CN111886224B - Atr激酶的杂环抑制剂 - Google Patents

Atr激酶的杂环抑制剂 Download PDF

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Publication number
CN111886224B
CN111886224B CN201880061041.8A CN201880061041A CN111886224B CN 111886224 B CN111886224 B CN 111886224B CN 201880061041 A CN201880061041 A CN 201880061041A CN 111886224 B CN111886224 B CN 111886224B
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alkyl
alkoxy
cycloalkyl
compound
membered heterocycloalkyl
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Chinese (zh)
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CN111886224A (zh
Inventor
M·E·迪弗朗西斯科
P·琼斯
C·L·卡罗尔
J·B·克劳斯
Z·康
M·G·约翰逊
S·莱夫利
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Smart Chemical Co
University of Texas System
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Smart Chemical Co
University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880061041.8A 2017-08-17 2018-08-17 Atr激酶的杂环抑制剂 Active CN111886224B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762546944P 2017-08-17 2017-08-17
US62/546,944 2017-08-17
PCT/US2018/046937 WO2019036641A1 (en) 2017-08-17 2018-08-17 HETEROCYCLIC INHIBITORS OF KINASE ATR

Publications (2)

Publication Number Publication Date
CN111886224A CN111886224A (zh) 2020-11-03
CN111886224B true CN111886224B (zh) 2024-07-23

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Country Status (5)

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US (1) US10800774B2 (enExample)
EP (1) EP3668839B1 (enExample)
JP (1) JP7290627B2 (enExample)
CN (1) CN111886224B (enExample)
WO (1) WO2019036641A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10421765B2 (en) 2017-05-26 2019-09-24 Board Of Regents, The University Of Texas System Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
US10377591B2 (en) 2017-07-07 2019-08-13 Zebra Technologies Corporation Input handling for media processing devices
EP3651768B1 (en) 2017-07-13 2023-12-20 Board of Regents, The University of Texas System Heterocyclic inhibitors of atr kinase
EP3668839B1 (en) 2017-08-17 2023-04-12 Board of Regents, The University of Texas System Heterocyclic inhibitors of atr kinase
CA3074719A1 (en) * 2017-09-08 2019-03-14 Bluevalley Pharmaceutical Llc Substituted pyrrolopyridines as atr inhibitors
US10894052B2 (en) 2018-03-16 2021-01-19 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of ATR kinase
EP3873905A4 (en) 2018-10-30 2022-08-17 Repare Therapeutics Inc. COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, METHODS FOR PREPARING COMPOUNDS AND THEIR USE AS KINASE ATR INHIBITORS
EP3967694A4 (en) * 2019-06-06 2022-12-07 Beijing Tide Pharmaceutical Co., Ltd. 2, 4, 6-TRI-SUBSTITUTED PYRIMIDINE COMPOUND AS ATR-KINASE INHIBITOR
PL4011881T3 (pl) * 2019-08-06 2025-04-07 Wuxi Biocity Biopharmaceutics Co., Ltd. Postacie krystaliczne inhibitora atr i ich zastosowanie
KR20230012586A (ko) * 2020-05-29 2023-01-26 썬전 링팡 바이오테크 컴퍼니 리미티드 플루오로 피롤로 피리딘계 화합물 및 이의 용도
JP7774621B2 (ja) * 2020-10-16 2025-11-21 シャンハイ ドーァ ノボ ファーマテック カンパニー，リミティド 三複素環誘導体、その医薬組成物及び使用
CN116178366B (zh) * 2021-11-26 2025-03-18 无锡瓴方生物医药科技有限公司 氟代吡啶并吡咯类化合物的晶型及其制备方法
WO2025181153A1 (en) 2024-03-01 2025-09-04 F. Hoffmann-La Roche Ag Use of atr inhibitors in combination with pi3k alpha inhibitors
WO2025217307A1 (en) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Methods for predicting response to a ras(on) inhibitor and combination therapies
WO2025229051A1 (en) 2024-05-03 2025-11-06 F. Hoffmann-La Roche Ag Use of atr inhibitors in combination with antiandrogen agent
WO2025233224A1 (en) 2024-05-09 2025-11-13 F. Hoffmann-La Roche Ag Use of atr inhibitors in combination with anti-pd(l)1 therapy
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101790525A (zh) * 2007-04-12 2010-07-28 霍夫曼-拉罗奇有限公司 药物化合物
CN102325764A (zh) * 2008-12-22 2012-01-18 阿斯利康(瑞典)有限公司 用于治疗癌症的嘧啶吲哚衍生物
CN103068391A (zh) * 2010-06-11 2013-04-24 阿斯利康(瑞典)有限公司 吗啉代嘧啶及其治疗用途

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE49570B1 (en) 1979-03-30 1985-10-30 Rhone Poulenc Ind 2-(pyrid-2-yl)tetrahydrothiophene derivatives
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
US20070244110A1 (en) * 2006-04-14 2007-10-18 Zenyaku Kogyo Kabushiki Kaisha Treatment of prostate cancer, melanoma or hepatic cancer
AU2007287428B2 (en) 2006-08-24 2011-08-11 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
WO2008032072A1 (en) * 2006-09-14 2008-03-20 Astrazeneca Ab 2-benzimidaz0lyl-6-m0rph0lin0-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
US20080292588A1 (en) 2007-05-17 2008-11-27 Anadys Pharmaceuticals, Inc. 1-methyl-benzo[1,2,4]thiadiazine 1-oxide derivatives
AU2008273892A1 (en) 2007-07-09 2009-01-15 Astrazeneca Ab Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
CA2692720A1 (en) 2007-07-09 2009-01-15 Astrazeneca Ab Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k
EA201000092A1 (ru) * 2007-07-09 2010-06-30 Астразенека Аб Тризамещенные пиримидиновые производные для лечения пролиферативных заболеваний
AU2009220605A1 (en) 2008-03-06 2009-09-11 Msd K.K. Alkylaminopyridine derivative
JP2011526931A (ja) 2008-07-03 2011-10-20 エグゼリクシス， インコーポレイテッド Ｃｄｋモジュレーター
TW201038567A (en) * 2009-03-27 2010-11-01 Pathway Therapeutics Ltd Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
JP2013032290A (ja) 2009-11-20 2013-02-14 Dainippon Sumitomo Pharma Co Ltd 新規縮合ピリミジン誘導体
WO2011103715A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Task channel antagonists
WO2011106276A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Task channel antagonists
US9249129B2 (en) 2010-03-04 2016-02-02 Cellzome Limited Morpholino substituted urea derivatives as mTOR inhibitors
UA112517C2 (uk) 2010-07-06 2016-09-26 Новартіс Аг Тетрагідропіридопіримідинові похідні
WO2012147890A1 (ja) * 2011-04-27 2012-11-01 持田製薬株式会社 新規アゾール誘導体
PL3808749T3 (pl) 2012-12-07 2023-07-10 Vertex Pharmaceuticals Incorporated Pirazolo[1,5-a]pirymidyny użyteczne jako inhibitory kinazy atr do leczenia chorób nowotworowych
PL3077397T3 (pl) 2013-12-06 2020-04-30 Vertex Pharmaceuticals Inc. Związek 2-amino-6-fluoro-n-[5-fluoro-pirydyn-3-ylo]pyrazolo [1,5-a]pirymidino-3-karboksamidu przydatny jako inhibitor kinazy atr, jego wytwarzanie, różne postacie stałe i ich radioznakowane pochodne
WO2015092592A1 (en) 2013-12-17 2015-06-25 Pfizer Inc. Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
SG10201902206QA (en) 2014-06-05 2019-04-29 Vertex Pharma Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof
TWI656121B (zh) 2014-08-04 2019-04-11 德商拜耳製藥公司 ２－（嗎啉－４－基）－１，７－萘啶
MX389198B (es) 2014-10-13 2025-03-20 Atrin Pharmaceuticals LLC Inhibidores de proteína-cinasas relacionados a ataxia-telengiectasia y rad3 (atr).
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
CN109153646B (zh) 2016-05-24 2022-08-02 葛兰素史克知识产权第二有限公司 作为溴结构域抑制剂的吡啶二甲酰胺衍生物
CA3026149A1 (en) * 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
US10421765B2 (en) 2017-05-26 2019-09-24 Board Of Regents, The University Of Texas System Tetrahydropyrido[4,3-d]pyrimidine inhibitors of ATR kinase
EP3651768B1 (en) 2017-07-13 2023-12-20 Board of Regents, The University of Texas System Heterocyclic inhibitors of atr kinase
EP3668839B1 (en) 2017-08-17 2023-04-12 Board of Regents, The University of Texas System Heterocyclic inhibitors of atr kinase
US10894052B2 (en) 2018-03-16 2021-01-19 Board Of Regents, The University Of Texas System Heterocyclic inhibitors of ATR kinase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101790525A (zh) * 2007-04-12 2010-07-28 霍夫曼-拉罗奇有限公司 药物化合物
CN102325764A (zh) * 2008-12-22 2012-01-18 阿斯利康(瑞典)有限公司 用于治疗癌症的嘧啶吲哚衍生物
CN103068391A (zh) * 2010-06-11 2013-04-24 阿斯利康(瑞典)有限公司 吗啉代嘧啶及其治疗用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RN1348114-89-5等;REGISTRY;《STN Columbus》 *

Also Published As

Publication number Publication date
WO2019036641A1 (en) 2019-02-21
CN111886224A (zh) 2020-11-03
US10800774B2 (en) 2020-10-13
EP3668839B1 (en) 2023-04-12
JP2020531447A (ja) 2020-11-05
US20190055240A1 (en) 2019-02-21
EP3668839A1 (en) 2020-06-24
EP3668839A4 (en) 2021-03-31
JP7290627B2 (ja) 2023-06-13

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