CN108524776A - A kind of drug and preparation method thereof for treating Qi and Yin deficiency diabetes mellitus - Google Patents
A kind of drug and preparation method thereof for treating Qi and Yin deficiency diabetes mellitus Download PDFInfo
- Publication number
- CN108524776A CN108524776A CN201810121763.XA CN201810121763A CN108524776A CN 108524776 A CN108524776 A CN 108524776A CN 201810121763 A CN201810121763 A CN 201810121763A CN 108524776 A CN108524776 A CN 108524776A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- drug
- diabetes mellitus
- yin deficiency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/37—Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/64—Orobanchaceae (Broom-rape family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
Abstract
The invention discloses a kind of drugs and preparation method thereof for treating Qi and Yin deficiency diabetes mellitus, are related to diabetes medicament preparing technical field, include the raw material of following parts by weight：20 30 parts of Radix Notoginseng, 20 30 parts of the stem of noble dendrobium, 20 30 parts of balsam pear, 25 35 parts of Radix Astragali, 20 30 parts of pueraria lobata, 10 20 parts of American Ginseng, 20 30 parts of Radix Salviae Miltiorrhizae, 25 35 parts of Radix Ophiopogonis, 10 20 parts of Herba Cistanches, 15 25 parts of radix polygonati officinalis, 10 20 parts of the membrane of a chicken's gizzard, 15 25 parts of Ramulus euonymi, 7 15 parts of peach kernel, 15 25 parts of sealwort.Symptom of the present invention for the deficiency of both qi and yin of diabetes mid-term, using the dialectical compatibility of a variety of Chinese herbal medicines, collective effect, the effect of playing nourishing yin to moisten dryness, strengthening the spleen and replenishing qi, heat-clearing kidney tonifying, it is effectively improved the deficiency of both qi and yin symptom of patient, blood glucose level is reduced, it is significant in efficacy, lasting, and be made of pure Chinese medicine, safe Small side effects, preparation method is simple, the effect of establishing good work and rest and on the basis of eating habit, can reach treating both manifestation and root cause of disease to diabetes.
Description
Technical field
The present invention relates to diabetes medicament preparing technical fields, and in particular to a kind of medicine for treating Qi and Yin deficiency diabetes mellitus
Object and preparation method thereof.
Background technology
Diabetes are the chronic incretion metabolism diseases characterized by hyperglycemia, pathologic basis be insulin definitely sum/
Or opposite shortage, and then cause sugar, fat, protein, water and a series of metabolic disorders of electrolyte.Global diabetes number is up to
4.22 hundred million, every 11 people just have 1 people to suffer from diabetes.Diabetes have become the third position after tumour and cardiovascular and cerebrovascular disease
The chronic disease for seriously endangering human health, is known as " disaster of 21 century " by the World Health Organization.
Diabetes Chinese medicine is classified as scope of quenching one's thirst, it is believed that mainly disorder of emotion, eating and drinking without temperance, labor are intended to excessive etc., are related to
And lesion internal organs mainly have spleen, stomach, lung and kidney etc., it is mainly then that taste excess heat hinders Tianjin and Tianjin wound with scorching that the interpretation of the cause, onset and process of an illness, which develops,
Gas consumption and deficiency of both qi and yin, ultimately cause deficiency in both YIN and YANG.Chinese medicine thinks that type of deficiency of both QI and YIN belongs to diabetes mid-term stage, treats with benefit
Based on gas yin-nourishing.Though traditional Western medicine hypoglycemic Regimen Chemotherapy diabetes have certain curative effect, the effect is unsatisfactory, to the liver of human body,
The organs such as kidney have certain damage, and cannot effectively control complication.Therefore, with the speciality of Chinese Traditional Medicine, increasing tradition has
The developmental research of efficacious prescriptions and Empirical formula is preferably diabetes clinical treatment service, be current traditional Chinese medicine circle struggle target it
One.
Invention content
In view of the deficiencies of the prior art, the present invention provides a kind of drug for treating Qi and Yin deficiency diabetes mellitus and its preparations
Method, effectively reduces the blood glucose level of patient, and curative effect is lasting.
In order to achieve the above object, the present invention is achieved by the following technical programs：
A kind of drug for treating Qi and Yin deficiency diabetes mellitus, includes the raw material of following parts by weight：20-30 parts of Radix Notoginseng, the stem of noble dendrobium
20-30 parts, 20-30 parts of balsam pear, 25-35 parts of Radix Astragali, 20-30 parts of pueraria lobata, 10-20 parts of American Ginseng, 20-30 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis
25-35 parts, 10-20 parts of Herba Cistanches, 15-25 parts of radix polygonati officinalis, 10-20 parts of the membrane of a chicken's gizzard, 15-25 parts of Ramulus euonymi, 7-15 parts of peach kernel, sealwort
15-25 parts.
Preferably, include the raw material of following parts by weight：22-27 parts of Radix Notoginseng, 22-27 parts of the stem of noble dendrobium, 24-29 parts of balsam pear, Radix Astragali
28-32 parts, 22-27 parts of pueraria lobata, 13-18 parts of American Ginseng, 22-27 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis 28-33 part, 15-20 parts of Herba Cistanches, radix polygonati officinalis
18-23 parts, 13-18 parts of the membrane of a chicken's gizzard, 17-22 parts of Ramulus euonymi, 9-13 parts of peach kernel, 17-22 parts of sealwort.
Preferably, include the raw material of following parts by weight：24 parts of Radix Notoginseng, 24 parts of the stem of noble dendrobium, 26 parts of balsam pear, 30 parts of Radix Astragali, pueraria lobata
25 parts, 15 parts of American Ginseng, 25 parts of Radix Salviae Miltiorrhizae, 30 parts of Radix Ophiopogonis, 17 parts of Herba Cistanches, 20 parts of radix polygonati officinalis, 15 parts of the membrane of a chicken's gizzard, 20 parts of Ramulus euonymi,
10 parts of peach kernel, 19 parts of sealwort.
The preparation method of the drug of above-mentioned treatment Qi and Yin deficiency diabetes mellitus, includes the following steps：
S1, Radix Notoginseng, the stem of noble dendrobium, balsam pear, Radix Astragali, pueraria lobata, American Ginseng, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Herba Cistanches, radix polygonati officinalis, the membrane of a chicken's gizzard, ghost are taken
Fletching, peach kernel, sealwort, mixing, beat powder, are sieved, and are transferred in three-dimensional mixer and are uniformly mixed, obtain mixture；
S2, mixture is transferred in oscillating granulator and is pelletized, obtain wet pellet；
S3, wet pellet is placed in hot air circulation drying oven, it is dry to water content≤10%, obtain dry granular material；
S4, dry granular material is placed in after the quick whole grain of vibrating screen cross 18 mesh sieve to get.
Preferably, in the S1,80-100 sieves are crossed.
Preferably, in the S1,20-30min is mixed in three-dimensional mixer.
Preferably, in the S3, drying temperature is 50-60 DEG C, drying time 4-5h.
It is as follows the effect of each raw material in the present invention：
Radix Notoginseng：Warm-natured, sweet in flavor, slight bitter, return liver warp, stomach have effects that dissipate stasis of blood hemostasis, detumescence ding-tong；Modern pharmacology
Studies have shown that Notogineng Extract has cardiac stimulant, decompression, liver protection, anti-inflammatory, reduction blood cholesterol, immunological regulation and antivirus action,
Have the effects that hemostasis, platelet aggregation-against and thrombolysis, haemolysis, hematopoiesis to blood and hemopoietic system, has to cardiovascular system
Anti-arrhythmia, antiatherosclerosis, resist oxygen lack and Hemorrhagic shock improve the effects that cerebral ischemia, have maincenter to nervous system
The effects that nerve inhibits, eases pain, goes back improving immunocompetence, and liver function protecting is antitumor, slows down aging, hypoglycemic, anti-inflammatory,
Auto-regulator is metabolized, and promotes growth.
The stem of noble dendrobium：Cold nature, it is sweet in flavor, return stomach, kidney channel, has effects that reinforcing stomach reg fluid, nourishing Yin and clearing heat；Modern pharmacological research
Show that the stem of noble dendrobium has the function of adjusting smooth muscle, has inhibiting effect to heart, body's immunity can be enhanced, slow down aging；It is dynamic
Object experiment shows that its decoction can promote gastric secretion, there is digestion-aid effect.
Balsam pear：It is cold in nature, the effect of there is driving away summer heat to wash heat for bitter, thoughts of returning home warp, the spleen channel, lung channel, improving eyesight, removing toxic substances；Pharmacological research
Show that balsam pear plays the role of hypoglycemic, anticancer, antiviral.
Radix Astragali：Slightly warm in nature, sweet in flavor, converge to the spleen channel, lung channel have invigorating qi for strengthening superficies, diuresis, pus draining and toxin expelling, myogenic；Pharmacological research
Show that Radix Astragali has facilitation to nucleic acid metabolism；Enhance hematopoiesis function；Improve myocardial function, to anti-infarction；With antioxygen
Change, antiviral, anticancer improve renal function and renal pathology change etc..
Pueraria lobata：It is cool in nature, sweet in flavor, pungent, converge to the spleen channel, stomach, have effects that expelling pathogenic factors from muscles and skin bring down a fever, promote the production of body fluid, promoting eruption, Shengyang Zhixie；
Pharmacological evaluation shows that pueraria lobata has p- receptor blocking pharmacon effects, is the basis of Cardiovascular；With apparent refrigeration function；
Collapsible or diastole smooth muscle；Also there is expansion of coronary artery and the cerebrovascular, increase coronary blood flow and brain blood flow
Amount, reduce myocardial oxygen consumption, increase oxygen supply, reduce blood pressure, it is hypoglycemic and release intestinal tube spasm the effects that.
American Ginseng：Cool in nature, sweet in flavor, slight bitter, thoughts of returning home warp, lung channel, kidney channel have effects that boosting qi and nourishing yin, clearing heat and promoting fluid；It is existing
Show that American Ginseng has protective effect to cardiovascular system for pharmacological research, resisting stress capability can be enhanced, work(is immunized in enhancing
Can, it protect the effects that erythrocyte membrane, antidiuresis.
Radix Salviae Miltiorrhizae：Cold nature, bitter, thoughts of returning home warp, Liver Channel have effects that stasis-dispelling and pain-killing, promoting blood circulation dysmenorrhoea, relieving restlessness that clears away heart-fire；Medicine
Reason studies have shown that red sage formulation can make experimental animal heart coronary artery expand, so that heart function is obviously improved, the heart can be protected
Brain system, reducing blood lipid, antiatherosclerosis is promoting blood circulation and removing blood stasis, enhances hypoxia-bearing capability, enhances immune function, anti-inflammatory and anti-mistake
Quick, protect liver, anti-gastric-ulcer is antitumor, sedation and analgesia, has a protective effect to respiratory system, improves renal function, anti-oxidant, antibacterial,
Promote skin wound, union.
Radix Ophiopogonis：Cold nature, sweet in flavor, slight bitter, thoughts of returning home warp, lung channel, stomach have effects that nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire；Medicine
Studies have shown that there is protection cardiovascular system in Radix Ophiopogonis, enhancing resist oxygen lack extends the time-to-live of normobaric hypoxia, enhances reason
Immune function, it is hypoglycemic, it slows down aging, inhibits gastrointestinal propulsive effect effect；Antibacterial.
Herba Cistanches：It is warm-natured, it is sweet in flavor, salty, return kidney channel, large intestine channel, has effects that kidney-replenishing, benefiting essence-blood, relaxes bowel；Medicine
For reason studies have shown that Herba Cistanches can enhance body fluid and cellular immune function, Central nervous system can increase norepinephrine
(NE) and 5-hydroxyindoleacetic acid (5-HIAA) content, and increase dopamine (DA) with two through phenylacetic acid (D0PAC) ratio, have and prolong
The effect of slow aging, can significantly improve mouse small intestine advance rate, shorten the defaecation time, be effective against the inhibition defecation of atropine
Effect, while also having obvious inhibiting effect to the moisture absorption of large intestine, has the effects that decompression, anti-mutation, have adjust endocrine,
Promote metabolism and strong effect.
Radix polygonati officinalis：Cold nature, sweet in flavor, distributed in lung channel, stomach has effects that nourishing yin to moisten dryness, promotes the production of body fluid to quench thirst；Animal experiment table
It is bright, rats gavaged preserved material is given, has inhibiting effect, methanol to carry hyperglycemia caused by adrenaline, glucose and alloxan
Water portion and n-butanol fraction in object is taken to have obvious inhibiting effect to streptozotocin hyperglycemia mouse.In addition, also having enhancing
Immune function.
The membrane of a chicken's gizzard：It is mild-natured, sweet in flavor, converge to the spleen channel, stomach, small intestinl channel, bladder warp, the work(with stomach strengthening and digestion promoting, arresting seminal emission
Effect；Modern pharmacological research thinks that the membrane of a chicken's gizzard mainly contains gastric hormone, keratin, and the ingredients such as amino acid have increase gastric secretion
With gastro-intestinal digestion ability.
Ramulus euonymi：Cold in nature, bitter, return liver warp, the spleen channel have effects that promoting circulation of blood promoting menstruation, removing blood stasis and analgesics；Pharmacological research table
Bright, Ramulus euonymi, which has, adjusts blood fat, reduces the effect of blood glucose.
Peach kernel：Mild-natured, bitter, sweet, thoughts of returning home warp, Liver Channel, large intestine channel have effects that activating blood circulation and dissipating phlegm, relax bowel；Pharmacology
Studies have shown that peach kernel has the effects that anticoagulation, resists straight bolt, improve blood flow, is anti-inflammatory, analgesia and antiallergy, and can cough-relieving, flat
Asthma, has certain curative effect to pulmonary tuberculosis.
Sealwort：Mild-natured, sweet in flavor, distributed in lung channel, the spleen channel, kidney channel have effects that boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing；Medicine
Reason is studies have shown that the effects that sealwort can increase coronary flow, Adjust-blood lipid, immune hypoglycemic, anti-aging and enhancing, coarse solomon's seal polysaccharide
Have immunoregulation effect, has protective effect to chemical damage, separately have anti-inflammatory and antivirus action, in addition, also having antibacterial, anti-
The effects that pathogenic microorganism, decompression, hemostasis.
Advantageous effect：The present invention for the deficiency of both qi and yin of diabetes mid-term symptom, using the dialectical compatibility of a variety of Chinese herbal medicines,
Collective effect, is effectively improved the deficiency of both qi and yin symptom of patient at the effect of playing nourishing yin to moisten dryness, strengthening the spleen and replenishing qi, heat-clearing kidney tonifying, reduces
Blood glucose level is treated 30 days efficient reachable 98.4%, significant in efficacy, lasting, and is made of pure Chinese medicine, safe side effect
Small, preparation method is simple, on the basis of establishing good work and rest and eating habit, can reach treating both manifestation and root cause of disease to diabetes
Effect.
Specific implementation mode
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is the present invention one
Divide embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making
The every other embodiment obtained under the premise of creative work, shall fall within the protection scope of the present invention.
Embodiment 1：
A kind of drug for treating Qi and Yin deficiency diabetes mellitus, includes the raw material of following parts by weight：20 parts of Radix Notoginseng, the stem of noble dendrobium 30
Part, 20 parts of balsam pear, 35 parts of Radix Astragali, 20 parts of pueraria lobata, 20 parts of American Ginseng, 20 parts of Radix Salviae Miltiorrhizae, 35 parts of Radix Ophiopogonis, 10 parts of Herba Cistanches, radix polygonati officinalis 25
Part, 10 parts of the membrane of a chicken's gizzard, 25 parts of Ramulus euonymi, 7 parts of peach kernel, 25 parts of sealwort.
The preparation method of the drug of above-mentioned treatment Qi and Yin deficiency diabetes mellitus, includes the following steps：
S1, Radix Notoginseng, the stem of noble dendrobium, balsam pear, Radix Astragali, pueraria lobata, American Ginseng, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Herba Cistanches, radix polygonati officinalis, the membrane of a chicken's gizzard, ghost are taken
Powder is beaten in fletching, peach kernel, sealwort, mixing, is crossed 80 sieves, is transferred in three-dimensional mixer and mixes 20min, obtain mixture；
S2, mixture is transferred in oscillating granulator and is pelletized, obtain wet pellet；
S3, wet pellet is placed in hot air circulation drying oven, the dry 4h at 50 DEG C is dry to water content≤10%, obtains
Dry granular material；
S4, dry granular material is placed in after the quick whole grain of vibrating screen cross 18 mesh sieve to get.
Embodiment 2：
A kind of drug for treating Qi and Yin deficiency diabetes mellitus, includes the raw material of following parts by weight：30 parts of Radix Notoginseng, the stem of noble dendrobium 20
Part, 30 parts of balsam pear, 25 parts of Radix Astragali, 30 parts of pueraria lobata, 10 parts of American Ginseng, 30 parts of Radix Salviae Miltiorrhizae, 25 parts of Radix Ophiopogonis, 20 parts of Herba Cistanches, radix polygonati officinalis 15
Part, 20 parts of the membrane of a chicken's gizzard, 15 parts of Ramulus euonymi, 15 parts of peach kernel, 15 parts of sealwort.
The preparation method of the drug of above-mentioned treatment Qi and Yin deficiency diabetes mellitus, includes the following steps：
S1, Radix Notoginseng, the stem of noble dendrobium, balsam pear, Radix Astragali, pueraria lobata, American Ginseng, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Herba Cistanches, radix polygonati officinalis, the membrane of a chicken's gizzard, ghost are taken
Powder is beaten in fletching, peach kernel, sealwort, mixing, is crossed 100 sieves, is transferred in three-dimensional mixer and mixes 30min, obtain mixture；
S2, mixture is transferred in oscillating granulator and is pelletized, obtain wet pellet；
S3, wet pellet is placed in hot air circulation drying oven, the dry 5h at 60 DEG C is dry to water content≤10%, obtains
Dry granular material；
S4, dry granular material is placed in after the quick whole grain of vibrating screen cross 18 mesh sieve to get.
Embodiment 3：
A kind of drug for treating Qi and Yin deficiency diabetes mellitus, includes the raw material of following parts by weight：22 parts of Radix Notoginseng, the stem of noble dendrobium 22
Part, 24 parts of balsam pear, 28 parts of Radix Astragali, 22 parts of pueraria lobata, 13 parts of American Ginseng, 22 parts of Radix Salviae Miltiorrhizae, 28 parts of Radix Ophiopogonis, 15 parts of Herba Cistanches, radix polygonati officinalis 18
Part, 13 parts of the membrane of a chicken's gizzard, 17 parts of Ramulus euonymi, 9 parts of peach kernel, 17 parts of sealwort.
The preparation method of the drug of above-mentioned treatment Qi and Yin deficiency diabetes mellitus, includes the following steps：
S1, Radix Notoginseng, the stem of noble dendrobium, balsam pear, Radix Astragali, pueraria lobata, American Ginseng, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Herba Cistanches, radix polygonati officinalis, the membrane of a chicken's gizzard, ghost are taken
Powder is beaten in fletching, peach kernel, sealwort, mixing, is crossed 90 sieves, is transferred in three-dimensional mixer and mixes 20min, obtain mixture；
S2, mixture is transferred in oscillating granulator and is pelletized, obtain wet pellet；
S3, wet pellet is placed in hot air circulation drying oven, the dry 4.5h at 50 DEG C, drying to water content≤10%,
Obtain dry granular material；
S4, dry granular material is placed in after the quick whole grain of vibrating screen cross 18 mesh sieve to get.
Embodiment 4：
A kind of drug for treating Qi and Yin deficiency diabetes mellitus, includes the raw material of following parts by weight：27 parts of Radix Notoginseng, the stem of noble dendrobium 27
Part, 29 parts of balsam pear, 32 parts of Radix Astragali, 27 parts of pueraria lobata, 18 parts of American Ginseng, 27 parts of Radix Salviae Miltiorrhizae, 33 parts of Radix Ophiopogonis, 20 parts of Herba Cistanches, radix polygonati officinalis 23
Part, 18 parts of the membrane of a chicken's gizzard, 22 parts of Ramulus euonymi, 13 parts of peach kernel, 22 parts of sealwort.
The preparation method of the drug of above-mentioned treatment Qi and Yin deficiency diabetes mellitus, includes the following steps：
S1, Radix Notoginseng, the stem of noble dendrobium, balsam pear, Radix Astragali, pueraria lobata, American Ginseng, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Herba Cistanches, radix polygonati officinalis, the membrane of a chicken's gizzard, ghost are taken
Powder is beaten in fletching, peach kernel, sealwort, mixing, is crossed 80 sieves, is transferred in three-dimensional mixer and mixes 30min, obtain mixture；
S2, mixture is transferred in oscillating granulator and is pelletized, obtain wet pellet；
S3, wet pellet is placed in hot air circulation drying oven, the dry 5h at 50 DEG C is dry to water content≤10%, obtains
Dry granular material；
S4, dry granular material is placed in after the quick whole grain of vibrating screen cross 18 mesh sieve to get.
Embodiment 5：
A kind of drug for treating Qi and Yin deficiency diabetes mellitus, includes the raw material of following parts by weight：25 parts of Radix Notoginseng, the stem of noble dendrobium 26
Part, 26 parts of balsam pear, 29 parts of Radix Astragali, 24 parts of pueraria lobata, 16 parts of American Ginseng, 24 parts of Radix Salviae Miltiorrhizae, 31 parts of Radix Ophiopogonis, 18 parts of Herba Cistanches, radix polygonati officinalis 21
Part, 16 parts of the membrane of a chicken's gizzard, 19 parts of Ramulus euonymi, 11 parts of peach kernel, 20 parts of sealwort.
The preparation method of the drug of above-mentioned treatment Qi and Yin deficiency diabetes mellitus, includes the following steps：
S1, Radix Notoginseng, the stem of noble dendrobium, balsam pear, Radix Astragali, pueraria lobata, American Ginseng, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Herba Cistanches, radix polygonati officinalis, the membrane of a chicken's gizzard, ghost are taken
Powder is beaten in fletching, peach kernel, sealwort, mixing, is crossed 90 sieves, is transferred in three-dimensional mixer and mixes 25min, obtain mixture；
S2, mixture is transferred in oscillating granulator and is pelletized, obtain wet pellet；
S3, wet pellet is placed in hot air circulation drying oven, the dry 4h at 55 DEG C is dry to water content≤10%, obtains
Dry granular material；
S4, dry granular material is placed in after the quick whole grain of vibrating screen cross 18 mesh sieve to get.
Embodiment 6：
A kind of drug for treating Qi and Yin deficiency diabetes mellitus, includes the raw material of following parts by weight：Including following parts by weight
Raw material：24 parts of Radix Notoginseng, 24 parts of the stem of noble dendrobium, 26 parts of balsam pear, 30 parts of Radix Astragali, 25 parts of pueraria lobata, 15 parts of American Ginseng, 25 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis 30
Part, 17 parts of Herba Cistanches, 20 parts of radix polygonati officinalis, 15 parts of the membrane of a chicken's gizzard, 20 parts of Ramulus euonymi, 10 parts of peach kernel, 19 parts of sealwort.
The preparation method of the drug of above-mentioned treatment Qi and Yin deficiency diabetes mellitus, includes the following steps：
S1, Radix Notoginseng, the stem of noble dendrobium, balsam pear, Radix Astragali, pueraria lobata, American Ginseng, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Herba Cistanches, radix polygonati officinalis, the membrane of a chicken's gizzard, ghost are taken
Powder is beaten in fletching, peach kernel, sealwort, mixing, is crossed 100 sieves, is transferred in three-dimensional mixer and mixes 30min, obtain mixture；
S2, mixture is transferred in oscillating granulator and is pelletized, obtain wet pellet；
S3, wet pellet is placed in hot air circulation drying oven, the dry 4.5h at 55 DEG C, drying to water content≤10%,
Obtain dry granular material；
S4, dry granular material is placed in after the quick whole grain of vibrating screen cross 18 mesh sieve to get.
Clinical test
1. case selection
The patients with NIDDM 124 for selecting the deficiency of both qi and yin made a definite diagnosis, makes a definite diagnosis through clinical examination, while meeting China
Traditional Chinese medicine and pharmacy can be formulated《Diabetes TCM prevention and cure guide》In related type of deficiency of both QI and YIN diagnostic criteria, clinical manifestation mainly has tired
Idle weak, dry throat, thirst and liking drink, dysphoria in chestpalms-soles, the lazy speech of shortness of breath, red constipation of urinating, palpitation and insomnia, red tongue with a little fluid, tongue are thin white
Dry, stringy,thready and rapid pulse etc., while excluding to merge the organ diseases patients such as serious conscience kidney；Patient is divided into experimental group and control at random
Group, every group each 62, man 35, female 27, age 45-75 Sui, average age 61.5 ± 4.2 years old, course of disease 3-12 in control group
Year, it is 7.4 ± 2.3 years average；Man 38 in control group, female 24, age 45-75 Sui, average age 60.7 ± 3.8 years old, disease
Journey 3-12,7.3 ± 1.9 years average, the general information of two groups of patients compares, and no significant difference (P ＞ 0.05) has
Comparativity.
2. therapy
Control group patient gives conventional western medicine glucose-lowering treatment, and daily early 0.5h takes orally gliclazid in tablets and controls before the meal, before dinner
It treats, 40mg/ times, and takes orally diformin tablet treatment after breakfast, lunch and dinner.
The drug that experimental group patient gives the preparation of the embodiment of the present invention 6 is treated, and is taken orally after daily breakfast, lunch and dinner, each taking
Active ingredient is 1g；Two groups of patient's continued treatment 30d.
3. observation index
(1) clinical efficacy of two groups of patients is compared in observation；
It is effective:After treatment, patient's fasting blood-glucose≤6.0mmol/L, the 3mmol/L of and 2h-plasma glucose≤8.；
Effectively:After treatment, patient's fasting blood-glucose is 6.1-7.0mmol/L, and 2h-plasma glucose is 8.4-10.0mmol/L；
In vain:After treatment, patient's fasting blood-glucose and 2h-plasma glucose are not up to effective and effective standard.
(2) it is (total to compare the pretherapy and post-treatment fasting blood-glucose of two groups of patients, 2h-plasma glucose, glycosylated hemoglobin and blood lipids index
Cholesterol, triacylglycerol, low density lipoprotein cholesterol), c reactive protein.
4. statistical method
Data analysis is carried out using SPSS17.0 statistics softwares.
5. treatment results
(1) clinical efficacy is shown in Table 1.From table 1 it follows that the clinical efficacy of experimental group will be substantially better than control group (P ＜
0.05), the effective percentage of experimental group is higher than control group by 14.5%, and obvious effective rate is then higher by 22.6%.
The pretherapy and post-treatment blood glucose clinical efficacy of 1 two groups of patients of table
| Effective/example | Effectively/example | In vain/example | Effective percentage/% | |
| Control group | 31 | 21 | 10 | 83.9 |
| Experimental group | 45 | 16 | 1 | 98.4 |
(2) blood glucose and glycosylated hemoglobin
As shown in table 2, before treatment, two groups of patient's fasting blood-glucoses, 2h-plasma glucose and glycosylated hemoglobin compare, difference without
Statistical significance (P ＜ 0.05)；After treatment, experimental group patient fasting blood-glucose, 2h-plasma glucose and glycosylated hemoglobin less than pair
According to group, difference is statistically significant (P ＜ 0.05), illustrates that drug made from the embodiment of the present invention can effectively reduce patient's blood
Sugar level, therapeutic effect are notable.
The pretherapy and post-treatment blood glucose of 2 two groups of patients of table and glycosylated hemoglobin data
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although with reference to the foregoing embodiments
Invention is explained in detail, it will be understood by those of ordinary skill in the art that：It still can be to aforementioned each implementation
Technical solution recorded in example is modified or equivalent replacement of some of the technical features；And these modification or
It replaces, the spirit and scope for various embodiments of the present invention technical solution that it does not separate the essence of the corresponding technical solution.
Claims (7)
1. a kind of drug for treating Qi and Yin deficiency diabetes mellitus, which is characterized in that include the raw material of following parts by weight：Radix Notoginseng 20-
30 parts, 20-30 parts of the stem of noble dendrobium, 20-30 parts of balsam pear, 25-35 parts of Radix Astragali, 20-30 parts of pueraria lobata, 10-20 parts of American Ginseng, Radix Salviae Miltiorrhizae 20-30
Part, Radix Ophiopogonis 25-35 part, 10-20 parts of Herba Cistanches, 15-25 parts of radix polygonati officinalis, 10-20 parts of the membrane of a chicken's gizzard, 15-25 parts of Ramulus euonymi, peach kernel 7-15
Part, 15-25 parts of sealwort.
2. the drug for the treatment of Qi and Yin deficiency diabetes mellitus as described in claim 1, which is characterized in that including following parts by weight
Raw material：22-27 parts of Radix Notoginseng, 22-27 parts of the stem of noble dendrobium, 24-29 parts of balsam pear, 28-32 parts of Radix Astragali, 22-27 parts of pueraria lobata, American Ginseng 13-18
Part, 22-27 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis 28-33 part, 15-20 parts of Herba Cistanches, 18-23 parts of radix polygonati officinalis, 13-18 parts of the membrane of a chicken's gizzard, Ramulus euonymi 17-
22 parts, 9-13 parts of peach kernel, 17-22 parts of sealwort.
3. the drug for the treatment of Qi and Yin deficiency diabetes mellitus as claimed in claim 2, which is characterized in that including following parts by weight
Raw material：24 parts of Radix Notoginseng, 24 parts of the stem of noble dendrobium, 26 parts of balsam pear, 30 parts of Radix Astragali, 25 parts of pueraria lobata, 15 parts of American Ginseng, 25 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis 30
Part, 17 parts of Herba Cistanches, 20 parts of radix polygonati officinalis, 15 parts of the membrane of a chicken's gizzard, 20 parts of Ramulus euonymi, 10 parts of peach kernel, 19 parts of sealwort.
4. the preparation method of the drug for the treatment of Qi and Yin deficiency diabetes mellitus as described in any one of claims 1-3, which is characterized in that
Include the following steps：
S1, take Radix Notoginseng, the stem of noble dendrobium, balsam pear, Radix Astragali, pueraria lobata, American Ginseng, Radix Salviae Miltiorrhizae, Radix Ophiopogonis, Herba Cistanches, radix polygonati officinalis, the membrane of a chicken's gizzard, Ramulus euonymi,
Peach kernel, sealwort, mixing, beat powder, are sieved, and are transferred in three-dimensional mixer and are uniformly mixed, obtain mixture；
S2, mixture is transferred in oscillating granulator and is pelletized, obtain wet pellet；
S3, wet pellet is placed in hot air circulation drying oven, it is dry to water content≤10%, obtain dry granular material；
S4, dry granular material is placed in after the quick whole grain of vibrating screen cross 18 mesh sieve to get.
5. the preparation method of the drug for the treatment of Qi and Yin deficiency diabetes mellitus as claimed in claim 4, which is characterized in that the S1
In, cross 80-100 sieves.
6. the preparation method of the drug for the treatment of Qi and Yin deficiency diabetes mellitus as claimed in claim 4, which is characterized in that the S1
In, 20-30min is mixed in three-dimensional mixer.
7. the preparation method of the drug for the treatment of Qi and Yin deficiency diabetes mellitus as claimed in claim 4, which is characterized in that the S3
In, drying temperature is 50-60 DEG C, drying time 4-5h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810121763.XA CN108524776B (en) | 2018-02-07 | 2018-02-07 | Medicine for treating qi-yin deficiency type diabetes and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810121763.XA CN108524776B (en) | 2018-02-07 | 2018-02-07 | Medicine for treating qi-yin deficiency type diabetes and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108524776A true CN108524776A (en) | 2018-09-14 |
| CN108524776B CN108524776B (en) | 2021-03-23 |
Family
ID=63485721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810121763.XA Active CN108524776B (en) | 2018-02-07 | 2018-02-07 | Medicine for treating qi-yin deficiency type diabetes and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108524776B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853130A (en) * | 2018-09-30 | 2018-11-23 | 北京济全生物科技有限公司 | A kind of hypoglycemic medicine composition and its preparation method and application comprising Catalpol |
| CN109010299A (en) * | 2018-09-30 | 2018-12-18 | 北京济全生物科技有限公司 | A kind of sustained release hypoglycemic medicine composition and its preparation method and application |
| CN111227224A (en) * | 2018-11-10 | 2020-06-05 | 江西乐迪医疗科技有限公司 | Medical formula food helpful for protecting kidney function of diabetic nephropathy patient |
| CN115088841A (en) * | 2022-06-17 | 2022-09-23 | 王常清 | Blood sugar reducing dietary therapy formula and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170600A (en) * | 1997-05-08 | 1998-01-21 | 曾力群 | Pure Chinese drug tangniaojing for curing diabetes |
| CN104115950A (en) * | 2014-05-15 | 2014-10-29 | 王腾鉴 | Tea with functions of reducing blood fat, blood pressure and blood glucose |
| CN104208420A (en) * | 2014-09-05 | 2014-12-17 | 苏赵珍 | Traditional Chinese medicine for treating diabetes mellitus |
| CN107137601A (en) * | 2017-06-17 | 2017-09-08 | 沈大海 | A kind of Chinese medicine for treating diabetes |
| CN107536955A (en) * | 2017-08-18 | 2018-01-05 | 如皋普惠医院 | Treat the Chinese medicine of diabetes |
-
2018
- 2018-02-07 CN CN201810121763.XA patent/CN108524776B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170600A (en) * | 1997-05-08 | 1998-01-21 | 曾力群 | Pure Chinese drug tangniaojing for curing diabetes |
| CN104115950A (en) * | 2014-05-15 | 2014-10-29 | 王腾鉴 | Tea with functions of reducing blood fat, blood pressure and blood glucose |
| CN104208420A (en) * | 2014-09-05 | 2014-12-17 | 苏赵珍 | Traditional Chinese medicine for treating diabetes mellitus |
| CN107137601A (en) * | 2017-06-17 | 2017-09-08 | 沈大海 | A kind of Chinese medicine for treating diabetes |
| CN107536955A (en) * | 2017-08-18 | 2018-01-05 | 如皋普惠医院 | Treat the Chinese medicine of diabetes |
Non-Patent Citations (2)
| Title |
|---|
| 何志军: "葛根丹参玉竹汤治疗2型糖尿病42例总结", 《湖南中医杂志》 * |
| 陈燕鸣等: "珍芪降糖丸治疗Ⅱ型糖尿病188例临床疗效观察", 《天津中医学院学报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853130A (en) * | 2018-09-30 | 2018-11-23 | 北京济全生物科技有限公司 | A kind of hypoglycemic medicine composition and its preparation method and application comprising Catalpol |
| CN109010299A (en) * | 2018-09-30 | 2018-12-18 | 北京济全生物科技有限公司 | A kind of sustained release hypoglycemic medicine composition and its preparation method and application |
| CN108853130B (en) * | 2018-09-30 | 2019-08-13 | 北京济全生物科技有限公司 | A kind of hypoglycemic medicine composition and preparation method thereof |
| CN111227224A (en) * | 2018-11-10 | 2020-06-05 | 江西乐迪医疗科技有限公司 | Medical formula food helpful for protecting kidney function of diabetic nephropathy patient |
| CN115088841A (en) * | 2022-06-17 | 2022-09-23 | 王常清 | Blood sugar reducing dietary therapy formula and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108524776B (en) | 2021-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108524776A (en) | A kind of drug and preparation method thereof for treating Qi and Yin deficiency diabetes mellitus | |
| CN107362213B (en) | Composition with bowel relaxing function and preparation method thereof | |
| CN102225139B (en) | Chenshu invigorating spleen paste and its preparation method | |
| CN104288412B (en) | A kind of Chinese medicine composition for treating metabolic syndrome | |
| CN104491342A (en) | Medicament for treating diabetes and preparation method thereof | |
| CN105687788A (en) | Pharmaceutical composition capable of softening blood vessels and application thereof | |
| CN102743455B (en) | Chinese patent medicine for treating diabetes mellitus | |
| CN104606511B (en) | A kind of Chinese medicine for preventing minimally-invasive treatment Lumbar Disc herniation resection rebound phenomenon | |
| CN106072556A (en) | For health food regulating blood glucose and preparation method thereof | |
| CN104324134A (en) | Traditional Chinese medicine composition for improving microcirculation and preparation method of traditional Chinese medicine composition | |
| CN104825777A (en) | Health capsule with energy invigorating and mind tranquillizing efficacies, and preparation method thereof | |
| CN104784472A (en) | Traditional Chinese medicine composition for decreasing blood sugar to treat diabetes | |
| CN104587300A (en) | Traditional Chinese medicine composition for treating acute leukemia and preparation method of traditional Chinese medicine composition | |
| CN104399040A (en) | Drug for treating gastrectasia and preparation method thereof | |
| CN108853340A (en) | A kind of Chinese medicine of nourishing the liver and kidney and preparation method thereof | |
| CN108836997A (en) | A kind of drug and preparation method for cancer rehabilitation treatment | |
| CN116211974B (en) | Traditional Chinese medicine composition for improving microcirculation of human body | |
| CN108186905A (en) | A kind of Chinese medicine composition for treating extreme heat due to deficiency of yin patients with type Ⅰ DM and preparation method thereof | |
| CN103479868B (en) | Traditional Chinese medicine for treating apprehensive and cowardly arrhythmia and preparation method | |
| CN114588228B (en) | Composition for treating type 2 diabetes | |
| CN107529439A (en) | A kind of medicine pill for treating rheumatic heart disease and preparation method thereof | |
| CN102406917A (en) | Antidepressive traditional Chinese medicine composition and preparation method thereof | |
| CN105878732A (en) | Traditional Chinese medicine for curing diabetes and preparation method thereof | |
| CN105125886A (en) | Traditional Chinese medicine composition for preventing and treating diabetes and complications of diabetes | |
| CN1895503A (en) | Hairy antler capsules |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |