CN111748001A - 一种n-乙酰神经氨酸及其应用 - Google Patents

一种n-乙酰神经氨酸及其应用 Download PDF

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CN111748001A
CN111748001A CN201910253187.9A CN201910253187A CN111748001A CN 111748001 A CN111748001 A CN 111748001A CN 201910253187 A CN201910253187 A CN 201910253187A CN 111748001 A CN111748001 A CN 111748001A
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acetylneuraminic acid
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unit cell
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高启合
晏礼明
毋鸿江
毋生龙
赵娟
刘晓鹏
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Hierand Biotech Co ltd
Institute of Microbiology of CAS
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Institute of Microbiology of CAS
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Abstract

本发明涉及本发明涉及精细化工领域，具体涉及一种N‑乙酰神经氨酸及其应用。本发明所述晶体结构为N‑乙酰神经氨酸的科学研究和实际应用提供了理论基础和科学依据。

Description

一种N-乙酰神经氨酸及其应用
技术领域
本发明涉及精细化工领域，具体涉及一种N-乙酰神经氨酸的晶体结构。
背景技术
N-乙酰基神经氨酸，俗名唾液酸(SA)，具有吡喃糖结构，是一种天然的碳水化合物，在人体的脑组织中唾液酸含量最高。唾液酸通常以低聚糖、糖脂或者糖蛋白的形式存在。唾液酸广泛存在于多种生物组织中，是构成细胞膜上糖蛋白和糖脂的重要成分。在大部分哺乳动物组织中，发现的唾液酸主要是N-乙酰神经氨酸，所以通常把N-乙酰神经氨酸称为唾液酸，它参与细胞表面的多种生理活性。
随着N-乙酰基神经氨酸研究的不断深入，N-乙酰基神经氨酸已经实现工业化成产，并成为新食品原料。为了方便科学研究和实际应用，本发明提供了一种N-乙酰基神经氨酸的晶体结构，为解决科学研究和实际应用遇到的问题，更微观的晶体结构提供分子层面的解决线索。
发明内容
本发明的目的在于提供一种N-乙酰神经氨酸，其分子式为C11H19NO9.2H2O，其结构式如(1)所示。
Figure BDA0002012893220000011
优选的，该化合物属于单斜晶系，空间群为P21，晶胞参数为：
Figure BDA0002012893220000021
β＝112.25(1)°，晶胞体积
Figure BDA0002012893220000022
晶胞内分子数Z＝2。
本发明还保护本发明所述的N-乙酰神经氨酸在食品、外消炎中的应用。
附图说明
图1为本发明N-乙酰神经氨酸的晶体结构图。
图2为本发明N-乙酰神经氨酸的绝对构型图。
具体实施方式
以下实施例用于说明本发明，但不用来限制本发明的范围。
实施例1
本实施例涉及一种N-乙酰神经氨酸的晶体结构，为N-乙酰神经氨酸晶体属于单斜晶系，空间群为P21，晶胞参数为：
Figure BDA0002012893220000023
Figure BDA0002012893220000024
β＝112.25(1)°，晶胞体积
Figure BDA0002012893220000025
晶胞内分子数Z＝2，其晶体结构图如图1，其绝对构型图如图2。
虽然，上文中已经用一般性说明、具体实施方式及试验，对本发明作了详尽的描述，但在本发明基础上，可以对之作一些修改或改进，这对本领域技术人员而言是显而易见的。因此，在不偏离本发明精神的基础上所做的这些修改或改进，均属于本发明要求保护的范围。

Claims (3)

1.一种N-乙酰神经氨酸，其特征在于，其结构式为：
Figure FDA0002012893210000011
2.根据权利要求1所述的N-乙酰神经氨酸，其特征在于，该化合物属于单斜晶系，空间群为P21，晶胞参数为：
Figure FDA0002012893210000012
Figure FDA0002012893210000013
β＝112.25(1)°，晶胞体积
Figure FDA0002012893210000014
Figure FDA0002012893210000015
晶胞内分子数Z＝2。
3.权利要求1或2所述的N-乙酰神经氨酸在食品、外消炎中的应用。
CN201910253187.9A 2019-03-29 2019-03-29 一种n-乙酰神经氨酸及其应用 Pending CN111748001A (zh)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104586862A (zh) * 2015-02-06 2015-05-06 武汉中科光谷绿色生物技术有限公司 N-乙酰神经氨酸单体、n-乙酰神经氨酸水合物或n-乙酰神经氨酸盐在外用型消炎药品中的应用
US20170073366A1 (en) * 2015-09-14 2017-03-16 Ultragenyx Pharmaceutical Inc. Crystal forms of sialic acid or salt or solvate thereof
CN109180749A (zh) * 2018-10-18 2019-01-11 中国科学院合肥物质科学研究院 一种利用过饱和结晶法制备高纯度n-乙酰神经氨酸水合物的方法
CN109232677A (zh) * 2018-10-18 2019-01-18 中国科学院合肥物质科学研究院 一种使n-乙酰神经氨酸水合物转化为n-乙酰神经氨酸的方法
CN109265497A (zh) * 2018-10-18 2019-01-25 武汉中科光谷绿色生物技术有限公司 一种利用有机溶剂转化n-乙酰神经氨酸水合物制备n-乙酰神经氨酸的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104586862A (zh) * 2015-02-06 2015-05-06 武汉中科光谷绿色生物技术有限公司 N-乙酰神经氨酸单体、n-乙酰神经氨酸水合物或n-乙酰神经氨酸盐在外用型消炎药品中的应用
US20170073366A1 (en) * 2015-09-14 2017-03-16 Ultragenyx Pharmaceutical Inc. Crystal forms of sialic acid or salt or solvate thereof
CN109180749A (zh) * 2018-10-18 2019-01-11 中国科学院合肥物质科学研究院 一种利用过饱和结晶法制备高纯度n-乙酰神经氨酸水合物的方法
CN109232677A (zh) * 2018-10-18 2019-01-18 中国科学院合肥物质科学研究院 一种使n-乙酰神经氨酸水合物转化为n-乙酰神经氨酸的方法
CN109265497A (zh) * 2018-10-18 2019-01-25 武汉中科光谷绿色生物技术有限公司 一种利用有机溶剂转化n-乙酰神经氨酸水合物制备n-乙酰神经氨酸的方法

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