CN111888389A - A semen Ziziphi Spinosae extract for treating interstitial pneumonia, and its preparation method - Google Patents
A semen Ziziphi Spinosae extract for treating interstitial pneumonia, and its preparation method Download PDFInfo
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Abstract
The invention discloses a Wangzao date extract for treating interstitial pneumonia and a preparation method thereof, belonging to the technical field of plant extraction and comprising the following steps: step 1: selecting materials, namely selecting the whole plant of the Wangzao date; step 2: ultrafine grinding, namely ultrafine grinding the whole herb of the Wangzao date seeds; and step 3: extracting, namely putting the Wangzao date powder into an extraction tank, adding water, and steaming for 3 times for extraction; and 4, step 4: removing impurities, adding ethanol, cleaning and removing impurities; and 5: recovering the reagent, namely recovering the ethanol in the step 4, and standing the extracted concentrated solution to obtain a supernatant; step 6: concentrating and drying, and concentrating and drying the supernatant to obtain the Wangzao date extract. The invention treats the interstitial pneumonia by the Wangzao extractive three times a day, the curing and recovery time of 1.5-2.6 g for each time is about one year, the curing and recovery time is shortened to one sixth of the traditional treatment time, and the time is saved.
Description
Technical Field
The invention relates to a Wangzao jujube extract and a preparation method thereof, in particular to a Wangzao jujube extract for treating interstitial pneumonia and a preparation method thereof, belonging to the technical field of plant extraction.
Background
The Wangzao is rich in a large amount of effective compounds corresponding to kaurane, wherein the Wangzao A, B and chlorogenic acid have remarkable physiological activity, the Wangzao A and B are effective components for resisting tumor, the chlorogenic acid is an effective component for resisting bacteria and diminishing inflammation, the Wangzao is bitter in taste and slightly cold in nature, has the effects of clearing away heat and toxic materials, diminishing inflammation and relieving pain and resisting tumor, and is commonly used for treating upper respiratory tract inflammation such as pharyngitis, laryngitis, tonsillitis, stomatitis and the like. The interstitial lung disease is a general term of clinical pathological entities formed by different disease groups with pathological basic changes of diffuse lung parenchyma, alveolitis and interstitial fibrosis, and clinical manifestations of active dyspnea, X-ray chest radiograph diffuse shadow, restrictive ventilation disturbance, diffuse function reduction and hypoxemia, and the idiopathic pulmonary interstitial fibrosis is a progressive disease, and the natural disease course of untreated patients can be prolonged to about 6 years since the application of adrenocortical hormone, wherein the natural disease course of the untreated patients is 2-4 years on average. Either early or late stage, treatment should be immediate, improving the absorption of newly emerging alveolitis, partial fibrosis may also improve and may arrest disease progression, with corticosteroids being the first choice and immunosuppressants and traditional Chinese medicines being the second. The adrenocortical hormone can regulate inflammation and immune process, reduce immune complex content, inhibit proliferation of macrophage in alveolus and T lymphocyte cytokine function, and can improve absorption of X-ray shadow in lung of part of patients in the stage of alveolitis and cell exudation, thereby remarkably improving clinical symptoms and improving lung function. Clinical symptoms may also improve to varying degrees if treatment is initiated at the late stages of extensive interstitial fibrosis and alveolar lung stage, but lung shadowing and lung function do not progress significantly. The chronic conventional initial dose is 40-60 mg/d of prednisone, and the chronic conventional initial dose is taken in 3-4 times. When the disease condition is stable, the X-ray shadow can be gradually reduced after no absorption, 5mg is reduced every time after the X-ray shadow is maintained for 4-8 weeks, 2.5mg is reduced every week when the X-ray shadow is reduced to 20mg/d, and the X-ray shadow is maintained for less than 1 year after 10 mg/d. If the disease condition is relapsed and aggravated in the process of reducing the dose, the dose should be increased again to control the disease condition, and the effect is still achieved. The treatment course can be prolonged to two years, and can be used for a lifetime if the disease condition needs. Care should be taken to detect side effects of the drug, with the smallest possible dose, the least side effects achieving the best results. The application of glucocorticoid should be attention to opportunistic pathogen infection, and attention to recurrence of pulmonary tuberculosis, and if necessary, combined application of antituberculosis drugs, and long-term application of glucocorticoid should be attention to fungal infection. For example, patients with severe disease progression or acute type disease can be treated with glucocorticoid impact therapy, such as methylprednisolone 500mg/d for 3-5 days, and then orally administered after stable disease, and finally the optimal maintenance amount is found out according to individual difference to avoid recurrence. The patients who cannot receive the hormone and cannot tolerate the hormone for special reasons can use the immunosuppressant instead, or the amount of the corticoid is reduced and the immunosuppressant is added, the traditional interstitial lung disease treatment time is long, the loss of stomach, lung and kidney and other internal organs can occur in the western medicine treatment process, and the immunity of the human body is reduced and complications are easily caused by long-time medicine taking.
Disclosure of Invention
The invention mainly aims to solve the problems of long time and great side effect of the existing medicines for treating interstitial pneumonia and provide the Wangzao seed extract for treating the interstitial pneumonia and the preparation method thereof.
The purpose of the invention can be achieved by adopting the following technical scheme:
a preparation method of Wangzao date extract for treating interstitial pneumonia comprises the following steps:
step 1: selecting materials, namely selecting the whole plant of the Wangzao date;
step 2: ultrafine grinding, namely ultrafine grinding the whole herb of the Wangzao date seeds;
and step 3: extracting, namely putting the Wangzao date powder into an extraction tank, adding water, and steaming for 3 times for extraction;
and 4, step 4: removing impurities, adding ethanol, cleaning and removing impurities;
and 5: recovering the reagent, namely recovering the ethanol in the step 4, and standing the extracted concentrated solution to obtain a supernatant;
step 6: concentrating and drying, and concentrating and drying the supernatant to obtain the Wangzao date extract.
Preferably, in the step 2, the entire plant of the Wangzao date is subjected to ultrafine grinding and is crushed into 50-110 meshes.
Preferably, in the step 3, water with negative pressure of 70 ℃ is added for cooking for 3 times, the cooking time is 1.5-2 h each time, and the extract is collected once after each time of cooking.
Preferably, the three extraction solutions are combined, and simultaneously ethanol is added for cleaning and impurity removal.
Preferably, in step 4, the concentration of the ethanol after impurity removal is 70%.
Preferably, in step 5, the alcohol recovery tower is used for recovering the purified ethanol.
Preferably, in the step 5, the extract solution after impurity removal is uniformly mixed and then is kept stand for 24-48 h, and the supernatant of the extract solution after standing is taken.
Preferably, a negative pressure of 70 ℃ is used throughout step 3 to step 6.
A dried powder extract for treating interstitial pneumonia is prepared from semen Ziziphi Spinosae extract.
The invention has the beneficial technical effects that: according to the Wangzao jujube extract for treating interstitial pneumonia and the preparation method thereof, the Wangzao jujube extract is used for treating interstitial pneumonia three times a day, the curing and healing time of 1.5-2.6 g of the Chinese medicinal composition for each time is about one year, the curing and healing time is shortened to one sixth of the traditional treatment time, and the time is saved; meanwhile, the Wangzao date extract has the effects of relieving cough and asthma, clearing away heat and toxic materials and improving immunity, and can recover the autoimmunity of patients during treatment; the Wangzao date extract has the advantages of no damage to stomach, lung, kidney and other internal organs, no irritation and no side effect.
Detailed Description
In order to make the technical solutions of the present invention more clear and definite for those skilled in the art, the present invention is further described in detail with reference to the following examples, but the embodiments of the present invention are not limited thereto.
The preparation method of the Wangzao date extract for treating interstitial pneumonia provided by the embodiment comprises the following steps: step 1: selecting materials, namely selecting the whole plant of the Wangzao date; step 2: ultrafine grinding, namely ultrafine grinding the whole herb of the Wangzao date seeds; and step 3: extracting, namely putting the Wangzao date powder into an extraction tank, adding water, and steaming for 3 times for extraction; and 4, step 4: removing impurities, adding ethanol, cleaning and removing impurities; and 5: recovering the reagent, namely recovering the ethanol in the step 4, and standing the extracted concentrated solution to obtain a supernatant; step 6: concentrating and drying, concentrating and drying the supernatant to obtain a Wangzao extract, wherein the Wangzao extract is used for treating interstitial pneumonia for three times a day, the recovery time of 1.5-2.6 g for each treatment is about one year, the traditional treatment time is shortened to one sixth, and the time is saved; meanwhile, the Wangzao date extract has the effects of relieving cough and asthma, clearing away heat and toxic materials and improving immunity, and can recover the autoimmunity of patients during treatment; the Wangzao date extract has the advantages of no damage to stomach, lung, kidney and other internal organs, no irritation and no side effect.
In the step 2, ultrafine grinding is carried out on the whole plant of the Wangzao date, the superfine grinding is carried out to 50-110 meshes, in the step 3, water with the negative pressure of 70 ℃ is added for cooking for 3 times, the cooking time is 1.5-2 h each time, an extracting solution is collected after each time of cooking, three times of extracting solutions are combined, simultaneously, ethanol is added for cleaning and impurity removal, in the step 4, the concentration of the ethanol for impurity removal is 70%, in the step 5, the ethanol for impurity removal is recovered by an ethanol recovery tower, in the step 5, the extracting solutions after impurity removal are uniformly mixed and then stand for 24-48 h, supernatant of the standing extracting solution is taken, and in the processes from the step 3 to the step 6, the negative pressure of 70 ℃ is adopted.
A dried powder extract for treating interstitial pneumonia is prepared from semen Ziziphi Spinosae extract.
Example 1:
a semen Ziziphi Spinosae extract for treating interstitial pneumonia and its preparation method comprises the following steps:
step 1: selecting materials, cleaning and drying the selected whole plant of the Wangzao date seeds;
step 2: ultrafine grinding, namely performing ultrafine grinding on the whole plant of the Wangzao jujube, and crushing to 50 meshes;
and step 3: extracting, namely putting the Wangzao date powder into an extraction tank, adding water with negative pressure of 70 ℃ for stewing for 3 times, wherein the stewing time is 1.5 each time, collecting an extracting solution after each time of stewing, and combining the extracting solutions obtained in three times;
and 4, step 4: removing impurities, adding 70% ethanol, cleaning and removing impurities;
and 5: recovering the reagent, recovering the impurity-removed ethanol by using an alcohol recovery tower, uniformly mixing the impurity-removed extracting solution, standing for 24 hours, and taking the supernatant of the standing extracting solution;
step 6: concentrating and drying, and concentrating and drying the supernatant to obtain the Wangzao date extract.
Example 2:
a semen Ziziphi Spinosae extract for treating interstitial pneumonia and its preparation method comprises the following steps:
step 1: selecting materials, cleaning and drying the selected whole plant of the Wangzao date seeds;
step 2: ultrafine grinding, namely performing ultrafine grinding on the whole plant of the Wangzao jujube, and crushing to 70 meshes;
and step 3: extracting, namely putting the Wangzao date powder into an extraction tank, adding water with negative pressure of 70 ℃ for stewing for 3 times, wherein the stewing time is 1.6h each time, collecting an extracting solution after each time of stewing, and combining the extracting solutions obtained in three times;
and 4, step 4: removing impurities, adding 70% ethanol, cleaning and removing impurities;
and 5: recovering the reagent, recovering the impurity-removed ethanol by using an alcohol recovery tower, uniformly mixing the impurity-removed extracting solution, standing for 30 hours, and taking the supernatant of the standing extracting solution;
step 6: concentrating and drying, and concentrating and drying the supernatant to obtain the Wangzao date extract.
Example 3:
a semen Ziziphi Spinosae extract for treating interstitial pneumonia and its preparation method comprises the following steps:
step 1: selecting materials, cleaning and drying the selected whole plant of the Wangzao date seeds;
step 2: ultrafine grinding, namely performing ultrafine grinding on the whole plant of the Wangzao jujube, and crushing to 80 meshes;
and step 3: extracting, namely putting the Wangzao date powder into an extraction tank, adding water with negative pressure of 70 ℃ for stewing for 3 times, wherein the stewing time is 1.7h each time, collecting an extracting solution after each time of stewing, and combining the extracting solutions obtained in three times;
and 4, step 4: removing impurities, adding 70% ethanol, cleaning and removing impurities;
and 5: recovering the reagent, recovering the impurity-removed ethanol by using an alcohol recovery tower, uniformly mixing the impurity-removed extracting solution, standing for 32 hours, and taking the supernatant of the standing extracting solution;
step 6: concentrating and drying, and concentrating and drying the supernatant to obtain the Wangzao date extract.
Example 4:
a semen Ziziphi Spinosae extract for treating interstitial pneumonia and its preparation method comprises the following steps:
step 1: selecting materials, cleaning and drying the selected whole plant of the Wangzao date seeds;
step 2: ultrafine grinding, namely performing ultrafine grinding on the whole plant of the Wangzao jujube, and crushing to 100 meshes;
and step 3: extracting, namely putting the Wangzao date powder into an extraction tank, adding water with negative pressure of 70 ℃ for stewing for 3 times, wherein the stewing time is 1.9h each time, collecting an extracting solution after each time of stewing, and combining the extracting solutions obtained in three times;
and 4, step 4: removing impurities, adding 70% ethanol, cleaning and removing impurities;
and 5: recovering the reagent, recovering the impurity-removed ethanol by using an alcohol recovery tower, uniformly mixing the impurity-removed extracting solution, standing for 40 hours, and taking the supernatant of the standing extracting solution;
step 6: concentrating and drying, and concentrating and drying the supernatant to obtain the Wangzao date extract.
Example 5:
a semen Ziziphi Spinosae extract for treating interstitial pneumonia and its preparation method comprises the following steps:
step 1: selecting materials, cleaning and drying the selected whole plant of the Wangzao date seeds;
step 2: ultrafine grinding, namely performing ultrafine grinding on the whole plant of the Wangzao jujube, and crushing to 110 meshes;
and step 3: extracting, namely putting the Wangzao date powder into an extraction tank, adding water with negative pressure of 70 ℃ for stewing for 3 times, wherein the stewing time is 2h each time, collecting primary extracting solution after each time of stewing, and combining the three extracting solutions;
and 4, step 4: removing impurities, adding 70% ethanol, cleaning and removing impurities;
and 5: recovering the reagent, recovering the impurity-removed ethanol by using an alcohol recovery tower, uniformly mixing the impurity-removed extracting solution, standing for 48 hours, and taking the supernatant of the standing extracting solution;
step 6: concentrating and drying, and concentrating and drying the supernatant to obtain the Wangzao date extract.
Clinical research section
First, clinical data
(I) the standard of diagnosis,
diagnostic criteria: symptoms and physical signs, dyspnea of patients mostly presents progressive manifestations, accompanied with symptoms of cough, expectoration and the like of different degrees, auscultation of two lungs with audible and Velcro Ro sounds, and some patients with cyanosis, clubbed fingers and the like; CT diagnosis 1, nodule shadow, ground glass shadow, alveolus change, leaflet interval thickening, latticed and honeycomb change; and (3) lung function detection: restricted ventilation dysfunction and gas exchange dysfunction, decreased lung capacity, and diffuse dysfunction.
Therapeutic and diagnostic standard for Wangzao date
The symptoms are shown as follows: chest distress, dyspnea, cough, white phlegm, difficult expectoration, cyanosis of lips and nails, or clubbing fingers, dark and bluish face, dark purple tongue with ecchymosis, thick and greasy coating, deep or wiry and slippery pulse, improvement of physical strength and immunity, etc.
The standard was included.
1. The diagnosis standard of the interstitial pneumonia is met;
2. the treatment performance of the Wangzao date is met;
3. the age is 15-75 years old, and the nature is not limited.
(II) Western medicine treatment group
Dexamethasone P.00.5mg/kg/day (30-40mg/d) was given as the standard hormone therapy.
(III) Wang jujube treatment group
The semen Ziziphi Spinosae extract is 0.5g for each time, and is administered three times daily.
Examination of pulmonary function
Before and after treatment, two indexes of Vital Capacity (VC) and CO dispersion (DLco) in the pulmonary function examination of the patient are recorded respectively, and the two indexes are compared according to the change of the percentage of the Vital Capacity (VC) and the CO dispersion (DLco) in the later period of the pulmonary function examination of the patient in the predicted value, so that the improvement condition of the pulmonary function after the treatment of each group of medicines is evaluated.
(IV) statistical method
Counting data adopts x test, metering data adopts paired t test and t test of independent samples, and clinical grade data comparison adopts Ridit analysis.
(V) observation index and therapeutic effect judgment
(1) Assessment of symptomatic efficacy
Will treat the symptoms of the patients before and after the treatment
Scoring and grading symptoms respectively, and calculating a curative effect index to evaluate the total effective rate after the drug treatment, wherein the total effective rate of each group comprises the percentage of the sum of cured, effective and effective cases in the total number of cases.
TABLE 1 comparison of general conditions of two groups of enrolled cases
Note: two gender comparison X2 test; course of disease is tested by t
TABLE 2 therapeutic index criteria
The efficacy index (n) is (total integral of symptoms before treatment-total integral of symptoms after treatment)/total integral of symptoms before treatment X100%.
TABLE 3 comparison of index percentages of VC.DLco pulmonary function before and after treatment
Note: group comparisons c P < 0.05: comparison between groups Δ P < 0.05.
(VI) results and analysis
The change of the lung function (x Shi S) before and after treatment is analyzed according to t test, and the two indexes (VC and DLco) of the lung function of a western medicine treatment group and a Chinese and western medicine combined treatment group are improved after treatment, and the two indexes before and after treatment of the Chinese and western medicine combined treatment group are obviously improved, (P & lt 0.05), the treatment result of the Wangzao date treatment group is superior to that of the western medicine treatment group, and the statistical difference (P & lt 0.05) exists.
In summary, in this embodiment, according to the wang jujube extract for treating interstitial pneumonia and the preparation method thereof in this embodiment, the extracts obtained by the extraction in the first to fifth embodiments are subjected to a pharmacodynamic test, the content of the wang jujube extract obtained in the fourth embodiment is the highest, and the pharmacodynamic effect is the best, the wang jujube extract treats interstitial pneumonia three times a day, the healing time of 1.5-2.6 g dosage treatment per time is about one year, the healing time is shortened to one sixth of the traditional treatment time, and the time is saved; meanwhile, the Wangzao date extract has the effects of relieving cough and asthma, clearing away heat and toxic materials and improving immunity, and can recover the autoimmunity of patients during treatment; the Wangzao date extract has the advantages of no damage to stomach, lung, kidney and other internal organs, no irritation and no side effect.
The above description is only for the purpose of illustrating the present invention and is not intended to limit the scope of the present invention, and any person skilled in the art can substitute or change the technical solution of the present invention and its conception within the scope of the present invention.
Claims (9)
1. A preparation method of Wangzao date extract for treating interstitial pneumonia is characterized by comprising the following steps:
step 1: selecting materials, namely selecting the whole plant of the Wangzao date;
step 2: ultrafine grinding, namely ultrafine grinding the whole herb of the Wangzao date seeds;
and step 3: extracting, namely putting the Wangzao date powder into an extraction tank, adding water, and steaming for 3 times for extraction;
and 4, step 4: removing impurities, adding ethanol, cleaning and removing impurities;
and 5: recovering the reagent, namely recovering the ethanol in the step 4, and standing the extracted concentrated solution to obtain a supernatant;
step 6: concentrating and drying, and concentrating and drying the supernatant to obtain the Wangzao date extract.
2. The method of claim 1, wherein in step 2, the whole plant of Wangzao date is subjected to ultrafine grinding and pulverized to 50-110 mesh.
3. The method of claim 1, wherein in step 3, water with a negative pressure of 70 ℃ is added for cooking 3 times, each cooking time is 1.5-2 h, and the extract is collected after each cooking.
4. The method of claim 3, wherein the three extractive solutions are combined and washed with ethanol to remove impurities.
5. The method of claim 1, wherein the ethanol concentration after removing impurities is 70% in step 4.
6. The method of claim 1, wherein the step 5 of recovering the ethanol from the supernatant is performed by an ethanol recovery tower.
7. The method of claim 5, wherein in step 5, the extracted solution after impurity removal is mixed uniformly and then kept stand for 24-48 h, and the supernatant of the kept stand extracted solution is taken.
8. The method of claim 1, wherein the step 3 to the step 6 are performed under a negative pressure of 70 ℃.
9. The dry powder extract of the Wangzao date seed for the treatment of interstitial pneumonia according to any one of claims 1 to 8.
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