CN111871912A

CN111871912A - Automatic plasma bag cleaning and breaking system and cleaning method

Info

Publication number: CN111871912A
Application number: CN202010606969.9A
Authority: CN
Inventors: 李佐; 李斌; 郑志华; 师秀梅; 孙丰斌
Original assignee: Shandong Taibang Biological Products Co ltd
Current assignee: Shandong Taibang Biological Products Co ltd
Priority date: 2020-06-30
Filing date: 2020-06-30
Publication date: 2020-11-03
Anticipated expiration: 2040-06-30
Also published as: CN111871912B

Abstract

The invention provides an automatic plasma bag cleaning and bag breaking system and a cleaning method, comprising the following steps: the plasma bag cleaning subsystem, the conveying mechanism and the bag feeding and breaking subsystem; the plasma bag cleaning subsystem is used for cleaning the outside of the plasma bag, and after the plasma bag is cleaned, the cleaned plasma bag is transmitted to the bag feeding and breaking subsystem through the conveying mechanism; go up bag broken bag subsystem includes: a bag feeding machine and a bag breaking machine; the bag feeding machine is used for conveying the plasma bag to the bag breaking machine; the plasma bag cleaning and disinfecting, arranging, sorting and automatic loading functions are realized, the bag breaking machine realizes the bag breaking, plasma pouring, liquid collecting and conveying of the plasma bag and the collecting function of a waste bag, the whole process is automatically completed, excessive human intervention is not needed, the problem that the equipment and the pipeline are self-polluted and then cleaned is solved, alkaline washing liquid and cleaning liquid can be recycled, the plasma bag cleaning degree can be reasonably utilized, and waste water is avoided.

Description

Automatic plasma bag cleaning and breaking system and cleaning method

Technical Field

The invention relates to the field of pharmaceutical equipment, in particular to an automatic plasma bag cleaning and bag breaking system and a cleaning method.

Background

The raw materials for producing the blood products are frozen plasma (the plasma is bagged and 600 g/bag) stored at the temperature of minus 20 ℃, and the processes of storing, transferring, selecting and the like of the plasma are all carried out in a common environment and are easily polluted by the external environment, so the outer surface of the plasma bag needs to be disinfected and cleaned by ethanol before feeding, the microorganisms and pyrogens on the outer surface of the plasma bag are removed, then the plasma bag is broken, the plasma in the bag is melted in a plasma melting tank, and the plasma is transferred to the subsequent product production. The cleaning and disinfection of the outer surface of the plasma bag are key steps for producing blood products, and the quality of subsequent products is influenced. At present, most blood product enterprises in China manually transfer frozen plasma into a plasma melting chamber and put the plasma into a pre-washing tank. Plasma bag is washed through the injection water in advance, gets rid of surface ice sediment, then takes out, and flat on the conveyer belt of plasma cleaning machine, according to the speed that sets up in proper order through spraying rough cleaning, disinfection (75% ethanol), fine purifiation, compress air and blow clean the back and transmit to melt the plasma room and break the bag, the cleaning process uses a large amount of injection water, and the self of equipment is clean manual, is difficult to guarantee clean effect.

In the prior art, a cleaning and disinfecting machine of a plasma bag automatic cleaning, disinfecting and bag breaking device is provided, so that manual operation is avoided, but the plasma bag cleaning machine adopts newly prepared injection water as cleaning water, and the cleaning water is not reasonably utilized according to the cleaning degree of a plasma bag, so that the injection water is wasted;

moreover, the possibility of bag breaking of the plasma bag exists in the use process, so that the plasma pollutes the equipment, and the problem of cleaning the equipment and the pipeline after self pollution is not completely solved.

Disclosure of Invention

In order to overcome the above-mentioned deficiencies in the prior art, the present invention provides an automatic plasma bag cleaning and bag breaking system, comprising: the plasma bag cleaning subsystem, the conveying mechanism and the bag feeding and breaking subsystem;

the plasma bag cleaning subsystem is used for cleaning the outside of the plasma bag, and after the plasma bag is cleaned, the cleaned plasma bag is transmitted to the bag feeding and breaking subsystem through the conveying mechanism;

go up bag broken bag subsystem includes: a bag feeding machine and a bag breaking machine;

the bag feeding machine is used for conveying the plasma bag to the bag breaking machine;

the bag breaking machine includes: a turntable mechanism;

a bag receiving station, a bag cutting station, an ice falling station, a liquid dropping station, a bag discharging station and a resetting station are uniformly distributed on the periphery of the turntable mechanism;

the bag receiving station is used for receiving the plasma bag which is grabbed and transmitted by the bag loading robot, after the plasma bag is in place, the bag clamp of the bag receiving station clamps the bag shoulder of the plasma bag for positioning, and the positioned bag clamp moves to a subsequent station along with the plasma bag;

the bag cutting station receives the plasma bags conveyed by the bag receiving station, and gradually moves the bag tail upwards to present an upwards inclined state of the bag tail; after the bag is in place, clamping the bag tail by a clamp of the bag cutting station, extruding the ice blocks in the bag backwards by a bag pressing device of the bag cutting station, cutting the bag tail by a cutter of the bag cutting station, and throwing the waste at the bag tail into a waste receiving box by the clamp;

the ice falling station is used for controlling the bag clamp to rotate, so that the bag tail is downward in a vertical state, and ice blocks and liquid in the bag fall into a liquid collecting tank below;

the liquid dropping station is used for collecting residual liquid in the bag after ice blocks in the bag fall out and enabling the collected liquid to flow into the slurry melting tank;

a bag discharging manipulator is arranged at the bag discharging station, the bag discharging manipulator takes down the blood plasma bag, and the waste bag is thrown into the waste collecting box;

the reset station is used for changing the bag clamp of the plasma bag from vertical to horizontal, transmitting the plasma bag to the next procedure and receiving the next batch of plasma bags.

It is further noted that the turntable mechanism is provided with at least four bag receiving stations;

each bag receiving station is provided with a receiving in-place detection sensor for detecting a signal that the robot grabs and transmits the plasma bag in place, a clamp in-place sensor for detecting a signal that the clamp clamps the plasma bag in place, and a positioning sensor for detecting a positioning signal of the plasma bag.

The bag feeding machine is provided with a bag feeding receiving station, a bag feeding pushing device and a bag feeding horizontal conveying belt;

the conveying mechanism is provided with a vertical conveying mechanism which is vertical to the horizontal conveying belt of the upper bag;

the output end of the vertical transmission mechanism is connected with the bag feeding receiving station;

the position of the bag feeding receiving station is respectively matched with the input end of the bag feeding pushing device and the bag feeding horizontal conveying belt, and after the bag feeding receiving station receives the plasma bag, the bag feeding pushing device pushes the plasma bag to the bag feeding horizontal conveying belt;

and the bag feeding machine robot is arranged at the output end of the upper bag horizontal conveying belt.

The bag feeding robot grabs the plasma bag into a bag receiving station of the bag breaking machine through the sucking disc.

It should be further noted that the conveying mechanism is also provided with a transverse transmission mechanism connected with the vertical transmission mechanism, a climbing mechanism connected with the transverse transmission mechanism, and a turning mechanism connected with the climbing mechanism;

the input end of the turning mechanism is connected with the plasma bag cleaning subsystem.

It is further noted that the plasma bag cleaning subsystem comprises: the pre-melting bin, the rough washing bin, the disinfection bin and the fine washing bin are connected in sequence;

the output end of the fine washing bin conveys the cleaned plasma bags to the conveying mechanism.

It is further noted that the plasma bag cleaning subsystem further comprises: an alkali tank and a water tank;

the alkali tank and the water tank are respectively connected with the fine washing bin through liquid supply pipelines; a liquid supply valve is arranged on the liquid supply pipeline;

and a liquid supply pump and a control valve are respectively arranged on connecting pipelines among the fine washing bin, the disinfection bin, the coarse washing bin and the pre-melting bin.

It is further noted that the pre-melting bin is connected with the alkali tank through a liquid return pipeline, and a liquid return conductivity meter is arranged on the liquid return pipeline;

an ethanol concentration detector is arranged inside the disinfection bin;

electric heating pipes are respectively arranged inside the pre-melting bin and the rough washing bin;

the liquid supply pipeline is also provided with a diaphragm valve;

the pre-melting bin, the coarse washing bin, the disinfection bin, the fine washing bin, the alkali tank and the water tank are respectively connected with a liquid discharge pipe.

The invention also provides an automatic plasma bag cleaning and breaking method, which comprises the following steps:

adding alkali liquor into the alkali liquor tank, opening a liquid supply pump A, cleaning the fine washing bin by the alkali liquor through a liquid supply pipeline, and conveying the alkali liquor to the disinfection bin for alkali liquor cleaning through a liquid supply pump E after the alkali liquor stays in the fine washing bin for a preset time;

then, cleaning the rough washing bin with alkali liquor by a liquor supply pump D;

cleaning the pre-melting bin with alkali liquor by a liquor supply pump C;

recycling the alkali liquor to the alkali tank through a liquor supply pump B;

purified water is added into the water tank, the liquid supply pump A is opened, the fine washing bin is cleaned by the purified water through the liquid supply pipeline, the purified water is cleaned by the purified water supply pump E after the purified water stays in the fine washing bin for a preset time, and the coarse washing bin and the pre-melting bin are cleaned by the liquid supply pump D and the liquid supply pump C in the same way;

discharging the wastewater through a liquid supply pump B until the liquid return conductivity meter is less than 5 us/cm; the cleaning of the four bin bodies, the pipeline and the pump is completed.

If purified water exists in the water tank, emptying;

adding injection water into the water tank, opening the liquid supply pump A, cleaning the fine washing bin with the injection water through the liquid supply pipeline, wherein the injection water can exist in the fine washing bin, cleaning the disinfection bin with the injection water through the liquid supply pump E, cleaning the rough washing bin and the pre-melting bin with the injection water through the liquid supply pump D and the liquid supply pump C in the same way, and discharging wastewater through the liquid supply pump B until the conductivity of the liquid return conductivity meter is less than 1.3 us/cm;

according to the liquid levels of the injection water in the pre-melting bin, the rough washing bin, the disinfection bin and the fine washing bin, stopping the liquid supply pump B, the liquid supply pump C, the liquid supply pump D, the liquid supply pump E and the liquid supply pump A in sequence; the water level of each bin is at a preset working height;

cleaning and disinfecting the plasma bag;

opening an ethanol diaphragm valve of the disinfection bin, filling 95% ethanol into the disinfection bin, starting a self-circulation mode of the disinfection bin by a liquid supply pump D to uniformly mix the injection water and the ethanol, and closing the ethanol diaphragm valve when the concentration of the ethanol reaches 75%;

an ethanol concentration detector is arranged in the disinfection bin, when the ethanol concentration in the disinfection bin is lower than a preset value, an ethanol diaphragm valve is opened, and 95% ethanol is added to increase the concentration to 75%;

after 75% ethanol is prepared, the plasma bag can be cleaned on line, a leaching device, a liquid supply pump B, a liquid supply pump C, a liquid supply pump D, a liquid supply pump E and a compressed gas blowing device in the disinfection bin work, an electric heating pipe works, and water in the pre-melting bin is heated to about 30 ℃;

the plasma bag is pre-melted through the pre-melting bin to melt the frozen plasma in the plasma bag, then is roughly washed through the rough washing bin, enters the disinfection bin to be disinfected, and finally is finely washed by injection water and dried by compressed air in the fine washing bin.

After the plasma bag is cleaned and disinfected, conveying the plasma bag to a conveying mechanism;

the plasma bag is conveyed into the climbing machine by the turning machine; eight plasma bags are arranged in a row, the height of the eight plasma bags is lifted by a climbing machine, the eight plasma bags enter a plasma melting chamber, and the eight plasma bags are transferred to a transverse conveying mechanism;

the transverse transmission mechanism conveys the plasma bag to the vertical transmission mechanism;

the plasma bags are separated by a preset distance;

the vertical transmission mechanism conveys a single plasma bag into the bag feeding machine;

the bag feeding machine arranges the single conveyed plasma bags according to the preset distance and position, and conveys the four bags into a group to a bag receiving station of the bag breaking machine after grouping;

the rotary table mechanism of the bag breaking machine is provided with 8 stations, and the difference of each station is 45 degrees;

the turntable mechanism rotates for 45 degrees every time a preset time length passes;

each station is provided with 4 working heads;

the bag receiving station receives the plasma bags grabbed and transmitted by the bag loading robot, after the plasma bags are in place, the bag clamp of the bag receiving station clamps the bag shoulders of the plasma bags for positioning, and the positioned bag clamp moves to a subsequent station along with the plasma bags;

the ice falling station controls the bag clamp to rotate, so that the tail of the bag is downward in a vertical state, and ice blocks and liquid in the bag fall into a liquid collecting tank below the bag;

the liquid dropping station collects the residual liquid in the bag after the ice blocks in the bag fall out, and the collected liquid flows into the slurry melting tank;

the bag discharging manipulator takes down the plasma bag, and the waste bag is thrown into the waste collecting box;

the reset station changes the bag clamp of the plasma bag from vertical to horizontal, transmits the plasma bag to the next procedure, and receives the next batch of plasma bags.

According to the technical scheme, the invention has the following advantages:

the automatic plasma bag cleaning and bag breaking system and the cleaning method realize the functions of cleaning, disinfecting, sorting, sequencing and automatic loading of plasma bags, the bag breaking machine realizes the functions of breaking the plasma bags, pouring plasma, collecting and conveying liquid and collecting waste bags, the whole process is automatically completed without excessive human intervention, the problem of cleaning after self pollution of equipment and pipelines is solved, alkaline washing liquid and cleaning liquid can be recycled, the alkaline washing liquid and the cleaning liquid can be reasonably utilized according to the cleaning degree of the plasma bags, and the waste of water is avoided.

Drawings

In order to more clearly illustrate the technical solution of the present invention, the drawings used in the description will be briefly introduced, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained based on these drawings without creative efforts.

FIG. 1 is a schematic diagram of an automated plasma bag cleaning and bag breaking system;

FIG. 2 is a schematic diagram of a bag feeding and breaking subsystem;

FIG. 3 is a schematic diagram of a plasma bag cleaning subsystem.

Detailed Description

The present invention provides an automatic plasma bag cleaning and bag breaking system, as shown in fig. 1 to 3, comprising: a plasma bag cleaning subsystem, a conveying mechanism 12 and a bag feeding and breaking subsystem;

go up bag broken bag subsystem includes: a bag feeding machine 13 and a bag breaking machine 11; the bag feeding machine 13 is used for conveying plasma bags to the bag breaking machine 11;

the bag breaker 11 includes: a turntable mechanism 28; a bag receiving station 21, a bag cutting station 22, an ice falling station 23, a liquid dropping station 24, a bag discharging station 25 and a reset station 26 are uniformly distributed on the periphery of the turntable mechanism 28;

the bag receiving station 21 is used for receiving the plasma bags grabbed and transmitted by the bag loading robot, after the plasma bags are in place, the bag clamp of the bag receiving station clamps the bag shoulders of the plasma bags for positioning, and the positioned bag clamp moves to a subsequent station along with the plasma bags;

the bag cutting station 22 receives the plasma bags conveyed by the bag receiving station, gradually moves the bag tail upwards, and shows an upward inclined state of the bag tail; after the bag is in place, clamping the bag tail by a clamp of the bag cutting station, extruding the ice blocks in the bag backwards by a bag pressing device of the bag cutting station, cutting the bag tail by a cutter of the bag cutting station, and throwing the waste at the bag tail into a waste receiving box by the clamp;

the ice falling station 23 is used for controlling the bag clamp to rotate, so that the bag tail is downward in a vertical state, and ice blocks and liquid in the bag fall into a liquid collecting tank below;

the dripping station 24 is used for collecting the residual liquid in the bag after the ice blocks in the bag fall out and leading the collected liquid to flow into the slurry melting tank 27;

the bag discharging station 25 is provided with a bag discharging manipulator, the bag discharging manipulator takes down the blood plasma bag, and the waste bag is thrown into the waste collecting box;

the reset station 26 is used to change the bag clamp of the plasma bag from vertical to horizontal and transfer the plasma bag to the next process and receive the next batch of plasma bags.

The plasma bag cleaning subsystem, the conveying mechanism and the bag feeding and breaking subsystem are adopted, the conveying mechanism achieves the functions of butt joint and transmission of the bag feeding and breaking subsystem and the plasma bag cleaning subsystem, the bag feeding and breaking subsystem achieves the functions of sorting, sequencing and automatic loading of plasma bags, and the bag breaking machine achieves the functions of bag breaking, plasma pouring, liquid collecting and conveying of the plasma bags and waste bag collecting.

The plasma bag cleaning system may include: the plasma bag cleaning and sterilizing device comprises an alkali tank, a water tank for injection, an alcohol tank, a primary recovery water tank, a secondary recovery water tank, a pump, a pipeline, a conveying belt, a spraying device and a compressed air blowing device, and the purpose of controlling the microbial pyrogen on the outer surface of the plasma bag is achieved by cleaning, sterilizing and blow-drying the plasma bag through the conveying belt.

It will be understood that when an element or layer is referred to as being "on," connected to, "or" coupled to "another element or layer, it can be directly on, connected or coupled to the other element or layer, and intervening elements or layers may also be present. In contrast, when an element is referred to as being "directly on," "directly connected to" or "directly coupled to" another element or layer, there are no intervening elements or layers present. Like numbers refer to like elements throughout. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

Spatially relative terms such as "under …", "below", "lower", "above", "over", and the like, as may be used herein for ease of description, describe one element or feature's relationship to another element or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" the other elements or features. Thus, the exemplary term "below" can encompass both an orientation of above and below. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative terms used herein should be interpreted accordingly.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the description in this document. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.

In the invention, the turntable mechanism is provided with at least four bag receiving stations; each bag receiving station is provided with a receiving in-place detection sensor for detecting a signal that the robot grabs and transmits the plasma bag in place, a clamp in-place sensor for detecting a signal that the clamp clamps the plasma bag in place, and a positioning sensor for detecting a positioning signal of the plasma bag.

As an embodiment of the invention, the bag feeding machine is provided with a bag feeding receiving station, a bag feeding pushing device 16 and a bag feeding horizontal conveying belt 17; the conveying mechanism is provided with a vertical conveying mechanism 34 which is vertical to the horizontal conveying belt of the upper bag; the output end of the vertical transmission mechanism 34 is connected with the bag feeding receiving station;

the position of the bag feeding receiving station is respectively matched with the input end of the bag feeding pushing device and the bag feeding horizontal conveying belt, and after the bag feeding receiving station receives the plasma bag, the bag feeding pushing device pushes the plasma bag to the bag feeding horizontal conveying belt; and the bag feeding machine robot is arranged at the output end of the upper bag horizontal conveying belt.

The conveying mechanism 12 is also provided with a transverse transmission mechanism 33 connected with a vertical transmission mechanism 34, a climbing mechanism 32 connected with the transverse transmission mechanism 33, and a turning mechanism 31 connected with the climbing mechanism 32;

the input end of the turning mechanism 31 is connected with the plasma bag cleaning subsystem.

As an embodiment of the present invention, a plasma bag cleaning subsystem includes: the pre-melting bin, the rough washing bin, the disinfection bin and the fine washing bin are connected in sequence; the output end of the fine washing bin conveys the cleaned plasma bags to the conveying mechanism.

As an embodiment of the present invention, the plasma bag cleaning subsystem further comprises: an alkali tank and a water tank; the alkali tank and the water tank are respectively connected with the fine washing bin through liquid supply pipelines; a liquid supply valve is arranged on the liquid supply pipeline; and a liquid supply pump and a control valve are respectively arranged on connecting pipelines among the fine washing bin, the disinfection bin, the coarse washing bin and the pre-melting bin.

The pre-melting bin is connected with an alkali tank through a liquid return pipeline, and a liquid return conductivity meter is arranged on the liquid return pipeline; an ethanol concentration detector is arranged inside the disinfection bin; electric heating pipes are respectively arranged inside the pre-melting bin and the rough washing bin; the liquid supply pipeline is also provided with a diaphragm valve; the pre-melting bin, the coarse washing bin, the disinfection bin, the fine washing bin, the alkali tank and the water tank are respectively connected with a liquid discharge pipe.

Based on the system, the invention also provides an automatic plasma bag cleaning and bag breaking method, which comprises the following steps:

and coating alkali liquor on the bin body and the pipeline of the system, wherein the step is carried out before the equipment is used for the first time or after the equipment A is used and purified water is cleaned.

Adding alkali liquor into the alkali liquor tank 201, opening the liquid supply pump A203, cleaning the alkali liquor in the fine cleaning bin 04 through a pipeline, enabling the alkali liquor to exist in the fine cleaning bin 04, cleaning the alkali liquor in the disinfection bin 03 through the liquid supply pump E207, respectively cleaning the alkali liquor in the rough cleaning bin 02 and the pre-melting bin 01 through the liquid supply pump D206 and the liquid supply pump C205 in the same manner, and finally recovering the alkali liquor into the alkali liquor tank 201 through the liquid supply pump B204; the step completes the cleaning of the pipeline and the pump of the equipment A while completing the cleaning of the four bin bodies.

The step of cleaning the purified water is carried out before the first use of the equipment or after the end of the use of the equipment A

Purified water is added into the water tank 202, the liquid supply pump A203 is opened, the fine cleaning bin 04 is cleaned by purified water through a CIP pipeline, the purified water can be stored in the fine cleaning bin 04, then the disinfection bin 03 is cleaned by purified water through the liquid supply pump E207, the coarse cleaning bin 02 and the pre-melting bin 01 are cleaned by purified water through the liquid supply pump D206 and the liquid supply pump C205 in the same mode, and finally, waste water is discharged through the liquid supply pump B204 until the liquid return conductivity meter 208 is smaller than 5 us/cm; the step completes the cleaning of the pipeline and the pump of the equipment A while completing the cleaning of the four bin bodies.

Water for injection, this step being carried out before use of the device a.

The water tank 202 is emptied first if there is purified water. The injection water is added into the water tank 202, the liquid supply pump A203 is opened, the fine cleaning bin 04 is cleaned by the injection water through a pipeline, the injection water can exist in the fine cleaning bin 04, then the disinfection bin 03 is cleaned by the injection water through the liquid supply pump E207, the coarse cleaning bin 02 and the pre-melting bin 01 are cleaned by the injection water through the liquid supply pump D206 and the liquid supply pump C205 in the same mode, finally, the waste water is discharged through the liquid supply pump B204 until the conductivity of the liquid return conductivity meter 208 is less than 1.3us/cm, and then the liquid supply pump B204, the liquid supply pump C205, the liquid supply pump D206, the liquid supply pump E207 and the liquid supply pump A203 are sequentially stopped according to the injection water liquid levels in the four bins. The step completes the cleaning of the pipelines and the pump of the equipment A while completing the cleaning of the four bin bodies, and simultaneously the water level of each bin is at a working level.

Self-cleaning of device B: after the system is used, alkali liquor is coated on the water tank 202 from the alkali tank 201 through the liquid supply pump 203 and the diaphragm valve 301, so that the microbial pollution of the water tank is prevented.

The plasma bag cleaning and disinfecting process:

and an ethanol diaphragm valve 302 of the disinfection bin 03 is opened, 95% ethanol is filled into the disinfection bin, the liquid supply pump D206 starts a self-circulation mode of the disinfection bin, the injection water and the ethanol are mixed uniformly, and the ethanol diaphragm valve is closed when the concentration of the ethanol reaches 75%. When the concentration of the ethanol in the bin is reduced, an ethanol diaphragm valve 302 is opened, and 95% ethanol is added to improve the concentration to 75%.

After 75% ethanol is prepared, the plasma bag can be cleaned on line, all the leaching devices, the liquid supply pump B204, the liquid supply pump C205, the liquid supply pump D206, the liquid supply pump E207 and the compressed gas blowing device work, the electric heating pipe 209 works, the water in the pre-melting bin is heated to about 30 ℃, and the water in the pre-melting bin can be heated to a certain temperature before the plasma bag is arranged.

The plasma bag is pre-melted through the pre-melting bin to slightly melt frozen plasma in the plasma bag, then is roughly washed through the rough washing bin, enters the disinfection bin for disinfection, and finally is finely washed by injection water and dried by compressed air in the fine washing bin.

The whole process only uses the injection water from the 201 tank in the fine washing bin.

Through actual use and calculation, before the equipment A is used, the water in the four bins can reach the standard of the injection water, the using amount of the injection water of the equipment is about 1 ton/ton of blood plasma, the injection water is saved by more than 50 percent, the microorganism on the outer surface of the blood plasma bag is less than 1 CFU/contact vessel after cleaning and disinfection, and the pyrogen of the residual water on the outer surface of the blood plasma bag meets the standard of the injection water. The plasma microbial level after bag breaking is less than 10 CFU/ml.

The washed plasma bags may be transported to the upper bag breaking system by a robot, or a conveyor belt, or a gripper arm.

In the method, the plasma bag cleaning subsystem and the bag feeding and breaking subsystem can be mutually isolated spaces and serve as a transmission medium through a conveying mechanism.

Conveying the plasma bag to an upper bag machine:

the transverse transmission mechanism conveys the plasma bag to the vertical transmission mechanism; the plasma bags are separated by a preset distance; the vertical transmission mechanism conveys a single plasma bag into the bag feeding machine;

sorting/bagging by a bagging machine:

the bag feeding machine arranges the single conveyed plasma bags according to the designated distance and position, and conveys the bags 4 in a group to the bag receiving station of the bag breaking machine after grouping.

The bag adjusting function of the bag feeding machine is realized by 16 bag receiving boxes on two sets of synchronous belts and two sets of independently driven servo systems. The bag receiving boxes are 8 in one group, and the bag receiving function and the bag sending function are alternately realized.

The bag feeding function can be configured on the basis of XY axes corresponding to the receiving station of the bag breaking machine, the horizontal conveying belt for feeding bags can be used as the X axis, and the vertical conveying mechanism can be used as the Y axis.

After the bags are received in place, the XY axes grab the bags 4 in a group into a bag receiving station of the bag breaking machine through the suction cups.

Breaking the bag of the bag breaking machine:

the whole structure of the bag breaking machine is a rotating disc type, 8 stations are arranged in total, each station rotates 45 degrees in a circulating mode, and the operation period is 5 seconds; each station has 4 heads. All parts of the bag breaking machine, which are in contact with the bag and the blood plasma, are made of 316L stainless steel and other GMP (good manufacturing practice) allowed materials, and all friction parts and moving parts adopt an oil-free or self-lubricating mode, so that foreign matters are prevented from falling into liquid.

The functions of 8 stations are as follows:

a bag receiving station: the bag is grabbed by the receiving robot, and the bag shoulder is clamped by the bag clamp for positioning after the bag is in place, so that the bag is prevented from falling off after being in a vertical state.

A bag cutting station: and in the process that the bag is received and moves to the bag cutting station, the bag tail gradually moves upwards to present an upward inclined state of the bag tail. After the bag is in place, the bag tail is clamped by the clamp of the bag cutting station, the ice blocks in the bag are pushed backwards by the bag pressing device, the bag tails of 4 bags are cut off by the cutter, and the bag tail waste materials are thrown into the waste receiving box by the clamp.

An ice falling station: after the bag tail is opened, the bag tail gradually falls down in the process of moving to the ice falling station, the bag becomes a vertical state with the bag tail downward, and ice cubes and liquid in the bag fall into a liquid collecting tank below. An opening for conveying the two slurry melting tanks is reserved at the lowest point of the liquid collecting tank, a guide plate is arranged at the branching position, and the position of the guide plate is changed once every cycle, so that ice blocks uniformly flow into the two slurry melting tanks.

Three dropping liquid stations: after the ice blocks in the bag fall out, the liquid remained in the bag continuously drops at the three stations and flows into the slurry melting tank through the collecting tank. The dropping time was 3 cycle times, about 15 seconds; in order to make the dripping more thorough, auxiliary devices such as a bag squeezing device, a bag shaking device and the like can be arranged at the three stations.

Bag discharging station: the empty bag is taken down by a manipulator, and the waste bag is thrown into a waste collecting box.

Resetting the station: the bag gripper is changed from vertical to horizontal and ready to receive bags for the next major cycle.

Like this, realized plasma bag cleaning and disinfecting, arrangement, sequencing and automatic operation function, the bag-breaking machine realizes that broken bag, plasma of plasma bag pour, liquid are collected and are carried and the collection function of useless bag, and whole automatic the completion does not need too much human intervention, solves equipment and pipeline self and pollutes the clean problem in back, and alkaline wash and washing liquid all can be retrieved and recycle, can avoid extravagant water according to plasma bag's clean degree rational utilization.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An automatic plasma bag cleaning and bag breaking system, comprising: the plasma bag cleaning subsystem, the conveying mechanism and the bag feeding and breaking subsystem;

the bag breaking machine includes: a turntable mechanism;

2. The automated plasma bag cleaning and bag breaking system of claim 1,

the turntable mechanism is provided with at least four bag receiving stations;

3. The automated plasma bag cleaning and bag breaking system of claim 1,

4. The automated plasma bag cleaning and bag breaking system of claim 3,

5. The automated plasma bag cleaning and bag breaking system of claim 1,

the conveying mechanism is also provided with a transverse conveying mechanism connected with the vertical conveying mechanism, a climbing mechanism connected with the transverse conveying mechanism and a turning mechanism connected with the climbing mechanism;

6. The automated plasma bag cleaning and bag breaking system of claim 1,

the plasma bag cleaning subsystem includes: the pre-melting bin, the rough washing bin, the disinfection bin and the fine washing bin are connected in sequence;

7. The automated plasma bag cleaning and bag breaking system of claim 6,

the plasma bag cleaning subsystem further comprises: an alkali tank and a water tank;

8. The automated plasma bag cleaning and bag breaking system of claim 6,

the pre-melting bin is connected with an alkali tank through a liquid return pipeline, and a liquid return conductivity meter is arranged on the liquid return pipeline;

an ethanol concentration detector is arranged inside the disinfection bin;

the liquid supply pipeline is also provided with a diaphragm valve;

9. An automatic plasma bag cleaning and bag breaking method, characterized in that the method comprises:

adding alkali liquor into the alkali liquor tank (201), opening a liquid supply pump A (203), cleaning the fine washing bin (04) by the alkali liquor through a liquid supply pipeline, and conveying the alkali liquor to the disinfection bin (03) for alkali liquor cleaning through a liquid supply pump E (207) after the alkali liquor stays in the fine washing bin (04) for a preset time;

then, cleaning the coarse washing bin (02) by alkali liquor through a liquor supply pump D (206);

cleaning the pre-melting bin (01) with alkali liquor by a liquid supply pump C (205);

recycling the alkali liquor to the alkali tank (201) through a liquid supply pump B (204);

purified water is added into the water tank (202), the liquid supply pump A (203) is opened, the purified water is cleaned in the fine washing bin (04) through the liquid supply pipeline, the purified water is cleaned in the disinfection bin (03) through the liquid supply pump E (207) after the purified water stays in the fine washing bin (04) for a preset time, and the coarse washing bin (02) and the pre-melting bin (01) are cleaned in the same way through the liquid supply pump D (206) and the liquid supply pump C (205);

discharging the wastewater through a liquid supply pump B (204) until a liquid return conductivity meter (208) is less than 5 us/cm; cleaning the four bin bodies, the pipelines and the pump;

purified water exists in the water tank (202) and is emptied;

adding injection water into a water tank (202), opening a liquid supply pump A (203), cleaning the fine washing bin (04) by the aid of the liquid supply pipeline, enabling the injection water to exist in the fine washing bin (04), cleaning the disinfection bin (03) by the aid of a liquid supply pump E (207), cleaning the rough washing bin (02) and the pre-melting bin (01) by the aid of a liquid supply pump D (206) and a liquid supply pump C (205) in the same manner, and discharging waste water by the aid of a liquid supply pump B (204) until conductivity of a liquid return conductivity meter (208) is smaller than 1.3 us/cm;

according to the injection water liquid levels in the pre-melting bin, the rough washing bin, the disinfection bin and the fine washing bin, sequentially stopping a liquid supply pump B (204), a liquid supply pump C (205), a liquid supply pump D (206), a liquid supply pump E (207) and a liquid supply pump A (203); the water level of each bin is at a preset working height;

cleaning and disinfecting the plasma bag;

an ethanol diaphragm valve (302) of the disinfection bin (03) is opened, 95% ethanol is filled into the disinfection bin, a liquid supply pump D (206) starts a self-circulation mode of the disinfection bin to uniformly mix the injection water and the ethanol, and the ethanol diaphragm valve is closed when the concentration of the ethanol reaches 75%;

an ethanol concentration detector (210) is arranged in the disinfection bin (03), when the ethanol concentration in the disinfection bin (03) is lower than a preset value, an ethanol diaphragm valve (302) is opened, and 95% ethanol is added to increase the concentration to 75%;

after 75% ethanol is prepared, the plasma bag can be cleaned on line, a leaching device, a liquid supply pump B (204), a liquid supply pump C (205), a liquid supply pump D (206), a liquid supply pump E (207) and a compressed gas blowing device in the disinfection bin (03) work, an electric heating pipe (209) works, and water in the pre-melting bin is heated to about 30 ℃;

10. The automated plasma bag cleaning and bag breaking method of claim 9, further comprising:

the plasma bags are separated by a preset distance;

each station is provided with 4 working heads;