CN111757731B - 三取代苯并三唑衍生物的使用方法 - Google Patents

三取代苯并三唑衍生物的使用方法 Download PDF

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Publication number
CN111757731B
CN111757731B CN201980014469.1A CN201980014469A CN111757731B CN 111757731 B CN111757731 B CN 111757731B CN 201980014469 A CN201980014469 A CN 201980014469A CN 111757731 B CN111757731 B CN 111757731B
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compound
cancer
cell lymphoma
diffuse large
hit
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Chinese (zh)
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CN111757731A (zh
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D.乌拉内特
S.E.崔
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Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980014469.1A 2018-02-20 2019-02-19 三取代苯并三唑衍生物的使用方法 Active CN111757731B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2018018679 2018-02-20
USPCT/US2018/018679 2018-02-20
PCT/US2019/018472 WO2019164794A1 (en) 2018-02-20 2019-02-19 Methods of use for trisubstituted benzotriazole derivatives

Publications (2)

Publication Number Publication Date
CN111757731A CN111757731A (zh) 2020-10-09
CN111757731B true CN111757731B (zh) 2024-06-25

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CN201980014469.1A Active CN111757731B (zh) 2018-02-20 2019-02-19 三取代苯并三唑衍生物的使用方法

Country Status (13)

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US (2) US11717512B2 (https=)
EP (1) EP3755324B1 (https=)
JP (2) JP7434185B2 (https=)
KR (1) KR102861339B1 (https=)
CN (1) CN111757731B (https=)
AU (1) AU2019223906B2 (https=)
BR (1) BR112020016929A8 (https=)
CA (1) CA3091792A1 (https=)
ES (1) ES3038736T3 (https=)
MA (1) MA51897A (https=)
MX (1) MX2020008678A (https=)
TW (1) TWI818954B (https=)
WO (1) WO2019164794A1 (https=)

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MA48459B1 (fr) * 2017-04-24 2021-09-30 Aurigene Discovery Tech Ltd Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase
US20180369206A1 (en) 2017-04-24 2018-12-27 Aurigene Discovery Technologies Limited Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
KR102861339B1 (ko) 2018-02-20 2025-09-19 르 라보레또레 쎄르비에르 삼치환 벤조트리아졸 유도체의 사용 방법
PE20212197A1 (es) * 2018-12-21 2021-11-16 Les Laboratoires Servier Sas Formas de sal y cristalinas de un compuesto organico y composiciones farmaceuticas del mismo
CN111662872A (zh) * 2020-05-06 2020-09-15 西南医科大学附属医院 一种急性t淋巴细胞白血病阿糖胞苷耐药细胞株构建方法
CA3184024A1 (en) * 2020-06-24 2021-12-30 Les Laboratoires Servier Use of a dhodh inhibitor compound in combination cancer therapy
WO2021262874A1 (en) 2020-06-24 2021-12-30 Servier Pharmaceuticals , Llc Use of a dhodh inhibitor compound in combination cancer therapy
KR20230078997A (ko) * 2020-08-27 2023-06-05 르 라보레또레 쎄르비에르 병용 암 요법에서의 dhodh 저해제 화합물의 용도

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KR102861339B1 (ko) * 2018-02-20 2025-09-19 르 라보레또레 쎄르비에르 삼치환 벤조트리아졸 유도체의 사용 방법
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BR112020016929A8 (pt) 2022-06-28
TWI818954B (zh) 2023-10-21
KR20200123137A (ko) 2020-10-28
KR102861339B1 (ko) 2025-09-19
MA51897A (fr) 2020-12-30
AU2019223906A1 (en) 2020-09-10
JP2023109974A (ja) 2023-08-08
US20240148697A1 (en) 2024-05-09
US11717512B2 (en) 2023-08-08
US20210113531A1 (en) 2021-04-22
AU2019223906B2 (en) 2024-11-21
JP2021514395A (ja) 2021-06-10
US12290508B2 (en) 2025-05-06
CN111757731A (zh) 2020-10-09
ES3038736T3 (en) 2025-10-14
EP3755324B1 (en) 2025-07-30
BR112020016929A2 (pt) 2020-12-15
CA3091792A1 (en) 2019-08-29
WO2019164794A1 (en) 2019-08-29
EP3755324A1 (en) 2020-12-30
MX2020008678A (es) 2020-09-25
TW201938543A (zh) 2019-10-01
EP3755324C0 (en) 2025-07-30
JP7434185B2 (ja) 2024-02-20

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Applicant before: AGIOS PHARMACEUTICALS, Inc.

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