain damage, and cannot effectively control complication.Therefore, with Chinese Traditional Medicine
Speciality, increasing tradition has the developmental research of efficacious prescriptions and Empirical formula, is preferably diabetes clinical treatment service, is current traditional Chinese medicine
One of target of boundary struggle.
Invention content
In view of the deficiencies of the prior art, the present invention provides a kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM and
Preparation method can effectively reduce blood glucose, the blood lipids index of extreme heat due to deficiency of yin diabetes mellitus type, improve clinical symptoms, curative effect
Significantly.
In order to achieve the above object, the present invention is achieved by the following technical programs：
A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM includes the raw material of following parts by weight：Radix Notoginseng 20-30
Part, 20-30 parts of the stem of noble dendrobium, 20-30 parts of balsam pear, 15-25 parts of American Ginseng, 10-20 parts of the coptis, 20-30 parts of radix scutellariae, 15-25 parts of lily,
15-25 parts of rhizoma anemarrhenae, 15-25 parts of prepared rehmannia root, 10-20 parts of brush-cherry seed, 7-15 parts of dark plum, 15-25 parts of Radix Glycyrrhizae.
Preferably, include the raw material of following parts by weight：25-30 parts of Radix Notoginseng, 22-27 parts of the stem of noble dendrobium, 22-27 parts of balsam pear, the West
17-22 parts of ginseng, 13-18 parts of the coptis, 24-29 parts of radix scutellariae, 17-22 parts of lily, 18-23 parts of rhizoma anemarrhenae, 17-22 parts of prepared rehmannia root, Yu Li
11-16 parts of benevolence, 8-12 parts of dark plum, 17-22 parts of Radix Glycyrrhizae.
Preferably, include the raw material of following parts by weight：28 parts of Radix Notoginseng, 25 parts of the stem of noble dendrobium, 25 parts of balsam pear, 20 parts of American Ginseng, Huang
15 parts of company, 26 parts of radix scutellariae, 20 parts of lily, 20 parts of rhizoma anemarrhenae, 20 parts of prepared rehmannia root, 14 parts of brush-cherry seed, 10 parts of dark plum, 20 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment extreme heat due to deficiency of yin patients with type Ⅰ DM, includes the following steps：
S1, Radix Notoginseng, balsam pear, brush-cherry seed, dark plum, Radix Glycyrrhizae are mixed, crushed, add water to cook extraction 2 times, filtering merges filter
Liquid, obtains Aqueous extracts and water carries filter residue, and Aqueous extracts are concentrated under reduced pressure into the clear cream (60 DEG C) that relative density is 1.10-1.12, Xiang Qi
Middle addition ethyl alcohol makes alcohol content stir, refrigerate, filter, filtrate is spare up to 55-70%；
S2, the stem of noble dendrobium, American Ginseng, the coptis, radix scutellariae, lily, rhizoma anemarrhenae, prepared rehmannia root are mixed, crushed, the water added in S1 proposes filter
Slag adds the ethanol solution of 70-75%, and refluxing extraction 2 times filters, and merging filtrate is spare；
S3, the filtrate in S1, S2 is merged, ethyl alcohol is recovered under reduced pressure, be concentrated into the clear cream that relative density is 1.22-1.26
(60 DEG C), vacuum drying, crush to get Chinese medicine composition.
Preferably, 20-30h is refrigerated in the S1.
Preferably, further include added in into Chinese medicine composition acceptable auxiliary material or complementary ingredient in pharmacy be prepared into it is scattered
Agent, granule, tablet or capsule.
It is as follows the effect of each raw material in the present invention：
Radix Notoginseng：Warm-natured, sweet in flavor, slight bitter, return liver warp, stomach have effects that dissipate stasis of blood hemostasis, detumescence ding-tong；Modern pharmacology
Research shows that Notogineng Extract has cardiac stimulant, decompression, liver protection, anti-inflammatory, reduction blood cholesterol, immunological regulation and antivirus action,
To blood and hemopoietic system there is hemostasis, platelet aggregation-against and thrombolysis, haemolysis, hematopoiesis, have to cardiovascular system
Anti-arrhythmia, antiatherosclerosis, resist oxygen lack and Hemorrhagic shock improve the effects that cerebral ischemia, have maincenter to nervous system
The effects that nerve inhibits, analgesia, goes back improving immunocompetence, and liver function protecting is antitumor, slows down aging, hypoglycemic, anti-inflammatory,
Auto-regulator is metabolized, and promotes growth.
The stem of noble dendrobium：Cold nature, it is sweet in flavor, return stomach, kidney channel, there is reinforcing stomach reg fluid, nourishing Yin and clearing heat；Modern pharmacological research
Show that the stem of noble dendrobium has the function of to adjust smooth muscle, have inhibiting effect to heart, body's immunity can be enhanced, slow down aging；It is dynamic
Object experiment shows that its decoction can promote gastric secretion, there is digestion-aid effect.
Balsam pear：It is cold in nature, the effect of there is driving away summer heat to wash heat for bitter, thoughts of returning home warp, the spleen channel, lung channel, improving eyesight, removing toxic substances；Pharmacological research
Show that balsam pear plays the role of hypoglycemic, anticancer, antiviral.
American Ginseng：Cool in nature, sweet in flavor, slight bitter, thoughts of returning home warp, lung channel, kidney channel have effects that boosting qi and nourishing yin, clearing heat and promoting fluid；It is existing
Show that American Ginseng has protective effect to cardiovascular system for pharmacological research, resisting stress capability, the immune work(of enhancing can be enhanced
Can, it protect the effects that erythrocyte membrane, antidiuresis.
The coptis：Cold in nature, bitter, thoughts of returning home warp, the spleen channel, stomach, Liver Channel, gallbladder channel, large intestine channel have heat-clearing and damp-drying drug, purging intense heat solution
The effect of malicious；The jamaicin that animal experiment shows in the coptis has antibacterial, antiviral and protozoon, cholagogic, anti diar rhea, anti-inflammatory and anti-
Cerebral ischemia, it is antimicrobial, be depressured, resist myocardial ischemia and myocardial infarction, anti-arrhythmia, inhibit central nervous system, only diarrhea,
Antiulcer, synthesis that is hypoglycemic, inhibiting DNA, inhibits the effects that platelet aggregation at cholagogic.
Radix scutellariae：It is cold in nature, bitter, distributed in lung channel, gallbladder channel, the spleen channel, large intestine channel, small intestinl channel, have heat-clearing and damp-drying drug, purging intense heat and detonicating,
The effect of hemostasis；Pharmacological research shows that radix scutellariae has wider antimicrobial spectrum, and water decoction has anti-inflammatory, Immune enhancement and calmness
Refrigeration function, have antimicrobial, antiallergic action, blood pressure lowering, diuresis, reducing blood lipid, platelet aggregation-against and anti-freezing, liver protection,
The effect of injury of kidney is protected, low dosage promotes immune cell propagation, and high dose then inhibits.
Lily：Cold in nature, sweet in flavor, thoughts of returning home warp, lung channel have effects that Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing；Modern pharmacology experiment knot
Fruit shows that lily has antibechic, relievings asthma, eliminating the phlegm, and resisting stress damage, tranquilizing soporific enhances immune function, increases peripheral leukocytes
Effect etc..
Rhizoma anemarrhenae：Cold in nature, bitter, sweet, distributed in lung channel, stomach, kidney channel have effects that clearing heat-fire, fluid dryness；Pharmacology is ground
Study carefully and think, rhizoma anemarrhenae has antipyretic, analgesia, anti-inflammatory and diuresis, can inhibit the activity of Na+-K+-ATP enzymes, adjust adrenaline
Can and cholinergic nerve system, can delay catabolism of the liver cell to cortisol, reduce blood glucose, can platelet aggregation-against, resist
Pathogenic microorganism, sleeping time caused by extending cyclobarbital have the effects that cholagogic, immunosupress.
Prepared rehmannia root：Slightly warm in nature, sweet in flavor, return liver warp, kidney channel have the effect of enriching yin of enriching blood, beneficial to spirit and marrow；Pharmacological research table
Bright, prepared rehmannia root water decoction can promote the recovery of the red blood cell of anaemia animal, hemoglobin, accelerate pluripotential hemopoietic stem cell proliferation,
Differentiation, additionally it is possible to liver hemorrhagic necrosis lesion and simple necrosis are significantly inhibited, to high in fat caused by food rich in fat
Vena hepatica bleeding plays the role of inhibition thrombosis caused by mass formed by blood stasis, fatty liver etc., also has the function of decompression.
Brush-cherry seed：Mild-natured, acrid flavour, hardship, sweet, converge to the spleen channel, large intestine channel, small intestinl channel have effects that laxative, diuresis；For
Treat the diseases such as constipation, oedema, oliguria；Pharmacological research shows that prunuside has strong discharge function, and saponins have only
Cough, eliminating the phlegm, antiasthmatic effect, protein component IR-AI and the IR-B intravenous injection of extraction have anti-inflammatory and analgesic effect.
Dark plum：It is mild-natured, sour, puckery, return liver warp, the spleen channel, lung channel, large intestine channel, have astringe the lung, puckery intestines, promote the production of body fluid, the work(of claming ascaris
Effect；Pharmacological evaluation proves that dark plum can make gallbladder contraction, promotes choleresis, and has anti-protein allergies to act on, to various pathogens
Have antibacterial action, also have inhibiting effect to various dermatophytes, there is ascarifuge, have antifatigue, anti-aging, radioresistance,
The effects that antagonism calcium ion, enhancing immune function.
Radix Glycyrrhizae：It is mild-natured, sweet in flavor, thoughts of returning home warp, stomach, the spleen channel, lung channel, have invigorate the spleen and benefit qi, cough-relieving apophlegmatic, emergency analgesic therapy,
The effect of mediation property of medicine；Pharmacological research shows that Radix Glycyrrhizae has a cortex hormone of aadrenaline effect, anti-inflammatory, antiulcer, antianaphylaxis,
Anticancer, antibacterial is antiviral, promotes pancreatic secretion, there is inhibition in vitro intestines, adjusts immune function, kobadrin, anti-mutation, solution
Poison, anti-oxidant, protection ear vestibular function, diuresis, liver protection prevent the works such as artery sclerosis, anti-cerebral ischemia, prevention diabetic complication
With.
Advantageous effect：The present invention is directed to the symptom of the extreme heat due to deficiency of yin of diabetes early stage, using Radix Notoginseng, the stem of noble dendrobium, balsam pear, the West
A variety of Chinese herbal medicines such as ginseng, the coptis, radix scutellariae, lily, rhizoma anemarrhenae, prepared rehmannia root, brush-cherry seed, dark plum, Radix Glycyrrhizae carry out dialectical compatibility, play taste
Cloudy heat-clearing, purging intense heat go it is dry, promote the production of body fluid and be tired of, can effectively reduce blood glucose, the blood lipids index of extreme heat due to deficiency of yin diabetes mellitus type, improve
Clinical symptoms, and be made of pure Chinese medicine, safe Small side effects are significant in efficacy, and rapid-action, preparation method is simple, establishing
The effect of good work and rest to diabetes with that on the basis of eating habit, can reach treating both manifestation and root cause of disease.
Specific embodiment
Purpose, technical scheme and advantage to make the embodiment of the present invention are clearer, below in conjunction with the embodiment of the present invention,
Technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is the present invention one
Divide embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making
All other embodiments obtained under the premise of creative work, shall fall within the protection scope of the present invention.
Embodiment 1：
A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM includes the raw material of following parts by weight：20 parts of Radix Notoginseng, stone
It is 30 parts of dry measure used in former times, 20 parts of balsam pear, 25 parts of American Ginseng, 10 parts of the coptis, 30 parts of radix scutellariae, 15 parts of lily, 25 parts of rhizoma anemarrhenae, 15 parts of prepared rehmannia root, strongly fragrant
20 parts of Li Ren, 7 parts of dark plum, 25 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment extreme heat due to deficiency of yin patients with type Ⅰ DM, includes the following steps：
S1, Radix Notoginseng, balsam pear, brush-cherry seed, dark plum, Radix Glycyrrhizae are mixed, crushed, add water to cook extraction 2 times, filtering merges filter
Liquid, obtains Aqueous extracts and water carries filter residue, and Aqueous extracts are concentrated under reduced pressure into the clear cream (60 DEG C) that relative density is 1.10, are added in thereto
Ethyl alcohol makes alcohol content, and up to 55%, stirring refrigerates 20h, filters, and filtrate is spare；
S2, the stem of noble dendrobium, American Ginseng, the coptis, radix scutellariae, lily, rhizoma anemarrhenae, prepared rehmannia root are mixed, crushed, the water added in S1 proposes filter
Slag adds 70% ethanol solution, and refluxing extraction 2 times filters, and merging filtrate is spare；
S3, the filtrate in S1, S2 is merged, ethyl alcohol is recovered under reduced pressure, be concentrated into the clear cream (60 DEG C) that relative density is 1.22,
Vacuum drying, crushes to get Chinese medicine composition.
Embodiment 2：
A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM includes the raw material of following parts by weight：30 parts of Radix Notoginseng, stone
It is 20 parts of dry measure used in former times, 30 parts of balsam pear, 15 parts of American Ginseng, 20 parts of the coptis, 20 parts of radix scutellariae, 25 parts of lily, 15 parts of rhizoma anemarrhenae, 25 parts of prepared rehmannia root, strongly fragrant
10 parts of Li Ren, 15 parts of dark plum, 15 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment extreme heat due to deficiency of yin patients with type Ⅰ DM, includes the following steps：
S1, Radix Notoginseng, balsam pear, brush-cherry seed, dark plum, Radix Glycyrrhizae are mixed, crushes, add water to cook extraction 2 times, add in medicinal material every time
10 times of water of initial mass decoct 2h, and filtering, merging filtrate, obtains Aqueous extracts and water carries filter residue, and Aqueous extracts are concentrated under reduced pressure into phase
To the clear cream (60 DEG C) that density is 1.12, adding in ethyl alcohol thereto makes alcohol content stir up to 70%, refrigerate 30h, filtering, filtrate
It is spare；
S2, the stem of noble dendrobium, American Ginseng, the coptis, radix scutellariae, lily, rhizoma anemarrhenae, prepared rehmannia root are mixed, crushed, the water added in S1 proposes filter
Slag, adds 75% ethanol solution, refluxing extraction 2 times, and 8 times of the ethanol solution reflux for adding in medicinal material initial mass every time carries
2h is taken, is filtered, merging filtrate is spare；
S3, the filtrate in S1, S2 is merged, ethyl alcohol is recovered under reduced pressure, be concentrated into the clear cream (60 DEG C) that relative density is 1.26,
Vacuum drying, crushes to get Chinese medicine composition.
Embodiment 3：
A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM includes the raw material of following parts by weight：25 parts of Radix Notoginseng, stone
It is 22 parts of dry measure used in former times, 22 parts of balsam pear, 17 parts of American Ginseng, 13 parts of the coptis, 24 parts of radix scutellariae, 17 parts of lily, 18 parts of rhizoma anemarrhenae, 17 parts of prepared rehmannia root, strongly fragrant
11 parts of Li Ren, 8 parts of dark plum, 17 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment extreme heat due to deficiency of yin patients with type Ⅰ DM, includes the following steps：
S1, Radix Notoginseng, balsam pear, brush-cherry seed, dark plum, Radix Glycyrrhizae are mixed, crushed, added water to cook extraction 2 times, add in medicine for the first time
10 times of water of material initial mass decoct 2h, and second of 7 times of water for adding in medicinal material initial mass decocts 1.5h, filter, merging filtrate,
It obtains Aqueous extracts and water carries filter residue, Aqueous extracts are concentrated under reduced pressure into the clear cream (60 DEG C) that relative density is 1.10, add in second thereto
Alcohol makes alcohol content, and up to 60%, stirring refrigerates 22h, filters, and filtrate is spare；
S2, the stem of noble dendrobium, American Ginseng, the coptis, radix scutellariae, lily, rhizoma anemarrhenae, prepared rehmannia root are mixed, crushed, the water added in S1 proposes filter
Slag, adds 70% ethanol solution, and refluxing extraction 2 times adds in 8 times of the ethanol solution reflux of medicinal material initial mass for the first time
2h is extracted, second of 6 times of ethanol solution refluxing extraction 1h for adding in medicinal material initial mass is filtered, and merging filtrate is spare；
S3, the filtrate in S1, S2 is merged, ethyl alcohol is recovered under reduced pressure, be concentrated into the clear cream (60 DEG C) that relative density is 1.23,
Vacuum drying, crushes to get Chinese medicine composition；
S4, into Chinese medicine composition, acceptable auxiliary material or complementary ingredient are prepared into powder in addition pharmacy.
Embodiment 4：
A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM includes the raw material of following parts by weight：30 parts of Radix Notoginseng, stone
It is 27 parts of dry measure used in former times, 27 parts of balsam pear, 22 parts of American Ginseng, 18 parts of the coptis, 29 parts of radix scutellariae, 22 parts of lily, 23 parts of rhizoma anemarrhenae, 22 parts of prepared rehmannia root, strongly fragrant
16 parts of Li Ren, 12 parts of dark plum, 22 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment extreme heat due to deficiency of yin patients with type Ⅰ DM, includes the following steps：
S1, Radix Notoginseng, balsam pear, brush-cherry seed, dark plum, Radix Glycyrrhizae are mixed, crushes, add water to cook extraction 2 times, add in medicinal material every time
8 times of water of initial mass decoct 1.5h, and filtering, merging filtrate, obtains Aqueous extracts and water carries filter residue, and Aqueous extracts are concentrated under reduced pressure into phase
To the clear cream (60 DEG C) that density is 1.11, adding in ethyl alcohol thereto makes alcohol content be stirred, refrigeration for 24 hours, is filtered, filtrate up to 65%
It is spare；
S2, the stem of noble dendrobium, American Ginseng, the coptis, radix scutellariae, lily, rhizoma anemarrhenae, prepared rehmannia root are mixed, crushed, the water added in S1 proposes filter
Slag, adds 75% ethanol solution, refluxing extraction 2 times, and 8 times of the ethanol solution reflux for adding in medicinal material initial mass every time carries
1.5h is taken, is filtered, merging filtrate is spare；
S3, the filtrate in S1, S2 is merged, ethyl alcohol is recovered under reduced pressure, be concentrated into the clear cream (60 DEG C) that relative density is 1.24,
Vacuum drying, crushes to get Chinese medicine composition.
S4, into Chinese medicine composition, acceptable auxiliary material or complementary ingredient are prepared into powder in addition pharmacy.
Embodiment 5：
A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM includes the raw material of following parts by weight：27 parts of Radix Notoginseng, stone
It is 26 parts of dry measure used in former times, 24 parts of balsam pear, 19 parts of American Ginseng, 16 parts of the coptis, 27 parts of radix scutellariae, 19 parts of lily, 21 parts of rhizoma anemarrhenae, 19 parts of prepared rehmannia root, strongly fragrant
15 parts of Li Ren, 9 parts of dark plum, 21 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment extreme heat due to deficiency of yin patients with type Ⅰ DM, includes the following steps：
S1, Radix Notoginseng, balsam pear, brush-cherry seed, dark plum, Radix Glycyrrhizae are mixed, crushed, added water to cook extraction 2 times, add in medicine for the first time
10 times of water of material initial mass decoct 2h, and second of 6 times of water for adding in medicinal material initial mass decocts 1h, filtering, and merging filtrate obtains
Aqueous extracts and water carry filter residue, and Aqueous extracts are concentrated under reduced pressure into the clear cream (60 DEG C) that relative density is 1.12, add in ethyl alcohol thereto
Making alcohol content, stirring refrigerates 26h, filters, and filtrate is spare up to 62%；
S2, the stem of noble dendrobium, American Ginseng, the coptis, radix scutellariae, lily, rhizoma anemarrhenae, prepared rehmannia root are mixed, crushed, the water added in S1 proposes filter
Slag, adds 72% ethanol solution, and refluxing extraction 2 times adds in 8 times of the ethanol solution reflux of medicinal material initial mass for the first time
2h is extracted, second of 6 times of ethanol solution refluxing extraction 1.5h for adding in medicinal material initial mass is filtered, and merging filtrate is spare；
S3, the filtrate in S1, S2 is merged, ethyl alcohol is recovered under reduced pressure, be concentrated into the clear cream (60 DEG C) that relative density is 1.24,
Vacuum drying, crushes to get Chinese medicine composition；
S4, acceptable auxiliary material or complementary ingredient preparation piece agent in pharmacy are added in into Chinese medicine composition.
Embodiment 6：
A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM includes the raw material of following parts by weight：28 parts of Radix Notoginseng, stone
It is 25 parts of dry measure used in former times, 25 parts of balsam pear, 20 parts of American Ginseng, 15 parts of the coptis, 26 parts of radix scutellariae, 20 parts of lily, 20 parts of rhizoma anemarrhenae, 20 parts of prepared rehmannia root, strongly fragrant
14 parts of Li Ren, 10 parts of dark plum, 20 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine composition of above-mentioned treatment extreme heat due to deficiency of yin patients with type Ⅰ DM, includes the following steps：
S1, Radix Notoginseng, balsam pear, brush-cherry seed, dark plum, Radix Glycyrrhizae are mixed, crushed, added water to cook extraction 2 times, add in medicine for the first time
10 times of water of material initial mass decoct 2.5h, and second of 7 times of water for adding in medicinal material initial mass decocts 1.5h, and filtering merges filter
Liquid, obtains Aqueous extracts and water carries filter residue, and Aqueous extracts are concentrated under reduced pressure into the clear cream (60 DEG C) that relative density is 1.12, are added in thereto
Ethyl alcohol makes alcohol content, and up to 65%, stirring refrigerates 28h, filters, and filtrate is spare；
S2, the stem of noble dendrobium, American Ginseng, the coptis, radix scutellariae, lily, rhizoma anemarrhenae, prepared rehmannia root are mixed, crushed, the water added in S1 proposes filter
Slag, adds 72% ethanol solution, and refluxing extraction 2 times adds in 8 times of the ethanol solution reflux of medicinal material initial mass for the first time
2.5h is extracted, second of 6 times of ethanol solution refluxing extraction 1.5h for adding in medicinal material initial mass is filtered, and merging filtrate is standby
With；
S3, the filtrate in S1, S2 is merged, ethyl alcohol is recovered under reduced pressure, be concentrated into the clear cream (60 DEG C) that relative density is 1.25,
Vacuum drying, crushes to get Chinese medicine composition；
S4, into Chinese medicine composition, acceptable auxiliary material or complementary ingredient are prepared into capsule in addition pharmacy.
Clinical test
1. case selection
The patients with NIDDM 78 of extreme heat due to deficiency of yin made a definite diagnosis is selected, is made a definite diagnosis through clinical examination, and according to " new drug
(Chinese medicine) treats technological guidance's principle of diabete (diabetes) clinical research " differentiation of symptoms and signs for classification of syndrome is carried out, patient is divided into reality at random
Group and control group are tested, each 39, man 22 in control group, female 17, age 45-75 Sui, average age 64.5 ± 3.5 years old is sick
Journey 3-12,7.5 ± 1.8 years average, hypertension 20 in complication, coronary heart disease 9, retinopathy 11, pulmonary tuberculosis 5
Example；Man 24 in control group, female 15, age 45-75 Sui, average age 64.1 ± 4.1 years old, course of disease 3-12, average 7.2 ±
1.5 years, hypertension 19 in complication, coronary heart disease 9, retinopathy 12, pulmonary tuberculosis 4, two groups of patients' was general
Data compares, and no significant difference (P ＞ 0.05) is comparable.
2. therapy
Control group patient gives conventional western medicine glucose-lowering treatment, and daily early 0.5h takes orally gliclazid in tablets and controls before the meal, before dinner
It treats, 40mg/ times, and diformin tablet treatment is taken orally after breakfast, lunch and dinner.
The Chinese medicinal tablet that experimental group patient gives the preparation of the embodiment of the present invention 6 is treated, and is taken orally after daily breakfast, lunch and dinner, every time
2, active constituent content is 20mg/ pieces wherein in Chinese medicinal tablet；Two groups of patient's continued treatment 30d.
3. observation index
(1) clinical efficacy of two groups of patients is compared in observation；
It is effective:After treatment, patient's fasting blood-glucose≤6.0mmol/L, and 2h-plasma glucose≤8.3mmol/L；
Effectively:After treatment, patient's fasting blood-glucose is 6.1-7.0mmol/L, and 2h-plasma glucose is 8.4-10.0mmol/L；
In vain:After treatment, patient's fasting blood-glucose and 2h-plasma glucose are not up to effective and effective standard.
(2) it is (total to compare the pretherapy and post-treatment fasting blood-glucose of two groups of patients, 2h-plasma glucose, glycosylated hemoglobin and blood lipids index
Cholesterol, triacylglycerol, low density lipoprotein cholesterol), c reactive protein.
4. statistical method
Data analysis is carried out using SPSS17.0 statistics softwares.
5. treatment results
(1) clinical efficacy is shown in Table 1.From table 1 it follows that the clinical efficacy of experimental group will be substantially better than control group (P ＜
0.05), the effective percentage of experimental group is higher than control group by 12.8%, and obvious effective rate is then higher by 25.6%.
The pretherapy and post-treatment blood glucose clinical efficacy of 1 two groups of patients of table
| Effective/example | Effectively/example | In vain/example | Effective percentage/% | |
| Control group | 19 | 13 | 7 | 82.1% |
| Experimental group | 29 | 8 | 2 | 94.9% |
(2) blood glucose and glycosylated hemoglobin
As shown in table 2, before treatment, two groups of patient's fasting blood-glucoses, 2h-plasma glucose and glycosylated hemoglobin compare, difference without
Statistical significance (P ＜ 0.05)；After treatment, experimental group patient fasting blood-glucose, 2h-plasma glucose and glycosylated hemoglobin less than pair
According to group, difference is statistically significant (P ＜ 0.05), illustrates that Chinese medicinal tablet made from the embodiment of the present invention can effectively reduce patient
Blood glucose level.
The pretherapy and post-treatment blood glucose of 2 two groups of patients of table and glycosylated hemoglobin data
(3) blood lipids index and c reactive protein are horizontal
As shown in table 3, before treatment, two groups of patient's fasting blood-glucoses, 2h-plasma glucose and glycosylated hemoglobin compare, difference without
Statistical significance (P ＜ 0.05)；After treatment, experimental group patient fasting blood-glucose, 2h-plasma glucose and glycosylated hemoglobin less than pair
According to group, difference is statistically significant (P ＜ 0.05), illustrates that Chinese medicinal tablet made from the embodiment of the present invention can effectively reduce patient
Blood lipid level alleviates the generation of Related complication, improves clinical symptoms.
The pretherapy and post-treatment blood lipids index of 3 two groups of patients of table and c reactive protein horizontal data
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
The present invention is described in detail, it will be understood by those of ordinary skill in the art that：It still can be to aforementioned each implementation
Technical solution recorded in example modifies or carries out equivalent replacement to which part technical characteristic；And these modification or
It replaces, the spirit and scope for various embodiments of the present invention technical solution that it does not separate the essence of the corresponding technical solution.
Claims (6)
1. a kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM, which is characterized in that include the raw material of following parts by weight：Three
Seven 20-30 parts, 20-30 parts of the stem of noble dendrobium, 20-30 parts of balsam pear, 15-25 parts of American Ginseng, 10-20 parts of the coptis, 20-30 parts of radix scutellariae, lily
15-25 parts, 15-25 parts of rhizoma anemarrhenae, 15-25 parts of prepared rehmannia root, 10-20 parts of brush-cherry seed, 7-15 parts of dark plum, 15-25 parts of Radix Glycyrrhizae.
2. the Chinese medicine composition for the treatment of extreme heat due to deficiency of yin patients with type Ⅰ DM as described in claim 1, which is characterized in that including following heavy
Measure the raw material of part：25-30 parts of Radix Notoginseng, 22-27 parts of the stem of noble dendrobium, 22-27 parts of balsam pear, 17-22 parts of American Ginseng, 13-18 parts of the coptis, radix scutellariae
24-29 parts, 17-22 parts of lily, 18-23 parts of rhizoma anemarrhenae, 17-22 parts of prepared rehmannia root, 11-16 parts of brush-cherry seed, 8-12 parts of dark plum, Radix Glycyrrhizae
17-22 parts.
3. the Chinese medicine composition for the treatment of extreme heat due to deficiency of yin patients with type Ⅰ DM as claimed in claim 2, which is characterized in that including following heavy
Measure the raw material of part：28 parts of Radix Notoginseng, 25 parts of the stem of noble dendrobium, 25 parts of balsam pear, 20 parts of American Ginseng, 15 parts of the coptis, 26 parts of radix scutellariae, 20 parts of lily,
20 parts of rhizoma anemarrhenae, 20 parts of prepared rehmannia root, 14 parts of brush-cherry seed, 10 parts of dark plum, 20 parts of Radix Glycyrrhizae.
4. the preparation method of the Chinese medicine composition for the treatment of extreme heat due to deficiency of yin patients with type Ⅰ DM as described in any one of claims 1-3, special
Sign is, includes the following steps：
S1, Radix Notoginseng, balsam pear, brush-cherry seed, dark plum, Radix Glycyrrhizae are mixed, crushed, add water to cook extraction 2 times, filtering, merging filtrate obtains
Aqueous extracts and water carry filter residue, and Aqueous extracts are concentrated under reduced pressure into the clear cream (60 DEG C) that relative density is 1.10-1.12, are added in thereto
Ethyl alcohol makes alcohol content stir, refrigerate, filter, filtrate is spare up to 55-70%；
S2, the stem of noble dendrobium, American Ginseng, the coptis, radix scutellariae, lily, rhizoma anemarrhenae, prepared rehmannia root being mixed, crushed, the water added in S1 carries filter residue,
The ethanol solution of 70-75% is added, refluxing extraction 2 times filters, and merging filtrate is spare；
S3, the filtrate in S1, S2 is merged, ethyl alcohol is recovered under reduced pressure, be concentrated into the clear cream (60 that relative density is 1.22-1.26
DEG C), vacuum drying is crushed to get Chinese medicine composition.
5. the preparation method of the Chinese medicine composition for the treatment of extreme heat due to deficiency of yin patients with type Ⅰ DM as claimed in claim 4, which is characterized in that
20-30h is refrigerated in the S1.
6. the preparation method of the Chinese medicine composition for the treatment of extreme heat due to deficiency of yin patients with type Ⅰ DM as claimed in claim 4, which is characterized in that
It further includes and acceptable auxiliary material or complementary ingredient in pharmacy are added in into Chinese medicine composition is prepared into powder, granule, tablet
Or capsule.
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| CN113577202A (en) * | 2021-09-13 | 2021-11-02 | 浙江理工大学 | Dendrobium officinale composition for treating diabetes and preparation method and application thereof |
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| CN104740345A (en) * | 2015-03-25 | 2015-07-01 | 廊坊市思科农业技术有限公司 | Traditional Chinese medicine composition for treating diabetes and preparation method of traditional Chinese medicine composition |
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2018
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104740345A (en) * | 2015-03-25 | 2015-07-01 | 廊坊市思科农业技术有限公司 | Traditional Chinese medicine composition for treating diabetes and preparation method of traditional Chinese medicine composition |
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