CN111821365A

CN111821365A - Composition for treating apoplexy sequela and preparation method thereof

Info

Publication number: CN111821365A
Application number: CN201910324024.5A
Authority: CN
Inventors: 英成楼
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-04-22
Filing date: 2019-04-22
Publication date: 2020-10-27

Abstract

The invention relates to a composition for treating sequela of apoplexy and a preparation method thereof, wherein the composition for treating sequela of apoplexy comprises the following raw material components: 360 parts of Chinese urine 280-containing materials, 350 parts of giant knotweed rhizome 250-containing materials, 250 parts of trumpet creeper 150-containing materials, 200 parts of pawpaw 100-containing materials, 80-160 parts of pubescent angelica root, 250 parts of snakegourd fruit 150-containing materials, 70-140 parts of rhizoma arisaematis, 50-70 parts of rhizoma typhonii, 600 parts of alum 400-containing materials, 280 parts of fish glue 220-containing materials and 700 parts of vinegar 500-containing materials. The composition for treating the stroke sequela, disclosed by the invention, has the effects of warming and activating meridian, regulating qi and activating blood circulation, and dispelling wind and reducing phlegm, has a good curative effect on the stroke sequela, and is high in cure rate, low in cost and free of toxic and side effects, and various medicines interact with each other to take effect synergistically.

Description

Composition for treating apoplexy sequela and preparation method thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for treating apoplexy sequelae and a preparation method thereof.

Background

Stroke is a disease with cerebral ischemia and hemorrhagic injury symptoms as main clinical manifestations, also called stroke or cerebrovascular accident, with extremely high fatality rate and disability rate, and mainly divided into hemorrhagic stroke (cerebral hemorrhage or subarachnoid hemorrhage) and ischemic stroke (cerebral infarction and cerebral thrombosis). The early mortality rate of hemorrhagic stroke is very high, about half of patients die within several days of disease, and most survivors have different degrees of sequelae such as dyskinesia, cognitive impairment, speech dysphagia and the like. The ischemic cerebral apoplexy patient has hemiplegia as main sequela clinically.

The prior art relates to the treatment of the apoplexy sequelae, including physical therapy and some rehabilitation function exercises, but the treatment time is long, the treatment cost is high, and the effect varies from person to person.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides a composition for treating sequela of apoplexy, which has the advantages of good curative effect, high cure rate, low cost and no toxic or side effect, and a preparation method thereof.

The technical scheme of the invention is as follows:

a composition for treating sequela of apoplexy comprises the following raw materials:

360 parts of Chinese urine 280-containing materials, 350 parts of giant knotweed rhizome 250-containing materials, 250 parts of trumpet creeper 150-containing materials, 200 parts of pawpaw 100-containing materials, 80-160 parts of pubescent angelica root, 250 parts of snakegourd fruit 150-containing materials, 70-140 parts of rhizoma arisaematis, 50-70 parts of rhizoma typhonii, 600 parts of alum 400-containing materials, 280 parts of fish glue 220-containing materials and 700 parts of vinegar 500-containing materials.

Further, the raw material components of the composition for treating the sequela of the stroke comprise:

300 parts of Chinese urine flower-.

320 parts of Chinese fevervine herb, 300 parts of giant knotweed, 180 parts of trumpet creeper, 150 parts of pawpaw, 120 parts of pubescent angelica root, 200 parts of snakegourd fruit, 100 parts of arisaema tuber, 60 parts of giant typhonium rhizome, 500 parts of melanterite, 250 parts of fish gelatin and 600 parts of vinegar.

Further, the composition is a pill.

The preparation method of the pill comprises the following steps:

(1) respectively drying and crushing Chinese fevervine herb, giant knotweed rhizome, Chinese trumpet creeper flower, pawpaw, radix angelicae pubescentis, snakegourd fruit, rhizoma arisaematis and rhizoma typhonii to obtain raw material powder; mixing the raw material powders to obtain mixed powder;

(2) removing impurities from Melanteritum, heating in a sealed container, calcining until juice is completely removed and red, taking out, cooling, and pulverizing to obtain Melanteritum powder;

(3) adding fish gelatin into vinegar, heating to melt fish gelatin, sequentially adding the mixed medicinal powder and soap alum powder, stirring, and making into pill.

Further, in the step (1), the drying temperature is 50-70 ℃, and the drying time is 2-3 h.

Further, in the step (1), the particle size of each raw material powder is 40 to 60 meshes.

Further, in the step (2), the heating time is 2.5-3.5h, and the heating is strong fire heating.

Further, in the step (2), the grain size of the soap alum powder is 40-60 meshes.

Further, in the step (3), the particle size of the pills is 6-10 mm.

In order to facilitate understanding of the present invention, the raw material drugs and the drug effects of the present invention will now be further described.

Herba Selaginellae Doederleinii, which is a perennial herb, is as high as about 6 cun, and has soft and succulent stem and leaf. The stem base is inclined to take root. The lower leaves of the stem are opposite, the tip leaves of the stem are mutualism, and the shape of the spoon is long round or inverted oval; there are small bulblet of globularia at the axillary of leaf, and new seedling can grow when it falls to the ground. Small, yellow, growing on the branch tips. Flowering in 4-5 months. The whole herb can be used for medicine, and has the effects of dispelling cold, regulating qi-flowing, relieving pain and preventing malaria. Can be used for treating abdominal pain due to food stagnation, rheumatic paralysis, and malaria.

Giant knotweed rhizome, also known as sour barrel stem, sour barrel reed, big coaptation, and Zhuzhuang root. The stem is upright, 1-2 m high, thick, hollow, with obvious longitudinal edges, small protrusions, no hair, and the rhizome is used for medicine. Dispel wind and remove dampness, dissipate blood stasis and relieve pain, relieve cough and resolve phlegm. Can be used for treating arthralgia, jaundice due to damp-heat pathogen, amenorrhea, abdominal mass, scald due to hot water or fire, traumatic injury, carbuncle, suppurative sore, cough, and excessive phlegm.

Campsis grandiflora, and latin school name Campsis grandiflora, distributed in the middle of China, and enjoying warm and humid environment with sunlight, and slightly shade-resistant. The aerial root is used for climbing other objects to grow upwards, and the feather-shaped compound leaves, the small leaves are oval, the edges of the small leaves are provided with sawteeth, flowers are bright red, corolla-shaped funnels and capsules are formed, so that the aerial root prefers to drain good soil, is relatively resistant to water and humidity and has certain saline-alkali resistance. Has medicinal value, has effects of cooling blood, removing blood stasis, dispelling pathogenic wind, and can be used for treating menoxenia, puerperal breast swelling, rubella, skin pruritus, and acne.

Papaya has the effects of relaxing muscles and tendons, activating collaterals, harmonizing stomach and eliminating dampness. Can be used for treating damp arthralgia, spasm, soreness and pain of waist and knee joint, summer dampness, emesis, diarrhea, spasm and pain of tendon, loempe, and edema.

Du Huo, dispelling wind and removing dampness, relieving pain and pain due to arthralgia. Can be used for treating arthralgia due to wind-cold-dampness, lumbago, gonalgia, headache due to wind-cold-yin deficiency, and headache due to wind-cold-dampness.

Fructus Trichosanthis has effects of clearing lung-heat, eliminating phlegm, promoting qi circulation, relieving chest stuffiness, moistening lung, eliminating phlegm, relieving constipation, resolving hard mass and eliminating swelling. Can be used for treating phlegm heat cough, thoracic obstruction, chest pain, intestinal dryness constipation, pulmonary abscess, and acute mastitis.

Tian nan xing has the actions of drying dampness and resolving phlegm, dispelling wind and relieving spasm, resolving masses and eliminating swelling. Can be used for treating cough due to damp phlegm, chest distress, dizziness due to wind phlegm, apoplexy, phlegm stagnation, tetanus, epilepsy, mania, carbuncle, and phlegm nodule.

Giant typhonium rhizome, rhizoma typhonii, acts to expel wind-phlegm, arrest convulsion, detoxify, dissipate nodulation and alleviate pain. Can be used for treating phlegm accumulation due to apoplexy, facial paralysis, slurred speech, convulsion, epilepsy, tetanus, phlegm syncope, headache, migraine, lymphoid tuberculosis, subcutaneous nodule, and snake bite.

Melanterite has the effects of detoxifying, healing sore, removing food retention, killing parasites, drying dampness, resolving phlegm, enriching blood and stopping bleeding.

Fish gelatin has effects of invigorating kidney, replenishing vital essence, nourishing channels, stopping bleeding, and removing blood stasis.

The invention has the beneficial effects that:

the composition for treating the apoplexy sequelae adopts the Chinese redwood herb, the giant knotweed rhizome, the trumpet creeper flower, the pawpaw, the pubescent angelica root, the snakegourd fruit, the arisaema tuber, the giant typhonium rhizome, the melanterite, the fish glue and the vinegar as raw materials and is subjected to proper weight proportion, wherein the Chinese redwood herb has the functions of dispelling cold and regulating vital energy; the giant knotweed rhizome, the trumpet creeper and the radix angelicae pubescentis are used for dispelling wind and promoting diuresis, and the three medicines are combined to strengthen the function of the Chinese herba fargesii in warming channels and dispelling cold; the combination of the whole snakegourd fruit, the rhizoma arisaematis and the giant typhonium rhizome strengthens the functions of clearing away the lung-heat, reducing phlegm, promoting qi circulation, relieving chest stuffiness and dispersing mass and relieving swelling; vinegar has effects of softening blood vessel; fish gelatin has effects in invigorating kidney and replenishing essence; the pawpaw has the effects of relaxing tendons, activating collaterals, harmonizing stomach and eliminating dampness; the melanterite is forged, so that the effects of drying dampness and resolving phlegm are enhanced, and meanwhile, the properties of various medicines can be improved. The finally prepared composition for treating the apoplexy sequelae has the functions of mutual interaction and synergistic effect of various medicines, has the functions of warming and activating meridian, regulating qi and activating blood, dispelling wind and eliminating phlegm, has better curative effect on the apoplexy sequelae, and has high cure rate, low cost and no toxic or side effect.

Detailed Description

The present invention is further illustrated by the following specific examples.

In the following examples, 1 part by weight represents 1 g.

Example 1

The embodiment provides a composition for treating sequela of apoplexy, which comprises the following raw material components:

280 parts of Chinese fevervine herb, 250 parts of giant knotweed, 150 parts of trumpet creeper, 100 parts of pawpaw, 80 parts of pubescent angelica root, 150 parts of snakegourd fruit, 70 parts of arisaema tuber, 50 parts of giant typhonium rhizome, 400 parts of melanterite, 220 parts of fish gelatin and 500 parts of vinegar.

The preparation method of the composition for treating the sequela of the stroke comprises the following steps:

(1) respectively taking Chinese fevervine herb, giant knotweed rhizome, Chinese trumpet creeper flower, pawpaw, doubleteeth pubescent angelica root, snakegourd fruit, arisaema tuber and giant typhonium rhizome, drying for 3 hours at 50 ℃ respectively, and crushing to obtain raw material powder with the particle size of 40 meshes; mixing the raw material powders to obtain mixed powder;

(2) removing impurities from Melanteritum, heating with strong fire in a sealed earthen jar for 2.5 hr, calcining until juice is completely removed and red, taking out, cooling, and pulverizing to obtain Melanteritum powder with particle size of 40 meshes;

(3) adding fish gelatin into vinegar, heating to melt fish gelatin, sequentially adding the mixed medicinal powder and soap alum powder, and stirring to obtain composition with particle diameter of 6mm for treating apoplexy sequela.

Example 2

360 parts of Chinese fevervine herb, 350 parts of giant knotweed, 250 parts of trumpet creeper, 200 parts of pawpaw, 160 parts of pubescent angelica root, 250 parts of snakegourd fruit, 140 parts of arisaema tuber, 70 parts of giant typhonium rhizome, 600 parts of melanterite, 280 parts of fish gelatin and 700 parts of vinegar.

(1) respectively taking Chinese redwood herb, giant knotweed rhizome, Chinese trumpet creeper, pawpaw, doubleteeth pubescent angelica root, snakegourd fruit, arisaema tuber and giant typhonium rhizome, drying for 2 hours at 70 ℃, and crushing to obtain raw material powder with the particle size of 60 meshes; mixing the raw material powders to obtain mixed powder;

(2) removing impurities from Melanteritum, heating with strong fire in a sealed earthen jar for 3.5 hr, calcining until juice is completely removed and red, taking out, cooling, and pulverizing to obtain 60 mesh Melanteritum powder;

(3) adding fish gelatin into vinegar, heating to melt fish gelatin, sequentially adding the mixed medicinal powder and soap alum powder, and stirring to obtain composition with particle diameter of 10mm for treating apoplexy sequela.

Example 3

300 parts of Chinese fevervine herb, 280 parts of giant knotweed, 160 parts of trumpet creeper, 130 parts of pawpaw, 100 parts of pubescent angelica root, 180 parts of snakegourd fruit, 90 parts of arisaema tuber, 55 parts of giant typhonium rhizome, 450 parts of melanterite, 240 parts of fish gelatin and 550 parts of vinegar.

(1) respectively taking Chinese redwood herb, giant knotweed rhizome, Chinese trumpet creeper, pawpaw, doubleteeth pubescent angelica root, snakegourd fruit, arisaema tuber and giant typhonium rhizome, drying for 2.5h at the temperature of 60 ℃ respectively, and crushing to obtain raw material powder with the particle size of 60 meshes; mixing the raw material powders to obtain mixed powder;

(2) removing impurities from Melanteritum, heating with strong fire in a sealed earthen jar for 3 hr, calcining until juice is completely removed and red, taking out, cooling, and pulverizing to obtain 60 mesh Melanteritum powder;

(3) adding fish gelatin into vinegar, heating to melt fish gelatin, sequentially adding the mixed medicinal powder and soap alum powder, and stirring to obtain composition with particle diameter of 8mm for treating apoplexy sequela.

Example 4

340 parts of Chinese fevervine herb, 320 parts of giant knotweed, 200 parts of trumpet creeper, 180 parts of pawpaw, 140 parts of pubescent angelica root, 220 parts of snakegourd fruit, 120 parts of arisaema tuber, 65 parts of giant typhonium rhizome, 550 parts of melanterite, 260 parts of fish gelatin and 650 parts of vinegar.

Example 5

Comparative example 1

The only difference from example 5 is that no polygonum cuspidatum is present.

Comparative example 2

The only difference from example 5 is that campsis grandiflora is not included.

Comparative example 3

The only difference from example 5 is that no pubescent angelica root is present.

Comparative example 4

The only difference from example 5 is that no melanterite is present.

Clinical trial

1. Selecting a standard: 100 clinically diagnosed stroke sequela patients with the age of 50-70 years are selected, wherein 52 patients are male and 48 patients are female. Manifested as hemiplegia, facial distortion, stiff tongue with stiff tongue or no speech, hemianesthesia, all patients voluntarily participated in the study, and discontinued taking other therapeutic drugs for more than 1 week.

2. The test method comprises the following steps: the patients are randomly divided into A, B, C, D, E5 groups (20 cases in each group), and the pills prepared in example 5 and comparative examples 1-4 are respectively taken by 8-10 pills (0.2 g/pill) each time, three times a day, 12 days as a treatment course, and 1-3 treatment courses are continuously taken.

3. Treatment criteria were:

effective, paralysis of limbs and movement function can be recovered, and facial distortion and stiff tongue and loss of speech;

ineffectiveness-no change in symptoms before and after treatment.

3. The results of the treatment are shown in table 1.

TABLE 1 results of clinical trials

	Number of test persons	Number of effective persons	Effective rate%
				Example 5	20	16	80
Comparative example 1	20	14	70
				Comparative example 2	20	15	75
Comparative example 3	20	14	70
				Comparative example 4	20	11	55

The results show that the effective rate of the composition for treating the apoplexy sequelae reaches 80 percent, if any one of giant knotweed rhizome, trumpetcreeper and pubescent angelica root in the composition is removed, the treatment effect is reduced, and the removal of the melanterite has a large influence on the treatment effect, which shows that the melanterite has the effect of improving the drug properties of various medicines.

The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. The composition for treating the sequela of the apoplexy is characterized by comprising the following raw material components:

2. The composition for treating sequelae of stroke as set forth in claim 1, wherein the raw material components comprise:

300 parts of Chinese urine flower-.

3. The composition for treating sequelae of stroke as set forth in claim 1, wherein the raw material components comprise:

4. The composition for treating sequelae of stroke as set forth in any of claims 1-3, wherein said composition is a pill.

5. A process for the preparation of a formulation according to claim 4, comprising the steps of:

6. The method according to claim 5, wherein in the step (1), the drying temperature is 50-70 ℃ and the drying time is 2-3 h.

7. The production method according to claim 5, wherein in the step (1), the particle diameter of each raw material powder is 40 to 60 mesh.

8. The method according to claim 5, wherein in the step (2), the heating time is 2.5 to 3.5 hours, and the heating is strong fire heating.

9. The method according to claim 5, wherein in the step (2), the grain size of the soap alum powder is 40 to 60 mesh.

10. The method according to claim 5, wherein in the step (3), the pellet has a particle size of 6 to 10 mm.