CN111888280A - Toothpaste with superoxide dismutase - Google Patents

Toothpaste with superoxide dismutase Download PDF

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Publication number
CN111888280A
CN111888280A CN202010792182.6A CN202010792182A CN111888280A CN 111888280 A CN111888280 A CN 111888280A CN 202010792182 A CN202010792182 A CN 202010792182A CN 111888280 A CN111888280 A CN 111888280A
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parts
raw materials
sodium
toothpaste
superoxide dismutase
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CN202010792182.6A
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Chinese (zh)
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彭超
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Xiamen Pengchi Daily Necessities Co ltd
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Xiamen Pengchi Daily Necessities Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to the technical field of toothpaste, and particularly relates to toothpaste with superoxide dismutase, which comprises the following raw materials: saccharin sodium, PEG-40 hydrogenated castor oil, SOD enzyme, glycerin, polyethylene glycol-8, hydrated silica, xanthan gum, hydroxypropyl guar gum, essence, sodium lauryl sulfate, CI 16035, titanium dioxide/CI 77891, sodium methyl hydroxybenzoate, sodium ethyl hydroxybenzoate and water, wherein the preparation method of the toothpaste with the superoxide dismutase comprises the following steps: s1: selecting raw materials: weighing the raw materials according to the mass proportion; s2: mixing raw materials: placing the raw materials weighed according to the mass proportion in the step S1 into a mixing device for uniformly mixing; s3: packaging a finished product: and (5) sealing and packaging the uniformly mixed raw materials in the step S2. The SOD enzyme toothpaste can inhibit labor pain, diminish inflammation and inhibit dental nerve sensitivity.

Description

Toothpaste with superoxide dismutase
Technical Field
The invention relates to the technical field of toothpaste, in particular to toothpaste with superoxide dismutase.
Background
The toothpaste is a cleaning article commonly used in daily life, is a dentifrice, is generally in a gel shape, can be usually smeared on a toothbrush for cleaning teeth, keeps the beauty and brightness of the teeth, has a long history, and with the continuous development of scientific technology, the continuous improvement and perfection of manufacturing technology and equipment, various types of toothpaste are appeared one after another, the quality and the grade of products are continuously improved, and as far as 2019, the variety of the toothpaste is changed from single cleaning type toothpaste, the toothpaste is developed into hundreds of multifunctional toothpastes with complete varieties and various functions, thereby meeting the requirements of different consumption levels.
The existing toothpaste is usually used for cleaning and nursing the surface of teeth, and has no relieving and treating effect on symptoms of gingival inflammation, pain and sensitive tooth nerves.
Disclosure of Invention
The invention aims to provide toothpaste with superoxide dismutase, which solves the problems that the existing toothpaste proposed in the background art is usually used for cleaning and nursing tooth surfaces and does not have relieving and treating effects on symptoms of gingival inflammation, paroxysmal pain and sensitive tooth nerves.
In order to achieve the purpose, the invention provides the following technical scheme: a toothpaste with superoxide dismutase, the toothpaste with superoxide dismutase comprises the following raw materials: saccharin sodium, PEG-40 hydrogenated castor oil, SOD enzyme, glycerin, polyethylene glycol-8, hydrated silica, xanthan gum, hydroxypropyl guar gum, essence, sodium lauryl sulfate, CI 16035, titanium dioxide/CI 77891, sodium methyl hydroxybenzoate, sodium ethyl hydroxybenzoate and water, wherein the raw materials respectively comprise the following components in percentage by mass: 0.1-0.3 part of saccharin sodium, 0.5-1.5 part of PEG-40 hydrogenated castor oil, 0.1-0.5 part of SOD enzyme, 10-40 parts of glycerin, 83.0-10.0 parts of polyethylene glycol-18-26 parts of hydrated silica, 0.2-0.6 part of xanthan gum, 0.2-0.6 part of hydroxypropyl guar gum, 0.8-1.6 parts of essence, 1.0-3.0 parts of sodium lauryl sulfate, 0.001-CI 160350.0001, 0.5-0.5 part of titanium dioxide/CI 778910.1, 0.1-0.3 part of sodium methyl hydroxybenzoate, 0.1-0.3 part of sodium ethyl hydroxybenzoate and the balance of water.
Preferably, the raw materials are respectively as follows according to mass proportion: 0.1 part of saccharin sodium, 0.5 part of PEG-40 hydrogenated castor oil, 0.1 part of SOD enzyme, 10 parts of glycerin, 83.0 parts of polyethylene glycol, 18 parts of hydrated silica, 0.2 part of xanthan gum, 0.2 part of hydroxypropyl guar gum, 0.8 part of essence, 1.0 part of sodium lauryl sulfate, 0.1 part of CI 160350.0001 part, titanium dioxide/CI 778910.1 part, 0.1 part of sodium methyl hydroxybenzoate, 0.1 part of sodium ethyl hydroxybenzoate and the balance of water.
Preferably, the raw materials are respectively as follows according to mass proportion: 0.2 part of saccharin sodium, 1 part of PEG-40 hydrogenated castor oil, 0.3 part of SOD enzyme, 25 parts of glycerol, 86.5 parts of polyethylene glycol, 22 parts of hydrated silica, 0.4 part of xanthan gum, 0.4 part of hydroxypropyl guar gum, 1.2 parts of essence, 2.0 parts of sodium lauryl sulfate, 0.2 part of CI 160350.00055 parts of titanium dioxide/CI 778910.3 parts, 0.2 part of sodium methyl hydroxybenzoate, 0.2 part of sodium ethyl hydroxybenzoate and the balance of water.
Preferably, the raw materials are respectively as follows according to mass proportion: 0.3 part of saccharin sodium, 1.5 parts of PEG-40 hydrogenated castor oil, 0.5 part of SOD enzyme, 40 parts of glycerin, 810.0 parts of polyethylene glycol, 26 parts of hydrated silica, 0.6 part of xanthan gum, 0.6 part of hydroxypropyl guar gum, 1.6 parts of essence, 3.0 parts of sodium lauryl sulfate, 0.3 part of CI 160350.001 parts, titanium dioxide/CI 778910.5 parts, 0.3 part of sodium methyl hydroxybenzoate, 0.3 part of sodium ethyl hydroxybenzoate and the balance of water.
Preferably, the preparation method of the toothpaste with superoxide dismutase comprises the following steps:
s1: selecting raw materials: weighing the raw materials according to the mass proportion;
s2: mixing raw materials: placing the raw materials weighed according to the mass proportion in the step S1 into a mixing device for uniformly mixing;
s3: packaging a finished product: and (5) sealing and packaging the uniformly mixed raw materials in the step S2.
Compared with the prior art, the invention has the beneficial effects that:
1) SOD enzyme (superoxide dismutase) is applied to toothpaste without separation and dehydration. The SOD enzyme toothpaste can inhibit labor pain, diminish inflammation and inhibit dental nerve sensitivity. Can be used as toothpaste for caring gingiva.
2) Through SOD enzyme activity characteristics, free radicals in the oral cavity are reduced, and oral inflammation and sensitivity of dental nerves are reduced.
Drawings
Fig. 1 is a flow chart of a preparation method of the toothpaste of the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention.
Referring to fig. 1, the present invention provides a technical solution: a toothpaste with superoxide dismutase, the toothpaste with superoxide dismutase comprises the following raw materials: saccharin sodium, PEG-40 hydrogenated castor oil, SOD enzyme, glycerin, polyethylene glycol-8, hydrated silica, xanthan gum, hydroxypropyl guar gum, essence, sodium lauryl sulfate, CI 16035, titanium dioxide/CI 77891, sodium methyl hydroxybenzoate, sodium ethyl hydroxybenzoate and water, wherein the raw materials respectively comprise the following components in percentage by mass: 0.1-0.3 part of saccharin sodium, 0.5-1.5 part of PEG-40 hydrogenated castor oil, 0.1-0.5 part of SOD enzyme, 10-40 parts of glycerin, 83.0-10.0 parts of polyethylene glycol-18-26 parts of hydrated silica, 0.2-0.6 part of xanthan gum, 0.2-0.6 part of hydroxypropyl guar gum, 0.8-1.6 parts of essence, 1.0-3.0 parts of sodium lauryl sulfate, 0.001-CI 160350.0001, 0.5-0.5 part of titanium dioxide/CI 778910.1, 0.1-0.3 part of sodium methyl hydroxybenzoate, 0.1-0.3 part of sodium ethyl hydroxybenzoate and the balance of water.
SOD is contained in vegetables and fruits, such as banana, hawthorn, roxburgh rose, kiwi fruit, garlic, etc., and other products such as scallop and chicken, etc. The activity of SOD is higher in the peel than in the pulp, and higher in fresh fruit than in the fruit after storage. And processed into health products and food additives in various forms, such as milk, beer, soft candy, etc. with SOD.
Skin aging and damage are important features of human aging, which is a consequence of obstacles to the accumulation or removal of reactive oxygen species free radicals, which cause cellular damage and pigmentation. Since human skin is directly exposed to oxygen, aging and damage of the skin may be caused. The supplement of the exogenous SOD is beneficial to delaying skin aging, resisting oxidation and removing color spots. Therefore, many cosmetic manufacturers both in China and abroad add SOD in certain proportion into their own products.
Because SOD is a special disproportionation reaction catalyst acting on superoxide anion free radicals, the SOD serving as a medical product has obvious curative effects on inflammation, autoimmunity, cardiovascular and cerebrovascular diseases and the like caused by the action of the free radicals. SOD can be used for inhibiting inflammation such as arthritis, pleuritis, acute tracheitis, etc. by its antioxidant effect.
The mixture ratio of the raw materials adopts the following three mixture ratio schemes as examples:
the first proportioning scheme is as follows: the raw materials are as follows according to mass proportion: 0.1 part of saccharin sodium, 0.5 part of PEG-40 hydrogenated castor oil, 0.1 part of SOD enzyme, 10 parts of glycerin, 83.0 parts of polyethylene glycol, 18 parts of hydrated silica, 0.2 part of xanthan gum, 0.2 part of hydroxypropyl guar gum, 0.8 part of essence, 1.0 part of sodium lauryl sulfate, 0.1 part of CI 160350.0001 part, titanium dioxide/CI 778910.1 part, 0.1 part of sodium methyl hydroxybenzoate, 0.1 part of sodium ethyl hydroxybenzoate and the balance of water.
The second proportioning scheme is as follows: the raw materials are as follows according to mass proportion: 0.2 part of saccharin sodium, 1 part of PEG-40 hydrogenated castor oil, 0.3 part of SOD enzyme, 25 parts of glycerol, 86.5 parts of polyethylene glycol, 22 parts of hydrated silica, 0.4 part of xanthan gum, 0.4 part of hydroxypropyl guar gum, 1.2 parts of essence, 2.0 parts of sodium lauryl sulfate, 0.2 part of CI 160350.00055 parts of titanium dioxide/CI 778910.3 parts, 0.2 part of sodium methyl hydroxybenzoate, 0.2 part of sodium ethyl hydroxybenzoate and the balance of water.
The third proportioning scheme is as follows: the raw materials are as follows according to mass proportion: 0.3 part of saccharin sodium, 1.5 parts of PEG-40 hydrogenated castor oil, 0.5 part of SOD enzyme, 40 parts of glycerin, 810.0 parts of polyethylene glycol, 26 parts of hydrated silica, 0.6 part of xanthan gum, 0.6 part of hydroxypropyl guar gum, 1.6 parts of essence, 3.0 parts of sodium lauryl sulfate, 0.3 part of CI 160350.001 parts, titanium dioxide/CI 778910.5 parts, 0.3 part of sodium methyl hydroxybenzoate, 0.3 part of sodium ethyl hydroxybenzoate and the balance of water.
Further, the preparation method of the toothpaste with superoxide dismutase comprises the following steps:
s1: selecting raw materials: weighing the raw materials according to the mass proportion;
s2: mixing raw materials: placing the raw materials weighed according to the mass proportion in the step S1 into a mixing device for uniformly mixing;
s3: packaging a finished product: and (5) sealing and packaging the uniformly mixed raw materials in the step S2.
The first embodiment is as follows:
the preparation method of the toothpaste with superoxide dismutase comprises the following steps:
s1: selecting raw materials: weighing the raw materials according to mass proportion, wherein the raw materials respectively comprise the following components in percentage by mass: 0.1g of saccharin sodium, 0.5g of PEG-40 hydrogenated castor oil, 0.1g of SOD enzyme, 10g of glycerol, 83.0 g of polyethylene glycol, 18g of hydrated silica, 0.2g of xanthan gum, 0.2g of hydroxypropyl guar gum, 0.8g of essence, 1.0g of sodium lauryl sulfate, CI 160350.0001 g, titanium dioxide/CI 778910.1 g, 0.1g of sodium methyl hydroxybenzoate, 0.1g of sodium ethyl hydroxybenzoate and the balance of water;
s2: mixing raw materials: placing the raw materials weighed according to the mass proportion in the step S1 into a mixing device for uniformly mixing;
s3: packaging a finished product: and (5) sealing and packaging the uniformly mixed raw materials in the step S2.
Example two:
the preparation method of the toothpaste with superoxide dismutase comprises the following steps:
s1: selecting raw materials: weighing the raw materials according to mass proportion, wherein the raw materials respectively comprise the following components in percentage by mass: 0.2g of saccharin sodium, 1g of PEG-40 hydrogenated castor oil, 0.3g of SOD enzyme, 25g of glycerol, 86.5 g of polyethylene glycol, 22g of hydrated silica, 0.4g of xanthan gum, 0.4g of hydroxypropyl guar gum, 1.2g of essence, 2.0g of sodium lauryl sulfate, 0.2g of CI 160350.00055 g, 10.3g of titanium dioxide/CI778910.3 g of sodium methyl hydroxybenzoate, 0.2g of sodium ethyl hydroxybenzoate and the balance of water;
s2: mixing raw materials: placing the raw materials weighed according to the mass proportion in the step S1 into a mixing device for uniformly mixing;
s3: packaging a finished product: and (5) sealing and packaging the uniformly mixed raw materials in the step S2.
Example three:
the preparation method of the toothpaste with superoxide dismutase comprises the following steps:
s1: selecting raw materials: weighing the raw materials according to mass proportion, wherein the raw materials respectively comprise the following components in percentage by mass: 0.3g of saccharin sodium, 1.5g of PEG-40 hydrogenated castor oil, 0.5g of SOD enzyme, 40g of glycerol, 810.0 g of polyethylene glycol, 26g of hydrated silica, 0.6g of xanthan gum, 0.6g of hydroxypropyl guar gum, 1.6g of essence, 3.0g of sodium lauryl sulfate, 0.3g of CI 160350.001 g, 10.5 g of titanium dioxide/CI778910.5 g of sodium methyl hydroxybenzoate, 0.3g of sodium ethyl hydroxybenzoate and the balance of water;
s2: mixing raw materials: placing the raw materials weighed according to the mass proportion in the step S1 into a mixing device for uniformly mixing;
s3: packaging a finished product: and (5) sealing and packaging the uniformly mixed raw materials in the step S2.
The toothpaste products prepared by the three embodiments are used as implementation products, three groups of users respectively use the toothpaste prepared by the three embodiments correspondingly, and the three groups of users randomly select patients suffering from symptoms of gingival inflammation, labor pain, dental nerve sensitivity and the like and with similar conditions;
one group of toothpastes corresponding to the first embodiment, two groups of toothpastes corresponding to the second embodiment and three groups of toothpastes corresponding to the third embodiment;
the using method comprises the following steps: three groups of users are the same, and are respectively used once in the morning and evening, 1-1.2g each time, and tooth brushing is carried out for 2-3 min;
after one month, the gum and tooth states of three groups of users are obviously improved, and the experimental verification shows that the scheme is effective and has obvious effect.
While there have been shown and described the fundamental principles and essential features of the invention and advantages thereof, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof; the present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein, and any reference signs in the claims are not intended to be construed as limiting the claim concerned.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (5)

1. A toothpaste with superoxide dismutase, characterized in that: the toothpaste with superoxide dismutase comprises the following raw materials: saccharin sodium, PEG-40 hydrogenated castor oil, SOD enzyme, glycerin, polyethylene glycol-8, hydrated silica, xanthan gum, hydroxypropyl guar gum, essence, sodium lauryl sulfate, CI 16035, titanium dioxide/CI 77891, sodium methyl hydroxybenzoate, sodium ethyl hydroxybenzoate and water, wherein the raw materials respectively comprise the following components in percentage by mass: 0.1-0.3 part of saccharin sodium, 0.5-1.5 part of PEG-40 hydrogenated castor oil, 0.1-0.5 part of SOD enzyme, 10-40 parts of glycerin, 83.0-10.0 parts of polyethylene glycol-18-26 parts of hydrated silica, 0.2-0.6 part of xanthan gum, 0.2-0.6 part of hydroxypropyl guar gum, 0.8-1.6 parts of essence, 1.0-3.0 parts of sodium lauryl sulfate, 0.001-CI 160350.0001, 0.5-0.5 part of titanium dioxide/CI 778910.1, 0.1-0.3 part of sodium methyl hydroxybenzoate, 0.1-0.3 part of sodium ethyl hydroxybenzoate and the balance of water.
2. The toothpaste with superoxide dismutase as claimed in claim 1 wherein: the raw materials are as follows according to mass proportion: 0.1 part of saccharin sodium, 0.5 part of PEG-40 hydrogenated castor oil, 0.1 part of SOD enzyme, 10 parts of glycerin, 83.0 parts of polyethylene glycol, 18 parts of hydrated silica, 0.2 part of xanthan gum, 0.2 part of hydroxypropyl guar gum, 0.8 part of essence, 1.0 part of sodium lauryl sulfate, 0.1 part of CI 160350.0001 part, titanium dioxide/CI 778910.1 part, 0.1 part of sodium methyl hydroxybenzoate, 0.1 part of sodium ethyl hydroxybenzoate and the balance of water.
3. The toothpaste with superoxide dismutase as claimed in claim 1 wherein: the raw materials are as follows according to mass proportion: 0.2 part of saccharin sodium, 1 part of PEG-40 hydrogenated castor oil, 0.3 part of SOD enzyme, 25 parts of glycerol, 86.5 parts of polyethylene glycol, 22 parts of hydrated silica, 0.4 part of xanthan gum, 0.4 part of hydroxypropyl guar gum, 1.2 parts of essence, 2.0 parts of sodium lauryl sulfate, 0.2 part of CI 160350.00055 parts of titanium dioxide/CI 778910.3 parts, 0.2 part of sodium methyl hydroxybenzoate, 0.2 part of sodium ethyl hydroxybenzoate and the balance of water.
4. The toothpaste with superoxide dismutase as claimed in claim 1 wherein: the raw materials are as follows according to mass proportion: 0.3 part of saccharin sodium, 1.5 parts of PEG-40 hydrogenated castor oil, 0.5 part of SOD enzyme, 40 parts of glycerin, 810.0 parts of polyethylene glycol, 26 parts of hydrated silica, 0.6 part of xanthan gum, 0.6 part of hydroxypropyl guar gum, 1.6 parts of essence, 3.0 parts of sodium lauryl sulfate, 0.3 part of CI 160350.001 parts, titanium dioxide/CI 778910.5 parts, 0.3 part of sodium methyl hydroxybenzoate, 0.3 part of sodium ethyl hydroxybenzoate and the balance of water.
5. The toothpaste with superoxide dismutase as claimed in claim 1 wherein: the preparation method of the toothpaste with superoxide dismutase comprises the following steps:
s1: selecting raw materials: weighing the raw materials according to the mass proportion;
s2: mixing raw materials: placing the raw materials weighed according to the mass proportion in the step S1 into a mixing device for uniformly mixing;
s3: packaging a finished product: and (5) sealing and packaging the uniformly mixed raw materials in the step S2.
CN202010792182.6A 2020-08-08 2020-08-08 Toothpaste with superoxide dismutase Pending CN111888280A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114588064A (en) * 2022-03-11 2022-06-07 姜巨波 SOD rose toothpaste
CN117618282A (en) * 2023-12-11 2024-03-01 广州中汉口腔用品有限公司 Toothpaste formula containing active SOD enzyme and preparation method thereof

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114588064A (en) * 2022-03-11 2022-06-07 姜巨波 SOD rose toothpaste
CN117618282A (en) * 2023-12-11 2024-03-01 广州中汉口腔用品有限公司 Toothpaste formula containing active SOD enzyme and preparation method thereof

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