CN111886224B - Atr激酶的杂环抑制剂 - Google Patents

Atr激酶的杂环抑制剂 Download PDF

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Publication number
CN111886224B
CN111886224B CN201880061041.8A CN201880061041A CN111886224B CN 111886224 B CN111886224 B CN 111886224B CN 201880061041 A CN201880061041 A CN 201880061041A CN 111886224 B CN111886224 B CN 111886224B
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alkyl
alkoxy
cycloalkyl
compound
membered heterocycloalkyl
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Chinese (zh)
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CN111886224A (zh
Inventor
M·E·迪弗朗西斯科
P·琼斯
C·L·卡罗尔
J·B·克劳斯
Z·康
M·G·约翰逊
S·莱夫利
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Smart Chemical Co
University of Texas System
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Smart Chemical Co
University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880061041.8A 2017-08-17 2018-08-17 Atr激酶的杂环抑制剂 Active CN111886224B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762546944P 2017-08-17 2017-08-17
US62/546,944 2017-08-17
PCT/US2018/046937 WO2019036641A1 (en) 2017-08-17 2018-08-17 HETEROCYCLIC INHIBITORS OF KINASE ATR

Publications (2)

Publication Number Publication Date
CN111886224A CN111886224A (zh) 2020-11-03
CN111886224B true CN111886224B (zh) 2024-07-23

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CN201880061041.8A Active CN111886224B (zh) 2017-08-17 2018-08-17 Atr激酶的杂环抑制剂

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US (1) US10800774B2 (https=)
EP (1) EP3668839B1 (https=)
JP (1) JP7290627B2 (https=)
CN (1) CN111886224B (https=)
WO (1) WO2019036641A1 (https=)

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Also Published As

Publication number Publication date
CN111886224A (zh) 2020-11-03
JP7290627B2 (ja) 2023-06-13
US10800774B2 (en) 2020-10-13
EP3668839A4 (en) 2021-03-31
WO2019036641A1 (en) 2019-02-21
US20190055240A1 (en) 2019-02-21
JP2020531447A (ja) 2020-11-05
EP3668839B1 (en) 2023-04-12
EP3668839A1 (en) 2020-06-24

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