CN111747429A - Active rubidium raw material for medicine and preparation method thereof - Google Patents
Active rubidium raw material for medicine and preparation method thereof Download PDFInfo
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- CN111747429A CN111747429A CN202010737509.XA CN202010737509A CN111747429A CN 111747429 A CN111747429 A CN 111747429A CN 202010737509 A CN202010737509 A CN 202010737509A CN 111747429 A CN111747429 A CN 111747429A
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- rubidium
- raw material
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01D—COMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
- C01D17/00—Rubidium, caesium or francium compounds
- C01D17/003—Compounds of alkali metals
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/80—Compositional purity
Abstract
The invention discloses an active rubidium raw material for medicine and a preparation method thereof, wherein the preparation method comprises the steps of crushing minerals rich in rubidium, and granulating after crushing; after granulation, adding zirconium oxide and water for ball milling, pouring the mixture into a container for standing after ball milling; standing, respectively taking the upper layer liquid and the precipitate with the thickness of 0.1-2mm on the upper layer of the precipitation layer, uniformly mixing the upper layer liquid and the precipitate, uniformly mixing, and drying in a microwave oven to obtain a powdery rubidium raw material; the content of active rubidium oxide in the powder is detected to be more than 0.2 percent by weight, and the powder can be used for preparing medicines containing rubidium, namely active rubidium raw materials for medicines. The preparation method is simple and low in cost, and the healthy and safe active rubidium raw material for the medicine can be obtained by the method, so that the blank that no rubidium-containing medicine raw material exists in the market is filled. The rubidium-containing compound is used for preparing rubidium-containing medicines, and lays a foundation for treating diseases such as nervous system, cardiovascular system, urinary system, senile cataract and the like by using the rubidium-containing medicines.
Description
Technical Field
The invention belongs to the technical field of raw materials for medicines, and particularly relates to an active rubidium raw material for manufacturing a rubidium-containing medicine and a preparation method thereof.
Background
Rubidium is a trace element which cannot be synthesized by human body and must be taken in from outside. Rubidium is a necessary product of human body, and is an essential trace element for human body when existing in animals and plants at a certain concentration. Rubidium concentration in human tissue is maintained or reduced with aging, and can stimulate or promote growth. In vivo metabolism, studies have found that a balance and regulatory mechanism for rubidium may exist and be available to the newborn through the placenta and mammary barrier. Through experimental research, rubidium can influence growth, reproductive function, brain development, brain aging and the like, and has an anticancer function. In medicine, rubidium is used for treating diseases of nervous system, cardiovascular system, urinary system, senile cataract, etc.
Rubidium is a very active alkali metal element, is very difficult to store and obtain, and rubidium metal obtained by various methods often has other associated harmful elements and cannot be used as a raw material of a medicine, so that no raw material of the medicine containing rubidium exists on the market at present, and diseases of a human body caused by rubidium deficiency can not be treated by the medicine.
Disclosure of Invention
Aiming at the problem that no rubidium-containing medicine raw material exists in the market at present, and some diseases caused by rubidium deficiency of human bodies cannot be treated by medicines. The invention provides an active rubidium raw material for medicines and a preparation method thereof, and a healthy and safe active rubidium raw material for medicines is obtained by adopting a new technology.
The technical scheme for realizing the aim of the invention is as follows:
a preparation method of active rubidium raw material for medicines comprises the following steps:
(1) selecting minerals rich in rubidium, cleaning, drying, crushing, and preparing into mineral powder with the particle size of 10-1000 mu m;
(2) putting the crushed mineral powder into a ball milling tank, adding a zirconium oxide grinding medium which is 1-20 times of the weight of the crushed mineral powder, adding purified water which is 1-100 times of the weight of the crushed mineral powder, performing ball milling for 1-5 hours, and pouring the mixture into a container to stand for 2-10 hours;
(3) standing, and collecting the upper liquid and the precipitate with a thickness of 0.1-2mm from the upper layer of the precipitation layer, but not the precipitate from the lower layer of the precipitation layer; uniformly mixing the upper layer liquid with the precipitate with the thickness of 0.1-2mm on the upper layer of the precipitation layer, uniformly mixing, and drying in a microwave oven to obtain a powdery rubidium raw material; the content of active rubidium oxide in the powder is detected to be more than 0.2 percent by weight, and the powder can be used for preparing medicines containing rubidium, namely active rubidium raw materials for medicines.
Further, the preferable scheme of the step (2) is as follows: and (3) putting the granulated mineral powder into a ball milling tank, adding a zirconium oxide grinding medium accounting for 1.5 times of the weight of the mineral powder, adding purified water accounting for 2 times of the weight of the mineral powder, ball milling for 2 hours, and pouring the mixture into a container to stand for 6 hours.
Another object of the present invention is to provide an active rubidium raw material for medicine prepared by the above preparation method.
It is well known in the art that rubidium and cesium are associated, i.e., rubidium is not separated from cesium, cesium is not separated from rubidium, and therefore cannot be separated by any method, and that cesium is radioactive and cannot be used as a pharmaceutical material, so that rubidium containing cesium cannot be used as a pharmaceutical raw material.
The active rubidium raw material for the medicine provided by the invention adopts minerals rich in rubidium, and does not contain cesium, so that the active rubidium raw material can be used for medicine.
In the preparation method, ball milling is not the key of preparation, and the key is that rubidium ions can be dissolved out under the action of water. Because the special mineral powder rich in rubidium is subjected to the action of natural force such as weathering, hydrothermal alteration and the like or the action of artificial crushing, rubidium oxide in the special mineral rich in rubidium is easy to chemically react with water molecules to generate rubidium hydroxide, and the chemical reaction equation is as follows:
Rb2O+H2O=2RbOH
the rubidium hydroxide is dissolved out from the special mineral powder rich in rubidium along with water molecules, and is dissolved in water to form an aqueous solution.
The tap water is natural water processed by water plants, and is used as source water for daily life after being subjected to chlorination disinfection or purification treatment and chlorination disinfection. Untreated source water is not tap water and is not potable.
The purified water is water which is prepared by taking water meeting the sanitary standard of drinking water as a raw material through an electrodialysis method, an ion exchange method, a distillation method and other proper processing methods, is sealed in a container and does not contain any additive and can be directly drunk. Therefore, the active rubidium raw material has better effect when being selected as purified water during preparation.
The preparation method is simple and low in cost, and the healthy and safe active rubidium raw material for the medicine can be obtained by the method, so that the blank that no rubidium-containing medicine raw material exists in the market is filled. The rubidium-containing compound is used for preparing rubidium-containing medicines, and lays a foundation for treating diseases such as nervous system, cardiovascular system, urinary system, senile cataract and the like by using the rubidium-containing medicines.
Detailed Description
The present invention will be further described with reference to the following examples, but the present invention is not limited thereto.
Example 1
A preparation method of active rubidium raw material for medicines comprises the following steps:
(1) selecting 10 kg of minerals rich in rubidium, cleaning, drying, crushing, and making into particle size D50100 mu m of mineral powder;
(2) putting the granulated mineral powder into a ball milling tank, adding a zirconium oxide grinding medium accounting for 1.5 times of the weight of the granulated mineral powder, adding purified water accounting for 2 times of the weight of the zirconium oxide grinding medium, performing ball milling for 2 hours, and pouring the mixture into a container to stand for 6 hours;
(3) after standing, respectively taking the upper liquid and the precipitate with the thickness of 1mm on the upper layer of the precipitation layer, uniformly mixing, and drying in a microwave oven to obtain a powdery rubidium raw material; the content of active rubidium oxide in the powder is 0.4% by weight through detection, and the powder can be used for preparing medicines containing rubidium.
Example 2
A preparation method of active rubidium raw material for medicines comprises the following steps:
(1) selecting 10 kg of minerals rich in rubidium, cleaning, drying, crushing, and making into particle size D50Mineral powder of 500 mu m;
(2) putting the granulated mineral powder into a ball milling tank, adding a zirconium oxide grinding medium accounting for 1.5 times of the weight of the granulated mineral powder, adding purified water accounting for 2 times of the weight of the zirconium oxide grinding medium, performing ball milling for 2 hours, and pouring the mixture into a container to stand for 6 hours;
(3) after standing, respectively taking the upper liquid and the precipitate with the thickness of 1mm on the upper layer of the precipitation layer, uniformly mixing, and drying in a microwave oven to obtain a powdery rubidium raw material; the content of active rubidium oxide in the powder is 0.36% by weight through detection, and the powder can be used for preparing medicines containing rubidium.
Example 3
A preparation method of active rubidium raw material for medicines comprises the following steps:
(1) selecting 10 kg of minerals rich in rubidium, cleaning, drying, crushing, and making into particle size D50Mineral powder of 1000 μm;
(2) putting the granulated mineral powder into a ball milling tank, adding a zirconium oxide grinding medium accounting for 1.5 times of the weight of the granulated mineral powder, adding purified water accounting for 2 times of the weight of the zirconium oxide grinding medium, performing ball milling for 2 hours, and pouring the mixture into a container to stand for 6 hours;
(3) after standing, respectively taking the upper liquid and the precipitate with the thickness of 1mm on the upper layer of the precipitation layer, uniformly mixing, and drying in a microwave oven to obtain a powdery rubidium raw material; the content of active rubidium oxide in the powder is 0.29% by weight through detection, and the powder can be used for preparing medicines containing rubidium.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the present specification and directly/indirectly applied to other related technical fields within the spirit of the present invention are included in the scope of the present invention.
Claims (3)
1. A preparation method of active rubidium raw material for medicines is characterized by comprising the following steps:
(1) selecting minerals rich in rubidium, cleaning, drying, crushing, and preparing into mineral powder with the particle size of 10-1000 mu m;
(2) putting the granulated mineral powder into a ball milling tank, adding a zirconium oxide grinding medium which is 1-20 times of the weight of the mineral powder, adding purified water which is 1-100 times of the weight of the mineral powder, performing ball milling for 1-5 hours, and pouring the mixture into a container to stand for 2-10 hours;
(3) standing, respectively taking the upper liquid and the precipitate with the thickness of 0.1-2mm on the upper layer of the precipitation layer, uniformly mixing, and drying in a microwave oven to obtain a powdery rubidium raw material;
the content of active rubidium oxide in the powder is detected to be more than 0.2 percent by weight, and the powder can be used for preparing medicines containing rubidium, namely active rubidium raw materials for medicines.
2. The method for producing active rubidium raw material for medicine as claimed in claim 1, wherein:
and (2) putting the granulated mineral powder into a ball milling tank, adding a zirconium oxide grinding medium accounting for 1.5 times of the weight of the mineral powder, adding purified water accounting for 2 times of the weight of the mineral powder, performing ball milling for 2 hours, and pouring the mixture into a container to stand for 6 hours.
3. Active rubidium raw material for medicine prepared by the preparation method according to one of claims 1-2.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010737509.XA CN111747429A (en) | 2020-07-28 | 2020-07-28 | Active rubidium raw material for medicine and preparation method thereof |
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| CN202010737509.XA CN111747429A (en) | 2020-07-28 | 2020-07-28 | Active rubidium raw material for medicine and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB872509A (en) * | 1956-09-12 | 1961-07-12 | Pfizer Ltd | Improvements in or relating to the preparation of rubidium compounds |
| US20150152033A1 (en) * | 2013-12-03 | 2015-06-04 | Cabot Corporation | Methods To Recover Cesium Formate From A Mixed Alkali Metal Formate Blend |
| CN107267777A (en) * | 2017-06-09 | 2017-10-20 | 北京矿冶研究总院 | Novel method for extracting rubidium from rubidium-containing ore |
| CN108624765A (en) * | 2018-06-14 | 2018-10-09 | 中南大学 | A kind of technique from the low-grade high efficiente callback of tailing containing rubidium rubidium |
| CN110550644A (en) * | 2019-10-08 | 2019-12-10 | 河北铸合集团兴隆县矿业有限公司 | method for separating and extracting battery-grade lithium carbonate, rubidium and cesium salts from lepidolite |
-
2020
- 2020-07-28 CN CN202010737509.XA patent/CN111747429A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB872509A (en) * | 1956-09-12 | 1961-07-12 | Pfizer Ltd | Improvements in or relating to the preparation of rubidium compounds |
| US20150152033A1 (en) * | 2013-12-03 | 2015-06-04 | Cabot Corporation | Methods To Recover Cesium Formate From A Mixed Alkali Metal Formate Blend |
| CN107267777A (en) * | 2017-06-09 | 2017-10-20 | 北京矿冶研究总院 | Novel method for extracting rubidium from rubidium-containing ore |
| CN108624765A (en) * | 2018-06-14 | 2018-10-09 | 中南大学 | A kind of technique from the low-grade high efficiente callback of tailing containing rubidium rubidium |
| CN110550644A (en) * | 2019-10-08 | 2019-12-10 | 河北铸合集团兴隆县矿业有限公司 | method for separating and extracting battery-grade lithium carbonate, rubidium and cesium salts from lepidolite |
Non-Patent Citations (1)
| Title |
|---|
| 顾翼东: "《化学词典》", 30 September 1989, 上海辞书出版社 * |
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