CN111789078B - 一种大鼠非肥胖非酒精性脂肪性肝病模型的建立方法 - Google Patents
一种大鼠非肥胖非酒精性脂肪性肝病模型的建立方法 Download PDFInfo
- Publication number
- CN111789078B CN111789078B CN202010699701.4A CN202010699701A CN111789078B CN 111789078 B CN111789078 B CN 111789078B CN 202010699701 A CN202010699701 A CN 202010699701A CN 111789078 B CN111789078 B CN 111789078B
- Authority
- CN
- China
- Prior art keywords
- rat
- rats
- feed
- liver
- obese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 24
- 238000013232 NAFLD rodent model Methods 0.000 title claims abstract description 10
- 241000700159 Rattus Species 0.000 claims abstract description 102
- 244000068988 Glycine max Species 0.000 claims abstract description 31
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 31
- 235000006486 human diet Nutrition 0.000 claims abstract description 18
- 230000001575 pathological effect Effects 0.000 claims abstract description 9
- 238000004088 simulation Methods 0.000 claims abstract description 9
- 238000012545 processing Methods 0.000 claims abstract description 6
- 210000004185 liver Anatomy 0.000 claims description 39
- 238000010171 animal model Methods 0.000 claims description 23
- 241001465754 Metazoa Species 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 9
- 210000002966 serum Anatomy 0.000 claims description 9
- 230000037396 body weight Effects 0.000 claims description 8
- 238000000465 moulding Methods 0.000 claims description 8
- 238000011156 evaluation Methods 0.000 claims description 6
- 230000003278 mimic effect Effects 0.000 claims description 6
- 230000037406 food intake Effects 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 235000012631 food intake Nutrition 0.000 claims description 4
- 239000008399 tap water Substances 0.000 claims description 4
- 235000020679 tap water Nutrition 0.000 claims description 4
- 230000003044 adaptive effect Effects 0.000 claims description 3
- 238000010276 construction Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract description 43
- 235000005911 diet Nutrition 0.000 abstract description 11
- 208000008589 Obesity Diseases 0.000 abstract description 8
- 230000037213 diet Effects 0.000 abstract description 8
- 235000020824 obesity Nutrition 0.000 abstract description 8
- 238000003745 diagnosis Methods 0.000 abstract description 7
- 230000008506 pathogenesis Effects 0.000 abstract description 6
- 238000011160 research Methods 0.000 abstract description 5
- 230000007547 defect Effects 0.000 abstract description 3
- 150000002632 lipids Chemical class 0.000 abstract description 3
- 206010006895 Cachexia Diseases 0.000 abstract description 2
- 208000026500 emaciation Diseases 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 description 20
- 230000000052 comparative effect Effects 0.000 description 14
- 206010016654 Fibrosis Diseases 0.000 description 13
- 230000008859 change Effects 0.000 description 13
- 231100000240 steatosis hepatitis Toxicity 0.000 description 12
- 206010019708 Hepatic steatosis Diseases 0.000 description 11
- 208000019425 cirrhosis of liver Diseases 0.000 description 11
- 230000004761 fibrosis Effects 0.000 description 11
- 206010061218 Inflammation Diseases 0.000 description 8
- 235000013305 food Nutrition 0.000 description 8
- 230000004054 inflammatory process Effects 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 208000004930 Fatty Liver Diseases 0.000 description 7
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 description 7
- 238000010186 staining Methods 0.000 description 7
- 206010022489 Insulin Resistance Diseases 0.000 description 6
- 208000010706 fatty liver disease Diseases 0.000 description 6
- 230000007863 steatosis Effects 0.000 description 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 6
- 206010067125 Liver injury Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 210000002640 perineum Anatomy 0.000 description 5
- 235000021067 refined food Nutrition 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 231100000753 hepatic injury Toxicity 0.000 description 4
- 210000003494 hepatocyte Anatomy 0.000 description 4
- 235000009200 high fat diet Nutrition 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 210000005228 liver tissue Anatomy 0.000 description 4
- 230000036542 oxidative stress Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000003642 reactive oxygen metabolite Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 208000004611 Abdominal Obesity Diseases 0.000 description 3
- 206010065941 Central obesity Diseases 0.000 description 3
- 206010019668 Hepatic fibrosis Diseases 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000000378 dietary effect Effects 0.000 description 3
- 235000008242 dietary patterns Nutrition 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000001338 necrotic effect Effects 0.000 description 3
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 3
- 230000000405 serological effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 108700037728 Glycine max beta-conglycinin Proteins 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 208000001145 Metabolic Syndrome Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 108010073771 Soybean Proteins Proteins 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102100040247 Tumor necrosis factor Human genes 0.000 description 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000007882 cirrhosis Effects 0.000 description 2
- 235000021316 daily nutritional intake Nutrition 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000012041 food component Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000002440 hepatic effect Effects 0.000 description 2
- 210000004969 inflammatory cell Anatomy 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 230000017074 necrotic cell death Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 238000011552 rat model Methods 0.000 description 2
- 235000013597 soy food Nutrition 0.000 description 2
- 235000019710 soybean protein Nutrition 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000016261 weight loss Diseases 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 206010057573 Chronic hepatic failure Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 108010010256 Dietary Proteins Proteins 0.000 description 1
- 102000015781 Dietary Proteins Human genes 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000010334 End Stage Liver Disease Diseases 0.000 description 1
- 206010048554 Endothelial dysfunction Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000001284 I-kappa-B kinase Human genes 0.000 description 1
- 108060006678 I-kappa-B kinase Proteins 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 208000017170 Lipid metabolism disease Diseases 0.000 description 1
- 208000000501 Lipidoses Diseases 0.000 description 1
- 206010024585 Lipidosis Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 235000019752 Wheat Middilings Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 210000000702 aorta abdominal Anatomy 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000020974 cholesterol intake Nutrition 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 208000011444 chronic liver failure Diseases 0.000 description 1
- 231100000012 chronic liver injury Toxicity 0.000 description 1
- 229940000425 combination drug Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000021245 dietary protein Nutrition 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 230000008694 endothelial dysfunction Effects 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 150000002333 glycines Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000001596 intra-abdominal fat Anatomy 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000004132 lipogenesis Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000018191 liver inflammation Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004066 metabolic change Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000003170 nutritional factors Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000011049 pearl Substances 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 230000003617 peroxidasic effect Effects 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/50—Feeding-stuffs specially adapted for particular animals for rodents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/25—Animals on a special diet
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Husbandry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Environmental Sciences (AREA)
- Physiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Birds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
蛋白源 | 大豆粕、鱼粉 |
脂肪源 | 植物油 |
纤维源 | 麸皮 |
碳水化合物源 | 玉米、次粉 |
维生素 | VA、VD、VE、VB1、VB2、VB6、泛酸等 |
矿物质 | 磷酸氢钙、石粉、铁、铜、锰、锌等 |
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010699701.4A CN111789078B (zh) | 2020-07-20 | 2020-07-20 | 一种大鼠非肥胖非酒精性脂肪性肝病模型的建立方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010699701.4A CN111789078B (zh) | 2020-07-20 | 2020-07-20 | 一种大鼠非肥胖非酒精性脂肪性肝病模型的建立方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111789078A CN111789078A (zh) | 2020-10-20 |
CN111789078B true CN111789078B (zh) | 2022-02-25 |
Family
ID=72808071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010699701.4A Active CN111789078B (zh) | 2020-07-20 | 2020-07-20 | 一种大鼠非肥胖非酒精性脂肪性肝病模型的建立方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111789078B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113180008A (zh) * | 2021-05-13 | 2021-07-30 | 邵建国 | 基于FibroTouch的非酒精性脂肪性肝病大鼠模型及制作、检测方法 |
CN114375905B (zh) * | 2022-01-05 | 2023-05-12 | 重庆医科大学附属儿童医院 | 一种肝纤维化动物模型的构建方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104509705A (zh) * | 2013-09-29 | 2015-04-15 | 中国人民解放军南京军区南京总医院 | 一种复合高脂饲料在构建非酒精性脂肪肝大鼠模型中的应用 |
CN105850868A (zh) * | 2016-03-28 | 2016-08-17 | 大连大学 | 一种利用ApoE-/-小鼠建立非酒精性脂肪肝模型的方法 |
CN107156049A (zh) * | 2017-06-20 | 2017-09-15 | 遵义医学院 | 一种代谢综合征的大鼠模型建立方法 |
CN107801691A (zh) * | 2017-12-06 | 2018-03-16 | 凯斯艾生物科技(苏州)有限公司 | 一种非酒精性慢性脂肪性肝炎大鼠模型及其构建方法和用途 |
-
2020
- 2020-07-20 CN CN202010699701.4A patent/CN111789078B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104509705A (zh) * | 2013-09-29 | 2015-04-15 | 中国人民解放军南京军区南京总医院 | 一种复合高脂饲料在构建非酒精性脂肪肝大鼠模型中的应用 |
CN105850868A (zh) * | 2016-03-28 | 2016-08-17 | 大连大学 | 一种利用ApoE-/-小鼠建立非酒精性脂肪肝模型的方法 |
CN107156049A (zh) * | 2017-06-20 | 2017-09-15 | 遵义医学院 | 一种代谢综合征的大鼠模型建立方法 |
CN107801691A (zh) * | 2017-12-06 | 2018-03-16 | 凯斯艾生物科技(苏州)有限公司 | 一种非酒精性慢性脂肪性肝炎大鼠模型及其构建方法和用途 |
Non-Patent Citations (2)
Title |
---|
过度煎炸油对大鼠氧化应激及相关基因表达的影响;周中凯等;《粮食与油脂》;20160510;第29卷(第5期);第43-46页 * |
远红外线烘烤干黄豆的营养效用——Ⅱ.用远红外线烘烤干黄豆的营养效果观察(动物实验);刘冬生等;《卫生研究》;19850630;第14卷(第3期);第25-30页 * |
Also Published As
Publication number | Publication date |
---|---|
CN111789078A (zh) | 2020-10-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SADIQ | SEX REVERSAL OF NILE TILAPIA Oreochromis niloticus (LINNEAUS, 1758) USING DIFFERENTLY PROCESSED Tribulus terrestris L. EXTRACTS | |
Genta et al. | Subchronic 4-month oral toxicity study of dried Smallanthus sonchifolius (yacon) roots as a diet supplement in rats | |
CN111789078B (zh) | 一种大鼠非肥胖非酒精性脂肪性肝病模型的建立方法 | |
CN102524536B (zh) | 茶黄素作为饲料添加剂的用途及相应饲料 | |
Tan et al. | Dietary Ginkgo biloba leaf extracts supplementation improved immunity and intestinal morphology, antioxidant ability and tight junction proteins mRNA expression of hybrid groupers (Epinephelus lanceolatus♂× Epinephelus fuscoguttatus♀) fed high lipid diets | |
Eissa et al. | Nano-selenium impacts on growth performance, digestive enzymes, antioxidant, immune resistance and histopathological scores of Nile tilapia, Oreochromis niloticus against Aspergillus flavus infection | |
JP5762693B2 (ja) | 生脈散エキスを利用した生脈散豆腐の製造方法(preparingmethodofsaengmaeksanbeancurdusingsaengmaeksanextract) | |
Bahari | Effect of Elateriospermum tapos extract as coadjuvant in ameliorating maternal obesity on female offspring at weaning | |
Jia et al. | Evaluation of silymarin extract from Silybum marianum in mice: anti-fatigue activity | |
Yu et al. | Dietary macroalgae Saccharina japonica ameliorates liver injury induced by a high-carbohydrate diet in swamp eel (Monopterus albus) | |
Yang et al. | Effects of dietary incorporation of Radix rehmanniae praeparata polysaccharide on growth performance, digestive physiology, blood metabolites, meat quality, and tibia characteristics in broiler chickens | |
Liu et al. | Eucommia ulmoides Oliver enhances the antioxidant capacity and protects Micropterus salmoides from liver damage and immune function impairment caused by a high starch diet | |
Yu et al. | The suppressive mechanism of dietary macroalgae Saccharina japonica against hepatic lipid accumulation in black seabream A. schlegelii | |
CN112057491A (zh) | 铁苋菜水提物在制备减肥降脂药物或减肥降脂保健品中的应用 | |
Balan et al. | Transgenerational evaluation of Elateriospermum tapos extracts on the male offspring of obesity-induced sprague dawley rats | |
CN105963327A (zh) | 一种预防及治疗肝功能损伤的维生素k2组合物 | |
Abdel-Tawwab et al. | Effects of exogenous bile acids (BAs) on growth, lipid profile, digestive enzymes, and immune responses of thinlip mullet, Liza ramada | |
CN108079217A (zh) | 一种轻身丸 | |
Zhang et al. | Ameliorating the effect and mechanism of chitosan oligosaccharide on nonalcoholic fatty liver disease in mice | |
Daniel et al. | Effects of olives and their constituents on the expression of ulcerative colitis: A systematic review of randomised controlled trials | |
Ayad et al. | Protective effect of pomegranate peel extract on dietary-induced non-alcoholic fatty liver disease | |
OLUBIYI et al. | Comparison of the impact of lauric acid and coconut oil on sperm quality and testicular function in streptozotocin-induced diabetic male Wistar rats. | |
Dewi et al. | EFFECT OF EXTRACT ACALYPHA INDICA L. ON LIPID PROFILE AND CARDIAC TROPONIN-T OF RATS FED WITH HIGH FRUCTOSE AND CHOLESTEROL DIET | |
Anggreini et al. | FORMULATION AND NUTRITIONAL EVALUATION OF HIGH-FAT DIET FEED FOR FATTY LIVER INDUCEMENT IN RODENT MODELS | |
CN101658576A (zh) | 化橘红总黄酮在制备治疗酒精性肝损伤的药物中的用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20211130 Address after: No.37 Xueyuan Road, Haidian District, Beijing Applicant after: BEIHANG University Applicant after: China Japan Friendship Hospital (China Japan Friendship Institute of clinical medicine) Applicant after: JINAN CENTER Hospital Address before: No.37 Xueyuan Road, Haidian District, Beijing Applicant before: BEIHANG University Applicant before: China Japan Friendship Hospital (China Japan Friendship Institute of clinical medicine) |
|
GR01 | Patent grant | ||
GR01 | Patent grant |