CN111801095A - 新型氨基硫醇减少局部缺血-再灌注诱发的细胞死亡 - Google Patents

新型氨基硫醇减少局部缺血-再灌注诱发的细胞死亡 Download PDF

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Publication number
CN111801095A
CN111801095A CN201980011285.XA CN201980011285A CN111801095A CN 111801095 A CN111801095 A CN 111801095A CN 201980011285 A CN201980011285 A CN 201980011285A CN 111801095 A CN111801095 A CN 111801095A
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CN
China
Prior art keywords
prc
compound
reperfusion
ischemia
organ
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Pending
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CN201980011285.XA
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English (en)
Chinese (zh)
Inventor
威廉姆·E·法赫
李宁峰
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Suzhou Ningge Biomedical Technology Co ltd
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Suzhou Ningge Biomedical Technology Co ltd
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Publication of CN111801095A publication Critical patent/CN111801095A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
CN201980011285.XA 2018-03-01 2019-01-04 新型氨基硫醇减少局部缺血-再灌注诱发的细胞死亡 Pending CN111801095A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862710838P 2018-03-01 2018-03-01
US62/710,838 2018-03-01
PCT/CN2019/070444 WO2019165851A1 (en) 2018-03-01 2019-01-04 Novel aminothiol reduction of ischemia-reperfusion-induced cell death

Publications (1)

Publication Number Publication Date
CN111801095A true CN111801095A (zh) 2020-10-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980011285.XA Pending CN111801095A (zh) 2018-03-01 2019-01-04 新型氨基硫醇减少局部缺血-再灌注诱发的细胞死亡

Country Status (8)

Country Link
US (1) US11690813B2 (https=)
EP (2) EP4588472A1 (https=)
JP (1) JP7121418B2 (https=)
KR (1) KR102490204B1 (https=)
CN (1) CN111801095A (https=)
AU (1) AU2019228134B2 (https=)
CA (1) CA3092596C (https=)
WO (1) WO2019165851A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022312709A1 (en) * 2021-07-16 2024-01-18 Obvia Pharmaceuticals Ltd. Prc-210 for use in the treatment of acute tissue injury
WO2024168231A1 (en) * 2023-02-10 2024-08-15 Obvia Pharmaceuticals, Ltd. Aminothiols for the treatment of conditions characterized by protein misfolding or aggregation, mitochondrial dysfunction, or chronic inflammation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006011273A1 (ja) * 2004-07-30 2006-02-02 Japan Science And Technology Agency 虚血後の再灌流性細胞死の抑制方法、および細胞死抑制剤
US20170002004A1 (en) * 2015-07-02 2017-01-05 Raptor Pharmaceuticals Inc. Ado-resistant cysteamine analogs and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6031006A (en) 1999-10-21 2000-02-29 Bionumerik Pharmaceuticals, Inc. Method of treating diabetic nephropathy
WO2005014524A2 (en) 2003-08-07 2005-02-17 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006011273A1 (ja) * 2004-07-30 2006-02-02 Japan Science And Technology Agency 虚血後の再灌流性細胞死の抑制方法、および細胞死抑制剤
US20170002004A1 (en) * 2015-07-02 2017-01-05 Raptor Pharmaceuticals Inc. Ado-resistant cysteamine analogs and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHERYL M SOREF ET AL: "A New Orally Active, Aminothiol Radioprotector-Free of Nausea and Hypotension Side Effects at Its Highest Radioprotective Doses", 《INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY》 *
RICHARD R. COPP ET AL: "Radioprotective efficacy and toxicity of a new family of aminothiol analogs", 《INT J RADIAT BIOL》 *
SHAO-ZE WU ET AL: "Amifostine Pretreatment Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Apoptosis and Oxidative Stress", 《OXIDATIVE MEDICINE AND CELLULAR LONGEVITY》 *

Also Published As

Publication number Publication date
EP4588472A1 (en) 2025-07-23
AU2019228134A1 (en) 2020-10-22
CA3092596A1 (en) 2019-09-06
AU2019228134B2 (en) 2022-03-03
US20210299066A1 (en) 2021-09-30
JP2021506982A (ja) 2021-02-22
EP3758691A4 (en) 2021-11-17
KR102490204B1 (ko) 2023-01-19
US11690813B2 (en) 2023-07-04
JP7121418B2 (ja) 2022-08-18
CA3092596C (en) 2024-05-21
WO2019165851A1 (en) 2019-09-06
EP3758691A1 (en) 2021-01-06
KR20200118851A (ko) 2020-10-16

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