CN111789933A

CN111789933A - Formula and preparation method of navel patch for assisting sleep and promoting gastrointestinal function recovery

Info

Publication number: CN111789933A
Application number: CN202010728220.1A
Authority: CN
Inventors: 彭统涛
Original assignee: Wuhan Kunyuan Technology Co ltd
Current assignee: Wuhan Kunyuan Technology Co ltd
Priority date: 2020-07-24
Filing date: 2020-07-24
Publication date: 2020-10-20

Abstract

The invention belongs to a traditional Chinese medicine composition for assisting sleep and promoting gastrointestinal function recovery, and particularly discloses a formula and a preparation method of a navel patch for assisting sleep and promoting gastrointestinal function recovery. The navel patch is prepared from the following traditional Chinese medicine raw materials in parts by weight: 60-120 parts of monkshood, 5-30 parts of roasted liquorice, 10-90 parts of ginger, 10-30 parts of cassia twig tip, 10-30 parts of bighead atractylodes rhizome, 10-20 parts of hawthorn, 10-30 parts of poria with hostwood, 10-30 parts of rhizoma acori graminei, 30-50 parts of cortex phellodendri, 10-30 parts of fructus amomi, 30-50 parts of pinellia ternate, 30-50 parts of red sorghum, 30 parts of herba epimedii, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale and 15 parts of pericarpium citri reticulatae viride. The method comprises decocting the medicinal materials in a certain proportion and concentrating into paste. The product of the invention has the effects of helping sleep, promoting the recovery of gastrointestinal functions, relieving gastrectasia and stomachache, improving immunity, assisting yang qi of human bodies and the like.

Description

Formula and preparation method of navel patch for assisting sleep and promoting gastrointestinal function recovery

Technical Field

The invention belongs to the field of traditional Chinese medicine compositions for assisting sleep and promoting gastrointestinal function recovery, and particularly relates to a formula and a preparation method of a navel patch for assisting sleep and promoting gastrointestinal function recovery.

Background

With the continuous acceleration of the life rhythm and the aging process of the population, symptoms such as low immunity, physical fatigue and the like are expressed in different degrees on almost all adults, and the symptoms are most prominent particularly for middle-aged and elderly people. The resistance of the human body to foreign invasion, recognition and elimination of foreign substances is generally called "immunity". Modern immunology considers that under normal conditions, the body keeps a balanced state, and depends on immune function, resists various infections, eliminates harmful substances in the body, namely self-recognition and heterosis elimination, and achieves self-stable physiological protection. However, when the immune function is abnormal, the homeostasis of the body is broken, which results in various autoimmune diseases, such as AIDS and other diseases, and is closely related to the aging of the body and the occurrence of tumors, hypertension, diabetes, etc. The modern medicine's immunity is also similar to the ' healthy qi ' in traditional Chinese medicine. The strength, weakness, exuberance and decline of healthy qi of a human body directly determine the occurrence, development and prognosis of diseases, if the healthy qi is vigorous, the body can eliminate pathogenic factors to go out, and diseases are prevented, namely the healthy qi stores and pathogenic factors cannot be dried. If the healthy qi is weakened, pathogenic qi will invade the body to cause disease, i.e., the political disease is caused by the beating of pathogenic qi and the deficiency of qi. Therefore, the traditional Chinese medicine proposes to solve the common traditional Chinese medicine deficiency syndromes of deficiency of both qi and blood, deficiency of liver and kidney, obstructed veins and the like, which is consistent with the method for enhancing the body immunity of the modern medicine. The yang qi of the whole body is kept abundant in spring and gradually exuberant, so that the consumption of yang qi and the obstruction of yang qi should help the lost yang qi in time. The hypoimmunity and the decline of life vitality are related to the insufficiency of yang qi and the insufficiency of healthy qi. Therefore, the health-care wine can help yang qi, enhance the immunity of human bodies, improve the usually weak constitution as soon as possible, and effectively prevent cold, infectious diseases, spring epidemics and the like. Yang qi deficiency: listlessness, cold body, low body temperature, cold hands and feet, or intolerance of cold in the back or cold in the area below the waist; stool is often thin and unformed, and urine is clear and long; hyposexual function, irregular menstruation, etc.

At present, a plurality of health-care foods for improving immunity appear in the market, and although the health-care foods have smaller side effects compared with western medicines, the health-care foods have slow effect and larger individual difference. Deficiency syndrome is usually seen in people with weak body and people suffering from long-term illness, while excess syndrome is usually caused by excess heat, phlegm-dampness and improper diet. The treatment of insomnia by traditional Chinese medicine is also the treatment of syndrome, wherein deficiency causes tonifying and excess causes purging. The traditional Chinese medicine treatment has the advantages of small side effect and low treatment cost, but most of the existing traditional Chinese medicines are oral preparations, and the problems of inconvenient administration, slow effect and unsatisfactory treatment effect exist in the treatment.

Meanwhile, the school of strengthening yang is called "fire school" in folk, and the official school is called "strengthening yang school". There are medical monographs "Yi Lie Zhen Chuan", "Yi Fa Yuan Tong" and "Shang Han Heng Lun" which are handed down from the world. The blood source "Huangdi's Nei Jing" and "Zhou Yi" Tai Ji, the middle energizer is that "the life stands all at one yang in Kam", emphasizes the important role of Yuan Yang genuine qi in life, and the therapeutic principle focuses on strengthening yang. The yang-strengthening therapy is also the inheritance and application of the essence in Huangdi's classic of traditional Chinese medicine and the treatise on the febrile diseases.

Disclosure of Invention

Aiming at the defects or improvement requirements of the prior art, the invention provides a navel patch formula for assisting sleep and promoting gastrointestinal function recovery and a preparation method thereof, and the navel patch formula has the effects of assisting sleep, promoting gastrointestinal function recovery, relieving stomach distension and stomachache, improving immunity, assisting yang qi of a human body and the like.

In order to achieve the purpose, according to one aspect of the invention, the invention provides a navel patch formula for assisting sleep and promoting gastrointestinal function recovery, which is prepared from the following traditional Chinese medicine raw materials in parts by weight:

60-120 parts of monkshood, 5-30 parts of roasted liquorice, 10-90 parts of ginger, 10-30 parts of cassia twig tip, 10-30 parts of bighead atractylodes rhizome, 10-20 parts of hawthorn, 10-30 parts of poria with hostwood, 10-30 parts of rhizoma acori graminei, 30-50 parts of cortex phellodendri, 10-30 parts of fructus amomi, 30-50 parts of pinellia ternate, 30-50 parts of red sorghum, 30 parts of herba epimedii, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale and 15 parts of pericarpium citri reticulatae viride.

Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 90 parts of monkshood, 20 parts of roasted liquorice, 50 parts of ginger, 20 parts of cassia twig tip, 20 parts of bighead atractylodes rhizome, 15 parts of hawthorn, 20 parts of poria with hostwood, 20 parts of rhizoma acori graminei, 40 parts of golden cypress, 20 parts of fructus amomi, 40 parts of pinellia ternate, 40 parts of red sorghum, 30 parts of epimedium herb, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale and 15 parts of pericarpium citri reticulatae viride.

As a further preference, the formulation further comprises a cream conditioner.

More preferably, the cream is yellow lead.

According to another aspect of the invention, a preparation method of the navel patch for assisting sleep and promoting gastrointestinal function recovery is provided, and comprises the following steps:

s1, weighing the medicinal materials according to the parts by weight, crushing and sieving monkshood, radix glycyrrhizae preparata, ginger, cassia twig tip, bighead atractylodes rhizome, hawthorn, poria with hostwood, rhizoma acori graminei, pinellia ternate, red sorghum, herba epimedii, fructus psoraleae, fennel, rheum officinale and pericarpium citri reticulatae viride for later use;

s2 removing impurities from cortex Phellodendri, fructus Amomi and jowar, parching in a pan at 40-60 deg.C respectively until the surface turns yellow, taking out, air cooling, and pulverizing;

s3 grinding Plumbum preparatium into powder, and sieving to obtain Plumbum preparatium powder;

s4, uniformly mixing the powder obtained by sieving in the steps S1 and S2, adding the powder into distilled water at the temperature of 80-90 ℃, uniformly stirring, soaking for 30 minutes, decocting with slow fire until the mixture is boiled, continuing to decoct, and stirring continuously until thick liquid is obtained;

s5 adding Plumbum preparatium powder into the thick liquid, decocting, stirring until the thick liquid becomes thick paste, and stopping heating;

s6, pouring the viscous paste into cold water to be soaked for 3-7 days and then taking out;

s7, uniformly coating the product obtained in the step S6 on paper plaster cloth, and rolling to obtain a finished product.

In the invention, the effective medicinal materials of the Chinese medicinal materials are as follows:

monkshood: is processed product of the root of Aconitum carmichaelii Debx belonging to Ranunculaceae, and is pungent, sweet, and strongly sexual-heat; heart, kidney and spleen meridians entered; reviving yang and rescuing from collapse, tonifying fire and supporting yang, dispelling cold and relieving pain; can be used for treating yang exhaustion, collapse, cold limbs, slight pulse, deficiency of heart-yang, thoracic obstruction, cardialgia, asthenia cold, emesis, diarrhea, abdominal psychroalgia, kidney yang deficiency, sexual impotence, cold womb, yin cold edema, yang deficiency, exogenous pathogenic factor, and arthralgia due to cold-dampness. Internal deficiency and dark eyes: to invigorate qi and nourish blood. Using Chinese angelica root (dried in the sun) six times two, aconite root (prepared by artillery) one time two times as powder, and refined honey pill (Chinese parasol and aconite root) as large as Chinese parasol. Thirty pills are taken every time, and the pill is named six pills with the effect of warming the wine. ("holy economic book"). Deficiency of qi and malaria, little fever and excessive cold, or single cold without heat, or deficiency heat without cold: is prepared from tsaoko nutlet, cooked aconite root, water, ginger, jujube and water through decocting. Named Guofu Fu Tang. (Jisheng Fang). For pain in the chest and abdomen, the two or two and half aconites of wolfsbane root are pounded and sieved, and the honeyed pill is large. One pill, two pills for two days and three pills for three days are taken once a day; the patients should be healed from one pill to three pills. ("rear of elbow").

And (3) liquorice moxibustion: the honey-fried licorice root is prepared by baking honey-fried licorice root, commonly called as processing, namely, putting honey into a pot, refining the honey into medium honey, adding raw licorice root slices with slow fire, uniformly stirring and frying the mixture, taking the mixture out of the pot for 3-5 min, putting the mixture into a baking room or an oven, taking the mixture out when the mixture is not sticky, and cooling the mixture. The honey-fried licorice root is a round-like or oval slice, the surface is reddish brown or grayish brown, the honey-fried licorice root is slightly glossy, the section is yellow to dark yellow, the cambium ring is obvious, and the rays are radial. The honey-fried licorice decoction has the treatment effects of tonifying qi, nourishing yin, activating yang and recovering pulse. Has the effects of nourishing yin and blood, tonifying qi and activating yang, and recovering pulse and stopping palpitation. The traditional Chinese medicine is mainly used for treating heart yin and yang deficiency, and later-aged physicians expand the traditional Chinese medicine to treat consumptive disease, consumptive lung disease, lung dryness and yin injury and other symptoms based on Zhang Zhongjing clinical application.

Ginger: fresh ginger, pungent and warm in property, has the actions of tonifying spleen and stomach, warming middle energizer, checking adverse rise of qi and arresting vomiting, removing dampness and relieving stuffiness, relieving cough and eliminating phlegm, and is good at checking adverse rise of qi and arresting vomiting.

Ramulus cinnamomi tip: is dry twig of Cinnamomum cassia Presl of Lauraceae, pungent, sweet and warm in nature, and enters heart, lung and bladder channels; the efficacy is as follows: supporting yang to relieve exterior syndrome, warming and dredging channels and collaterals, activating yang to promote diuresis, warming and dredging chest yang, warming spleen and stomach to dispel cold; the main treatment is as follows: it is indicated for wind-cold exterior syndrome, soreness and pain of shoulder, back and limbs, obstruction of qi in the chest, phlegm and retained fluid, and amenorrhea.

White atractylodes rhizome: bitter, sweet and warm in taste. It enters spleen and stomach meridians. The main functions are strengthening the spleen and replenishing qi, eliminating dampness and promoting diuresis, arresting sweating and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. The "treatise on herb properties" carries it: monarch drug, sweet and pungent in flavor, and non-toxic. Can be used for treating arthralgia due to wind-evil, perennial dysentery with qi, distending pain in heart and abdomen, eliminating indigestion, stimulating appetite, removing phlegm and saliva, removing cold and heat, and stopping diarrhea. The main face is bright and beautiful, and the face is kept youthful and black. It is indicated for edema, vomiting, abdominal cold pain, vomiting and diarrhea, and cold dysentery due to qi deficiency of stomach.

Hawthorn fruit: sour and sweet, slightly warm. Tang Ben Cao (materia Medica of Tang Dynasty): sour, cold and non-toxic. Daily herbal medicine: sweet and sour in taste and is non-toxic. The herbal Meng quan: sweet and pungent taste, mild smell and no toxicity. Compendium (compendium): sour and sweet, slightly warm.

Poria with hostwood: poria is part of sclerotium of Poria cocos (Poria cocos Schw.) of Polyporaceae with pine root, and the original species is lower plant and is fungus parasitized on pine tree. The medicinal part is white part of dry karyophyte core body with pine root. Sweet in nature and taste, bland and mild. Has effects in eliminating dampness, invigorating spleen, and calming heart. Can be used for treating phlegm retention, edema, dysuresia, diarrhea, palpitation, and vertigo. Distributed around the world. The poria cocos is a traditional Chinese medicine product of plant poria cocos, the original plant is usually parasitized on masson pine or cut log, and the growth and development of the plant poria cocos can be divided into two stages: namely a hyphal (white filaments) stage and a sclerotium stage. In the hypha growth stage, hypha mainly absorbs moisture and nutrition from the surface of the wood, and simultaneously secretes enzyme to decompose and convert organic matters (cellulose) in the wood, so that the hypha can spread in the wood to grow vigorously. In the second stage, the hyphae are agglomerated into clusters in the middle and later stages, and sclerotia (also called knots) are gradually formed. The medicine taste is sweet and bland. Processing white part of pine root in the middle of selected sclerotium, and drying in the sun. The meridian entered heart and spleen meridians function to calm heart, induce tranquilization and induce diuresis. It can be used for treating palpitation, amnesia, insomnia, and epilepsy due to heart deficiency.

Grassleaf sweelflag rhizome: is a perennial herb rhizome in the form of grass of Acorus gramineus of the family framycetaceae; pungent, bitter and warm in nature, entering heart and stomach meridians; the efficacy is as follows: resolving dampness, promoting appetite, inducing resuscitation, eliminating phlegm, refreshing mind, and improving intelligence; the main treatment is as follows: a dirty feeling, fullness, inappetence, dysentery, coma, epilepsy, abscess, amnesia, or deafness. Regulating qi, promoting blood circulation, dispelling pathogenic wind, and removing dampness. For epilepsy, abscess, phlegm syncope, fever, coma, amnesia, qi block, deafness, vexation, stomach ache, abdominal pain, arthralgia due to wind-cold-dampness, superficial infection, toxic swelling, and traumatic injury.

Pinellia ternata: (scientific name: Pinellia ternata), also known as Digitalis and Sagittaria, etc., belonging to the order Arales, Araceae and Pinellia. The medicinal plants have the functions of eliminating dampness and phlegm, lowering adverse qi and preventing vomiting, and are used for relieving furuncle and swelling by a veterinarian. Dry dampness and resolve phlegm, check adverse rise of qi and arrest vomiting, relieve stuffiness and dissipate nodulation. Can be used for treating cough with asthma due to excessive phlegm, dizziness and palpitation due to phlegm and fluid retention, dizziness due to wind-phlegm, headache due to phlegm syncope, emesis, regurgitation, chest and gastric fullness, and globus hystericus; unprocessed for treating abscess and phlegm nodule. The function of a digestive system: 1. vomiting arresting and vomiting promoting: ban Xia can activate the efferent activity of vagus nerve and has the action of stopping vomiting, while ban Xia can activate the actions of Ji ren Hou and Zhi Xue. The pinellia ternate can prolong the incubation period of dog vomiting caused by copper sulfate or prevent the dog from vomiting, and can antagonize the vomiting of the dog injected with the dehydrated morphine hydrochloride subcutaneously, and the effect is not influenced by the monkshood. 2. Antiulcer effect: the rhizoma Pinelliae decoction with water and ethanol can reduce gastric secretion, reduce free acidity and total acidity of gastric juice, inhibit pepsin activity, protect gastric mucosa, promote gastric mucosa repair, and resist pyloric ligation ulcer, indomethacin ulcer and stress ulcer of rat. 3. Effects on liver and gallbladder: the pinellia ternate can promote bile secretion of rabbits, increase corticosterone in blood of mice, enhance the induction effect of corticosterone on liver tyrosine aminotransferase, and increase the activity of liver tyrosine aminotransferase.

Red sorghum: sweet in taste, warm in nature, astringent, entering spleen and stomach meridians. Induce diuresis, stop diarrhea, astringe intestine and stomach, stop cholera.

Herba epimedii: the icariin bud is dry aerial part of a small-family plant, namely, an icariin bud brevicornum Maxim, an arrow leaf icariin bud sagittum (Sieb. et Zucc.) Maxim.), a pubescent icariin bud umber Maxim, a Wushan icariin bud wushunhanse T.S.Ying, or an Korean icariin bud epicedium koreanum Nakai; pungent, sweet and warm in nature, entering liver and kidney meridians; the efficacy is as follows: tonifying kidney yang, strengthening tendons and bones, and dispelling pathogenic wind and dampness; the main treatment is as follows: yang-qi Yi ren, tendons and bones numbness, wind-damp arthralgia, numbness and spasm.

Psoralea fruit: (scientific name: Psoralea coriylifolia Linn.) also known as: fructus Psoraleae, semen Strychni, and semen Allii Tuberosi. The fruit has effects of invigorating kidney, tonifying yang, invigorating spleen and stomach, and can be used for treating dermatoses such as psoriasis. Has effects in invigorating kidney, supporting yang, arresting spontaneous emission, arresting polyuria, treating lumbago due to kidney deficiency, frequent micturition, infantile enuresis, renal leak, warming spleen, relieving diarrhea, and relieving asthma.

Fennel: has effects of dispelling cold, relieving pain, regulating qi-flowing and regulating stomach. Can be used for treating cold hernia with abdominal pain, testis tenesmus, dysmenorrhea, cold pain of lower abdomen, abdominal distention and pain, anorexia, vomiting and diarrhea. The book Ben Cao Hui Yan (treatise on materia Medica): herbs that warm middle energizer and promote qi flow also.

Rhubarb: rhubarb, named Huangliang, is also called Turcang, and Turkey red ginseng, for instance Wupu. The ancient people mainly get rid of blood stasis, block blood, cold and heat, and craving for illness and accumulation, stay on food, wash intestines and stomach, push old to get new, promote diuresis, regulate middle-jiao to digest food, and calm five internal organs. The rhubarb is used for treating burn and scald in long history in China. The "materia medica Mongolia identification" records: rhubarb, radix et rhizoma Rhei is bitter in taste, cold in nature and yin in yin, so it is indicated for treating fire sores if it is ground into powder and the powder is clear and thick. The record of the medicine identification is as follows: the ripe rhubarb is indicated for various fire-toxin sores and will not heal after a long time. When the large yellow wine is used thoroughly, the toxic fire sores can be eliminated, and the swelling can be relieved and the pain can be relieved. The main indications of rhubarb, Dahuang for treating fire sores, is recorded in the seventeenth volume of the section of the grass, Ben Cao gang mu. The traditional Chinese medicine theory considers that the burn and scald are caused by fire toxin, local stagnation of qi and blood, meridian blockage and blood and flesh corruption, and the rhubarb has the effects of attacking and purging fire, clearing heat and stopping drug addiction and cooling blood and removing weakness, and is the essential medicine for treating the burn and the scald. Modern medicine also proves that rhubarb has the effects of promoting blood circulation, stopping bleeding, inhibiting bacteria, eliminating endotoxin, improving immunity of organisms, reducing body temperature, easing pain and the like. The rhubarb contains the derivatives of the onion ketone and the onion ketone, and has stronger antibacterial effect on staphylococcus and streptococcus; the tanned rhubarb has good astringency on wound surface and can promote wound healing.

Amomum fruit: (scientific name: Amomum villosum Lour.) is a perennial herb of the genus Amomum of the family Zingiberaceae. The fruits are used for medicine, have the best quality of Guangdong Yangchun and are mainly used for treating qi stagnation of spleen and stomach, indigestion, abdominal pain and distension, dysphagia and vomiting, cold diarrhea and cold dysentery. Fructus Amomi has high ornamental value, and can be used for ornamental flower in early summer and fruit in midsummer. Pungent taste and warm nature; it enters spleen, stomach and kidney meridians. Treatise on herb Property: bitter and pungent in flavor. Materia Medica Shi Yi: and (5) acid taste. The materia Medica of sea drugs: pungent, even and salty in flavor. The book of Kaibao Ben Cao: warm and non-toxic. The herbal decoction (Ben Cao Tang Ye): the three channels are the hand, foot Taiyin, Yangming, Taiyang and foot shaoyin channels. The book Ben Cao Pin Hui Jing Yao (materia Medica of materia Medica): qi rubbing is also called yang. Has fragrance. Compendium (compendium): pungent, warm, astringent and nontoxic. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): pungent taste, temperature, no toxicity; enter foot taiyin, yangming, boy, jueyin, hand taiyin, yangming, jueyin. Can be lifted and lowered, and the lifting is more than the lifting, thereby realizing the positive industry. The herbal Zhenzhen: it is specially used in spleen and stomach, lung and kidney, large and small intestine and bladder. The functional indications are as follows: move qi and regulate middle energizer, harmonize stomach and activate spleen. It is indicated for abdominal pain, distention and fullness, anorexia, dysphagia, emesis, cold diarrhea, dysentery, and fetal movement during pregnancy.

Phellodendron bark: clear heat and dry dampness, purge fire and remove steam, remove toxicity and cure sore. Can be used for treating damp-heat dysentery, jaundice, leukorrhagia, stranguria caused by heat, tinea pedis, abdominal mass, hectic fever due to yin-deficiency, night sweat, spermatorrhea, pyocutaneous disease, toxic swelling, and eczema with spasm and itching. Phellodendron bark, cortex Phellodendri, radix Et rhizoma Rhei, cortex Phellodendri, radix Angelicae sinensis, etc. has effects of nourishing yin and lowering fire. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone. Huang Bai, the one in Chinese pharmacopoeia, with the action of clearing heat and drying dampness, is similar to Huang answering and Huang Lian, but is better to remove damp-heat in the lower energizer.

Myrrh dispels blood and removes weakness, detumescence and relieving pain. It can be used for treating traumatic injury, incised wound, pain of bones and muscles, pain of heart and abdomen, addiction, amenorrhea, carbuncle, swelling and pain, hemorrhoid, and vision disorder. Bitter, pungent and even. (xi) treatise on drug Property: "Weikuxin". ② 'materia medica of sea drugs': bitter and pungent taste, warm and non-toxic. (iii) Kaibao Ben Cao: bitter and mild taste, and no toxicity. It enters liver, spleen, heart and kidney meridians. (ii) Ben Cao Jing Shu (fundamental and sparse of materia Medica): enter the foot-Jueyin meridian. '2' New materia Medica: enter spleen and kidney meridians. (iii) materia Medica: "enter heart and liver. The frankincense is matched with the frankincense, the blood circulation is promoted, the nodules are removed, the circulation of qi is promoted, and the muscles and the tendons are relaxed; matching with pangolin scales, activating blood and dispersing nodules, and relieving swelling and pain. It is combined with Xue Jie to activate blood and dissipate nodule, and alleviate pain. With the combination of realgar, the medicine can eliminate swelling, promote tissue regeneration, eliminate dampness and remove toxicity.

Green tangerine peel: bitter and pungent in flavor and warm in nature. It enters liver, gallbladder and stomach meridians. Has the effects of soothing liver, breaking qi, removing food retention and resolving stagnation. Can be used for treating distending pain in chest and hypochondrium, hernia pain, nodules of breast, mammary abscess, food stagnation, qi stagnation, and abdominal pain. Green tangerine peel powder from syndrome pulse therapy: for epigastric and abdominal pain due to qi stagnation, it is combined with Da Fu Pi. Compendium of materia Medica: it is indicated for adverse qi of chest and diaphragm, hypochondriac pain, hernia in lower abdomen, eliminating mammary swelling, soothing liver-gallbladder and purging lung-qi. The "the herbal atlas" (the book's Manual of medical science): governing qi stagnation, descending food, breaking accumulation and diaphragmatic qi.

Generally, compared with the prior art, the above technical solution conceived by the present invention mainly has the following technical advantages:

in the invention, the monkshood is pungent and sweet in flavor and is strongly hot in nature; heart, kidney and spleen meridians entered; reviving yang and rescuing from collapse, tonifying fire and supporting yang, dispelling cold and relieving pain, Poria has the advantages of sweet and mild flavor, dampness eliminating, spleen invigorating, and heart calming, and ramulus Cinnamomi is pungent, sweet and warm in nature, and enters heart, lung, and shoulder skin channels. Phellodendron bark, cortex Phellodendri, radix Angelicae sinensis, radix rehmanniae Preparata, and radix rehmanniae Preparata. Simultaneously other components are matched as follows: the traditional Chinese medicines are extracted and processed to prepare the traditional Chinese medicine navel plaster, the synergistic effect is shown, and the traditional Chinese medicine navel plaster has the effects of helping sleep, enhancing immunity, relieving fatigue, promoting gastrointestinal function recovery and stomach distension and stomachache in the process.

In the invention, the poria with hostwood, the grassleaf sweelflag rhizome, the amur corktree bark, the villous amomum fruit, the red sorghum and the pinellia tuber are combined to play a role in guiding yang to enter yin, communicating heart and kidney and promoting sleep, and the honey-fried licorice root, the largehead atractylodes rhizome, the hawthorn fruit and the green tangerine orange peel have functions of building spleen and stomach and promoting digestion, are matched with other components to realize the synergistic interaction of the medicines, and therefore have the functions of helping sleep, enhancing immunity, relieving fatigue, promoting gastrointestinal function recovery and stomach distension and stomachache in the process.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

The invention aims to research a navel patch formula for assisting sleep and promoting gastrointestinal function recovery aiming at the causes and pathogenesis characteristics of poor sleep quality, gastrointestinal disorder, low immunity, insufficiency of yang qi, deficiency of both qi and blood, deficiency of liver and kidney and the like. In the traditional Chinese medicine navel patch, monkshood, poria with hostwood, cassia twig tip, phellodendron and pinellia ternate are combined for the first time, and other components are matched simultaneously, such as: the traditional Chinese medicine navel plaster is prepared from ginger, bighead atractylodes rhizome, hawthorn, rhizoma acori graminei, fructus amomi, pinellia ternate, red sorghum, herba epimedii, fructus psoraleae, fennel, rheum officinale, pericarpium citri reticulatae viride and the like, shows the synergistic effect, and has the effects of assisting sleep, enhancing immunity, relieving fatigue, resisting aging, promoting gastrointestinal function recovery and stomach swelling and pain in the process of treating stomach. The traditional Chinese medicine navel patch formula is prepared from the following traditional Chinese medicine raw materials in parts by weight:

As a further preference, the formulation further comprises a cream conditioner.

More preferably, the cream is yellow lead.

According to another aspect of the invention, a preparation method of a navel patch for enhancing immunity and supporting yang qi is provided, which comprises the following steps:

weighing the medicinal materials of each component according to parts by weight, and crushing and sieving monkshood, radix glycyrrhizae preparata, ginger, cassia twig tip, bighead atractylodes rhizome, hawthorn, poria with hostwood, rhizoma acori graminei, pinellia ternate, red sorghum, herba epimedii, fructus psoraleae, fennel, rheum officinale and pericarpium citri reticulatae viride for later use;

removing impurities from the phellodendron, the fructus amomi and the red sorghum, respectively putting the phellodendron, the fructus amomi and the red sorghum into a pot at 40-60 ℃, frying until the surfaces turn yellow, taking out the phellodendron, the fructus amomi and the red sorghum, cooling and crushing the phellodendron, the fructus amomi and the red sorghum for later use;

grinding a proper amount of yellow lead into powder, and sieving to obtain yellow lead powder for later use;

step four, uniformly mixing the powder obtained by sieving in the step one and the step two, adding the powder into distilled water at the temperature of 80-90 ℃, uniformly stirring, soaking for 30 minutes, then decocting with slow fire until the mixture is boiled, then continuing to decoct, and stirring continuously until thick liquid is obtained;

adding yellow lead powder into the thick liquid, continuously decocting and continuously stirring until the thick liquid becomes thick paste, and stopping heating;

step six, pouring the viscous paste into cold water to be soaked for 3-7 days and then taking out the viscous paste;

and step seven, uniformly coating the product obtained in the step six on paper plaster cloth, and rolling to obtain a finished product.

Example 1

The traditional Chinese medicine navel plaster is prepared from the following traditional Chinese medicine raw materials in parts by weight: 60 parts of monkshood, 15 parts of roasted liquorice, 25 parts of ginger, 10 parts of cassia twig tip, 25 parts of bighead atractylodes rhizome, 10 parts of hawthorn, 10 parts of poria with hostwood, 10 parts of rhizoma acori graminei, 300 parts of golden cypress, 12 parts of fructus amomi, 35 parts of pinellia ternate, 40 parts of red sorghum, 30 parts of herba epimedii, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale and 15 parts of pericarpium citri reticulatae viride.

The preparation process comprises the following steps:

removing impurities from the phellodendron, the fructus amomi and the red sorghum, respectively putting the phellodendron, the fructus amomi and the red sorghum into a pot at 40 ℃, frying until the surfaces turn yellow, taking out the phellodendron, the fructus amomi and the red sorghum, and crushing the phellodendron, the fructus amomi and the red sorghum for later use after cooling;

step four, uniformly mixing the powder obtained by sieving in the step one and the step two, adding the powder into distilled water at the temperature of 80 ℃, uniformly stirring, soaking for 30 minutes, decocting with slow fire until the mixture is boiled, continuing to decoct, and stirring continuously until thick liquid is obtained;

step five, continuously decocting the thick liquid and continuously stirring until the thick liquid becomes thick paste, and turning off fire;

step six, pouring the viscous paste into cold water to be soaked for 3 days and then taking out the viscous paste;

Example 2

The traditional Chinese medicine navel plaster is prepared from the following traditional Chinese medicine raw materials in parts by weight: 90 parts of monkshood, 20 parts of roasted liquorice, 50 parts of ginger, 20 parts of cassia twig tip, 20 parts of bighead atractylodes rhizome, 15 parts of hawthorn, 20 parts of poria with hostwood, 20 parts of rhizoma acori graminei, 40 parts of golden cypress, 20 parts of fructus amomi, 40 parts of pinellia ternate, 40 parts of red sorghum, 30 parts of epimedium herb, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale, 15 parts of pericarpium citri reticulatae viride and a proper amount of yellow lead. Then the following method is adopted for preparation:

removing impurities from the phellodendron, the fructus amomi and the red sorghum, respectively putting the phellodendron, the fructus amomi and the red sorghum into a pot at 50 ℃, frying until the surfaces turn yellow, taking out the phellodendron, the fructus amomi and the red sorghum, and crushing the phellodendron, the fructus amomi and the red sorghum for later use after cooling;

step four, uniformly mixing the powder obtained by sieving in the step one and the step two, adding the powder into distilled water at 85 ℃, uniformly stirring, soaking for 30 minutes, decocting with slow fire until the mixture is boiled, continuing to decoct, and stirring continuously until thick liquid is obtained;

step six, pouring the viscous paste into cold water to be soaked for 7 days, and taking out the viscous paste;

Example 3

The traditional Chinese medicine navel plaster is prepared from the following traditional Chinese medicine raw materials in parts by weight: 120 parts of monkshood, 27 parts of roasted liquorice, 56 parts of ginger, 30 parts of cassia twig tip, 17 parts of bighead atractylodes rhizome, 17 parts of hawthorn, 30 parts of poria with hostwood, 10-30 parts of rhizoma acori graminei, 50 parts of cortex phellodendri, 22 parts of fructus amomi, 43 parts of pinellia ternate, 20 parts of red sorghum, 30 parts of herba epimedii, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale, 15 parts of pericarpium citri reticulatae viride and a proper amount of yellow. Then the following method is adopted for preparation:

removing impurities from the phellodendron, the fructus amomi and the red sorghum, respectively putting the phellodendron, the fructus amomi and the red sorghum into a pot at 60 ℃, frying until the surfaces turn yellow, taking out the phellodendron, the fructus amomi and the red sorghum, and crushing the phellodendron, the fructus amomi and the red sorghum for later use after cooling;

step four, uniformly mixing the powder obtained by sieving in the step one and the step two, adding the powder into distilled water at 90 ℃, uniformly stirring, soaking for 30 minutes, decocting with slow fire until the mixture is boiled, continuing to decoct, and stirring continuously until thick liquid is obtained;

step six, pouring the viscous paste into cold water to be soaked for 6 days, and taking out the viscous paste;

Example 4

The traditional Chinese medicine navel plaster is prepared from the following traditional Chinese medicine raw materials in parts by weight: 70 parts of monkshood, 5-30 parts of roasted liquorice, 60 parts of ginger, 15 parts of cassia twig tip, 18 parts of bighead atractylodes rhizome, 13 parts of hawthorn, 15 parts of poria with hostwood, 17 parts of rhizoma acori graminei, 36 parts of cortex phellodendri, 10-30 parts of fructus amomi, 35 parts of pinellia ternate, 35 parts of red sorghum, 30 parts of herba epimedii, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale, 15 parts of pericarpium citri reticulatae viride and a proper amount of yellow. Then the following method is adopted for preparation:

removing impurities from the phellodendron, the fructus amomi and the red sorghum, respectively putting the phellodendron, the fructus amomi and the red sorghum into a 40-degree pot, frying until the surfaces turn yellow, taking out the phellodendron, the fructus amomi and the red sorghum, and crushing the phellodendron, the fructus amomi and the red sorghum for later use after cooling;

step four, uniformly mixing the powder obtained by sieving in the step one and the step two, adding the powder into 80 parts of distilled water, uniformly stirring, soaking for 30 minutes, decocting with slow fire until the mixture is boiled, continuing to decoct, and stirring continuously until thick liquid is obtained;

Example 5

The traditional Chinese medicine navel plaster is prepared from the following traditional Chinese medicine raw materials in parts by weight: 60-120 parts of monkshood, 5-30 parts of roasted liquorice, 10-90 parts of ginger, 10-30 parts of cassia twig tip, 10-30 parts of bighead atractylodes rhizome, 10-20 parts of hawthorn, 10-30 parts of poria with hostwood, 10-30 parts of rhizoma acori graminei, 30-50 parts of cortex phellodendri, 10-30 parts of fructus amomi, 30-50 parts of pinellia ternate, 30-50 parts of red sorghum, 30 parts of herba epimedii, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale, 15 parts of pericarpium citri reticulatae viride and a proper amount of yellow.

Example 6

The traditional Chinese medicine navel plaster is prepared from the following traditional Chinese medicine raw materials in parts by weight: 110 parts of monkshood, 10 parts of roasted liquorice, 20 parts of ginger, 15 parts of cassia twig tip, 15 parts of bighead atractylodes rhizome, 15 parts of hawthorn, 25 parts of poria with hostwood, 25 parts of rhizoma acori graminei, 45 parts of cortex phellodendri, 15 parts of fructus amomi, 40 parts of pinellia ternate, 40 parts of red sorghum, 30 parts of herba epimedii, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale, 15 parts of pericarpium citri reticulatae viride and a proper amount of yellow.

Experimental example 1:

clinical selection: in order to verify the effects of the traditional Chinese medicine navel patch for assisting sleep, enhancing immunity and supporting yang qi, 510 chronic patients with low immunity are randomly selected and subjected to medicine experiments, the chronic patients are averagely divided into three groups, namely a first experiment group, a second experiment group and a control group, and the two groups have no significant difference in the aspects of age, clinical performance and the like through statistical analysis.

Wherein, the selected patients are all patients who randomly draw to see a doctor, and all patients have the following symptoms: poor gastrointestinal function, low immunity, heavy dampness, difficulty in falling asleep, dreaminess accompanied by listlessness, general fatigue, slow reaction, hypomnesis, headache, yellowish complexion, deficiency of both blood and liver, fatigue and debilitation, etc.

The treatment method adopted in the experiment of the invention comprises the following steps:

the first experimental group adopts the traditional Chinese medicine navel patch prepared in the embodiment 1 of the invention for treatment, 1 time per day.

The second experimental group was treated with the navel patch of the traditional Chinese medicine prepared in example 2 of the present invention 1 time a day.

Control group: no medicine is applied and taken.

The criteria for determining the therapeutic effect are divided into three cases:

(1) the method has the following advantages: gastrointestinal dysfunction, hypoimmunity, dampness, difficulty in falling asleep, and dreaminess accompanied by listlessness, general fatigue, reaction retardation, hypomnesis, headache, yellowish complexion, deficiency of both qi and blood, deficiency of liver and kidney, and fatigue.

(2) The effect is shown: the immunity is improved, the invasion of damp is improved, the sleep quality is improved, the complexion is improved, the gastrointestinal function is improved, and the symptoms such as hypodynamia and the like do not exist.

(3) And (4) invalidation: after treatment, the patient's symptoms did not improve.

The test results are shown in Table 1:

as can be seen from the comparison table 1, the navel patch prepared in example 2 of the present invention has a good physiotherapy effect on gastrointestinal dysfunction, hypoimmunity, heavy moisture, difficulty in falling asleep, dreaminess accompanied by cachexia, weakness of limbs, reaction retardation, hypomnesis, headache, yellowish complexion, deficiency of both qi and blood, deficiency of liver and kidney, fatigue and hypodynamia, and the like, and the effective rate reaches 91.2%.

Experimental example 2:

the medicine is the traditional Chinese medicine navel patch prepared in the embodiment 2 of the invention.

1. ConA-induced splenic lymphocyte transformation experiment for mice

20 mice (clean-grade Kunming mice, male, 6-8 weeks old, 18-22 g in weight) were randomly divided into a blank control group and a traditional Chinese medicine navel patch group 2, and the gavage amount was 0.5mL and was administered once a day. After continuous gavage for 30 days, the mice were sacrificed by cervical dislocation, the spleen was aseptically removed, and gently ground with forceps to prepare a single cell suspension. Filtered through a 200-mesh screen, washed with Hank's solution, centrifuged lOmin at 1000r/min, and washed twice in total. Then, the cell concentration was adjusted to 3X 106 cells/mL. Each spleen cell suspension was added to a 24-well plate at 1 mL/well, 2 wells/sample, one well was filled with 75 uLCoA (equivalent to 7.5ug/mL), and the other well was used as a control and 5% CO was added₂,37℃CO₂Culturing in an incubator for 72 h. 4 hours before the end of the culture, 0.7mL of the supernatant was gently aspirated from each well, and 0.7mL of calf serum-free RPMI1640 culture medium was added thereto together with 50 uL/well of MTT (5mg/mL), and the culture was continued for 4 hours. After the culture is finished, 1mL of acidic isopropanol is added into each hole, and the mixture is uniformly blown and beaten to ensure that the purple crystals are completely dissolved. Then the cells were divided into 96-well culture plates, 3 replicates were prepared per well, and the optical density was measured at a wavelength of 570nm using a microplate reader.

2. Experiment for phagocytosis of chicken red blood cells by macrophages in abdominal cavity of mouse

The 20 mice were randomly divided into blank control group and Chinese medicinal navel patch group 2, and the gavage amount was 0.5mL, once a day. After continuous gavage for 30 days, 1mL of 20% chicken red blood cell suspension was injected into the abdominal cavity of each mouse. At an interval of 30min, the animal is killed by dislocation of cervical vertebrae, fixed on a mouse plate in an upward position, the abdominal wall skin is cut off in the middle, 2mL of physiological saline is injected into the abdominal cavity, and the mouse plate lmin is rotated. Then sucking out 1mL of abdominal cavity washing solution, evenly dropping on 2 glass slides, placing into a ceramic box filled with wet gauze, and moving out of an incubator at 37 ℃ for incubation for 30 min. After completion, the cells were rinsed in physiological saline to remove non-patch cells. Drying in air, and mixing the raw materials in a ratio of 1: fixing with 1 acetone methanol solution, staining with 4% (v/v) Giemsa-phosphate buffer solution for 3min, rinsing with distilled water, and air drying.

Macrophages were counted under the oil lens, 100 per tablet, and the percent phagocytosis was calculated as follows:

TABLE 2 test results

As can be seen from the above table, the traditional Chinese medicine navel patch in embodiment 2 of the invention can significantly improve the optical density difference and phagocytosis percentage, significantly improve the lymphocyte proliferation capacity and macrophage phagocytosis capacity compared with the blank control group and the positive control group, and has definite effect.

3. Effect on immune organ weight in immunosuppressed mice

SPF-level KM mice are randomly divided into 5 groups of 10 mice each, including a blank control group, a model control group and 3 high, medium and low doses of the Chinese medicinal navel patch. On the 1 st day of the experiment, animals were gavaged for 7 consecutive days 1 time per day, and normal control groups were gavaged with distilled water. On day 4 of the experiment, animals were subjected to immunosuppression model by intraperitoneal administration of cyclophosphamide at 50 mg/kg body weight for 3 consecutive days, except for the normal control group. Animals were sacrificed 1h after the last dose, body weights were weighed, thymus and spleen were dissected and weighed, and organ indices were calculated.

The results show that compared with the normal control group, the spleen index and the thymus index of the model control group are obviously smaller than those of the normal control group ((P < 0. O1). compared with the model control group, the spleen index and the thymus index of the mice can be obviously increased in each dosage group of the traditional Chinese medicine navel patch (P < 0.05-0. O1). see the following table 3.

The traditional Chinese medicine navel plaster is prepared by taking monkshood, radix glycyrrhizae preparata, ginger, cassia twig tip, bighead atractylodes rhizome, hawthorn, poria with hostwood, rhizoma acori graminei, golden cypress, fructus amomi, pinellia ternate, red sorghum, herba epimedii, fructus psoraleae, fennel, rheum officinale and pericarpium citri reticulatae viride as raw materials and carrying out proper weight proportion, and the traditional Chinese medicine plaster with the effects of helping sleep, enhancing immunity, assisting yang qi, relieving fatigue, promoting gastrointestinal function recovery, relieving gastric distention and stomachache and the like is finally prepared. The poria cocos, the grassleaf sweelflag rhizome, the golden cypress, the fructus amomi, the red sorghum and the pinellia ternate are combined to play a role in guiding yang to enter yin, communicating heart and kidney and promoting sleep, and the honey-fried licorice root, the bighead atractylodes rhizome, the hawthorn and the green tangerine peel have functions of building spleen and stomach and promoting digestion, are matched with other components to realize a synergistic interaction effect of the medicines, and therefore have functions of helping sleep, enhancing immunity, relieving fatigue, promoting gastrointestinal function recovery and stomach distention and stomachache.

It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the invention, and that any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. The navel patch formula for assisting sleep and promoting gastrointestinal function recovery is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight:

2. The navel patch formula for assisting sleep and promoting gastrointestinal function recovery as claimed in claim 1, which is prepared from the following Chinese medicinal raw materials in parts by weight: 90 parts of monkshood, 20 parts of roasted liquorice, 50 parts of ginger, 20 parts of cassia twig tip, 20 parts of bighead atractylodes rhizome, 15 parts of hawthorn, 20 parts of poria with hostwood, 20 parts of rhizoma acori graminei, 40 parts of golden cypress, 20 parts of fructus amomi, 40 parts of pinellia ternate, 40 parts of red sorghum, 30 parts of epimedium herb, 30 parts of fructus psoraleae, 15 parts of fennel, 15 parts of rheum officinale and 15 parts of pericarpium citri reticulatae viride.

3. The navel patch formulation for aiding sleep and promoting gastrointestinal function recovery according to claim 1, wherein the formulation further comprises a conditioning paste.

4. The navel patch formulation for aiding sleep and promoting recovery of gastrointestinal function according to claim 3, wherein the cream modifier is yellow lead.

5. A navel patch formulation for aiding sleep and promoting recovery of gastrointestinal functions as claimed in any one of claims 1 to 4, comprising the steps of: