CN111773348B

CN111773348B - Traditional Chinese medicine composition for treating cough and preparation method and application thereof

Info

Publication number: CN111773348B
Application number: CN202010838265.4A
Authority: CN
Inventors: 王国斌; 黄艳; 周淼; 车志英; 崔丽红
Original assignee: Individual
Current assignee: Henan Huilin Medical Equipment Co.,Ltd.
Priority date: 2020-08-19
Filing date: 2020-08-19
Publication date: 2021-11-23
Anticipated expiration: 2040-08-19
Also published as: CN111773348A

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating cough and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-10 parts of fried radish seed, 10-20 parts of fried perilla seed, 9-20 parts of radix peucedani, 10-20 parts of ginger magnolia bark, 10-20 parts of pummelo peel, 10-22 parts of rhizoma pinellinae praeparata, 12-23 parts of angelica, 20-40 parts of fried spina date seed, 10-20 parts of roasted loquat leaf, 12-22 parts of roasted aster and 5-11 parts of fructus amomi. The traditional Chinese medicine composition for treating cough provided by the invention follows the principle of clinical dialectical treatment and prescription selection, has the rigor of monarch, minister, assistant and guide compatibility of the prescription, is deeply combined with modern clinic, and repeatedly carries out addition and subtraction according to the feedback of relevant clinical curative effects, so that a prescription with stable efficacy and wide application range is formed.

Description

Traditional Chinese medicine composition for treating cough and preparation method and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating cough and a preparation method and application thereof.

Background

Cough is a lung disease, which is caused by the failure of the lung to disperse and descend and the adverse rising of lung qi due to the external attack of six pathogens or internal injury of viscera, and further causes an impact on the airways, resulting in the generation of cough sound or the accompanying expectoration. Patients often have cough with excessive phlegm, excessive phlegm easy to cough, aggravated in the morning or after eating, and heavy and stuffy cough, and the diseases are caused by spleen failure, dampness accumulation, phlegm generation and airway obstruction.

In traditional Chinese medicine, cough is divided into two types, namely internal injury cough and exogenous cough, and the cough with phlegm-dampness in lung is one of internal injury cough. The traditional Chinese medicine 'cough' category comprises lung diseases such as chronic bronchitis, bronchiectasis and the like, and the main clinical symptoms comprise cough, expectoration, accompanied (not accompanied) asthma and the like. Western medicines mostly treat the disease by anti-infection, spasmolysis and asthma-relieving medicines, but secondary infection and bacterial resistance are easily caused by long-term use of antibiotics, and the use of the antibiotics often causes spleen and stomach injuries of patients, generates phlegm-dampness, and causes the occurrence of phlegm-dampness lung-accumulating type cough. The existing traditional Chinese medicine similar products mostly adopt a single traditional Chinese medicine extract with single component, so that drug resistance is easy to appear, the performance of the medicine is reduced, or the traditional Chinese medicine extracts with similar efficacies are used for overcoming the limitation of the single traditional Chinese medicine, and the superposition of the medicines with similar efficacies makes the situation of complicated disease transmission and diversification some people catch the witness.

Disclosure of Invention

Aiming at the problems, the traditional Chinese medicine composition for treating cough provided by the invention follows the principle of clinical dialectical treatment and prescription taking, has the rigor of monarch, minister, assistant and guide compatibility of the prescription, is deeply combined with modern clinic, and repeatedly carries out addition and reduction according to relevant clinical curative effect feedback, so that a prescription with stable efficacy and wide application range is formed.

The traditional Chinese medicine composition for treating cough provided by the invention is prepared from the following raw materials in parts by weight: 5-10 parts of fried radish seed, 10-20 parts of fried perilla seed, 9-20 parts of radix peucedani, 10-20 parts of ginger magnolia bark, 10-20 parts of pummelo peel, 10-22 parts of rhizoma pinellinae praeparata, 12-23 parts of angelica, 20-40 parts of fried spina date seed, 10-20 parts of roasted loquat leaf, 12-22 parts of roasted aster and 5-11 parts of fructus amomi.

Preferably, the feed additive is prepared from the following raw materials in parts by weight: 10 parts of fried radish seed, 18 parts of fried perilla seed, 20 parts of radix peucedani, 18 parts of ginger-processed magnolia bark, 18 parts of pummelo peel, 22 parts of rhizoma pinellinae praeparata, 23 parts of angelica, 40 parts of fried spina date seed, 18 parts of fried loquat leaf, 22 parts of fried aster and 11 parts of fructus amomi.

The invention also provides a preparation method of the traditional Chinese medicine composition for treating cough, which comprises the following steps:

s1, weighing 5-10 parts of fried radish seeds, 10-20 parts of fried perilla seeds, 9-20 parts of radix peucedani, 10-20 parts of cortex magnoliae officinalis, 10-20 parts of pummelo peel, 10-22 parts of rhizoma pinellinae praeparata, 12-23 parts of angelica sinensis, 20-40 parts of fried spina date seeds, 10-20 parts of roasted loquat leaves, 12-22 parts of roasted aster tataricus and 5-11 parts of fructus amomi for later use;

s2, mixing the fried radish seeds, the fried perilla seeds, the peucedanum roots, the gingered mangnolia officinalis, the pummelo peel, the rhizoma pinellinae praeparata, the angelica sinensis, the fried spina date seeds, the fried loquat leaves, the fried aster, the fructus amomi and the mangnolia officinalis weighed in the step S1, adding water which is 10 times of the total weight of the medicinal materials, soaking for 40min, decocting until the liquid medicine amount is 3/8 times of the volume of the added water amount, filtering, collecting first decoction, adding water which is 8 times of the total weight of the medicinal materials into the obtained dregs, continuing to decoct until the liquid medicine amount is 1/2 times of the volume of the second added water amount, filtering, collecting second decoction, combining the first decoction and the second decoction, and concentrating until the volume of the raw material is 1/10 times of the volume of the two decoctions, so as to obtain the traditional Chinese medicine composition.

Preferably, the traditional Chinese medicine composition can be further prepared into a pharmaceutically acceptable traditional Chinese medicine preparation.

More preferably, the traditional Chinese medicine preparation is granules, syrup, tablets, capsules and oral liquid.

The traditional Chinese medicine composition can be used for preparing a medicine for treating phlegm-dampness lung-accumulation type cough.

When treating lung qi as regulating spleen, cough is usually caused by invasion of exogenous pathogenic factors, lung-wei stasis and failure of lung qi to disperse and disperse; it can also occur due to the dysfunction of zang-fu organs and the failure of lung to clear and descend, with the spleen being the source of phlegm generation and the pivot of qi movement and the lung being the means for storing phlegm, which mainly plays the role of qi of the whole body and is closely related to the two. Although there are discussions that five zang-organs and six fu-organs are all cough, the occurrence of cough is closely related to the dysfunction of lung and spleen. As described in the Qing dynasty Chen Zhengzheng Young baby ensemble: all the symptoms of cough and lung qi injury caused by sound and phlegm; phlegm is not loud, so it is called cough, spleen dampness moves, and it is called cough, which is firstly hurted to lung and then spleen dampness moves.

The selected prescription of the application is good at using drugs with the functions of freeing lung and relieving exterior syndrome, lowering qi and reducing phlegm, such as perilla fruit, roasted loquat leaf, radix peucedani, ginger-processed magnolia bark and the like, and products with the functions of promoting qi circulation and relieving exterior syndrome, lowering qi and reducing phlegm, such as tangerine peel, pinellia tuber, radish seed and the like, and has the effects of removing stagnation and relieving epigastric distention, changing spleen qi into normal, transporting and transforming food, transporting body fluid into the body fluid, transforming phlegm into stagnation and relieving cough. Sha ren warms stomach and helps spleen and stomach to transform, so it can promote the transportation of spleen and stomach and body fluids, so it is not necessary to induce phlegm, so it is based on the theory of "earthing up and generating metal", and it is more in accordance with the principle of treating both lung and spleen.

The invention provides a traditional Chinese medicine composition for treating cough, wherein whiteflower hogfennel root and stir-fried perilla fruit are monarch drugs, and the lung diffusing effect of whiteflower hogfennel root and the lung diffusing and phlegm resolving effect of perilla fruit are used for jointly achieving the effects of diffusing lung so as to lead pathogenic factors to emerge and lead cough and asthma to be self-leveling; rhizoma Pinelliae Preparata and exocarpium Citri Grandis are herbs for resolving phlegm, and the combination of the two herbs can make the cough and asthma of phlegm resolving self-calm; the fried radish seed and the ginger magnolia bark are used as qi-moving products, so that qi can be moved without breaking qi, the qi can be moved without damaging the body resistance, the dampness can be removed automatically when the qi is moved, and the spleen and the qi can be strengthened and moved to avoid phlegm generation as ministerial drugs; angelica sinensis can enrich blood to reduce phlegm without damaging blood components, radix asteris preparata and loquat can moisten lung to reduce phlegm without damaging yin, fructus amomi can warm stomach and assist the transportation and transformation of spleen and stomach, so that the spleen and stomach can transport body fluid and invigorate the circulation without causing accumulation to generate phlegm, thereby achieving the purposes of banking up earth and generating metal, spina date seeds can soothe nerves and promote fluid production, the mind can be calmed, and the Chinese angelica sinensis is matched with the pathogenesis of emphysema and chronic bronchitis which are difficult to calm due to lung qi stagnation and long-term heart spirit malnutrition, and is used as an adjuvant medicine. The formula has strict compatibility, stable curative effect, and the effect of tightly fastening the etiology and pathogenesis, has the effect of treating the disease and seeking the basis, and can treat various lung diseases conforming to the condition that phlegm dampness accumulates in the lung.

Detailed Description

Several embodiments of the present invention are described in detail below, but it should be understood that the scope of the present invention is not limited to the embodiments.

The invention provides a traditional Chinese medicine composition for treating cough, which is prepared from the following raw materials in parts by weight: 5-10 parts of fried radish seed, 10-20 parts of fried perilla seed, 9-20 parts of radix peucedani, 10-20 parts of ginger magnolia bark, 10-20 parts of pummelo peel, 10-22 parts of rhizoma pinellinae praeparata, 12-23 parts of angelica, 20-40 parts of fried spina date seed, 10-20 parts of roasted loquat leaf, 12-22 parts of roasted aster and 5-11 parts of fructus amomi.

s2, mixing the fried radish seeds, the fried perilla seeds, the peucedanum roots, the gingered mangnolia officinalis, the pummelo peel, the rhizoma pinellinae praeparata, the angelica sinensis, the fried spina date seeds, the fried loquat leaves, the fried aster, the fructus amomi and the mangnolia officinalis weighed in the step S1, adding water which is 10 times of the total weight of the medicinal materials, soaking for 40min, decocting until the liquid medicine amount is 3/8 times of the volume of the added water amount, filtering, collecting first decoction, adding water which is 8 times of the total weight of the raw medicinal materials into the obtained decoction dregs, continuing to decoct until the liquid medicine amount is 1/2 times of the volume of the second added water amount, filtering, collecting second decoction, combining the first decoction and the second decoction, and concentrating until the volume of the first decoction is 1/10 times of the volume of the two decoctions, thereby obtaining the traditional Chinese medicine composition.

The following description will be given with reference to specific examples.

Example 1

A traditional Chinese medicine composition for treating cough is prepared from the following raw materials: 5g of fried radish seed, 10g of fried perilla seed, 9g of radix peucedani, 10g of ginger officinal magnolia bark, 10g of pummelo peel, 10g of rhizoma pinellinae praeparata, 12g of angelica, 20g of fried spina date seed, 10g of fried loquat leaf, 12g of fried aster and 5g of amomum fruit.

The traditional Chinese medicine composition is prepared according to the following steps:

s1, weighing 5g of fried radish seed, 10g of fried perilla seed, 9g of radix peucedani, 10g of ginger magnolia bark, 10g of pummelo peel, 10g of rhizoma pinellinae praeparata, 12g of angelica, 20g of fried spina date seed, 10g of roasted loquat leaf, 12g of roasted aster and 5g of fructus amomi for later use;

s2, mixing the fried radish seed, the fried perilla seed, the peucedanum root, the ginger-processed magnolia bark, the pummelo peel, the rhizoma pinellinae praeparata, the angelica, the fried spina date seed, the fried loquat leaf, the fried aster, the fructus amomi and the magnolia bark which are weighed in the step S1, adding 1150mL of water for soaking for 40min, boiling with strong fire, decocting with slow fire until the volume of the liquid medicine is 450mL, filtering, adding 900mL of water into the dregs of a decoction until the volume of the liquid medicine is 450mL, combining the two decoctions, and concentrating to 90mL to obtain the traditional Chinese medicine composition;

s3, adding a mixture of sucrose powder and dextrin (the mass ratio of sucrose to dextrin is 3:1) and ethanol with the mass fraction of 70% into the traditional Chinese medicine composition, blending into a soft material, extruding and sieving (12-14 meshes) to prepare granules, drying at 60 ℃, grading, and subpackaging by 10g per bag.

The using method comprises the following steps: orally taken one bag at a time and twice a day.

Example 2

A traditional Chinese medicine composition for treating cough is prepared from the following raw materials: 10g of fried radish seed, 20g of fried perilla seed, 20g of radix peucedani, 20g of ginger-processed magnolia bark, 20g of pummelo peel, 22g of rhizoma pinellinae praeparata, 23g of angelica, 40g of fried spina date seed, 20g of fried loquat leaf, 22g of fried aster and 11g of fructus amomi.

s1, weighing 10g of fried radish seed, 20g of fried perilla seed, 20g of radix peucedani, 20g of ginger magnolia bark, 20g of pummelo peel, 22g of rhizoma pinellinae praeparata, 23g of angelica, 40g of fried spina date seed, 20g of roasted loquat leaf, 22g of roasted aster and 11g of fructus amomi for later use;

s2, mixing the fried radish seed, the fried perilla seed, the peucedanum root, the ginger-processed magnolia bark, the pummelo peel, the rhizoma pinellinae praeparata, the angelica, the fried spina date seed, the fried loquat leaf, the fried aster, the amomum villosum and the magnolia bark which are weighed in the step S1, adding 2300mL of water for soaking for 40min, boiling with strong fire, decocting with slow fire until the volume of the liquid medicine is 900mL, filtering, adding 1800mL of water into the dregs of a decoction, decocting until the volume of the liquid medicine is 900mL, combining the two decoctions, and concentrating to 180mL to obtain the traditional Chinese medicine composition;

s3, drying the Chinese medicinal composition at 60 deg.C, pulverizing into fine powder, and encapsulating to give capsule shell with a weight of 0.3 g.

The using method comprises the following steps: orally administered 3-5 granules per day three times a day.

Example 3

A traditional Chinese medicine composition for treating cough is prepared from the following raw materials: 10g of fried radish seed, 18g of fried perilla seed, 20g of radix peucedani, 18g of ginger magnolia bark, 18g of pummelo peel, 22g of rhizoma pinellinae praeparata, 23g of angelica, 40g of fried spina date seed, 18g of fried loquat leaf, 22g of fried aster and 11g of fructus amomi.

The preparation method of the traditional Chinese medicine composition specifically comprises the following steps:

s1, weighing 10g of fried radish seed, 18g of fried perilla seed, 20g of radix peucedani, 18g of ginger-processed magnolia bark, 18g of pummelo peel, 22g of rhizoma pinellinae praeparata, 23g of angelica, 40g of fried spina date seed, 18g of roasted loquat leaf, 22g of roasted aster and 11g of fructus amomi for later use;

s2, mixing the fried radish seed, the fried perilla seed, the peucedanum root, the ginger-processed magnolia bark, the pummelo peel, the rhizoma pinellinae praeparata, the angelica, the fried spina date seed, the fried loquat leaf, the fried aster, the amomum villosum and the magnolia bark which are weighed in the step S1, adding 2200mL of water for soaking for 40min, boiling with strong fire, decocting with slow fire until the volume of the liquid medicine is 850mL, filtering, adding 1800mL of water into the dregs of a decoction, decocting until the volume of the liquid medicine is 900mL, combining the two decoctions, and concentrating to 175mL to obtain the traditional Chinese medicine composition;

s3, adding water to 200mL of the traditional Chinese medicine composition, adjusting the pH value to 5.5-6.5, standing, filtering, adding 10% simple syrup and 0.1% potassium sorbate into the filtrate according to mass fraction, fixing the volume to 350mL, and subpackaging to obtain the traditional Chinese medicine composition.

The using method comprises the following steps: it is administered orally at a dose of 10-20mL twice a day.

Example 4

A traditional Chinese medicine composition for treating cough is prepared from the following raw materials: 6g of fried radish seed, 12g of fried perilla seed, 15g of radix peucedani, 15g of ginger officinal magnolia bark, 15g of pummelo peel, 18g of rhizoma pinellinae praeparata, 16g of angelica, 32g of fried spina date seed, 15g of fried loquat leaf, 16g of fried aster and 8g of amomum fruit.

s1, weighing 6g of fried radish seeds, 12g of fried perilla seeds, 15g of radix peucedani, 15g of ginger-processed magnolia officinalis, 15g of pummelo peel, 18g of rhizoma pinellinae praeparata, 16g of angelica sinensis, 32g of fried spina date seeds, 15g of roasted loquat leaves, 16g of roasted aster and 8g of fructus amomi for later use;

s2, mixing the fried radish seed, the fried perilla seed, the peucedanum root, the ginger-processed magnolia bark, the pummelo peel, the rhizoma pinellinae praeparata, the angelica, the fried spina date seed, the fried loquat leaf, the fried aster, the amomum villosum and the magnolia bark which are weighed in the step S1, adding 1700mL of water for soaking for 40min, boiling with strong fire, decocting with slow fire until the volume of the liquid medicine is 650mL, filtering, adding 1350mL of water into the dregs of a decoction until the volume of the liquid medicine is 650mL, combining the two decoctions, and concentrating to 130mL to obtain the traditional Chinese medicine composition;

Example 5

A traditional Chinese medicine composition for treating cough is prepared from the following raw materials: 9g of fried radish seed, 15g of fried perilla seed, 18g of radix peucedani, 12g of ginger officinal magnolia bark, 15g of pummelo peel, 22g of rhizoma pinellinae praeparata, 15g of angelica, 35g of fried spina date seed, 18g of fried loquat leaf, 15g of fried aster and 10g of amomum fruit.

s1, weighing 9g of fried radish seed, 15g of fried perilla seed, 18g of radix peucedani, 12g of cortex magnoliae officinalis, 15g of exocarpium citri grandis, 22g of rhizoma pinellinae praeparata, 15g of angelica sinensis, 35g of fried spina date seed, 18g of roasted loquat leaf, 15g of roasted aster and 10g of fructus amomi for later use;

Since the effects of the chinese medicinal preparations provided in examples 1 to 5 were substantially the same, the effect evaluation was performed using the chinese medicinal preparation prepared in example 3 as follows.

1. Data and method

1.1, clinical data: selected from 781 total outpatients and inpatients with complete data from 12 months 2014 to 12 months 2018, and randomly divided into 391 treatment groups and 390 control groups. The age of the treatment group is 18-80 years, the disease course is 2-4 weeks, the age of the control group is 18-80 years, the disease course is 2-3.5 weeks, and the age and the disease course are tested by chi-square test (p is more than 0.05) and have no statistical difference.

1.2, treatment method: the treatment group uses the traditional Chinese medicine preparation provided by the embodiment 3 of the invention, 10-20mL of the traditional Chinese medicine preparation is taken each time, twice a day, 7 days are taken as a treatment course, and the control group takes the Mushutaneambroxol oral liquid orally, 10mL of the Shanghai Boringer Yiger John pharmaceutical industry Co., Ltd, 2 times a day.

2. Basis of diagnosis

2.1, cough with noise or accompanied with pharynx itch and expectoration;

2.2, exogenous cough with an acute onset accompanied by exterior syndromes such as cold and heat;

2.3 cough due to internal injury, which is usually caused by repeated attack of exogenous pathogens and has a long course of disease and can be accompanied by asthma;

2.4, the total number of leucocytes and neutrophils in the acute phase are examined to be increased;

2.5 auscultation of two lungs can hear and breath sound is thickened, or accompanied by dry and wet rales;

2.6, examining a lung X-ray photograph, and thickening and disordering normal or lung textures;

3. and (3) symptom: cough with heavy and turbid sound, white and abundant sputum, a severe morning feeling, chest stuffiness, epigastric fullness and poor appetite. White and greasy tongue coating and slippery pulse;

4. evaluation of therapeutic Effect

4.1, curing: cough and disappearance of clinical signs; the cough caused by internal injury is not cured clinically in more than two weeks;

4.2, improvement: cough was relieved, sputum volume decreased;

4.3, no cure: no obvious change in symptoms.

5. Determination of therapeutic effect

The results are shown in Table 1.

TABLE 1 control of cure rates in two groups

Grouping	Number of examples	Cure of disease	Improvement of life	Not cured	Effective rate (%)
						Group of embodiments	391	220	150	21	94.63％
Control group	390	170	140	80	79.49％

Typical cases

Case 1

Basic condition of patient (somebody in the week, woman, age 45, 18 months in 2017)

The main complaints are: cough, cough with more than five years of expectoration, aggravate half a month.

The current medical history: cough, expectoration, chest distress and asthma appear after catching cold before five years, and the treatment is mainly carried out on the symptoms and is not paid attention. The patient subsequently becomes more severe with symptoms that occur at about 3 months per year with longer duration (1-3 months). The patient visits at our hospital for many times, and the chest CT and the lung function examination are carried out, and the diagnosis is determined as follows: chronic bronchitis, emphysema. The administration of symptomatic treatment and the administration of anti-infective drugs (amoxicillin capsules, roxithromycin capsules, azithromycin dispersible tablets, etc.) results in unsatisfactory control of symptoms. After a patient is cold before half a month, nasal obstruction, thin nasal discharge, dry throat, cough and yellow and sticky sputum appear again, chest distress and asthma are even caused by cough, aggravation is caused by movement, and the treatment with the medicaments such as the Pudilan oral liquid, the niaci' ci cough syrup, the heat clearing cough powder and the like obviously relieves the nasal obstruction, the thin nasal discharge, the dry throat and the like before the treatment, but the cough is recurrent. The patients are treated in the national hospital and the medical center, and the current symptoms are as follows: the cough and the expectoration are large in white sputum, the sputum is flat, the cough is severe in the morning and after eating, the cough is severe, the chest is stuffy and epigastric, the throat is dry, the throat is itchy, the nasal discharge is avoided, the appetite is good, abnormal appetite is not seen, and the sleep is common. Tongue diagnosis and pulse condition: a pale-red tongue with white and greasy coating, a wiry and slippery pulse and even slippery right guan.

Syndrome differentiation: syndrome of phlegm-dampness in the lung (eliminating dampness and phlegm, ventilating and smoothing lung and relieving cough)

(thinking: cough, expectoration, nasal obstruction and disease location in lung, abundant expectoration, heavy and turbid cough, repeated attack, pale red tongue with white greasy coating, wiry and slippery pulse, slippery right-hand gate, and phlegm-dampness syndrome)

Twice diagnosis in 2017, 10 months and 27 days:

after the patient takes 7 doses of the medicine, the phlegm quantity of cough is obviously reduced earlier, the cough is easy to appear, the cough is reduced, the chest distress and the short breath are obviously relieved earlier, the epigastric fullness and the fullness basically disappear, the appetite is good, abnormal food intake is not seen, and the sleep is improved earlier, and the patient can take the medicine for treating the cough and the dyspnea. Tongue diagnosis and pulse condition: a pale-red tongue with white and greasy coating and a wiry and slippery pulse. According to the principle of no better effect, the patient should take 15 doses of the above medicines.

Three diagnoses in 11 months and 15 days in 2017:

after a patient takes the above 15 doses of the traditional Chinese medicine, cough is greatly reduced, expectoration basically disappears, white sticky phlegm is occasionally seen, the cough easily appears, chest distress and short breath basically disappear, and epigastric fullness and fullness disappear only after activity. The appetite is obviously improved before the first time, the appetite can be taken, and the sleep can be improved. Tongue diagnosis and pulse condition: the tongue is pale red, the coating is thin and white, and the pulse is wiry and thready.

30 doses are taken continuously on the upper part.

Visit 3 month 10 day 2018:

the follow-up visit of the telephone today shows that cough, expectoration, chest distress and asthma basically disappear after patients complain of 15 doses of the medicine. Shortness of breath after exercise; no discomfort of the gastric cavity was observed. After the oral administration of 15 doses is continued, the shortness of breath of a patient is obviously improved before, and the conscious diet and sleep are obviously reduced.

Visit 12/6/2018:

the follow-up telephone call of this day, the patient complains that cough, expectoration, chest distress, shortness of breath only appear once after the air conditioner is cooled in August in recent year, and the symptoms disappear by orally taking 15 doses according to the original prescription in the pharmacy at the gate of the district. The subjective physique is obviously improved compared with the prior art.

Visit 7 month and 10 days in 2019:

the patients are required to take the plaster orally in clinic at present, so as to treat winter diseases in summer and improve physique. Patients occasionally cough, cough with little white thin sputum, easy coughing, easy chest distress, short breath and other discomfort after fatigue, no discomfort of gastrointestinal tract, and good sleep. Tongue diagnosis and pulse condition: the tongue is pale red, the coating is thin and white, and the pulse is wiry and thready. The plaster is decocted in the original prescription according to the symptoms, physical signs and tongue pulse of the patient for 3 months.

Visit 11/15/2019:

after the patient complains of the oral medicine for three months, the cough and the expectoration of the patient are not seen, and the chest distress and the short breath of the patient are disappeared. Gastrointestinal tract has no discomfort, and sleep is good. Tongue diagnosis and pulse condition: the tongue is pale red, the coating is thin and white, and the pulse is wiry and thready. Stopping the medicine treatment.

Case 2

Basic conditions of patients (Taozao, male, age 57, 1 month and 7 days of 2017)

The main complaints are: intermittent cough and expectoration for 10 years, aggravation with chest distress for 7 days

The current medical history: patients have intermittent cough, white and sticky sputum, little sputum and difficult expectoration in 10 years, and the cough and the sputum are severe after catching cold and eating spicy and greasy food. Fever, sore throat and lassitude of the whole body occur before one month due to cold, the patient is in a local hospital with a visit, relevant examination is given, and blood is shown in a routine way: the leucocyte is obviously increased, the neutrophil is mainly increased, the chlamydia pneumoniae and the mycoplasma are negative, the acute attack of the chronic bronchitis is diagnosed, the body temperature is reduced to normal after 7 days of antibiotic treatment, but the cough and the expectoration are not considered. Cough, expectoration aggravation, cough sound shortness, chest distress, short breath, fatigue, no speaking, less phlegm, yellow and sticky color with blood, dry throat and pharyngalgia appear in patients before 7 days after eating spicy food, and the CT examination of the chest in local hospitals shows that: double lung emphysema, local bullous formation, and double lung texture thickening disorder, with multiple lymphadenectasis. The symptoms of patients are not relieved after treatment by administration of heat-clearing and detoxifying drugs, and the patients are treated by outpatient service with the following symptoms: mental clarity, poor spirit, shortness of breath, disinclination to talk, cough, shortness of breath, heavy turbidity, chest distress, shortness of breath, wheezing, cough with excessive white sputum, expectoration, poor appetite, anorexia, poor sleep, dreaminess, 2-day defecation, dry texture, difficult defecation and desire to drink.

Tongue diagnosis and pulse condition: a red tongue with white, thick and greasy coating and a slippery pulse.

(thinking: cough, expectoration, chest distress, lung syndrome, abundant expectoration, heavy and turbid cough, recurrent attack, red tongue, white, thick and greasy coating, slippery pulse, syndrome of phlegm-dampness in lung)

Twice diagnosis in 2017, 1 month and 14 days:

when the medicine is taken above, the symptoms of cough and expectoration of a patient are obviously relieved earlier, and the patient suffers from chest distress, shortness of breath and strong asthmatic respiration, and then the medicine is taken 7 times after the medicine is taken above the patient.

Three diagnoses in 1 month and 21 days in 2017:

patients with cough, expectoration, chest distress and asthma are obviously relieved, appetite is improved earlier, food intake is obviously increased earlier, sleep is improved, and dreaminess is obviously reduced. The stool is small and easy to defecate in 1-2 days. Tongue diagnosis and pulse condition: the tongue is pale red, the coating is white and slightly greasy, and the pulse is deep and forceful. The patient requires a chest CT examination again near spring festival, and the results show: local lung bullae are formed, and the texture of both lungs is clear. According to the clinical symptoms and imaging of the patients. Prompting the patient that the condition is basically stable. The patient requires the oral ointment to continue the treatment and the ointment is used for the treatment.

Follow-up visit of 12 months and 7 days in 2018:

the follow-up visit of the telephone today shows that the patient complains of taking the ointment formula by himself for half a month, the cough, the expectoration, the chest distress and the asthma disappear, and the physique is obviously improved compared with the prior art.

Case 3

Basic condition of patient (Dongzhi, male, age 46, initial diagnosis No. 3 and 5 in 2019)

The main complaints are: intermittent cough and dyspnea, chest distress for 5 years, aggravation with short breath for 5 days.

The current medical history: cough, expectoration and chest distress appear after a patient catches a cold 5 years ago, symptoms of the patient are slightly relieved before symptomatic treatment, but the patient can recover from the symptoms after the patient is slightly cold, so that the patient can be diagnosed in Zhengzhou city people hospitals, and after relevant examination, the patient is definitely diagnosed as: chronic bronchitis, chronic obstructive pulmonary disease, and emphysema. The budesonide formoterol inhalant is combined with tiotropium bromide powder inhalant for inhalation therapy, and the oral medicine for relieving spasm and asthma is used. The symptoms of the patients are more obvious after the treatment. Patients complain of cough, expectoration, chest distress and asthma symptoms in the last two years, and the symptoms are aggravated when the patients meet cold. The symptoms of the patients are aggravated after going out for shopping and catching cold before 5 days, and the symptoms are not well controlled after the medicine for relieving spasm and asthma is applied. The patient is outpatient for further treatment. The symptoms are as follows: mental retardation, cough, expectoration, nasal obstruction, watery nasal discharge, headache, chest distress, asthma, short breath, asthenia, aversion to wind, fatigue, poor appetite, anorexia, epigastric fullness, poor sleep, easy waking, 1 time/day defecation, thin texture, and normal urination.

Tongue diagnosis and pulse condition: a pale-red tongue with white and greasy coating and a weak pulse.

Syndrome differentiation: syndrome of phlegm-dampness in the lung (invigorating spleen to resolve dampness, ventilating and smoothing lung to relieve cough)

(thinking: cough, expectoration, chest distress and syndrome differentiation in lung of patient; cough, expectoration, nasal obstruction, watery nasal discharge, headache and slight pain, chest distress, asthma, short breath, asthenia, pale red tongue, white and greasy tongue coating, and weak pulse; syndrome differentiation of phlegm-dampness in lung)

Twice diagnosis in 3 months and 13 days in 2019:

patients taking the above 7 preparations have cough and expectoration reduced earlier, chest distress and asthma obviously reduced earlier, nasal obstruction and thin nasal discharge basically disappear, whole body fatigue is reduced earlier, appetite is improved, epigastric fullness is obviously reduced, insomnia is improved, and stool is 1 time/day, and the patients are soft and small. Tongue diagnosis and pulse condition: the tongue is pale red, the coating is white and slightly greasy, and the pulse is weak. 15 doses are taken continuously on the upper part.

Three diagnoses in 3 months and 29 days in 2019:

after taking 15 doses of the medicine, the patient has no nasal obstruction and thin nasal discharge, and the cough, the expectoration, the chest distress and the asthma are obviously improved before. The whole body is basically free of fatigue, the epigastric fullness is relieved, the insomnia is improved, and the stool is 1 time/day, soft and small. Tongue diagnosis and pulse condition: the tongue is pale red, the coating is white and slightly greasy, and the pulse is weak. After ten days, the patient is expected to go to Hainan, requires the ointment for treatment, and orders the patient to store in a refrigerator.

Four diagnoses in 7 months and 12 days in 2019:

the patient sees a doctor today, cough occasionally, expectoration disappears, epigastric fullness basically disappears, and the cough is easy to see only after eating. Obviously improving sleep earlier, conscious of light body earlier, obviously improving fatigue earlier when moving, and enabling people to have soft and small stool in one row in 1-2 days. Tongue diagnosis and pulse condition: the tongue is pale red, the coating is white and slightly greasy, and the pulse is weak. The patient requires winter disease to be cured in summer and continues to be treated with the ointment formula for 3 months.

Follow-up visit 12 month 7 day 2019:

the follow-up visit of the telephone today shows that cough, expectoration, chest distress and asthma disappear after patients complain of the ointment formula, the stomach and the stomach do not feel full and uncomfortable, the appetite is good, the sleep is good, and the physique is obviously improved compared with the former.

It should be noted that the steps and methods adopted in the claims of the present invention are the same as those of the above-mentioned embodiments, and for the sake of avoiding redundancy, the present invention describes the preferred embodiments, but those skilled in the art can make other changes and modifications to these embodiments once they learn the basic inventive concept. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims

1. The traditional Chinese medicine composition for treating cough is characterized by being prepared from the following raw materials in parts by weight: 5-10 parts of fried radish seed, 10-20 parts of fried perilla seed, 9-20 parts of radix peucedani, 10-20 parts of ginger magnolia bark, 10-20 parts of pummelo peel, 10-22 parts of rhizoma pinellinae praeparata, 12-23 parts of angelica, 20-40 parts of fried spina date seed, 10-20 parts of roasted loquat leaf, 12-22 parts of roasted aster and 5-11 parts of fructus amomi.

2. The traditional Chinese medicine composition for treating cough according to claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of fried radish seed, 18 parts of fried perilla seed, 20 parts of radix peucedani, 18 parts of ginger-processed magnolia bark, 18 parts of pummelo peel, 22 parts of rhizoma pinellinae praeparata, 23 parts of angelica, 40 parts of fried spina date seed, 18 parts of fried loquat leaf, 22 parts of fried aster and 11 parts of fructus amomi.

3. The preparation method of the traditional Chinese medicine composition for treating cough according to claim 1, which is characterized by comprising the following steps:

4. The method for preparing a traditional Chinese medicine composition for treating cough according to claim 3, wherein the traditional Chinese medicine composition can be further prepared into a pharmaceutically acceptable traditional Chinese medicine preparation.

5. The method for preparing a traditional Chinese medicine composition for treating cough according to claim 4, wherein the traditional Chinese medicine preparation is granules, syrup, tablets, capsules and oral liquid.

6. The use of the traditional Chinese medicine composition for treating cough according to claim 1 in the preparation of a medicament for treating cough with phlegm-dampness accumulation in the lung.