CN111886022A - 葎草花粉重组疫苗及其制备方法 - Google Patents

葎草花粉重组疫苗及其制备方法 Download PDF

Info

Publication number
CN111886022A
CN111886022A CN201980019111.8A CN201980019111A CN111886022A CN 111886022 A CN111886022 A CN 111886022A CN 201980019111 A CN201980019111 A CN 201980019111A CN 111886022 A CN111886022 A CN 111886022A
Authority
CN
China
Prior art keywords
recombinant
humulus
seq
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201980019111.8A
Other languages
English (en)
Other versions
CN111886022B (zh
Inventor
周俊雄
尹佳
李欣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Peking Union Medical College Hospital Chinese Academy of Medical Sciences
Original Assignee
Peking Union Medical College Hospital Chinese Academy of Medical Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peking Union Medical College Hospital Chinese Academy of Medical Sciences filed Critical Peking Union Medical College Hospital Chinese Academy of Medical Sciences
Publication of CN111886022A publication Critical patent/CN111886022A/zh
Application granted granted Critical
Publication of CN111886022B publication Critical patent/CN111886022B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

本发明涉及一种重组混合葎草花粉变应原疫苗及其制备方法，用于有效诊断由葎草花粉诱发的变态反应疾病并对其进行特异性免疫治疗。本发明重组疫苗涵盖了15种葎草花粉变应原蛋白，可以有效诊断由葎草花粉诱发的变态反应疾病并对其进行特异性免疫治疗。

Description

PCT国内申请，说明书已公开。

Claims (27)

  1. PCT国内申请，权利要求书已公开。
CN201980019111.8A 2018-03-22 2019-03-22 葎草花粉重组疫苗及其制备方法 Active CN111886022B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018102420072 2018-03-22
CN201810242007 2018-03-22
PCT/CN2019/079173 WO2019179510A1 (zh) 2018-03-22 2019-03-22 葎草花粉重组疫苗及其制备方法

Publications (2)

Publication Number Publication Date
CN111886022A true CN111886022A (zh) 2020-11-03
CN111886022B CN111886022B (zh) 2022-05-06

Family

ID=67986707

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980019111.8A Active CN111886022B (zh) 2018-03-22 2019-03-22 葎草花粉重组疫苗及其制备方法

Country Status (2)

Country Link
CN (1) CN111886022B (zh)
WO (1) WO2019179510A1 (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101392023A (zh) * 2007-09-21 2009-03-25 中国医学科学院北京协和医院 葎草花粉主要致敏蛋白
CN101392017A (zh) * 2007-09-21 2009-03-25 中国医学科学院北京协和医院 葎草花粉主要致敏蛋白的分离纯化方法
CN101993888A (zh) * 2009-08-25 2011-03-30 中国医学科学院北京协和医院 诱导分泌表达生产重组葎草主要致敏蛋白Hum j 3的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101318017B (zh) * 2007-06-05 2013-04-10 中国农业大学 一种预防和/或治疗过敏性哮喘的疫苗

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101392023A (zh) * 2007-09-21 2009-03-25 中国医学科学院北京协和医院 葎草花粉主要致敏蛋白
CN101392017A (zh) * 2007-09-21 2009-03-25 中国医学科学院北京协和医院 葎草花粉主要致敏蛋白的分离纯化方法
CN101993888A (zh) * 2009-08-25 2011-03-30 中国医学科学院北京协和医院 诱导分泌表达生产重组葎草主要致敏蛋白Hum j 3的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MAU SINHA等: "Current overview of allergens of plant pathogenesis related protein families", 《SCIENTIFIC WORLD JOURNAL》 *
刘昀等: "葎草花粉cDNA表达文库的构建和初步鉴定", 《西安交通大学学报(医学版)》 *
徐晶等: "从葎草花粉cDNA表达文库中筛选过敏性哮喘特异性变应原", 《中华医学杂志》 *

Also Published As

Publication number Publication date
WO2019179510A1 (zh) 2019-09-26
CN111886022B (zh) 2022-05-06

Similar Documents

Publication Publication Date Title
CN107686520A (zh) 抗pd‑l1纳米抗体及其应用
CN109939226B (zh) 一种大籽蒿花粉变应原浸提物、其浸液及其制备方法
CN108586618A (zh) 一种猪流行性腹泻亚单位疫苗的制备及应用
CN111840530B (zh) 一种柔嫩艾美耳球虫重组多肽疫苗vnqs的制备及其在抗鸡球虫病中的应用方法
CN116284339A (zh) 一种重组iii型胶原蛋白、核酸、表达载体、菌株及其应用
CN113122617B (zh) 一种筛选特异bcr/tcr的方法及其系统
CN111886022B (zh) 葎草花粉重组疫苗及其制备方法
CN110201188B (zh) 一种地肤花粉变应原浸提物、其浸提液及其制备方法
CN109939227A (zh) 一种豚草花粉变应原浸提物、其浸液及其制备方法
CN104945490B (zh) 分离的植物防御素多肽及其制备方法和在治疗肺癌中的用途
CN101928348A (zh) 一种人tshr胞外段融合蛋白及其制备方法
CN111840529B (zh) 一种柔嫩艾美耳球虫重组多肽疫苗vkvq的制备及其在抗鸡球虫病中的应用方法
WO1992020797A1 (en) Neurotrophic factor, preparation and uses thereof
CN114891779A (zh) 一种克隆tcr序列的检测方法及其应用
CN115029341A (zh) 一种快速克隆配对tcr序列检测方法及其应用
CN110064052B (zh) 一种英国梧桐花粉变应原浸提物、其浸液及其制备方法
CN104804090B (zh) 一种抗b细胞生长刺激因子的纳米抗体和用途
CN110124028A (zh) 一种葎草花粉变应原浸提物、浸液及其制备方法
CN102250239B (zh) 一种与兔出血症病毒vp60蛋白相结合的蛋白及其应用
CN108707589A (zh) 一种牛病毒性腹泻病毒SMU-Z6/1a/SC/2016分离株及其应用
Hakkaart et al. Lack of lysozyme activity of natural and yeast-derived recombinant Der p 2
CN110078803B (zh) 一种洋白蜡花粉变应原浸提物、其浸液及其制备方法
CN110064051B (zh) 一种白桦花粉变应原浸提物、其浸液及其制备方法
CN107119072A (zh) 一种过表达zeb2基因质粒及其构建方法和应用
CN108004214A (zh) Homer2单克隆抗体及其应用

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant