CN111773373A - Hip-protecting preparation and application thereof in paper diapers - Google Patents
Hip-protecting preparation and application thereof in paper diapers Download PDFInfo
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- CN111773373A CN111773373A CN202010484388.2A CN202010484388A CN111773373A CN 111773373 A CN111773373 A CN 111773373A CN 202010484388 A CN202010484388 A CN 202010484388A CN 111773373 A CN111773373 A CN 111773373A
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- A61K38/00—Medicinal preparations containing peptides
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- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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Abstract
The invention relates to the field of sanitary external products, and particularly discloses a hip-protecting preparation and application thereof in preparation of paper diapers.
Description
Technical Field
The invention relates to the field of sanitary external products, in particular to a hip-protecting preparation and application thereof in preparation of paper diapers.
Background
Along with the improvement of living standard of people, the use of disposable articles is more and more common, in particular to the application of paper diapers, the sales volume of the paper diapers for children or adults is increased year by year, but the long-term friction of the coating layer to the skin in the process of frequently putting on and taking off the paper diaper easily causes mechanical physical damage, meanwhile, as the basement membrane of the anti-leakage paper diaper is made of organic fiber materials, the local environment has higher temperature and humidity and bacteria are easy to propagate, particularly, urine and amino components in excrement easily cause skin microenvironment imbalance, blockage and damage to skin barriers, the epidermis of an infant is more easily affected by hydration and finally causes skin injuries such as diaper rash, the diaper rash is a common skin inflammatory lesion of the infant and is mostly generated by urine immersion stimulation and bacterial breeding in a humid environment, the lipid layer of the skin of the infant is damaged to aggravate local inflammatory reaction, red swelling and even ulceration are generated, and bacterial infection and general urethral diseases are caused more seriously.
In the prior art, the air permeability or the water absorption performance of absorbent resin of the surface layer of the paper diaper is improved, so that the dry, soft and water-guiding performance of the paper diaper is enhanced, and skin damage is avoided, or skin care ingredients, pH regulation and the like are added, for example, CN110946712A discloses an infant paper diaper which can play a role in nursing the hip-softening and fat-building, wherein the surface coating layer is provided with a surface layer and a flow guide layer, and the surface coating layer contains the skin care ingredients; the absorption core layer is added with pH control component, the skin care component contains alcohol formate, diglycerol, mefenamic acid, biguanide, aloe gel, vitamin E, citric acid, etc., and the pH control component and ammonia inhibiting component include ethanol ester and tea polyphenols. It is primarily intended to prevent skin irritation and diaper rash from occurring by controlling the pH. However, the addition of acidic components to change the pH may result in a change in the pH of the normal skin surface, and there is no additional benefit to the skin when used without urine and other fecal matter; in addition, it does not reduce harmful substances and adhesion of excrement itself and improve odor. The moisture content of the skin of infants is quite high, and can reach 40%, so that the skin of infants appears very young and tender, and skin diseases can occur when the moisture content of the horny layer is lower than 10%. Is sensitive to external stimulation, and natural moisturizing and allergy-relieving skin care products are more needed.
Disclosure of Invention
The invention aims to overcome the defects and provide a hip-care product, which weakens the damage of excrement to the skin and obviously reduces the odor through natural active substances and the synergistic action thereof, not only forms a natural barrier to the skin and ensures that the excrement is not easy to adhere to the skin, but also has the effects of preventing and treating diaper rash, urethritis and the like through natural active antibacterial and anti-inflammatory ingredients. The adhesive mainly comprises the following components in parts by mass: 1-3 parts of yeast polypeptide freeze-dried powder, 0.5-3 parts of pomegranate seed extract, 1-6 parts of cranberry extract, 1-10 parts of yarrow extract, 0.5-1 part of bletilla powder, 2-3 parts of sodium pyrrolidone carboxylate, 0.1-1 part of menthyl lactate and 0.1-1 part of hydrogenated polyisobutene.
The extraction process of semen Granati extract comprises drying cleaned semen Granati, pulverizing into coarse powder, adding 5-50 times of 70-95 deg.C hot water, ultrasonic extracting for 1-2 hr, repeating for 3 times, mixing extractive solutions, filtering, concentrating, and freeze drying to obtain semen Granati extract A component; adding the filter residues into 35-85% ethanol water solution, stirring and standing for 0.5-1h, filtering, extracting the filtrate, repeating for three times, mixing the filtrates, heating and concentrating, oven drying to obtain component B of semen Granati extract, and mixing the above A, B components to obtain semen Granati extract powder.
The extraction process of the cranberry extract comprises the following steps: pulverizing cranberry fruit, adding 65-85% ethanol water solution, extracting at 30-60 deg.C under countercurrent for 4-6 hr, filtering, mixing filtrates, concentrating, and drying to obtain cranberry extract powder.
The yarrow extract is prepared by washing yarrow, drying, pulverizing in a pulverizer, grinding in a mill, adding into a Soxhlet extractor, adding ethanol solution, heating under reflux for 0.5-2h, collecting ethanol to obtain yarrow extract liquid, and spray drying or freeze drying to obtain yarrow extract powder.
The preparation product of the invention is in the form of spray, emulsion, cream or ointment, and can be directly smeared on the surface of the skin or sprayed on the bottom of the surface layer of the paper diaper.
The invention also provides a hip-protecting emulsion which is characterized by comprising the following components:
1-3 parts of yeast polypeptide freeze-dried powder
0.5-3 parts of pomegranate seed extract powder
1-6 parts of cranberry extract powder
1-10 parts of yarrow extract powder
0.5-1 part of bletilla striata powder
2-3 parts of sodium pyrrolidone carboxylate
Menthyl lactate 0.1-1 part
0.1 to 1 portion of hydrogenated polyisobutene
0.2-1 part of hydrogenated lecithin
0.1-2 parts of vitamin E acetate
0.5 to 1 portion of zinc oxide
1.5-10 parts of sesame oil
0.1-1 part of dipotassium glycyrrhizinate
0.1 to 2 portions of surfactant
0.1 to 0.2 portion of preservative
2-9 parts of deionized water.
The emulsion is prepared by sequentially adding menthyl lactate, hydrogenated polyisobutene, hydrogenated lecithin, vitamin E acetate, and oleum Sesami into an emulsifying pot, mixing, adding zinc oxide, and stirring at 60-80 deg.C for 15-45 min to obtain component A; adding a surfactant and sodium pyrrolidone carboxylate into deionized water, heating to 60-90 ℃, stirring, mixing or sequentially adding bletilla striata powder, yarrow extract powder, pomegranate seed extract powder and cranberry extract powder, stirring for 15-30 minutes, adding dipotassium glycyrrhizinate, uniformly stirring to obtain a component B, mixing, adding the component B into an emulsion pot A under the condition of heat preservation, homogenizing at 1500 revolutions per minute at the bottom of the emulsion pot, stirring at 30 revolutions per minute with a scraper in the emulsion pot at 60-90 ℃, stirring for 10-50 minutes, naturally cooling to room temperature, sequentially adding yeast polypeptide freeze-dried powder and a preservative into the emulsion pot, continuously stirring for 20 minutes, and uniformly mixing to obtain the yeast polypeptide. The surfactant is selected from one or more of dodecyl betaine, cetearyl glucoside and glycerol stearate. The preservative is selected from iodopropynyl butylcarbamate or bis (hydroxymethyl) imidazolidinyl urea.
The invention also provides a liquid-permeable surface layer of the hip-protecting antibacterial paper diaper, which is characterized in that the surface layer is made of non-woven fabric materials or natural fiber materials and contains the preparation components of claim 1. The preparation method comprises using non-woven fabric material or natural fiber material, cleaning, drying, pulverizing and grinding 0.5-3 parts of pomegranate seed, 1-6 parts of cranberry and 1-10 parts of yarrow respectively, mixing, adding 5-50 times of ethanol, stirring, adding 0.5-1 part of bletilla striata powder, subjecting the mixture to ultrasonic treatment at 40-80 deg.C for 0.5-1h, standing, recovering ethanol to obtain plant extract, adding 2-3 parts of sodium pyrrolidone carboxylate, 0.1-1 part of menthyl lactate and 0.1-1 part of hydrogenated polyisobutene, adding deionized water, stirring, mixing uniformly to obtain medicinal solution, soaking the non-woven fabric material or natural fiber material into the medicinal solution at a squeezing rate of 30-40% and a temperature of 25-45 deg.C, treating for 0.5-1h, and sterilizing with ultraviolet rays, 1-3 parts of yeast polypeptide freeze-dried powder is dissolved in deionized water, the concentration is 0.5g/100ml, after uniform spraying, low-temperature drying and shaping are carried out, and the liquid-permeable surface layer of the paper diaper is obtained.
The above plant extracts can be prepared by conventional methods or purchased as commercially available products, and are preferably prepared by the above methods. Wherein the cranberry extract contains procyanidin, ellagic acid, phenolic acid, resveratrol, etc., and has antibacterial effect. The cranberry has the effect of effectively preventing urinary tract infection, particularly urinary tract infection caused by escherichia coli, and the procyanidin not only resists bacterial adhesion, but also prevents pathogenic bacteria such as escherichia coli and the like from adhering to epithelial cells and bladder walls of the urinary tract, and the pathogenic bacteria flow away along with urine, so that the occurrence of urinary tract infection is prevented. The semen Granati extract contains punicosides and anthocyanins, and has broad-spectrum antibacterial effect on Shigella shigella, Staphylococcus aureus, Streptococcus hemolyticus, Vibrio cholerae, and Bacillus dysenteriae. The Achillea millefolium extract has effects of cleaning skin, keeping skin moisture, relieving skin sensitivity phenomenon and repairing astringency. Bletilla striata is slightly cold in nature and bitter and astringent in taste, enters lung channel, has the functions of astringing to stop bleeding, tonifying lung and promoting tissue regeneration, can reduce swelling and promote tissue regeneration, and is used for treating carbuncle, sore and toxin, and scald caused by water and fire.
The saccharomycete polypeptide as humectant and antisenility material is used in skin care product, and the application of the saccharomycete polypeptide in protecting diaper rash of infant paper diaper can improve the smell of excrement obviously, lower the sensitivity of skin to excrement and lower the incidence of diaper rash caused by combining the saccharomycete polypeptide with plant extract.
The invention has the advantages that the natural substances are combined for use, so that urine excrement is mildly isolated, skin adhesion excrement is reduced, bacteria are remarkably inhibited, diseases such as diaper rash and urethritis are effectively prevented and treated, and the smell of excrement is also improved. The bletilla striata can provide dry and comfortable skin feeling and improve the stability of polypeptide substances, the yeast polypeptide not only improves the taste of excrement, but also enhances the antibacterial effect of the plant extract and simultaneously promotes the skin to keep a healthy and clean state, and the combined use of the plant extract inhibits the breeding of bacteria without irritation and skin sensitivity. After the whole surface layer of the paper diaper prepared by the method is used, diaper rash and complications thereof are obviously reduced, excrement is not easy to adhere, odor disappears, and the skin is easier to keep a healthy and clean state. The sodium pyrrolidone carboxylate is used as cuticle softening agent, has moisture retention, water absorption and antistatic properties, the menthyl lactate has a skin cooling feeling after being used, and the hydrogenated polyisobutene is also called shark oil and has skin lipophilicity. The dipotassium glycyrrhizinate has multiple effects of bacteriostasis, inflammation diminishing, detoxification, anti-allergy, deodorization and the like. Has wide application in the industries of medicine, cosmetics, daily chemicals, food and the like. The hip care preparation prepared by the auxiliary materials is easy to spread and is mild in isolation when being used as a skin care health care product.
Detailed Description
Example 1 preparation of extract of raw materials
The plant extracts of the present invention can be prepared using commercially available raw materials or by conventional methods, preferably by the following processes: drying and pulverizing cleaned semen Granati into coarse powder, adding 5-50 times of 70-95 deg.C hot water, ultrasonic extracting for 1-2 hr, repeating for 3 times, mixing extractive solutions, filtering, concentrating, and freeze drying to obtain semen Granati extract A component; adding the filter residues into 35-85% ethanol water solution, stirring and standing for 0.5-1h, filtering, extracting the filtrate, repeating for three times, mixing the filtrates, heating and concentrating, oven drying to obtain component B of semen Granati extract, and mixing the above A, B components to obtain semen Granati extract powder. Pulverizing cranberry fruit, adding 65-85% ethanol water solution, extracting at 30-60 deg.C under countercurrent for 4-6 hr, filtering, mixing filtrates, concentrating, and drying to obtain cranberry extract powder. Cleaning Achillea millefolium L, drying, pulverizing in a pulverizer, grinding in a mill, adding into a Soxhlet extractor, adding ethanol solution, heating and refluxing for 0.5-2h, collecting ethanol to obtain Achillea millefolium L extract liquid, and spray drying or freeze drying to obtain Achillea millefolium L extract powder.
The yeast polypeptide is obtained from Guangdong Jinbaolai Biotech, and is lyophilized by conventional method, such as selecting purified water, deionized water, osmotic water and distilled water, etc. to adjust the concentration of yeast polypeptide to be(W/W) of the polypeptide solution; homogenizing with a high-speed homogenizer at a controlled rotation speed ofThe treatment time isObtaining homogenized solution, transferring into freezing tray for pre-freezing at pre-freezing temperatureThe pre-freezing time isThen the vacuum freeze dryer is arranged in a freezing bin of the vacuum freeze dryer,controlling the vacuum degree to be less than the lOPa, and the vacuum freeze-drying time to beThus obtaining the yeast polypeptide freeze-dried powder.
Example 2 preparation of solutions, gels and emulsions, respectively
Solution preparation: 2g of yeast polypeptide freeze-dried powder, 1.5g of pomegranate seed extract powder, 4g of cranberry extract powder, 5g of yarrow extract powder, 0.7g of bletilla striata powder, 2.5g of sodium pyrrolidone carboxylate, 0.5g of menthyl lactate and 0.5g of hydrogenated polyisobutene. . Adding the plant extract and the polypeptide freeze-dried powder into an organic phase: the water phase is 20: and (4) stirring the mixed solution of 80-40:60, wherein the organic phase is ethanol or acetone, and the water phase is deionized water or distilled water to obtain the mixed solution.
Preparing a gel agent: adding the mixed solution into transparent chitosan hydrogel or sodium alginate hydrogel, shaking in a shaking table, and adding dipotassium glycyrrhizinate 0.7g and antiseptic 0.1g to obtain hydrogel preparation of the composition.
Preparing an emulsion: sequentially putting 0.8g of menthyl lactate, 0.7g of hydrogenated polyisobutene, 0.7g of hydrogenated lecithin, 1g of vitamin E acetate and 8g of sesame oil into an emulsifying pot, uniformly mixing, then putting 0.7g of zinc oxide, and stirring for 15-45 minutes at 70 ℃ to obtain a component A for mixing; adding 1g of dodecyl betaine and 2.5g of sodium pyrrolidone carboxylate into deionized water, heating to 80 ℃, stirring, mixing or sequentially adding 1g of bletilla striata powder, 3g of achillea millefolium extract powder, 1g of pomegranate seed extract powder and 6g of cranberry extract powder, stirring for 20 minutes, adding 1g of dipotassium glycyrrhizinate, uniformly stirring to obtain a component B, mixing the component B under the condition of heat preservation to obtain a component B, adding the component B into an emulsion pot A, homogenizing the bottom of the emulsion pot at 1500 rpm, scraping a scraper in the emulsion pot at 30 rpm and 60-90 ℃, stirring for 10-50 minutes, naturally cooling to room temperature, sequentially adding 2g of yeast polypeptide freeze-dried powder, 0.1g of iodopropynyl butylcarbamate and 0.1g of bis (hydroxymethyl) imidazolidinyl urea into the emulsion pot, continuously stirring for 20 minutes, and uniformly mixing to obtain the composition.
Example 3 safety test
The hip care hydrogel/emulsion and solution formulations described in the examples of the invention were tested separately, with warm water for the control group. 15 young mice are used and divided into three groups, and the health meets the test requirements. The hydrogel/emulsion and the solution preparation are respectively tested, autologous left and right depilatory skins are used for comparison and test, the comparison side is only smeared with warm water, the preparation is smeared on the right depilatory skin once a day, and the preparation is cleaned after 12h and is continuously smeared for 7 days. And (6) observing the result.
The results showed that all animals had no skin allergy stress and no body toxicity. The preparation has no skin irritation.
Example 4 preparation of liquid-permeable surface layer of hip-protecting antibacterial paper diaper
Using non-woven fabric materials, taking 2g of pomegranate seeds, 3g of cranberry and 6g of yarrow, respectively cleaning, drying, crushing and grinding, mixing, adding 500 ml of 60% ethanol, stirring, adding 0.5g of bletilla striata powder, carrying out ultrasonic treatment on the mixture for 0.5h at 70 ℃, standing, recovering ethanol to obtain a plant extract, adding 2g of sodium pyrrolidone carboxylate, 0.5g of menthyl lactate and 0.5g of hydrogenated polyisobutene, adding deionized water until stirring and mixing uniformly to obtain a medicinal solution, using an impregnation method, immersing the non-woven fabric materials or natural fiber materials into the solution, carrying out ultraviolet disinfection after treating at 35 ℃ for 0.5h, dissolving 2g of yeast polypeptide freeze-dried powder into the deionized water, carrying out concentration of 0.5g/100ml, uniformly spraying, and carrying out low-temperature drying and shaping to obtain the liquid permeable surface layer of the paper diaper.
Example 5 antimicrobial testing
Experimental group 1: the liquid-permeable top layer containing the preparation of the invention prepared in example 4 was cut into 10 × 10cm square pieces, 20mL of physiological saline was poured, and after complete absorption, the liquid-permeable top layer was placed in a closed environment (37 ℃, relative humidity of 75%) in which an open-cell cultured E.coli culture and a Streptococcus culture were placed.
Experimental group 2: the nonwoven material was cut into 10 × 10cm square pieces, the emulsion prepared in example 2 was applied, 20mL of physiological saline was poured, and after complete absorption, the mixture was placed in a closed environment (37 ℃, relative humidity of 75%), and the open culture of escherichia coli and streptococcus was placed in the closed environment.
Experimental group 3: the nonwoven material was cut into 10 × 10cm square pieces, applied with the hydrogel prepared in example 2, poured with 20mL of physiological saline, placed in a closed environment (37 ℃, relative humidity 75%) after complete absorption, and the open culture of escherichia coli and streptococcus was placed in the closed environment.
Experimental group 4: the nonwoven material was cut into 10 × 10cm square pieces, smeared with the emulsion prepared in example 2, but not containing the yeast polypeptide lyophilized powder, poured with 20mL of physiological saline, placed in a closed environment (37 ℃, relative humidity of 75%) after it was completely absorbed, and placed in the closed environment with the open culture of escherichia coli and streptococcus culture.
Experimental group 5: the nonwoven material was cut into 10 × 10cm square pieces, applied with the emulsion prepared in example 2, but without the addition of the yarrow extract, pomegranate seed extract, and cranberry extract, and poured in 20mL of physiological saline, and after complete absorption, placed in a closed environment (37 ℃, relative humidity of 75%), and the open culture of escherichia coli and the culture of streptococcus were placed in the closed environment.
Control group: the non-woven fabric material is cut into 10 × 10cm square pieces, 20mL of physiological saline is poured, after the physiological saline is completely absorbed, the non-woven fabric material is placed in a closed environment (37 ℃, the relative humidity is 75%), and an open culture of escherichia coli and a culture of streptococcus are placed in the closed environment.
After the experimental group and the control group are respectively placed for 20min, 3h and 7h, the colony count (CFU/mL) on the paper diapers of the experimental group and the control group is measured, the specific measurement method is that the non-woven fabric material is cut into pieces and then is dispersed in 50mL of deionized water, the soaked and filtered, 1mL of sample is taken to be cultured in an incubator (37 ℃) for 48h, the total number of the colonies is measured, and the average value is taken in 5 batches of tests. The test results are shown in the following table:
therefore, the antibacterial performance of the preparation is gradually shown along with the increase of time, the control group has poor antibacterial performance, the colony number is increased along with the increase of time, the antibacterial effect of the emulsion group is best, the components have synergistic effect, and the drug effect is exerted to the maximum extent by the combined use of the saccharomycete polypeptide and the plant extract, so that the paper diaper and the preparation prepared by the invention have good antibacterial performance.
EXAMPLE 6 deodorizing Effect
Taking paper diapers of the same brand, cutting the paper diapers into square pieces of 15 x 15cm, putting the square pieces into a sealing box for fixing, and dividing the paper diapers into two groups, wherein the emulsion prepared in the embodiment 2 of the invention is completely coated on one group of the paper diapers, and the extract group is the emulsion prepared in the embodiment 2, but does not contain saccharomycete polypeptide; the yeast polypeptide group was the emulsion prepared by the method of example 2 but without the addition of yarrow extract, pomegranate seed extract, cranberry extract, and the other blank group was not coated with any formulation. Odorous substances are injected through the needle holes of the box cover, the odorous substances are three groups, one group is urine and excrement mixed liquor, the other group is female physiological secretion, and the other group is provided with a control group and adopts distilled water. The three groups of samples are placed in an environment with room temperature and 40% humidity, 10ml of the samples are extracted after the samples are placed for 4-5 hours, and the injection needle tubes are injected into the samples and the blank group of closed boxes. Adopting a sensory evaluation method, opening the box body by 10-20 testers under the double-blind condition, carrying out smell-smelling scoring within a distance of 5cm, testing each sample for 3 times, and taking an average value. The degree of malodor is calculated using the score. 5: strong malodor; 4: strong odor; 3: unpleasant odors that are easily smelled; 2: a tolerable odor; 1: a weak taste; 0: without any taste. The measurement evaluation was performed 5min, 30min and 50min after the sample injection. The extract group and the yeast polypeptide group were evaluated after 50 min.
It can be seen that the deodorant effect of the preparation is enhanced with time, probably due to the composition inhibiting urease in the excreta or the decrease of odor-causing substances in the excreta, the deodorant effect of the yeast polypeptide is remarkable, and the extract group probably eliminates a small amount of odor by the effect of inhibiting bacteria.
Example 7 skin Effect test
A commercially available ordinary diaper was selected, the test subjects were infants aged 0-2 years with a history of diaper rash, the test groups were applied with the emulsion described in example 2 of the present invention, the control group was applied with the ordinary diaper rash cream, and the blank group was applied without any formulation. No antiallergic agent or external preparation is used 24 hours before use. Using a multicenter randomized controlled study, 15 each of the test/control/blank groups were compared for 7 days with the emulsion of example 2/hospital normal cream and without any formulation, two coating observations per day.
The test result of the baby shows that: the composition preparation can improve the adhesion of excrement, the skin is cleaner and drier, and the diaper rash and skin damage conditions are better than the common diaper rash cream in hospitals.
According to the test results, the composition has a synergistic effect, has a good effect of protecting and isolating skin, and not only improves the adhesion of excrement and eliminates the odor of the excrement after being coated, but also has the effects of natural antibiosis, bacteriostasis, skin care and allergy relief. The skin has improved dry and comfortable feeling, the yeast polypeptide not only improves the taste of excrement, but also enhances the antibacterial effect of the plant extract, and the combined use of the plant extract inhibits the breeding of bacteria, and has no irritation and skin sensitivity. After the whole surface layer of the paper diaper prepared by the method is used, diaper rash and complications thereof are obviously reduced, odor disappears, and the skin is easier to keep a healthy and clean state.
Based on the above teachings, those skilled in the art can make improvements and modifications, and the specific embodiments of the present invention are merely illustrative and not restrictive, and those skilled in the art can make modifications and equivalent substitutions without departing from the spirit and scope of the present invention, and such technical solutions should be covered by the claims of the present invention.
Claims (10)
1. A hip care preparation is characterized by comprising the following components by weight: 1-3 parts of yeast polypeptide freeze-dried powder, 0.5-3 parts of pomegranate seed extract, 1-6 parts of cranberry extract, 1-10 parts of yarrow extract, 0.5-1 part of bletilla powder, 2-3 parts of sodium pyrrolidone carboxylate, 0.1-1 part of menthyl lactate and 0.1-1 part of hydrogenated polyisobutene.
2. The hip care formulation according to claim 1, wherein: the extraction process of semen Granati extract comprises drying cleaned semen Granati, pulverizing into coarse powder, adding 5-50 times of 70-95 deg.C hot water, ultrasonic extracting for 1-2 hr, repeating for 3 times, mixing extractive solutions, filtering, concentrating, and freeze drying to obtain semen Granati extract A component; adding the filter residues into 35-85% ethanol water solution, stirring and standing for 0.5-1h, filtering, extracting the filtrate, repeating for three times, mixing the filtrates, heating and concentrating, oven drying to obtain component B of semen Granati extract, and mixing the above A, B components to obtain semen Granati extract powder.
3. The formulation of claim 1, wherein the cranberry extract is extracted by a process comprising: pulverizing cranberry fruits, adding 65-85% ethanol water solution, extracting under countercurrent at 30-60 deg.C for 4-6 hr, filtering, mixing filtrates, concentrating, and drying to obtain cranberry extract powder.
4. The preparation according to claim 1, wherein the yarrow extract is prepared by washing yarrow, drying, pulverizing in a pulverizer, grinding thoroughly in a mill, adding into a Soxhlet extractor, adding ethanol solution, heating under reflux for 0.5-2h, collecting ethanol to obtain a yarrow extract liquid, and spray-drying or freeze-drying to obtain a yarrow extract powder.
5. The hip-protecting emulsion is characterized by comprising the following components:
1-3 parts of yeast polypeptide freeze-dried powder
0.5-3 parts of pomegranate seed extract powder
1-6 parts of cranberry extract powder
1-10 parts of yarrow extract powder
0.5-1 part of bletilla striata powder
2-3 parts of sodium pyrrolidone carboxylate
Menthyl lactate 0.1-1 part
0.1 to 1 portion of hydrogenated polyisobutene
0.2-1 part of hydrogenated lecithin
0.1-2 parts of vitamin E acetate
0.5 to 1 portion of zinc oxide
1.5-10 parts of sesame oil
0.1-1 part of dipotassium glycyrrhizinate
0.1 to 2 portions of surfactant
0.1 to 0.2 portion of preservative
2-9 parts of deionized water.
6. The emulsion according to claim 5, wherein the preparation method comprises sequentially adding menthyl lactate, hydrogenated polyisobutene, hydrogenated lecithin, vitamin E acetate, and oleum Sesami in parts by weight into an emulsifying pot, mixing well, adding zinc oxide, stirring at 60-80 deg.C for 15-45 min to obtain component A, and mixing; adding a surfactant and sodium pyrrolidone carboxylate into deionized water, heating to 60-90 ℃, stirring, mixing or sequentially adding bletilla striata powder, yarrow extract powder, pomegranate seed extract powder and cranberry extract powder, stirring for 15-30 minutes, adding dipotassium glycyrrhizinate, uniformly stirring to obtain a component B, mixing, adding the component B into an emulsion pot A under the condition of heat preservation, homogenizing at 1500 revolutions per minute at the bottom of the emulsion pot, stirring at 30 revolutions per minute with a scraper in the emulsion pot at 60-90 ℃, stirring for 10-50 minutes, naturally cooling to room temperature, sequentially adding yeast polypeptide freeze-dried powder and a preservative into the emulsion pot, continuously stirring for 20 minutes, and uniformly mixing to obtain the yeast polypeptide.
7. An emulsion according to claims 5-6, characterized in that the surfactant is selected from one or more of dodecyl betaine, cetearyl glucoside, glyceryl stearate; the preservative is selected from iodopropynyl butylcarbamate or bis (hydroxymethyl) imidazolidinyl urea.
8. The preparation according to claim 1, characterized in that it is prepared in the form of a gel, spray, emulsion, cream or ointment, which is applied directly to the skin surface or to the bottom of the top layer of a diaper.
9. A liquid-permeable surface layer of a hip-protecting antibacterial paper diaper, which is characterized in that the surface layer is made of a non-woven fabric material or a natural fiber material and contains the combined components of claim 1.
10. A method for preparing a liquid-permeable surface layer of a hip-protecting antibacterial paper diaper is characterized in that a non-woven fabric material or a natural fiber material is used and is prepared by the following steps of taking 0.5-3 parts of pomegranate seeds, 1-6 parts of cranberry and 1-10 parts of achillea, respectively cleaning, drying, grinding, mixing, adding 5-50 times of ethanol, stirring, adding 0.5-1 part of bletilla striata powder, carrying out ultrasonic treatment on the mixture at 40-80 ℃ for 0.5-1h, standing, recovering ethanol to obtain a plant extract, adding 2-3 parts of sodium pyrrolidone carboxylate, 0.1-1 part of menthyl lactate and 0.1-1 part of hydrogenated polyisobutene, adding deionized water, stirring and mixing uniformly to obtain a medicinal solution, using an impregnation method, immersing the non-woven fabric material or the natural fiber material into the solution, wherein the liquid rolling rate is 30-40%, ultraviolet sterilization is carried out after the treatment for 0.5-1h at the temperature of 25-45 ℃, 1-3 parts of yeast polypeptide freeze-dried powder is dissolved in deionized water with the concentration of 0.5g/100ml, and after the yeast polypeptide freeze-dried powder is uniformly sprayed, the liquid-permeable surface layer of the paper diaper is obtained after low-temperature drying and shaping.
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CN116870043A (en) * | 2023-08-07 | 2023-10-13 | 河北瑞龙生物科技有限公司 | Method for extracting antioxidant from pomegranate seeds |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101966137A (en) * | 2010-09-30 | 2011-02-09 | 天津市中科健新材料技术有限公司 | Multi-efficacy skin-care preparation composition as well as preparation method and application thereof |
CN102908656A (en) * | 2012-10-17 | 2013-02-06 | 天津市中科健新材料技术有限公司 | Coolness delivery composition for absorptive product and preparation method thereof |
CN103690451A (en) * | 2013-12-30 | 2014-04-02 | 青蛙王子(中国)日化有限公司 | W/O diaper cream for babies and children as well as preparation method thereof |
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CN101966137A (en) * | 2010-09-30 | 2011-02-09 | 天津市中科健新材料技术有限公司 | Multi-efficacy skin-care preparation composition as well as preparation method and application thereof |
CN102908656A (en) * | 2012-10-17 | 2013-02-06 | 天津市中科健新材料技术有限公司 | Coolness delivery composition for absorptive product and preparation method thereof |
CN103690451A (en) * | 2013-12-30 | 2014-04-02 | 青蛙王子(中国)日化有限公司 | W/O diaper cream for babies and children as well as preparation method thereof |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116870043A (en) * | 2023-08-07 | 2023-10-13 | 河北瑞龙生物科技有限公司 | Method for extracting antioxidant from pomegranate seeds |
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