CN111748001A - 一种n-乙酰神经氨酸及其应用 - Google Patents
一种n-乙酰神经氨酸及其应用 Download PDFInfo
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- CN111748001A CN111748001A CN201910253187.9A CN201910253187A CN111748001A CN 111748001 A CN111748001 A CN 111748001A CN 201910253187 A CN201910253187 A CN 201910253187A CN 111748001 A CN111748001 A CN 111748001A
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Abstract
本发明涉及本发明涉及精细化工领域,具体涉及一种N‑乙酰神经氨酸及其应用。本发明所述晶体结构为N‑乙酰神经氨酸的科学研究和实际应用提供了理论基础和科学依据。
Description
技术领域
本发明涉及精细化工领域,具体涉及一种N-乙酰神经氨酸的晶体结构。
背景技术
N-乙酰基神经氨酸,俗名唾液酸(SA),具有吡喃糖结构,是一种天然的碳水化合物,在人体的脑组织中唾液酸含量最高。唾液酸通常以低聚糖、糖脂或者糖蛋白的形式存在。唾液酸广泛存在于多种生物组织中,是构成细胞膜上糖蛋白和糖脂的重要成分。在大部分哺乳动物组织中,发现的唾液酸主要是N-乙酰神经氨酸,所以通常把N-乙酰神经氨酸称为唾液酸,它参与细胞表面的多种生理活性。
随着N-乙酰基神经氨酸研究的不断深入,N-乙酰基神经氨酸已经实现工业化成产,并成为新食品原料。为了方便科学研究和实际应用,本发明提供了一种N-乙酰基神经氨酸的晶体结构,为解决科学研究和实际应用遇到的问题,更微观的晶体结构提供分子层面的解决线索。
发明内容
本发明的目的在于提供一种N-乙酰神经氨酸,其分子式为C11H19NO9.2H2O,其结构式如(1)所示。
本发明还保护本发明所述的N-乙酰神经氨酸在食品、外消炎中的应用。
附图说明
图1为本发明N-乙酰神经氨酸的晶体结构图。
图2为本发明N-乙酰神经氨酸的绝对构型图。
具体实施方式
以下实施例用于说明本发明,但不用来限制本发明的范围。
实施例1
本实施例涉及一种N-乙酰神经氨酸的晶体结构,为N-乙酰神经氨酸晶体属于单斜晶系,空间群为P21,晶胞参数为: β=112.25(1)°,晶胞体积晶胞内分子数Z=2,其晶体结构图如图1,其绝对构型图如图2。
虽然,上文中已经用一般性说明、具体实施方式及试验,对本发明作了详尽的描述,但在本发明基础上,可以对之作一些修改或改进,这对本领域技术人员而言是显而易见的。因此,在不偏离本发明精神的基础上所做的这些修改或改进,均属于本发明要求保护的范围。
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104586862A (zh) * | 2015-02-06 | 2015-05-06 | 武汉中科光谷绿色生物技术有限公司 | N-乙酰神经氨酸单体、n-乙酰神经氨酸水合物或n-乙酰神经氨酸盐在外用型消炎药品中的应用 |
US20170073366A1 (en) * | 2015-09-14 | 2017-03-16 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
CN109180749A (zh) * | 2018-10-18 | 2019-01-11 | 中国科学院合肥物质科学研究院 | 一种利用过饱和结晶法制备高纯度n-乙酰神经氨酸水合物的方法 |
CN109232677A (zh) * | 2018-10-18 | 2019-01-18 | 中国科学院合肥物质科学研究院 | 一种使n-乙酰神经氨酸水合物转化为n-乙酰神经氨酸的方法 |
CN109265497A (zh) * | 2018-10-18 | 2019-01-25 | 武汉中科光谷绿色生物技术有限公司 | 一种利用有机溶剂转化n-乙酰神经氨酸水合物制备n-乙酰神经氨酸的方法 |
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- 2019-03-29 CN CN201910253187.9A patent/CN111748001A/zh active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104586862A (zh) * | 2015-02-06 | 2015-05-06 | 武汉中科光谷绿色生物技术有限公司 | N-乙酰神经氨酸单体、n-乙酰神经氨酸水合物或n-乙酰神经氨酸盐在外用型消炎药品中的应用 |
US20170073366A1 (en) * | 2015-09-14 | 2017-03-16 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
CN109180749A (zh) * | 2018-10-18 | 2019-01-11 | 中国科学院合肥物质科学研究院 | 一种利用过饱和结晶法制备高纯度n-乙酰神经氨酸水合物的方法 |
CN109232677A (zh) * | 2018-10-18 | 2019-01-18 | 中国科学院合肥物质科学研究院 | 一种使n-乙酰神经氨酸水合物转化为n-乙酰神经氨酸的方法 |
CN109265497A (zh) * | 2018-10-18 | 2019-01-25 | 武汉中科光谷绿色生物技术有限公司 | 一种利用有机溶剂转化n-乙酰神经氨酸水合物制备n-乙酰神经氨酸的方法 |
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